KR101848527B1 - 생물학적 유체 내 중간 및 단백질 결합 요독의 함량 측정 방법 및 장치 - Google Patents

생물학적 유체 내 중간 및 단백질 결합 요독의 함량 측정 방법 및 장치 Download PDF

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KR101848527B1
KR101848527B1 KR1020137002066A KR20137002066A KR101848527B1 KR 101848527 B1 KR101848527 B1 KR 101848527B1 KR 1020137002066 A KR1020137002066 A KR 1020137002066A KR 20137002066 A KR20137002066 A KR 20137002066A KR 101848527 B1 KR101848527 B1 KR 101848527B1
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wavelength
biological fluid
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dialysis
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KR20130038347A (ko
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이보 프리돌린
프레드릭 우흘린
야나 예로츠카야
리스토 탄네르
유에르겐 아룬드
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옵토플루이드 테크놀로지스 오유
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00

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  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
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  • Optics & Photonics (AREA)
  • Biophysics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Biotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • External Artificial Organs (AREA)
KR1020137002066A 2010-06-28 2011-06-28 생물학적 유체 내 중간 및 단백질 결합 요독의 함량 측정 방법 및 장치 Active KR101848527B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EEP201000056A EE05676B1 (et) 2010-06-28 2010-06-28 Optiline meetod ja seade keskmise suurusega ja valkudega seotud ureemiliste toksiinide m„„ramiseks bioloogilistes vedelikes
EEP201000056 2010-06-28
EEP201000085 2010-12-10
EEP201000085A EE05669B1 (et) 2010-12-10 2010-12-10 Optiline meetod ja seade keskmise suurusega ja valkudega seotud ureemiliste toksiinide m„„ramiseks bioloogilistes vedelikes
PCT/EE2011/000008 WO2012000521A1 (en) 2010-06-28 2011-06-28 A method and device for determining content of the middle and protein bound uremic toxins in a biological fluid

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KR20130038347A KR20130038347A (ko) 2013-04-17
KR101848527B1 true KR101848527B1 (ko) 2018-04-12

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US (1) US9103789B2 (enExample)
EP (1) EP2585830B1 (enExample)
JP (1) JP5957450B2 (enExample)
KR (1) KR101848527B1 (enExample)
CN (1) CN102985822A (enExample)
AU (1) AU2011274009B2 (enExample)
BR (1) BR112012033625A2 (enExample)
CA (1) CA2837488C (enExample)
NZ (1) NZ605685A (enExample)
WO (1) WO2012000521A1 (enExample)

Families Citing this family (8)

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DE102012112790A1 (de) * 2012-12-20 2014-06-26 B. Braun Avitum Ag Verfahren und Vorrichtung zur Bestimmung von Abfallprodukten wie Indoxyl Sulfate in der Dialyse
US10150983B2 (en) * 2013-02-19 2018-12-11 Nipro Corporation Method for measuring indoxyl sulfuric acid
CN104991026A (zh) * 2015-06-29 2015-10-21 苏州东辰林达检测技术有限公司 尿液中甲基马尿酸的检测方法
EP3537135A1 (en) * 2018-03-05 2019-09-11 Tallinn University of Technology A device and method for assessment of a concentration of free pentosidine in a spent dialysate
JP7207702B2 (ja) * 2018-11-06 2023-01-18 国立研究開発法人農業・食品産業技術総合研究機構 成分抽出方法、蛍光指紋測定装置、及びコンピュータが実行可能なプログラム
GB202104698D0 (en) * 2021-03-31 2021-05-12 Tallinn Univ Of Technology Multiparametric optical method and apparatus for the determination of uremic solutes, including uremic toxins, in biological fluids
TWI838830B (zh) * 2022-04-08 2024-04-11 財團法人工業技術研究院 β2-微球蛋白濃度的分析方法及裝置
CN120948421A (zh) * 2025-10-15 2025-11-14 天津医科大学 一种定量-判别一体化尿毒症智能检测系统

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053556A1 (en) 1998-05-08 2001-12-20 Anderson Charles W. Miniature immuno-optical rapid analyte sensor platform
US20030231294A1 (en) 2002-06-12 2003-12-18 Ramesh Wariar Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance
US20060170914A1 (en) * 2003-07-03 2006-08-03 Wako Pure Chemical Industries, Ltd. Specific component measuring method by spectral measurement

Family Cites Families (12)

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JP3261264B2 (ja) 1994-07-13 2002-02-25 株式会社堀場製作所 多成分水溶液の分析方法およびその分析装置
WO1998019592A1 (en) * 1996-11-01 1998-05-14 Rio Grande Medical Technologies, Inc. Dialysis monitoring method and apparatus
SE525639C2 (sv) 1998-06-04 2005-03-22 Thore Falkvall Bestämning av slaggprodukter i dialysvätska med hjälp av optisk sensor
AUPR748501A0 (en) * 2001-09-04 2001-09-27 Life Therapeutics Limited Renal dialysis
US8337444B2 (en) * 2001-05-22 2012-12-25 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution for hemodialysis
RU2212029C1 (ru) 2001-12-03 2003-09-10 Общество с ограниченной ответственностью "Клиника экстракорпоральной гемокоррекции" Способ анализа жидкой биологической среды в процессе мониторинга
US7427508B2 (en) 2003-10-09 2008-09-23 Organotek Defense System Corporation Method for assaying multi-component mixtures
WO2005069737A2 (en) * 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Method and system for detecting analytes
EP1751523B1 (en) 2004-05-13 2017-10-04 NarTest AS A portable device and method for on-site detection and quantification of drugs
US7966051B2 (en) * 2005-01-11 2011-06-21 Olympus Corporation Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method
DE102005020384A1 (de) * 2005-05-02 2006-11-09 Therainvention Gmbh Spektroskopisches Verfahren zum Nachweis von Analyten
WO2009071102A1 (en) 2007-12-04 2009-06-11 Tallinn University Of Technology Optical method and device for measuring concentrations of substances in biological fluids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053556A1 (en) 1998-05-08 2001-12-20 Anderson Charles W. Miniature immuno-optical rapid analyte sensor platform
US20030231294A1 (en) 2002-06-12 2003-12-18 Ramesh Wariar Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance
US20060170914A1 (en) * 2003-07-03 2006-08-03 Wako Pure Chemical Industries, Ltd. Specific component measuring method by spectral measurement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Med. Biol. Eng. Comput., Vol. 41, pp. 263-270 (2003.05.01.)*

Also Published As

Publication number Publication date
AU2011274009B2 (en) 2016-06-23
WO2012000521A1 (en) 2012-01-05
EP2585830A1 (en) 2013-05-01
EP2585830B1 (en) 2018-04-25
US20130193347A1 (en) 2013-08-01
CA2837488A1 (en) 2012-01-05
CN102985822A (zh) 2013-03-20
BR112012033625A2 (pt) 2016-10-25
JP2013534630A (ja) 2013-09-05
US9103789B2 (en) 2015-08-11
NZ605685A (en) 2014-10-31
AU2011274009A1 (en) 2013-01-31
JP5957450B2 (ja) 2016-07-27
KR20130038347A (ko) 2013-04-17
CA2837488C (en) 2021-10-26

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