KR101941724B1 - 계통발생군 1과 계통발생군 2의 인플루엔자 a형 바이러스 및 인플루엔자 b형 바이러스를 중화시킬 수 있는 인간 결합분자 - Google Patents

계통발생군 1과 계통발생군 2의 인플루엔자 a형 바이러스 및 인플루엔자 b형 바이러스를 중화시킬 수 있는 인간 결합분자 Download PDF

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KR101941724B1
KR101941724B1 KR1020137035132A KR20137035132A KR101941724B1 KR 101941724 B1 KR101941724 B1 KR 101941724B1 KR 1020137035132 A KR1020137035132 A KR 1020137035132A KR 20137035132 A KR20137035132 A KR 20137035132A KR 101941724 B1 KR101941724 B1 KR 101941724B1
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테오도루스 헨드리쿠스 자코부스 곽스
다비드 에이.티.엠. 주이즈게스트
로날드 보겔스
로버트 하인즈 에드워드 프리젠
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얀센 백신스 앤드 프리벤션 비.브이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C12N15/09—Recombinant DNA-technology
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

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KR1020137035132A 2011-07-14 2012-07-12 계통발생군 1과 계통발생군 2의 인플루엔자 a형 바이러스 및 인플루엔자 b형 바이러스를 중화시킬 수 있는 인간 결합분자 Active KR101941724B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161572417P 2011-07-14 2011-07-14
US61/572,417 2011-07-14
EP11173953 2011-07-14
EP11173953.8 2011-07-14
PCT/EP2012/063637 WO2013007770A1 (en) 2011-07-14 2012-07-12 Human binding molecules capable of neutralizing influenza a viruses of phylogenetic group 1 and phylogenetic group 2 and influenza b viruses

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KR20140095017A KR20140095017A (ko) 2014-07-31
KR101941724B1 true KR101941724B1 (ko) 2019-01-23

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US (2) US8961978B2 (https=)
EP (1) EP2731967B1 (https=)
JP (1) JP5683752B2 (https=)
KR (1) KR101941724B1 (https=)
CN (1) CN103906763B (https=)
AU (1) AU2012282504B2 (https=)
BR (1) BR112014000263B1 (https=)
CA (1) CA2838999C (https=)
DK (1) DK2731967T3 (https=)
EA (1) EA027054B1 (https=)
ES (1) ES2608321T3 (https=)
HR (1) HRP20161740T1 (https=)
IL (1) IL230222A (https=)
IN (1) IN2014CN00953A (https=)
MX (1) MX346206B (https=)
MY (1) MY166282A (https=)
PH (1) PH12013502479A1 (https=)
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Publication number Publication date
EA027054B1 (ru) 2017-06-30
KR20140095017A (ko) 2014-07-31
MY166282A (en) 2018-06-25
US9593159B2 (en) 2017-03-14
WO2013007770A1 (en) 2013-01-17
CN103906763A (zh) 2014-07-02
US20150274811A1 (en) 2015-10-01
CA2838999A1 (en) 2013-01-17
JP5683752B2 (ja) 2015-03-11
BR112014000263A2 (pt) 2017-02-14
AU2012282504B2 (en) 2017-07-20
MX346206B (es) 2017-03-09
DK2731967T3 (en) 2017-01-16
EP2731967B1 (en) 2016-10-12
EP2731967A1 (en) 2014-05-21
ES2608321T3 (es) 2017-04-07
MX2014000373A (es) 2014-03-31
EA201490288A1 (ru) 2014-05-30
CA2838999C (en) 2021-02-16
CN103906763B (zh) 2016-10-12
US8961978B2 (en) 2015-02-24
BR112014000263B1 (pt) 2022-01-18
AU2012282504A1 (en) 2014-02-06
PH12013502479A1 (en) 2014-01-20
HRP20161740T1 (hr) 2017-02-10
JP2014527403A (ja) 2014-10-16
IL230222A (en) 2017-09-28
IN2014CN00953A (https=) 2015-04-10
US20140120113A1 (en) 2014-05-01
NZ618530A (en) 2016-05-27

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