IN2014CN03391A - - Google Patents
Info
- Publication number
- IN2014CN03391A IN2014CN03391A IN3391CHN2014A IN2014CN03391A IN 2014CN03391 A IN2014CN03391 A IN 2014CN03391A IN 3391CHN2014 A IN3391CHN2014 A IN 3391CHN2014A IN 2014CN03391 A IN2014CN03391 A IN 2014CN03391A
- Authority
- IN
- India
- Prior art keywords
- buffer
- aluminum
- phosphate
- adjuvant
- methods
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 229940047712 aluminum hydroxyphosphate Drugs 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000011067 equilibration Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/36—Aluminium phosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161563213P | 2011-11-23 | 2011-11-23 | |
| PCT/US2012/065741 WO2013078102A1 (en) | 2011-11-23 | 2012-11-19 | Method for preparation of aluminum hydroxyphosphate adjuvant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN03391A true IN2014CN03391A (cg-RX-API-DMAC7.html) | 2015-07-03 |
Family
ID=48470220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3391CHN2014 IN2014CN03391A (cg-RX-API-DMAC7.html) | 2011-11-23 | 2012-11-19 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9573811B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2782594B1 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102032002B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2729111T3 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2014CN03391A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013078102A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202100130T1 (it) * | 2015-06-12 | 2021-05-07 | Biological E Ltd | Metodo per la preparazione di gel di fosfato di alluminio per applicazione in formulazioni vaccinali |
| US20190314486A1 (en) | 2016-10-21 | 2019-10-17 | Merck Sharp & Dohme Corp. | Influenza hemagglutinin protein vaccines |
| JP2021501144A (ja) * | 2017-10-25 | 2021-01-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アジュバントワクチン |
| US11566051B2 (en) | 2018-01-29 | 2023-01-31 | Merck Sharp & Dohme Llc | Stabilized RSV F proteins and uses thereof |
| EP3556728A1 (en) * | 2018-04-16 | 2019-10-23 | Croda Denmark A/S | Organically modified mineral micro-particles, methods of preparing the same and uses thereof |
| JP6677428B1 (ja) * | 2018-05-23 | 2020-04-08 | 一般財団法人阪大微生物病研究会 | リン酸アルミニウム化合物 |
| WO2020081933A1 (en) * | 2018-10-19 | 2020-04-23 | Translate Bio, Inc. | Pumpless encapsulation of messenger rna |
| CN111803627B (zh) | 2019-04-11 | 2023-01-03 | 厦门万泰沧海生物技术有限公司 | 唑来膦酸锌微纳米颗粒佐剂的制备及作为疫苗佐剂的用途 |
| US12419951B2 (en) | 2019-05-30 | 2025-09-23 | Xiamen University | Preparation of zinc risedronate micro/nano adjuvant and use thereof as vaccine adjuvant |
| CN113666404B (zh) * | 2021-09-23 | 2023-07-28 | 北京智飞绿竹生物制药有限公司 | 一种适合规模化生产的高浓度纳米级氢氧化铝佐剂配制方法 |
| KR20230047827A (ko) * | 2021-10-01 | 2023-04-10 | 에스케이바이오사이언스(주) | 향상된 효능을 갖는 알루미늄계 애주번트를 제조하는 방법 |
| KR20240147612A (ko) * | 2023-03-31 | 2024-10-08 | 에스케이바이오사이언스(주) | 향상된 효능을 갖는 알루미늄계 애주번트를 제조하는 방법 |
| US20240376157A1 (en) | 2023-05-08 | 2024-11-14 | Merck Sharp & Dohme Llc | Polynucleotides encoding norovirus vp1 antigens and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4016252A (en) | 1972-04-06 | 1977-04-05 | Institut Pasteur | Calcium phosphate gel for adsorbing vaccines |
| FR2181426B1 (cg-RX-API-DMAC7.html) | 1972-04-06 | 1974-12-20 | Pasteur Institut | |
| US8540955B2 (en) * | 2007-07-10 | 2013-09-24 | Wyeth Llc | Process for producing aluminum phosphate |
| EP2430040A1 (en) | 2009-05-11 | 2012-03-21 | Novartis AG | Antigen purification process for pertactin antigen |
| TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
-
2012
- 2012-11-19 IN IN3391CHN2014 patent/IN2014CN03391A/en unknown
- 2012-11-19 EP EP12851733.1A patent/EP2782594B1/en active Active
- 2012-11-19 US US14/359,840 patent/US9573811B2/en active Active
- 2012-11-19 ES ES12851733T patent/ES2729111T3/es active Active
- 2012-11-19 KR KR1020147016728A patent/KR102032002B1/ko active Active
- 2012-11-19 WO PCT/US2012/065741 patent/WO2013078102A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2729111T3 (es) | 2019-10-30 |
| US9573811B2 (en) | 2017-02-21 |
| KR20140100530A (ko) | 2014-08-14 |
| KR102032002B1 (ko) | 2019-10-14 |
| WO2013078102A1 (en) | 2013-05-30 |
| US20140314653A1 (en) | 2014-10-23 |
| EP2782594A1 (en) | 2014-10-01 |
| EP2782594B1 (en) | 2019-04-17 |
| EP2782594A4 (en) | 2015-07-29 |
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