CA2837488C - A method and device for determining content of the middle and protein bound uremic toxins in a biological fluid - Google Patents
A method and device for determining content of the middle and protein bound uremic toxins in a biological fluid Download PDFInfo
- Publication number
- CA2837488C CA2837488C CA2837488A CA2837488A CA2837488C CA 2837488 C CA2837488 C CA 2837488C CA 2837488 A CA2837488 A CA 2837488A CA 2837488 A CA2837488 A CA 2837488A CA 2837488 C CA2837488 C CA 2837488C
- Authority
- CA
- Canada
- Prior art keywords
- protein bound
- uremic toxins
- bound uremic
- biological fluid
- determining content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000002441 uremic toxin Substances 0.000 title abstract 3
- 239000013060 biological fluid Substances 0.000 title abstract 2
- BXFFHSIDQOFMLE-UHFFFAOYSA-N indoxyl sulfate Chemical compound C1=CC=C2C(OS(=O)(=O)O)=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-N 0.000 abstract 4
- 102000015736 beta 2-Microglobulin Human genes 0.000 abstract 2
- 108010081355 beta 2-Microglobulin Proteins 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- 230000003595 spectral effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EEP201000056A EE05676B1 (et) | 2010-06-28 | 2010-06-28 | Optiline meetod ja seade keskmise suurusega ja valkudega seotud ureemiliste toksiinide mramiseks bioloogilistes vedelikes |
| EEP201000056 | 2010-06-28 | ||
| EEP201000085 | 2010-12-10 | ||
| EEP201000085A EE05669B1 (et) | 2010-12-10 | 2010-12-10 | Optiline meetod ja seade keskmise suurusega ja valkudega seotud ureemiliste toksiinide mramiseks bioloogilistes vedelikes |
| PCT/EE2011/000008 WO2012000521A1 (en) | 2010-06-28 | 2011-06-28 | A method and device for determining content of the middle and protein bound uremic toxins in a biological fluid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2837488A1 CA2837488A1 (en) | 2012-01-05 |
| CA2837488C true CA2837488C (en) | 2021-10-26 |
Family
ID=44508544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2837488A Active CA2837488C (en) | 2010-06-28 | 2011-06-28 | A method and device for determining content of the middle and protein bound uremic toxins in a biological fluid |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9103789B2 (enExample) |
| EP (1) | EP2585830B1 (enExample) |
| JP (1) | JP5957450B2 (enExample) |
| KR (1) | KR101848527B1 (enExample) |
| CN (1) | CN102985822A (enExample) |
| AU (1) | AU2011274009B2 (enExample) |
| BR (1) | BR112012033625A2 (enExample) |
| CA (1) | CA2837488C (enExample) |
| NZ (1) | NZ605685A (enExample) |
| WO (1) | WO2012000521A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012112790A1 (de) * | 2012-12-20 | 2014-06-26 | B. Braun Avitum Ag | Verfahren und Vorrichtung zur Bestimmung von Abfallprodukten wie Indoxyl Sulfate in der Dialyse |
| US10150983B2 (en) * | 2013-02-19 | 2018-12-11 | Nipro Corporation | Method for measuring indoxyl sulfuric acid |
| CN104991026A (zh) * | 2015-06-29 | 2015-10-21 | 苏州东辰林达检测技术有限公司 | 尿液中甲基马尿酸的检测方法 |
| EP3537135A1 (en) * | 2018-03-05 | 2019-09-11 | Tallinn University of Technology | A device and method for assessment of a concentration of free pentosidine in a spent dialysate |
| JP7207702B2 (ja) * | 2018-11-06 | 2023-01-18 | 国立研究開発法人農業・食品産業技術総合研究機構 | 成分抽出方法、蛍光指紋測定装置、及びコンピュータが実行可能なプログラム |
| GB202104698D0 (en) * | 2021-03-31 | 2021-05-12 | Tallinn Univ Of Technology | Multiparametric optical method and apparatus for the determination of uremic solutes, including uremic toxins, in biological fluids |
| TWI838830B (zh) * | 2022-04-08 | 2024-04-11 | 財團法人工業技術研究院 | β2-微球蛋白濃度的分析方法及裝置 |
| CN120948421A (zh) * | 2025-10-15 | 2025-11-14 | 天津医科大学 | 一种定量-判别一体化尿毒症智能检测系统 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3261264B2 (ja) | 1994-07-13 | 2002-02-25 | 株式会社堀場製作所 | 多成分水溶液の分析方法およびその分析装置 |
| WO1998019592A1 (en) * | 1996-11-01 | 1998-05-14 | Rio Grande Medical Technologies, Inc. | Dialysis monitoring method and apparatus |
| US6261848B1 (en) * | 1998-05-08 | 2001-07-17 | The Johns Hopkins University | Miniature immuno-optical rapid analyte sensor platform |
| SE525639C2 (sv) | 1998-06-04 | 2005-03-22 | Thore Falkvall | Bestämning av slaggprodukter i dialysvätska med hjälp av optisk sensor |
| AUPR748501A0 (en) * | 2001-09-04 | 2001-09-27 | Life Therapeutics Limited | Renal dialysis |
| US8337444B2 (en) * | 2001-05-22 | 2012-12-25 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution for hemodialysis |
| RU2212029C1 (ru) | 2001-12-03 | 2003-09-10 | Общество с ограниченной ответственностью "Клиника экстракорпоральной гемокоррекции" | Способ анализа жидкой биологической среды в процессе мониторинга |
| US7002670B2 (en) * | 2002-06-12 | 2006-02-21 | Baxter International Inc. | Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance |
| EP1643240A4 (en) * | 2003-07-03 | 2010-09-22 | Wako Pure Chem Ind Ltd | METHOD FOR MEASURING CERTAIN COMPONENTS BY MEANS OF SPECTRAL MEASUREMENT |
| US7427508B2 (en) | 2003-10-09 | 2008-09-23 | Organotek Defense System Corporation | Method for assaying multi-component mixtures |
| WO2005069737A2 (en) * | 2004-01-27 | 2005-08-04 | Ramot At Tel Aviv University Ltd. | Method and system for detecting analytes |
| EP1751523B1 (en) | 2004-05-13 | 2017-10-04 | NarTest AS | A portable device and method for on-site detection and quantification of drugs |
| US7966051B2 (en) * | 2005-01-11 | 2011-06-21 | Olympus Corporation | Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method |
| DE102005020384A1 (de) * | 2005-05-02 | 2006-11-09 | Therainvention Gmbh | Spektroskopisches Verfahren zum Nachweis von Analyten |
| WO2009071102A1 (en) | 2007-12-04 | 2009-06-11 | Tallinn University Of Technology | Optical method and device for measuring concentrations of substances in biological fluids |
-
2011
- 2011-06-28 CN CN2011800323962A patent/CN102985822A/zh active Pending
- 2011-06-28 CA CA2837488A patent/CA2837488C/en active Active
- 2011-06-28 EP EP11740556.3A patent/EP2585830B1/en not_active Not-in-force
- 2011-06-28 JP JP2013517023A patent/JP5957450B2/ja active Active
- 2011-06-28 BR BR112012033625A patent/BR112012033625A2/pt not_active Application Discontinuation
- 2011-06-28 US US13/807,688 patent/US9103789B2/en active Active
- 2011-06-28 NZ NZ60568511A patent/NZ605685A/en unknown
- 2011-06-28 KR KR1020137002066A patent/KR101848527B1/ko active Active
- 2011-06-28 WO PCT/EE2011/000008 patent/WO2012000521A1/en not_active Ceased
- 2011-06-28 AU AU2011274009A patent/AU2011274009B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011274009B2 (en) | 2016-06-23 |
| WO2012000521A1 (en) | 2012-01-05 |
| EP2585830A1 (en) | 2013-05-01 |
| EP2585830B1 (en) | 2018-04-25 |
| US20130193347A1 (en) | 2013-08-01 |
| CA2837488A1 (en) | 2012-01-05 |
| CN102985822A (zh) | 2013-03-20 |
| BR112012033625A2 (pt) | 2016-10-25 |
| JP2013534630A (ja) | 2013-09-05 |
| US9103789B2 (en) | 2015-08-11 |
| KR101848527B1 (ko) | 2018-04-12 |
| NZ605685A (en) | 2014-10-31 |
| AU2011274009A1 (en) | 2013-01-31 |
| JP5957450B2 (ja) | 2016-07-27 |
| KR20130038347A (ko) | 2013-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160530 |