GR1007638B - Μεθοδος για την παρασκευη αλατος του 3-(ν-μεθυλ-ν-πεντυλ) αμινο-1-υδροξυπροπανιο-1,1-διφωσφονικου οξεος ή παραγωγων αυτου - Google Patents

Μεθοδος για την παρασκευη αλατος του 3-(ν-μεθυλ-ν-πεντυλ) αμινο-1-υδροξυπροπανιο-1,1-διφωσφονικου οξεος ή παραγωγων αυτου

Info

Publication number
GR1007638B
GR1007638B GR20110100398A GR20110100398A GR1007638B GR 1007638 B GR1007638 B GR 1007638B GR 20110100398 A GR20110100398 A GR 20110100398A GR 20110100398 A GR20110100398 A GR 20110100398A GR 1007638 B GR1007638 B GR 1007638B
Authority
GR
Greece
Prior art keywords
hydroxypropane
pentyl
derivatives
amino
methyl
Prior art date
Application number
GR20110100398A
Other languages
English (en)
Other versions
GR20110100398A (el
Inventor
Θεοχαρης Βασιλειου Κοφτης
Αριστοτελης Κυριακου Μενησιου
Rohit - Ravikant Bapulal Soni
Original Assignee
Φαρματεν Αβεε,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Φαρματεν Αβεε, filed Critical Φαρματεν Αβεε,
Publication of GR20110100398A publication Critical patent/GR20110100398A/el
Publication of GR1007638B publication Critical patent/GR1007638B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε μια βελτιωμένη μέθοδο παρασκευής 3-(Ν-μεθυλο-Ν-πεντυλο)αμινο-1-υδροξυπροπανιο-1,1-διφωσφονικού οξέος, μονονάτριο άλας, ή των παραγώγων αυτού σε ουσιαστικά καθαρή κρυσταλλική μορφή.
GR20110100398A 2010-07-14 2011-07-07 Μεθοδος για την παρασκευη αλατος του 3-(ν-μεθυλ-ν-πεντυλ) αμινο-1-υδροξυπροπανιο-1,1-διφωσφονικου οξεος ή παραγωγων αυτου GR1007638B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2010/004269 WO2012007021A1 (en) 2010-07-14 2010-07-14 Process for the preparation of 3-(n-methyl-n-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid salt or derivatives thereof

Publications (2)

Publication Number Publication Date
GR20110100398A GR20110100398A (el) 2012-03-05
GR1007638B true GR1007638B (el) 2012-07-06

Family

ID=43984040

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20110100398A GR1007638B (el) 2010-07-14 2011-07-07 Μεθοδος για την παρασκευη αλατος του 3-(ν-μεθυλ-ν-πεντυλ) αμινο-1-υδροξυπροπανιο-1,1-διφωσφονικου οξεος ή παραγωγων αυτου

Country Status (4)

Country Link
EP (1) EP2609101B1 (el)
GR (1) GR1007638B (el)
WO (1) WO2012007021A1 (el)
ZA (1) ZA201105117B (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103030661B (zh) * 2012-11-16 2015-12-02 湖南方盛制药股份有限公司 伊班膦酸钠的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en) 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PL1848727T3 (pl) 2005-02-01 2015-11-30 Hoffmann La Roche Polimorf b ibandronianu
EP1848728B1 (en) 2005-02-01 2014-06-11 F.Hoffmann-La Roche Ag Ibandronate polymorph a
WO2007013097A1 (en) * 2005-07-25 2007-02-01 Natco Pharma Limited Improved process for the preparation of ibandronate sodium
WO2008014510A2 (en) * 2006-07-28 2008-01-31 Dr. Reddy's Laboratories Limited Crystalline form a of ibandronic acid and process for the preparation
WO2009093258A2 (en) 2008-01-24 2009-07-30 Fleming Laboratories Limited A new and improved process for the preparation of ibandronate sodium monohydrate

Also Published As

Publication number Publication date
GR20110100398A (el) 2012-03-05
ZA201105117B (en) 2012-03-28
EP2609101B1 (en) 2015-01-28
WO2012007021A1 (en) 2012-01-19
EP2609101A1 (en) 2013-07-03

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PG Patent granted

Effective date: 20120903

ML Lapse due to non-payment of fees

Effective date: 20160202