KR101926439B1 - Composition for Improving Skin Hydration Using Monosaccharide - Google Patents
Composition for Improving Skin Hydration Using Monosaccharide Download PDFInfo
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- KR101926439B1 KR101926439B1 KR1020160036333A KR20160036333A KR101926439B1 KR 101926439 B1 KR101926439 B1 KR 101926439B1 KR 1020160036333 A KR1020160036333 A KR 1020160036333A KR 20160036333 A KR20160036333 A KR 20160036333A KR 101926439 B1 KR101926439 B1 KR 101926439B1
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- acetylgalactosamine
- galactose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a composition for skin moisturizing, and more particularly, to a composition for skin moisturizing, which comprises at least one monosaccharide selected from the group consisting of glucose and N-acetylgalactosamine, and is selected from the group consisting of galactose, fucose and N-acetylglucosamine The present invention relates to a cosmetic composition for skin moisturizing and a pharmaceutical composition which can further contain one or more selected monosaccharides. The composition of the present invention is useful for the development of a cosmetic composition or a pharmaceutical composition capable of improving dry skin through moisturizing the skin by rapidly increasing the moisture of the skin through one application to normal skin and diseased skin Can be used.
Description
The present invention relates to a composition for improving skin moisturizing, and more particularly, to a cosmetic composition or a pharmaceutical composition capable of improving dry skin symptoms through moisturizing by applying water to normal and diseased skin to increase water content.
The moisture content of the skin is one of the important indicators of the physiological state of the skin. The higher the moisture content, the healthier and moisturized skin, and the lower the moisture content, the more dry and damaged the skin. Generally, the moisture content of the skin is determined by measuring the moisture content of the skin surface by an electric method using a corneometer and the evaporation amount per unit time (transdermal water loss) of the moisture on the skin surface depending on the state of the barrier function, Can be quantitatively assessed by measuring the transdermal water loss using a transdermal water loss tester (Tewameter). It is evaluated that as the water level increases, the transdermal water loss decreases as the value decreases.
Molecular mechanisms affecting water permeability and transdermal water loss are diverse and different from each other. Therefore, two factors should be controlled basically. However, the two factors are related to each other, and thus they may be indirectly influenced. The most commonly used moisturizing agents, such as ceramides, supplement the barrier of the skin to prevent the loss of transdermal water, while the moisturizing effect is enhanced by the addition of lipid. However, the mechanism to increase the natural moisturizing factor is to increase the moisture content It can be said that the moisturizing effect is produced through the mechanism.
However, since it is not difficult to directly measure the moisturizing effect through the application of human body, it is possible to increase the water content by the human body application test of the natural product extract or the lipid component, You can screen for components that reduce or repair loss.
On the other hand, as a substance for increasing skin moisture, jasmine, arnica and Yarrow extract are used (patent document 1), aloe vera and marshmallow extract are used (patent document 2) There have been attempts to use various kinds of natural materials such as a combination herbal extract using licorice, licorice, orchid, etc. (Patent Document 3), or using red ginseng oil or red ginseng butter (Patent Document 4 and Patent Document 5). However, there are many prior studies using the natural extracts themselves, but the natural extracts themselves have limitations in maintaining the moisturizing degree, and there are few studies on the skin moisturizing effect using the saccharide ingredients.
Therefore, the inventors of the present invention have found that when a single concentration of glucose or N-acetylgalactosamine is used alone, or when a mixture of five monosaccharides containing galactose, fucose and N-acetylglucosamine is additionally applied, And the effect of increasing the water content is obtained.
Disclosed herein is a composition for improving skin moisturization, which provides a composition which is safe for humans and exhibits a superior skin moisturizing degree, and which increases the water content when the monosaccharide is applied alone or in combination to human skin. do.
In order to achieve the above object, the present invention provides a skin moisturizing composition containing at least one monosaccharide selected from the group consisting of glucose and N-acetylgalactosamine. According to a preferred embodiment of the present invention, the skin moisturizing composition of the present invention is preferably in the form of a cosmetic composition or a pharmaceutical composition, but is not limited thereto.
According to one embodiment of the present invention, the composition of the present invention may further contain at least one monosaccharide selected from the group consisting of galactose, fucose, and N-acetylglucosamine, in addition to glucose and / or N-acetylgalactosamine But is not limited thereto.
According to another embodiment of the present invention, the composition of the present invention may contain, but is not limited to, a mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine. According to a preferred embodiment of the present invention, the mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine is glucose: N-acetylgalactosamine: galactose: fucose: N-acetylglucosamine- 1: 0.5 to 2: 0.5 to 2: 0.5 to 2: 0.5 to 2, but the present invention is not limited thereto.
According to one embodiment of the present invention, the glucose may be contained in an amount of 2 to 10% by weight of the whole composition, but is not limited thereto.
According to another embodiment of the present invention, the N-acetyl galactose may be contained in an amount of 0.001 to 10% by weight, but not limited thereto.
According to another embodiment of the present invention, the mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine may be contained in an amount of 0.001 to 10 wt% no.
According to one embodiment of the present invention, the composition may have an external preparation for skin, which may be a softening agent, a nutritional lotion, a massage cream, a nutritional cream, a pack, a gel, a lotion, an ointment, a gel, a cream, But is not limited thereto.
According to one embodiment of the present invention, the composition can be used for skin moisturization in diseases associated with a decrease in skin moisture. According to a preferred embodiment of the present invention, the disease may be selected from the group consisting of dry skin, eczema, psoriasis, atopic dermatitis, asthma and pemphigus, but is not limited thereto.
According to one embodiment of the present invention, the composition may be in the form of a parenteral dosage form selected from the group consisting of solid, semisolid and liquid phases, but is not limited thereto.
The composition of the present invention is useful for the development of a cosmetic composition or a pharmaceutical composition capable of improving dry skin through moisturizing the skin by rapidly increasing the moisture of the skin through one application to normal skin and diseased skin Can be used.
FIG. 1 is a graph showing the effect of increasing the water content of a mixture (5-Mix) of N-acetyl galactose, glucose, and five monosaccharides such as glucose, galactose, fucose, N-acetylglucosamine and N-acetylgalactosamine.
In order to achieve the above object, the present invention provides a skin moisturizing composition containing at least one monosaccharide selected from the group consisting of glucose and N-acetylgalactosamine.
According to one embodiment of the present invention, the composition of the present invention further comprises, as a monosaccharide, at least one monosaccharide selected from the group consisting of galactose, fucose and N-acetylglucosamine in addition to glucose and / can do. According to a preferred embodiment of the present invention, a mixture of five monosaccharides of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine (hereinafter referred to as "5-Mix" Is used.
According to one embodiment of the present invention, the 5-Mix may be selected from the group consisting of glucose: N-acetylgalactosamine: galactose: fucose: N-acetylglucosamine = 1: 0.5-2: 0.5-2: 0.5-2: 2, and it is more preferable that they are mixed at a weight ratio of 1: 1: 1: 1: 1, but the ratio of each component constituting the mixture may be somewhat different from the above.
In the present invention, the monosaccharide contained in the composition of the present invention may be produced by any one of the methods well known in the art, or may be readily available commercially.
According to one embodiment of the present invention, the glucose is preferably contained in an amount of 2 to 10% by weight, preferably 3 to 8% by weight, more preferably 4 to 6% by weight in the whole composition. According to another embodiment of the present invention, the N-acetyl galactose is contained in an amount of 0.001 to 10% by weight, preferably 0.005 to 8% by weight, more preferably 0.01 to 5% by weight in the whole composition . According to another embodiment of the present invention, a mixture (5-Mix) of the five monosaccharides of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine is added in an amount of 0.001 to 10% By weight, preferably 0.005 to 8% by weight, more preferably 0.01 to 5% by weight. If the monosaccharide components contained in the composition of the present invention are present below the lower limit value, the skin moisturizing effect is insignificant. If the monosaccharide component is present in excess of the upper limit value, not only the miscibility with other components and the stability of formulation are deteriorated, There is a problem that is not economical.
In the present invention, improvement of skin moisture can be applied to normal skin and diseased skin, and when applied to skin of a disease, it may be helpful in relieving, alleviating, and treating symptoms of the disease. According to one embodiment of the present invention, the disease is not limited to any disease which is affected by a reduction in skin moisture or whose skin moisture is reduced as a result of the disease. According to a preferred embodiment of the present invention, the diseases include, but are not limited to, skin dryness, eczema, psoriasis, atopic dermatitis, asthma, pemphigus, etc., Any diseases that cause discomfort such as pulling, itching, or feeling of stiffness due to a decrease in skin moisture due to skin can be included in the scope of the diseases of the present invention.
The formulation of the composition of the present invention is not particularly limited, but is preferably a formulation of external preparation for skin. As a preferable form of the composition for external application for skin, softening agent, nutritional lotion, massage cream, nutritional cream, Type cosmetic composition, and other preferred forms include transdermal dosage forms such as lotions, ointments, gels, creams, patches or sprays. Further, in the external preparation for each formulation, components other than the above-mentioned essential components can be mixed and selected without difficulty by those of ordinary skill in the art depending on the formulation or purpose of use of other external preparations.
According to a preferred embodiment of the present invention, the skin moisturizing composition of the present invention is preferably in the form of a cosmetic composition or a pharmaceutical composition, but is not limited thereto.
When the skin moisturizing composition of the present invention is formulated as a cosmetic composition, the ingredients contained in the cosmetic composition of the present invention may contain, in addition to the monosaccharide component as described above as an active ingredient, And may contain conventional adjuvants and carriers such as, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments and flavoring agents.
The cosmetic composition according to the present invention is not particularly limited in its formulation and may be manufactured into any formulation conventionally produced in the art, and examples thereof include softening longevity, nutrition lotion, essence, lotion, A cream, a pack, a gel, an ointment, a patch, a spray, a liniment, a pasta or a plasma. When the formulation is ointment, it is prepared to contain 50.0 to 97.0% by weight of petrolatum and 0.1 to 5.0% by weight of polyoxyethylene oleyl-ether phosphate, in addition to the effective components as described above, 1.0 to 10.0% by weight of polyhydric alcohols such as glycerin, and 0.05 to 2.0% by weight of a surfactant such as polyethylene oleyl ether, polyoxyethylene hardened castor oil and the like. The nutritional lotion and nutritional cream contain 5.0 to 20.0% by weight of an oil such as squalane, vaseline, and octyldodecanol, and 3.0 to 15.0% by weight of a wax component such as cetanol, stearyl alcohol, and wax, and the essence is glycerin, And 5.0 to 30.0% by weight of polyhydric alcohols such as glycols. The massage cream is prepared by adding 30.0 to 70.0% by weight of an oil such as liquid paraffin, petrolatum, isononylisononanoate, etc. in addition to the active ingredient, and the pack is peel off containing 5.0 to 20.0% by weight of polyvinyl alcohol, A pack or a general emulsion type cosmetic can be produced with a wash off pack containing 5.0 to 30.0% by weight of pigment such as kaolin, talc, zinc oxide, titanium dioxide and the like.
According to one embodiment of the present invention, when the composition of the present invention is applied to cosmetics, it preferably contains a cosmetically acceptable medium or base. It may be in any form suitable for topical application, for example as a solution, a gel, a solid or a paste anhydrous product, an emulsion obtained by dispersing an oil phase in water, a suspension, a microemulsion, a microcapsule, a microgranule or an ionic form (liposome) and / In the form of a non-ionic follicle dispersing agent, or in the form of creams, skins, lotions, powders, ointments, sprays or conical sticks. It can also be prepared in the form of a foam or an aerosol composition further containing a compressed propellant. In addition, the cosmetic composition according to the present invention can be prepared in the form of adjuvants which can be applied locally or systemically, which are conventionally used in the field of dermatology by containing dermatologically acceptable mediums or bases, , ≪ / RTI >
When the composition of the present invention is applied to cosmetics, the cosmetic composition may contain at least one selected from the group consisting of fatty substances, organic solvents, solubilizers, thickening and gelling agents, softening agents, antioxidants, suspending agents, stabilizers, foaming agents, As used herein means any emulsion or emulsion which is commonly used in emulsifying or emulsifying agents, fillers, sequestering and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics Adjuvants commonly used in the cosmetics field, such as other ingredients. These adjuvants are introduced in amounts commonly used in the cosmetics field.
According to another preferred embodiment of the present invention, the skin moisturizing composition of the present invention can be prepared in the form of a pharmaceutical composition for moisturizing skin in a disease associated with a decrease in skin moisture.
According to one embodiment of the present invention, when the improvement of the skin moisture is applied to the skin of a disease, it may be helpful in relieving, alleviating, and treating symptoms of the disease. The disease can be, without limitation, any disease which is affected by a decrease in skin moisture or whose skin moisture is reduced as a result of the disease. According to a preferred embodiment of the present invention, the diseases include, but are not limited to, skin dryness, eczema, psoriasis, atopic dermatitis, asthma, pemphigus, etc., Any disorder that causes discomfort such as pulling, itching, or feeling of stiffness due to a decrease in skin moisture due to skin irritation may be included in the range of diseases to be treated with the composition of the present invention.
The administration route of the pharmaceutical composition according to the present invention includes oral, intravenous, intramuscular, intraarterial, transdermal, subcutaneous, intraperitoneal, intranasal, intestinal, topical, sublingual or rectal administration, and parenteral administration is also selected , And more preferably by a topical application by application. The parenteral route includes subcutaneous, intradermal, intravenous, intramuscular, intralesional injection or infusion techniques. Examples of the preparation for parenteral administration include, but are not limited to, topical injection preparations, ointments, lotions, sprays, suspensions, and the like. According to one embodiment of the present invention, the pharmaceutical composition may be in the form of a parenteral dosage form selected from the group consisting of solid, semisolid and liquid phases, but is not limited thereto.
The pharmaceutical composition of the present invention may contain one or more components which exhibit the same or similar functions in addition to the above-mentioned active ingredients. The compositions may be formulated in the form of powders, granules, tablets, capsules, oral preparations such as suspensions, emulsions and syrups, external preparations, suppositories, and sterile injection solutions according to conventional methods known in the art have.
Solid form preparations for oral administration include powders, granules, tablets, hard capsules, soft capsules, loaves and the like. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . As the agent for parenteral administration, the external preparation such as powders, granules, tablets, capsules, sterilized aqueous solutions, liquid preparations, non-aqueous solutions, suspensions, emulsions, syrups, suppositories and aerosols, The composition may be formulated in the form of a cream, a gel, a patch, a spray, an ointment, a warning agent, a lotion, a liniment, a pasta or a cataplasma, But is not limited thereto. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.
The pharmaceutical compositions may additionally contain preservatives, stabilizers, wettable or emulsifying accelerators, adjuvants such as salts and / or buffers for the control of osmotic pressure, and other therapeutically useful substances, Or can be formulated according to the coating method. The pharmaceutical composition according to the present invention may be variously varied depending on various factors including the age, body weight, general health, sex, administration time, route of administration, rate of excretion, drug combination and severity of a specific disease.
A suitable dosage of the pharmaceutical composition of the present invention may vary depending on such factors as formulation method, administration method, age, body weight, sex, pathological condition, food, administration time, route of administration, excretion rate, . Dosage determinations based on these factors are within the level of ordinary skill in the art and may be applied at the level of ordinary skill in the art, such as topical application to topical sites for agents other than injectables, Injections can be injected topically to the dermis and subcutaneous fat, but not always limited thereto. Generally, the dosage of the pharmaceutical composition according to the present invention is in the range of about 0.001 mg / kg / day to 2,000 mg / kg / day. A more preferable dosage is 1 占 퐂 / kg / day to 100 占 퐂 / kg / day. Dosage units may contain, for example, 1, 2, 3 or 4 times, or 1/2, 1/3 or 1/4 times the individual dosage. The individual dosages contain amounts of the active ingredient administered in a single dose, which usually corresponds to the full, half, one-third, or one-fourth of the daily dose.
The pharmaceutical composition according to the present invention can be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy and biological response modifiers.
According to another preferred embodiment of the present invention, the skin moisturizing composition of the present invention may be prepared in the form of a health food.
The content of the monosaccharide, which is an active ingredient contained in the above-mentioned health food, can be appropriately determined according to the purpose of use. In addition, when the composition of the present invention is prepared as a health food, it may contain components that are ordinarily added in food production, and may include, for example, proteins, carbohydrates, fats, nutrients, flavoring agents, and flavoring agents . Examples of such carbohydrates are monosaccharides, such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And polysaccharides such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol, and erythritol. As the flavor, natural flavoring agents such as tautatin, stevia extract and synthetic flavor can be used. For example, when the health food of the present invention is prepared as a drink, it may further contain citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, juice, natural extract,
There is no particular limitation on the kind of the health food. Examples of foods to which the active ingredient according to the present invention can be added include meat products, sausages, breads, chocolate, candies, snacks, confectionery, pizza, ramen noodles, other noodles, dairy products including ice- , Tea, a drink, an alcoholic beverage, and a vitamin complex, all of which include health foods in a conventional sense.
According to a preferred embodiment of the present invention, there is provided a pharmaceutical composition comprising 1% glucose, galactose, fucose, N-acetylglucosamine (N-Glc), N-acetylgalactosamine (N-Gal), glucose at a concentration of 5% (5-Mix) containing N-acetylgalactosamine (N-Gal), galactose, fucose and N-acetylglucosamine (N-Glc) (AU) was measured after 20 minutes and 2 hours, and the degree of increase (? AU) relative to the baseline measurement value immediately before each application was calculated for each individual, and the control composition (vehicle) The N-acetylgalactosamine (N-Gal) concentration of 1%, the glucose of 5% concentration, and the 5-Mix were observed for 20 minutes after application , The water content of the control composition was significantly increased compared with the control composition application site, Each of the compositions containing glucose at 1% concentration, galactose, fucose and N-acetylglucosamine (N-Glc) alone did not show a water-increasing effect. In addition, the 5% concentration of glucose and 5-Mix showed significant increase of moisture even after 2 hours of application (see FIG. 1). Therefore, it was confirmed that when all five monosaccharides are included, the synergistic effect of the mixing of the monosaccharides can be maintained and the moisturizing effect can be maintained for a longer time.
Hereinafter, the present invention will be described in detail by way of examples.
However, the following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
Example 1. Moisture-increasing effect of compositions containing various monosaccharides as active ingredients in human skin
The normal skin of the human body contains 1% of glucose, 1% of galactose, 1% of fucose, 1% of N-acetylglucosamine, 1% of N-acetylgalactosamine and 5% of glucose, or glucose, galactose, fucose after the mixture N- acetylglucosamine and N- (5-mix) composition or control composition which does not contain those containing, including acetyl galactosamine each 1% applied once, the water is also meter (Corneometer TM) (N = 9) were measured after 0 minutes (before application), 20 minutes after application and 2 hours after application, respectively. The composition was applied in the same manner as in the case of using a pipette for a viscous substance in a square of 1.5 cm x 1.5 cm wide by 15 쨉 l, and the degree of increase (ΔAU) was calculated for each individual relative to the baseline measurement immediately before application, The amount of increase in the area to which the control composition was applied was corrected, and the limit value was shown in a graph.
As a result, in the case of 1% N-acetylglucosamine (N-Glc), 5% glucose and 5-Mix, the water content measured at 20 minutes after application was significantly higher than that of the control composition = 9), and each composition containing glucose at 1% concentration, galactose, fucose, and N-acetylglucosamine (N-Glc) alone did not exhibit a water-increasing effect. In the case of 5% glucose and 5-Mix, it was confirmed that water uptake was significantly increased up to 2 hours in some monosaccharides at 2 hours after application (Fig. 1 ). Therefore, when the composition containing all of the above five monosaccharides is applied to the skin, it has been confirmed that the mixing of the monosaccharides exerts a synergistic effect and the moisturizing effect can be maintained for a longer time.
Manufacturing example One. Cosmetics Preparation of composition
1.1. Cosmetic manufacturing of emulsified formulations
Cosmetic products of the emulsified form were prepared according to the compositions shown in Table 1. The production method is as follows.
(1) A mixture of
(2) The raw material of 10 was added to the mixture of step (1).
(3) The mixture of raw materials 11 to 13 was completely dissolved by heating to 65 to 70 占 폚.
(4) While the step (3) was carried out, the mixture of (2) was gradually added and emulsified at 8,000 rpm for 2 to 3 minutes.
(5) The raw material of 14 was dissolved in a small amount of water, added to the mixture of step (4), and further emulsified for 2 minutes.
(6) The raw materials of 15 to 19 were respectively weighed, and then put into the mixture of the step (5) and further emulsified for 30 seconds.
(7) The mixture of step (6) was degassed after emulsification and cooled to 25 to 35 캜 to prepare an emulsifier-type cosmetic.
Monolauric acid ester
1.2. Solubilization formulation Cosmetics Manufacturing
Cosmetic products of the solubilized formulations were prepared with the compositions shown in Table 2. The production method is as follows.
(1) The raw materials of 2 to 8 were put into 1 raw material (purified water) and dissolved by using a mixer.
(2) The raw materials of 10 to 13 were completely dissolved in 9 raw materials (alcohol).
(3) The mixture of step 2) was slowly added to the mixture of step 1) while being solubilized.
Hydrogene diester
Manufacturing example 2. Preparation of pharmaceutical compositions
2.1. Manufacture of ointment for external skin
Skin ointments containing the composition of the present invention as an active ingredient were prepared according to the composition shown in Table 3 below.
2.2. Skin external Patchy Produce
An external skin patch containing the composition of the present invention as an active ingredient was prepared according to the composition shown in Table 4 below.
Claims (18)
Wherein the glucose is contained in an amount of 2 to 10% by weight in the total composition, and the N-acetylgalactosamine is contained in an amount of 0.001 to 10% by weight in the whole composition.
Wherein the cosmetic composition further comprises at least one monosaccharide selected from the group consisting of galactose, fucose, and N-acetylglucosamine.
A cosmetic composition comprising a mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine.
The mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine is a mixture of glucose: N-acetylgalactosamine: galactose: fucose: N-acetylglucosamine = 1: 0.5-2: : 0.5 to 2: 0.5 to 2 by weight.
Wherein the mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine is contained in an amount of 0.001 to 10% by weight in the whole composition.
A cosmetic composition having an external preparation for skin.
Wherein the formulation is selected from the group consisting of a softening agent, a nutritional lotion, a massage cream, a nutritional cream, a pack, a gel, a lotion, an ointment, a gel, a cream, a patch and a spray.
Wherein the glucose is contained in an amount of 2 to 10% by weight of the total composition, and the N-acetylgalactosamine is contained in an amount of 0.001 to 10% by weight of the whole composition, for the treatment of dry skin or eczema.
Wherein the composition further comprises at least one monosaccharide selected from the group consisting of galactose, fucose, and N-acetylglucosamine.
A pharmaceutical composition comprising a mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine.
The mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine is a mixture of glucose: N-acetylgalactosamine: galactose: fucose: N-acetylglucosamine = 1: 0.5-2: : 0.5 to 2: 0.5 to 2 by weight.
Wherein the mixture of glucose, N-acetylgalactosamine, galactose, fucose and N-acetylglucosamine is contained in an amount of 0.001 to 10% by weight of the whole composition.
Wherein said pharmaceutical composition is in the form of a parenteral dosage unit selected from the group consisting of solid, semi-solid and liquid.
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| KR102022338B1 (en) * | 2018-08-06 | 2019-09-18 | 이건무 | A stable infusion solution comprising saccharide and amino acid |
| KR102282246B1 (en) * | 2020-10-27 | 2021-07-27 | 쿼럼바이오 주식회사 | Composition for preventing, alleviating, or treating atopic dermatitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165630A1 (en) * | 2002-10-15 | 2006-07-27 | Gilles Rubinstenn | Use of amide or ester of sugar and of fatty acid, for treating and/or preventing dry skin |
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2016
- 2016-03-25 KR KR1020160036333A patent/KR101926439B1/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165630A1 (en) * | 2002-10-15 | 2006-07-27 | Gilles Rubinstenn | Use of amide or ester of sugar and of fatty acid, for treating and/or preventing dry skin |
Non-Patent Citations (1)
| Title |
|---|
| https://m.blog.naver.com/PostView.nhn?blogId=tonyforlife&logNo=220621816046 네이버 블로그 제품설명 자료(2016.2.9.자 공지)* |
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| KR20170111281A (en) | 2017-10-12 |
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