KR101950717B1 - 유방암 환자의 화학치료 유용성 예측 방법 - Google Patents

유방암 환자의 화학치료 유용성 예측 방법 Download PDF

Info

Publication number
KR101950717B1
KR101950717B1 KR1020160156824A KR20160156824A KR101950717B1 KR 101950717 B1 KR101950717 B1 KR 101950717B1 KR 1020160156824 A KR1020160156824 A KR 1020160156824A KR 20160156824 A KR20160156824 A KR 20160156824A KR 101950717 B1 KR101950717 B1 KR 101950717B1
Authority
KR
South Korea
Prior art keywords
breast cancer
chemotherapy
gene
usefulness
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020160156824A
Other languages
English (en)
Korean (ko)
Other versions
KR20180058118A (ko
Inventor
조상래
문영호
한진일
신영기
Original Assignee
주식회사 젠큐릭스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020160156824A priority Critical patent/KR101950717B1/ko
Application filed by 주식회사 젠큐릭스 filed Critical 주식회사 젠큐릭스
Priority to CN201780072701.8A priority patent/CN110023512A/zh
Priority to JP2019527430A priority patent/JP2019535286A/ja
Priority to ES17874597T priority patent/ES2963390T3/es
Priority to PCT/KR2017/013404 priority patent/WO2018097614A2/ko
Priority to CN202310347279.XA priority patent/CN116377075A/zh
Priority to EP17874597.2A priority patent/EP3524690B1/en
Priority to US15/938,331 priority patent/US10718030B2/en
Publication of KR20180058118A publication Critical patent/KR20180058118A/ko
Application granted granted Critical
Publication of KR101950717B1 publication Critical patent/KR101950717B1/ko
Priority to JP2022106805A priority patent/JP7430415B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020160156824A 2016-11-23 2016-11-23 유방암 환자의 화학치료 유용성 예측 방법 Active KR101950717B1 (ko)

Priority Applications (9)

Application Number Priority Date Filing Date Title
KR1020160156824A KR101950717B1 (ko) 2016-11-23 2016-11-23 유방암 환자의 화학치료 유용성 예측 방법
JP2019527430A JP2019535286A (ja) 2016-11-23 2017-11-23 乳がん患者の化学治療の有用性を予測する方法
ES17874597T ES2963390T3 (es) 2016-11-23 2017-11-23 Método para predecir la eficacia de la quimioterapia en pacientes con cáncer de mama
PCT/KR2017/013404 WO2018097614A2 (ko) 2016-11-23 2017-11-23 유방암 환자의 화학치료 유용성 예측 방법
CN201780072701.8A CN110023512A (zh) 2016-11-23 2017-11-23 用于预测乳腺癌患者的化疗有效性的方法
CN202310347279.XA CN116377075A (zh) 2016-11-23 2017-11-23 用于预测乳腺癌患者的化疗有效性的方法
EP17874597.2A EP3524690B1 (en) 2016-11-23 2017-11-23 Method for predicting effectiveness of chemotherapy in breast cancer patients
US15/938,331 US10718030B2 (en) 2016-11-23 2018-03-28 Methods for predicting effectiveness of chemotherapy for a breast cancer patient
JP2022106805A JP7430415B2 (ja) 2016-11-23 2022-07-01 乳がん患者の化学治療の有用性を予測する方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160156824A KR101950717B1 (ko) 2016-11-23 2016-11-23 유방암 환자의 화학치료 유용성 예측 방법

Publications (2)

Publication Number Publication Date
KR20180058118A KR20180058118A (ko) 2018-05-31
KR101950717B1 true KR101950717B1 (ko) 2019-02-21

Family

ID=62196020

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020160156824A Active KR101950717B1 (ko) 2016-11-23 2016-11-23 유방암 환자의 화학치료 유용성 예측 방법

Country Status (7)

Country Link
US (1) US10718030B2 (https=)
EP (1) EP3524690B1 (https=)
JP (2) JP2019535286A (https=)
KR (1) KR101950717B1 (https=)
CN (2) CN116377075A (https=)
ES (1) ES2963390T3 (https=)
WO (1) WO2018097614A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101950717B1 (ko) * 2016-11-23 2019-02-21 주식회사 젠큐릭스 유방암 환자의 화학치료 유용성 예측 방법
KR102221206B1 (ko) * 2019-03-08 2021-03-02 서울대학교산학협력단 유방암 샘플에서 질량분석법 의한 her2 정량 방법 및 이를 이용한 her2 상태 스코어링
US20220221460A1 (en) * 2019-03-08 2022-07-14 Seoul National University R&Db Foundation Method of quantifying her2 in breast cancer sample by mass spectrometry and scoring her2 status using the same
CN111118146B (zh) * 2020-02-10 2020-08-25 山东大学齐鲁医院(青岛) LncRNA在乳腺癌化疗相关心肌损伤患者诊断中的应用
KR102490338B1 (ko) * 2020-03-24 2023-01-19 (의료)길의료재단 질병의 치료 및 예방을 위한 신약 타겟 유전자 예측 방법
KR102422610B1 (ko) * 2020-05-12 2022-07-18 서울대학교 산학협력단 초기 유방암 환자의 예후 예측 방법
US20240060138A1 (en) * 2022-02-25 2024-02-22 The Regents Of The University Of California Breast cancer-response prediction subtypes
JP7446376B1 (ja) 2022-09-06 2024-03-08 株式会社キャタラー パティキュレートフィルタ

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2374311T3 (es) * 2002-03-13 2012-02-15 Genomic Health, Inc. Obtención de perfil de expresión génica en tejidos tumorales biopsiados.
CA2624086A1 (en) * 2005-09-28 2007-04-05 H. Lee Moffitt Cancer Center Individualized cancer treatments
WO2007070621A2 (en) * 2005-12-13 2007-06-21 Children's Medical Center Corporation Prognosis indicators for solid human tumors
US20090311700A1 (en) * 2006-09-27 2009-12-17 Siemens Healthcare Diagnositcs Inc. Methods for Breast Cancer Prognosis
ES2338843B1 (es) * 2008-07-02 2011-01-24 Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas Huella genomica de cancer de mama.
WO2011122857A2 (ko) * 2010-03-30 2011-10-06 서울대학교 산학협력단 유방암 예후 예측을 위한 조성물 및 이를 포함하는 키트
EP2845911B1 (en) * 2010-03-31 2016-05-18 Sividon Diagnostics GmbH Method for breast cancer recurrence prediction under endocrine treatment
KR101287600B1 (ko) * 2011-01-04 2013-07-18 주식회사 젠큐릭스 초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법
WO2013071247A1 (en) * 2011-11-10 2013-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Gene expression signatures of neoplasm responsiveness to theraphy
CA2874492C (en) * 2012-05-22 2021-10-19 British Columbia Cancer Agency Branch Nano46 genes and methods to predict breast cancer outcome
KR101725985B1 (ko) * 2013-01-28 2017-04-13 주식회사 젠큐릭스 초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법
KR101672531B1 (ko) * 2013-04-18 2016-11-17 주식회사 젠큐릭스 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도
KR101748867B1 (ko) 2013-04-19 2017-06-20 주식회사 젠큐릭스 조기 유방암 예후 예측 진단용 자동화 시스템
KR101632628B1 (ko) * 2014-03-31 2016-06-23 제이더블유중외제약 주식회사 유방암 재발 또는 전이 억제용 제제의 스크리닝 방법
US10174382B2 (en) * 2015-05-13 2019-01-08 University Of Notre Dame Breast cancer prognostication and screening kits and methods of using same
KR101950717B1 (ko) * 2016-11-23 2019-02-21 주식회사 젠큐릭스 유방암 환자의 화학치료 유용성 예측 방법
KR101896545B1 (ko) * 2016-11-25 2018-09-07 주식회사 젠큐릭스 유방암 환자의 예후 예측 방법

Also Published As

Publication number Publication date
KR20180058118A (ko) 2018-05-31
CN110023512A (zh) 2019-07-16
JP2022141708A (ja) 2022-09-29
CN116377075A (zh) 2023-07-04
WO2018097614A2 (ko) 2018-05-31
EP3524690C0 (en) 2023-08-30
EP3524690B1 (en) 2023-08-30
ES2963390T3 (es) 2024-03-26
US10718030B2 (en) 2020-07-21
WO2018097614A3 (ko) 2018-08-09
JP2019535286A (ja) 2019-12-12
JP7430415B2 (ja) 2024-02-13
EP3524690A4 (en) 2020-06-17
US20180216198A1 (en) 2018-08-02
EP3524690A2 (en) 2019-08-14

Similar Documents

Publication Publication Date Title
KR101896545B1 (ko) 유방암 환자의 예후 예측 방법
KR101950717B1 (ko) 유방암 환자의 화학치료 유용성 예측 방법
KR101530689B1 (ko) 직장결장암용 예후 예측
JP6246845B2 (ja) 遺伝子発現を用いた前立腺癌の予後を定量化する方法
JP6351112B2 (ja) 前立腺癌の予後を定量化するための遺伝子発現プロフィールアルゴリズムおよび試験
AU2020204502B2 (en) Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer
US8030060B2 (en) Gene signature for diagnosis and prognosis of breast cancer and ovarian cancer
KR101672531B1 (ko) 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도
CN113444804B (zh) 宫颈癌预后相关基因及其在制备宫颈癌预后预测诊断产品中的应用
US11840733B2 (en) Method for predicting prognosis of breast cancer patient
WO2014171800A1 (ko) 조기 유방암 예후 예측 진단용 자동화 시스템
CN118291620A (zh) 乳腺癌复发相关mRNA组合物及其在制备复发性乳腺癌预后诊断产品中的应用
KR101504818B1 (ko) 위암에 대한 예후 예측 시스템
NZ711680B2 (en) Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer
NZ752676B2 (en) Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PX0901 Re-examination

St.27 status event code: A-2-3-E10-E12-rex-PX0901

PX0701 Decision of registration after re-examination

St.27 status event code: A-3-4-F10-F13-rex-PX0701

X701 Decision to grant (after re-examination)
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 7