KR101964195B1 - 금속효소 억제제 화합물 - Google Patents
금속효소 억제제 화합물 Download PDFInfo
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- KR101964195B1 KR101964195B1 KR1020147001615A KR20147001615A KR101964195B1 KR 101964195 B1 KR101964195 B1 KR 101964195B1 KR 1020147001615 A KR1020147001615 A KR 1020147001615A KR 20147001615 A KR20147001615 A KR 20147001615A KR 101964195 B1 KR101964195 B1 KR 101964195B1
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- 0 **=C*CC(C(C1=C*C(c(cc2)ccc2OC(F)(F)F)=C*1)(F)F)(c(c(F)c1)ccc1F)O Chemical compound **=C*CC(C(C1=C*C(c(cc2)ccc2OC(F)(F)F)=C*1)(F)F)(c(c(F)c1)ccc1F)O 0.000 description 2
- IIEUXQCYTHNIMO-UHFFFAOYSA-N CN1N=CN(CC(C(c2nc(Br)c[s]2)(F)F)(c(ccc(F)c2)c2F)O)N1 Chemical compound CN1N=CN(CC(C(c2nc(Br)c[s]2)(F)F)(c(ccc(F)c2)c2F)O)N1 IIEUXQCYTHNIMO-UHFFFAOYSA-N 0.000 description 1
- RYUBZLWHLBOAIJ-UHFFFAOYSA-N OC(C[n]1nnnc1)(C(c(nc1)cnc1-c(cc1)ccc1Br)(F)F)c(ccc(F)c1)c1F Chemical compound OC(C[n]1nnnc1)(C(c(nc1)cnc1-c(cc1)ccc1Br)(F)F)c(ccc(F)c1)c1F RYUBZLWHLBOAIJ-UHFFFAOYSA-N 0.000 description 1
- BSWSAXNDRRRWHT-UHFFFAOYSA-N OC(C[n]1nnnc1)(C(c1nc(cccc2)c2[s]1)(F)F)c(ccc(F)c1)c1F Chemical compound OC(C[n]1nnnc1)(C(c1nc(cccc2)c2[s]1)(F)F)c(ccc(F)c1)c1F BSWSAXNDRRRWHT-UHFFFAOYSA-N 0.000 description 1
- GPLQUAMQMYCLMQ-UHFFFAOYSA-N OC(C[n]1nnnc1)(C(c1nc2ccccc2cc1)(F)F)c(ccc(F)c1)c1F Chemical compound OC(C[n]1nnnc1)(C(c1nc2ccccc2cc1)(F)F)c(ccc(F)c1)c1F GPLQUAMQMYCLMQ-UHFFFAOYSA-N 0.000 description 1
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Applications Claiming Priority (5)
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| US201161500372P | 2011-06-23 | 2011-06-23 | |
| US61/500,372 | 2011-06-23 | ||
| US201261611917P | 2012-03-16 | 2012-03-16 | |
| US61/611,917 | 2012-03-16 | ||
| PCT/US2012/043292 WO2012177725A1 (en) | 2011-06-23 | 2012-06-20 | Metalloenzyme inhibitor compounds |
Publications (2)
| Publication Number | Publication Date |
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| KR20140053970A KR20140053970A (ko) | 2014-05-08 |
| KR101964195B1 true KR101964195B1 (ko) | 2019-04-01 |
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| EP (2) | EP2723730A4 (enExample) |
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| PH (1) | PH12013502622A1 (enExample) |
| UY (1) | UY34156A (enExample) |
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| NZ601085A (en) | 2010-02-01 | 2015-04-24 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| JP6159318B2 (ja) * | 2011-06-19 | 2017-07-05 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 金属酵素阻害化合物 |
| WO2012177728A1 (en) * | 2011-06-23 | 2012-12-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| SI2788343T1 (sl) | 2011-12-11 | 2019-09-30 | Viamet Pharmaceuticals (NC), Inc. | Spojine inhibitorja metaloencimov |
| EA026209B1 (ru) | 2012-01-20 | 2017-03-31 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| US9414596B2 (en) * | 2012-01-20 | 2016-08-16 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| WO2013135674A1 (en) * | 2012-03-12 | 2013-09-19 | Syngenta Participations Ag | Insecticidal 2-aryl-acetamide compounds |
| US9655363B2 (en) * | 2013-02-04 | 2017-05-23 | Syngenta Participations Ag | Microbiocides |
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| CA2909217A1 (en) | 2013-04-12 | 2014-10-16 | Bayer Cropscience Aktiengesellschaft | Novel triazole derivatives |
| US9550752B2 (en) | 2013-04-12 | 2017-01-24 | Bayer Cropscience Aktiengesellschaft | Triazolinthione derivatives |
| US9447073B2 (en) | 2013-05-28 | 2016-09-20 | Viamet Pharmaceuticals, Inc. | Fungicidal compositions |
| KR20160018811A (ko) * | 2013-06-12 | 2016-02-17 | 비아멧 파마슈티컬즈, 인코포레이티드 | 금속 효소 억제 화합물 |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
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| AR099120A1 (es) | 2014-01-20 | 2016-06-29 | Bayer Cropscience Ag | Derivados de quinolina como insecticidas y acaricidas |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| US10399943B2 (en) | 2014-03-19 | 2019-09-03 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| WO2015143192A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| BR112016021257B1 (pt) | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
| EP3119749A4 (en) * | 2014-03-19 | 2017-12-13 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| JP6572234B2 (ja) | 2014-03-19 | 2019-09-04 | ヴィアメット ファーマスーティカルズ(エヌシー),インコーポレイテッド | 抗真菌化合物の調製方法 |
| EP3119771B1 (en) | 2014-03-19 | 2020-05-06 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| MX365494B (es) * | 2014-03-19 | 2019-06-05 | Us Health | Procedimiento de compuesto antifungico. |
| JP2017514790A (ja) * | 2014-03-19 | 2017-06-08 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 抗真菌化合物の調製方法 |
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| JP6623015B2 (ja) * | 2014-09-29 | 2019-12-18 | 国立研究開発法人理化学研究所 | 植物の耐塩性向上剤 |
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| CN104844652A (zh) * | 2015-02-10 | 2015-08-19 | 扬子江药业集团南京海陵药业有限公司 | 艾沙康唑磷酸酯及其制备方法和用途 |
| EP3277674B1 (en) | 2015-04-02 | 2019-09-11 | Bayer CropScience Aktiengesellschaft | Triazol derivatives as fungicides |
| DK3297998T3 (da) | 2015-05-18 | 2020-03-16 | Viamet Pharmaceuticals Nc Inc | Antisvampeforbindelser |
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| EP3376866A4 (en) | 2015-11-17 | 2019-04-10 | Dow Agrosciences LLC | 4 - ((6- (2- (2,4-DIFLUORPHENYL) -1,1-DIFLUOR-2-OXOETHYL) PYRIDIN-3-YL) BENZONITRIL AND METHOD OF PREPARING THEREOF |
| EP3377475A4 (en) | 2015-11-17 | 2019-04-10 | Dow Agrosciences Llc | 4 - ((6-2- (2,4-difluorophenyl) -1,1-difluoro-2-hydroxy-3- (1H-1,2,4-triazol-1-YL) PROPYL) PYRIDINE-3-YL ) OXY) BENZONITRIL AND METHOD OF PREPARING THEREOF |
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| CN106905273B (zh) * | 2017-01-18 | 2019-05-14 | 中山大学 | 4-氧杂-4,5,6,7-四氢苯并[b]呋喃-3-羧酸类化合物及其应用 |
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| WO2020023560A1 (en) | 2018-07-24 | 2020-01-30 | F. Hoffmann-La Roche Ag | Isoquinoline compounds and uses thereof |
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| CN110672753B (zh) * | 2019-11-04 | 2022-05-20 | 青海省农林科学院 | 一种氟咯草酮异构体的拆分和检测方法 |
| GB201916600D0 (en) * | 2019-11-14 | 2020-01-01 | Syngenta Crop Protection Ag | 81991-gb-reg-org-nat-1 |
| GB202001564D0 (en) * | 2020-02-05 | 2020-03-18 | Kings College | Compounds |
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-
2012
- 2012-06-20 WO PCT/US2012/043295 patent/WO2012177728A1/en not_active Ceased
- 2012-06-20 EP EP12801805.8A patent/EP2723730A4/en not_active Withdrawn
- 2012-06-20 WO PCT/US2012/043292 patent/WO2012177725A1/en not_active Ceased
- 2012-06-20 AU AU2012273004A patent/AU2012273004B2/en not_active Ceased
- 2012-06-20 CA CA2838916A patent/CA2838916C/en not_active Expired - Fee Related
- 2012-06-20 EA EA201490052A patent/EA201490052A1/ru unknown
- 2012-06-20 US US13/528,283 patent/US8940735B2/en active Active
- 2012-06-20 IN IN286DEN2014 patent/IN2014DN00286A/en unknown
- 2012-06-20 KR KR1020147001615A patent/KR101964195B1/ko not_active Expired - Fee Related
- 2012-06-20 AU AU2012273007A patent/AU2012273007A1/en not_active Abandoned
- 2012-06-20 MX MX2013015159A patent/MX2013015159A/es unknown
- 2012-06-20 CN CN201811257707.5A patent/CN109400594A/zh active Pending
- 2012-06-20 JP JP2014517112A patent/JP6223329B2/ja not_active Expired - Fee Related
- 2012-06-20 EA EA201490088A patent/EA025266B1/ru not_active IP Right Cessation
- 2012-06-20 CA CA2839883A patent/CA2839883A1/en not_active Abandoned
- 2012-06-20 JP JP2014517113A patent/JP2014523880A/ja active Pending
- 2012-06-20 PH PH1/2013/502622A patent/PH12013502622A1/en unknown
- 2012-06-20 KR KR1020147001619A patent/KR20140039059A/ko not_active Withdrawn
- 2012-06-20 CN CN201280040552.4A patent/CN103930418A/zh active Pending
- 2012-06-20 US US13/528,319 patent/US8883797B2/en active Active
- 2012-06-20 EP EP12802142.5A patent/EP2723731B1/en not_active Not-in-force
- 2012-06-20 CN CN201280040551.XA patent/CN103857675A/zh active Pending
- 2012-06-22 AR ARP120102236A patent/AR094127A1/es not_active Application Discontinuation
- 2012-06-22 UY UY0001034156A patent/UY34156A/es not_active Application Discontinuation
- 2012-06-25 BR BRBR102012015457-9A patent/BR102012015457A2/pt not_active Application Discontinuation
-
2013
- 2013-12-20 CL CL2013003679A patent/CL2013003679A1/es unknown
-
2014
- 2014-01-17 CO CO14008727A patent/CO6930358A2/es not_active Application Discontinuation
- 2014-01-20 EC ECSP14013159 patent/ECSP14013159A/es unknown
-
2016
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Patent Citations (3)
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| EP0548553A1 (en) | 1991-11-25 | 1993-06-30 | Takeda Chemical Industries, Ltd. | Optically active azole compounds, their production and use |
| US6015825A (en) | 1995-06-25 | 2000-01-18 | Pfizer Inc. | Triazole antifungal agents |
| WO2008064311A2 (en) * | 2006-11-21 | 2008-05-29 | Viamet Pharmaceuticals, Inc. | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties |
Non-Patent Citations (1)
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| CAS Registry Number: 959334-94-2* |
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