KR101770420B1 - Composition for promoting hair growth and preventing hair loss and dandruff comprising black-ginseng fermentation extract - Google Patents

Abstract

The present invention provides a detergent composition containing black germ extract fermented product as an active ingredient to prevent hair loss, prevent dandruff and prevent itching of the scalp. The composition of the present invention has a small stimulus to the scalp and an excellent antibacterial activity, It is effective for improvement and is very useful for preventing hair loss.

Description

Technical Field [0001] The present invention relates to a detergent composition for preventing hair loss, preventing hair loss, preventing dandruff and preventing itching of the scalp by containing a black ginseng extract fermented product as an active ingredient.

The present invention relates to a dermatological composition, particularly a soap composition, and a shampoo composition having an anti-dandruff effect. More particularly, the present invention relates to a composition for preventing hair loss, Dermatological compositions, in particular soap compositions and shampoo compositions.

Dandruff generally refers to a keratinous mass formed by the dead or peeled cells of the scalp caused by the vigorous metabolism of the human body, dried up with the secretions of the scalp sebaceous glands. Dandruff gradually has a clear boundary with the normal skin, and becomes reddish to increase the scar on the scalp, and it usually goes to the dermatitis with itching and inflammation.

The fundamental cause of such dandruff has not yet been clarified. However, it is generally considered to be caused by imbalance of endocrine hormone, imbalance of nutritional metabolism, neural factors such as stress, biochemical change of epithelial tissue due to excessive proliferation of scalp cells, The growth of microorganisms and the increase of activity, and the inflammation due to air pollution.

In particular, the proliferation and activity increase of microorganisms called Pityrosporum Ovalae, which are present in the unclean scalp, have been recognized for a long time as a main factor for aggravating dandruff and itching, and they have been widely accepted in recent years.

Therefore, the currently used dandruff treatment agent is focused on effectively inhibiting the proliferation and activity of the phytolosformovalle, which is a major cause of dandruff, and normalizing the abnormal metabolism activity of the scalp cell. Meanwhile, selenium sulfide and zinc pyrithione are examples of components mainly used in a commercially available anti-dandruff composition (refer to Korean Patent Laid-Open No. 10-2008-0109440, Korean Patent Laid-Open No. 10-2008-0108706)

Although studies on methods and components for preventing or treating dandruff have been continuing, studies on the components that are eco-friendly, harmless to the environment and humans, and capable of reducing the number of dandruff germs are still insufficient . In addition, components that can prevent hair loss while preventing dandruff are not yet known.

Accordingly, the inventor of the present invention has found that when a natural substance having excellent dandruff-inhibiting effect is provided in order to provide a dermatological composition for external use having an excellent anti-dandruff effect and an effect of preventing itching of scalp, the black ginseng fermented product has excellent antimicrobial activity, And also found anti-hair-loss effects on components having excellent dandruff-inhibiting effect, thus completing the present invention.

Accordingly, an object of the present invention is to provide a detergent composition having an antimicrobial activity, which is excellent in anti-dandruff effect and anti-dandruff effect and has a hair-loss preventing effect.

According to an aspect of the present invention,

The present invention provides a detergent composition containing black ginseng extract fermented product as an active ingredient to prevent hair loss, prevent dandruff and prevent itching of the scalp.

In the present invention, the fermented black ginseng extract may be obtained by fermenting Saccharomyces cerevisiae into black ginseng hot-water extract.

In the present invention, the black ginseng extract fermented product

Washing the washed ginseng at 70 to 150 DEG C for 3 to 10 hours;

Mixing the edible coating agent with water and heating to prepare a viscous coating solution, and then applying the coating solution to the entire surface of the fresh ginseng after completing the first steaming step;

A second tillage step of irradiating ultraviolet rays for 7 to 20 hours by mixing the fresh ginseng after completion of the coating step at 70 to 150 ° C for 3 to 10 hours;

Preparing a black ginseng in which the ginseng having been subjected to the second tea boiling step is melted at 70 to 150 ° C for 3 to 10 hours and irradiated with ultraviolet light for 7 to 20 hours,

An extraction step of extracting the black ginseng with the black ginseng preparation step with hot water at 70 to 100 캜;

An enzyme treatment step of adding alpha-amylase and cellulase to the extract of the extraction step and enzyme treatment at 25 to 65 DEG C for 2 to 7 hours; And

And may be produced through a fermentation step in which Saccharomyces cerevisiae is added to the enzyme-treated extract and fermented at 20 to 40 ° C for 10 to 48 hours.

In the present invention, the detergent composition may be a soap composition or a shampoo composition.

The composition according to the present invention may further comprise an acid hydrothermal extract as an active ingredient.

The composition containing the fermented black ginseng extract according to the present invention is excellent in antimicrobial activity due to its small stimulus to the scalp, effective for preventing dandruff and improving symptoms, and also excellent in preventing hair loss.

The anti-depressant and anti-dandruff dermatological composition according to the present invention contains a fermented product extracted from black ginseng as an active ingredient.

The fermented product of black ginseng extract according to the present invention is not particularly limited as long as it is known in the art to which the present invention belongs. For example, after extracting black ginseng with an extraction solvent such as water or ethanol, Saccharomyces cerevisiae , lactic acid bacteria, Bifidobacterium species, and the like.

More specifically, the production of fermented black ginseng extract according to the present invention

Washing the washed ginseng at 70 to 150 DEG C for 3 to 10 hours; Washing the washed ginseng at 70 to 150 DEG C for 3 to 10 hours;

Mixing the edible coating agent with water and heating to prepare a viscous coating solution, and then applying the coating solution to the entire surface of the fresh ginseng after completing the first steaming step;

A second tillage step of irradiating ultraviolet rays for 7 to 20 hours by mixing the fresh ginseng after completion of the coating step at 70 to 150 ° C for 3 to 10 hours;

Preparing a black ginseng in which the ginseng having been subjected to the second tea boiling step is melted at 70 to 150 ° C for 3 to 10 hours and irradiated with ultraviolet light for 7 to 20 hours,

An extraction step of extracting the black ginseng with the black ginseng preparation step with hot water at 70 to 100 캜;

An enzyme treatment step of adding alpha-amylase and cellulase to the extract of the extraction step and enzyme treatment at 25 to 65 DEG C for 2 to 7 hours; And

And the fermentation step in which Saccharomyces cerevisiae is added to the enzyme-treated extract and fermented at 20 to 40 ° C for 10 to 48 hours.

The anti-depressant and anti-dandruff dermatological composition according to the present invention preferably contains the black germ extract fermentation product in an amount of 0.5 to 15% by weight based on the total weight of the composition. If the content of the active ingredient is less than 0.5% by weight, the effect or effect is insufficient. If the content is more than 15% by weight, there is a problem in formulation stability.

In addition to the fermented black ginseng extract, the present invention may further include a hydrothermal extract of a lily of the genus (Disocorea japonica) or a root of Discoorea batatas, which is a perennial herbaceous perennial belonging to the family Disocoreaceae as an active ingredient And the acid hydrothermal extract is preferably contained in an amount of 0.5 to 15% by weight based on the total weight of the composition. If the content of the active ingredient is less than 0.5% by weight, the effect or effect is insufficient. If the content is more than 15% by weight, there is a problem in formulation stability.

The anti-depilation and anti-dandruff detergent composition according to the present invention is not particularly limited in formulation, but may be a composition having formulations such as soap, hair rinse, hair shampoo, and the like. The composition of each of these formulations may contain various components that are formulated into a conventional composition according to the various formulations described above or suitable for the final purpose, and the kind and amount of these components may be readily selected by those skilled in the art.

Hereinafter, the hair-loss preventing and anti-dandruff dermatological compositions according to the present invention will be described with reference to representative base ingredients and additives, taking as an example a typical soap composition and a shampoo composition of the composition.

For example, in the case of a soap composition, in addition to a conventional soap base, it further includes a moisturizing agent, an antioxidant, a light shielding agent, a detergent, and purified water. The moisturizing agent is used for maintaining moisture and supplying various nutrients to the skin and hair after use, and a humectant that can be used in this field can be usually used. Preferred are glycerin, propylene glycol (PG), buthylene glycol (BG), hexylene glycol (HG), urea, dexpanthenol, isopentyldiol, A mixture of one or more selected from the group consisting of pyrrolidone carboxylic acid and its salt (sodium) is used.

The antioxidant can further increase the anti-dandruff effect and anti-dandruff effect of the soap composition. Antioxidants include tocopheryl acetate, butylated hydroxy anisole (BHA), ascorbyl palmitate, and etidronic acid.

The shading agent acts as a decolorizing agent to prevent the color change of the soap itself and to maintain the color of the soap inherently. Titanium dioxide, dipropylene glycol salicylate, and methyl salicylate are used as shading agents.

The detergent imparts a cleaning effect and a foaming power of the soap to improve the feeling of use of the soap and serves as a conditioner for the hair. Examples of the cleaning agent include cocamidopropyl betaine, coco-betaine, alkylbetaine, cocamide DEA, cocamide MEA, and the like, which contain an amphoteric surfactant C 8 -C 22 alkyl group. (cocamide MEA), and glyceryl cocoate.

Purified water or distilled water is used to dissolve the solid component in the additive and is added 2-4 times by weight of the solid component. In addition, preservatives, pH adjusters, perfumes, dyes, and other additives may be added to the soap composition by those skilled in the art.

Also, in the case of having a shampoo formulation, in a shampoo composition composed of a synthetic surfactant as a cleaning component, a preservative, a thickening agent and a viscosity adjusting agent, a pH adjusting agent, a perfume, a dye, a hair conditioning agent and water, May be any selected from anionic, amphoteric, and nonionic surfactants. The synthetic surfactant may be contained in an amount of 10 to 70% by weight, preferably 10 to 30% by weight, based on the total weight of the composition.

Examples of the synthetic anionic surfactant include alkyl and alkyl ether sulfates. Specific examples thereof include sodium lauryl sulfate, ammonium lauryl sulfate, triethanolamine lauryl sulfate, sodium polyoxyethylene lauryl sulfate and polyoxyethylene lauryl sulfate. have.

The synthetic amphoteric surfactants are alkyl betaines and alkylamidopropyl betaines. Specific examples thereof include cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethyl alpha-carboxyethylbetaine, cetyldimethylcarboxymethyl Betaine, cocamidopropyl betaine, and the like.

Examples of the synthetic nonionic surfactant include alkanolamide and amine oxide. Specific examples thereof include lauryldiethylamine oxide, palm oil alkyldimethylamine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid monoethanolamide .

The above-mentioned surfactants can be selectively used alone or in combination in the composition of the present invention.

The optional ingredients used in the compositions of the present invention are well known to those skilled in the art as conventional optional ingredients to maintain basic properties and quality. Such optional ingredients include preservatives, thickeners, viscosity modifiers, pH adjusting agents, perfumes, dyes, hair conditioning agents, and the like.

The composition according to the present invention may be used according to a conventional method of use, and may be used in a number of times depending on the condition or taste of the user's scalp.

Hereinafter, the present invention will be described in more detail with reference to examples and test examples, but the present invention is not limited to these examples.

[ Example  1] Black ginseng extract Fermented  Produce

After purchasing 5-year-old roots, which were produced and distributed in Geumsan, they were lightly washed with water to remove soil and then put into a ginseng steamer and firstly mixed under pressure at 123 ° C for 5 hours. Subsequently, the first-milled swine was dried for about 12 hours in a drying chamber maintained at 60 ° C.

After the first boiling, the water remaining in the boiling water was further added with water to make 1 L, 300 g of gelatin was added thereto, and the food coating solution was dissolved or warmed with stirring to dissolve well in water, followed by cooling to about 40 ° C The first step of mixing was put in a container containing edible coating agent, and then the mixture was applied to the front surface of the swarf, and then the swarf was dried to a certain extent, and then the swarf was repeated 4 times to complete the coating step.

Next, a total of 9 rinsing steps were carried out by repeating 8 times of the second mashing step of irradiating ultraviolet rays for 14 hours after coating the coated mash at 82 DEG C for 9 hours.

Subsequently, the 9-fold washed millet was crushed finely and then extracted with 5 liters of hot water at 85 ° C for 72 hours. Then, the extract was lowered to 55 ° C, 30 g of each of α-amylase and cellulase was added, Enzyme treatment was performed for a period of time.

After the enzyme treatment, the temperature was raised to 85 ° C, and then the temperature was maintained for 6 hours to inactivate the enzyme and sterilize the extract. Saccharomyces cerevisiae was added to the mixture and the mixture was fermented for 24 hours. After the temperature was raised to 85 ° C., the mixture was kept for 24 hours and sterilized to obtain a black ginseng extract The preparation of the fermentation product was completed.

[ Comparative Example  1] Red ginseng extract Fermented  Produce

After the red ginseng sold in the market was purchased, it was extracted with 5 L of hot water at 85 캜 for 72 hours. The extract was cooled to 34 캜, Saccharomyces cerevisiae was added, fermented for 24 hours, The temperature was elevated to 85 캜 and maintained for 24 hours to be sterilized to complete the preparation of red ginseng extract fermented product.

[ Formulation Example  1 and Comparative Formulation Example  1] Preparation of composition 1

Soaps were prepared with the compositions shown in Table 1 below, and the manufacturing process was in accordance with a method widely known to those skilled in the art.

ingredient Formulation Example 1 (% by weight) Comparative Formulation Example 1 (% by weight) Distilled water 15.60 15.60 Sodium palm oil 51.65 51.65 glycerin 16.00 16.00 Sorbitol 8.20 8.20 Sodium chloride 0.50 0.50 Black germ extract 7.00 - Fermented red ginseng extract - 7.00 Sodium hyaluronate 1.00 1.00 Tocopherol 0.05 0.05 total 100 100

[ Formulation Example  2 and Comparative Formulation Example  2] Preparation of composition 2

The shampoos were prepared with the composition shown in Table 2 below, and the manufacturing process was in accordance with a method widely known to a person having ordinary skill in the art to which the present invention belongs.

ingredient Formulation Example 2 (% by weight) Comparative Formulation Example 2 (% by weight) Ammonium lauryl sulfate 10 10 Ammonium polyoxyethylene uryl sulfate 5 5 Cocoamidopropyl betaine 2 2 Ethylene glycol distearate 1.5 1.2 Cottoyl monoethanolamide 0.8 0.8 Fermented black ginseng extract 5.0 - Red ginseng extract fermented water - 5.0 Polyquaternium-10 0.2 0.2 Blue No. 1 0.0002 0.0002 Yellow No. 4 0.0001 0.0001 Methyl paraben 0.1 0.1 Spices 0.8 0.8 Citric acid 0.1 0.1 Dimethicone 1.0 1.0 Distilled water to 100 to 100

[ Test Example  One] Dandruff  evaluation

The dandruff force of the above-mentioned formulation example was measured and compared. At this time, as a test strain, dicembryum Pityrosporum Ovalae (ATCC 12078) was used.

The skin disc diffusion method was used to measure the antibacterial activity. The skin disc diffusion method (SDDM) is the method closest to the consumer's habits and is a method of measuring the antimicrobial activity against guinea pig skin similar to human skin.

Specifically, guinea pig skin was peeled off, treated with 70% ethanol, uniformly spread, and skin discs cut to a certain size were used. The sterilized skin discs were treated with a formulation for 3 minutes and then rinsed with running water. Then, the skin discs were placed on a solid medium inoculated with the test bacteria, and then the test bacteria were cultured. After the culture, the size of the clear zone in which the growth of the bacteria was inhibited was measured, and the relative antibacterial activity was measured. The experimental results are shown in Table 3 below as the average value of the results of three measurements.

division Restraining Size (mm) Formulation Example 1 Comparative Formulation Example 1 Formulation Example 2 Comparative Formulation Example 2 Strain Reduction Size 6.7 3.1 5.9 3.1

As shown in Table 3 above, Formulation Examples 1 and 2 according to the present invention have twice as much effect of reducing dandruff as compared to Comparative Formulations 1 and 2 containing red ginseng. In particular, it was confirmed that anti-dandruff effect which is slightly better than shampoo in the case of Formulation Example 1 according to the present invention is obtained.

[ Test Example  2] Dandruff reduction effect test

Forty - eight males aged 19 to 35 years with a relatively large number of dandruff were selected and divided into four groups. The dandruff reduction rate was measured after each group was used for the first month in the following manner.

The dandruff accumulated for 2 days before the start of the test was collected, and the weight of collected dandruff was compared with the weight of the dandruce accumulated for 2 days after completion of the test. The accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated according to the following equation (1). The results are shown in Table 4 below.

&Quot; (1) "

Dandruff reduction rate (%) = pre-test dandruff weight (mg) -1 month later dandruff weight (mg) / pre-test dandruff weight (mg) x 100

Formulation Example 1 Comparative Formulation Example 2 Formulation Example 2 Comparative Formulation Example 2 90.1 51.8 89.9 44.2 90.1 54.5 77.8 45.6 90.5 47.8 90.1 44.8 89.8 49.5 85.2 49.1 99.2 50.2 89.5 45.2 95.2 51.5 90.2 41.2 91.3 47.3 89.0 42.6 90.5 44.2 81.9 42.7 89.0 47.6 90.2 43.1 91.9 45.2 89.0 44.2 93.2 51.0 90.2 41.2 92.0 52.9 88.3 45.2

As can be seen from Table 4, the anti-dandruff effect of the black ginseng-containing formulation of the present invention was about twice as good as that of the comparative formulation containing red ginseng. Especially in the case of the formulation according to the present invention, And the dandruff effect was better.

[ Test Example  3] Scalp itching prevention effect test

A total of 36 men and women aged 25 to 45 years with severe scalp itching were selected and divided into 3 groups of 12 persons. Each formulation was used once every 3 days for 2 weeks. The results are shown in Table 5 below.

[Evaluation standard]

Very good - 5 points

Excellent - 4 points

Usually - 3 points

Poor - 2 points

Very bad - 1 point

division Formulation Example 1 Comparative Formulation Example 2 Formulation Example 2 Comparative Formulation Example 2 Scalp itching removal effect 4.7 3.2 4.3 3.1

As can be seen from the above Table 5, the formulation containing the black ginseng of the present invention was twice as effective as the anti-itch effect of the comparative formulation containing red ginseng. In particular, Example 1 was found to be effective in preventing scalp itching, which is more excellent.

[ Test Example  4] Anti-hair loss test

In order to confirm the effect of preventing hair loss, 10 of 40 male subjects with alopecia were given Formulation Examples 1 and 1 and Comparative Formulation Examples 1 and 2, respectively. The degree of efficacy was evaluated and shown in Table 6. The evaluation criteria were 5 points when the hair loss reduction effect was remarkable, 4 points when the hair loss was moderate, 3 points when the light hair was weak, 2 points when the hair loss was unchanged, , And a total judgment was made as an average value.

division Formulation Example 1 Comparative Formulation Example 2 Formulation Example 2 Comparative Formulation Example 2 Anti-hair loss effect 4.8 3.0 4.5 3.1

As can be seen from the above Table 6, the formulation containing black ginseng of the present invention was twice as good as the anti-depilatory effect, as compared with the comparative formulation containing red ginseng. In particular, Example 1 was found to be effective in preventing scalp itching, which is more excellent.

[ Formulation Example  3] Preparation of composition 3

As shown in Table 7 below, soaps were prepared with a composition further containing a mild hot water extract, and the manufacturing process was in accordance with a method widely known to those having ordinary skill in the art to which the present invention belongs.

ingredient Formulation Example 3 (% by weight) Distilled water 15.60 Sodium palm oil 44.65 glycerin 16.00 Sorbitol 8.20 Sodium chloride 0.50 Black germ extract 7.00 Acid hydrothermal extract 7.00 Sodium hyaluronate 1.00 Tocopherol 0.05 total 100

[ Test Example  5] Dandruff  evaluation

The anti-dandruff of Formulation Example 3 was measured, and the results are shown in Table 8, and the measurement method was the same as in Test Example 1. [

division Restraining Size (mm) Strain Reduction Size 9.5

Table 8 shows better results than the case of containing only the black ginseng extract fermentation product.

[ Test Example  6] Anti-hair loss test

The anti-hair loss effect of Formulation Example 3 was measured, and the results are shown in Table 9, and the measurement method is the same as in Test Example 4. [

division Formulation Example 3 Hair loss prevention effect 4.9

Table 9 shows better results than the case of containing only black ginseng extract fermented product.

Claims (7)

0.5 to 15% by weight of black ginseng extract fermentation product and 0.5 to 15% by weight of acid hydrothermal extract as an active ingredient based on the total weight of the composition,
Wherein the black ginseng extract fermented product is obtained by fermenting Saccharomyces cerevisiae into black ginseng hot water extract to prevent hair loss, prevent dandruff and prevent itching of the scalp.
The fermented product according to claim 1,
Washing the washed ginseng at 70 to 150 DEG C for 3 to 10 hours;
Mixing the edible coating agent with water and heating to prepare a viscous coating solution, and then applying the coating solution to the entire surface of the fresh ginseng after completing the first steaming step;
A second tillage step of irradiating ultraviolet rays for 7 to 20 hours by mixing the fresh ginseng after completion of the coating step at 70 to 150 ° C for 3 to 10 hours;
Preparing a black ginseng in which the ginseng having been subjected to the second tea boiling step is melted at 70 to 150 ° C for 3 to 10 hours and irradiated with ultraviolet light for 7 to 20 hours,
An extraction step of extracting the black ginseng with the black ginseng preparation step with hot water at 70 to 100 캜;
An enzyme treatment step of adding alpha-amylase and cellulase to the extract of the extraction step and enzyme treatment at 25 to 65 DEG C for 2 to 7 hours; And
Characterized in that the saccharomyces cerevisiae is added to the enzyme-treated extract and fermented at 20 to 40 DEG C for 10 to 48 hours to prevent hair loss, prevent dandruff and scalp itching . ≪ / RTI >
3. The method according to any one of claims 1 to 3,
Wherein the detergent composition is a soap composition. The detergent composition of claim 1, wherein the detergent composition is a soap composition.
3. The method according to any one of claims 1 to 3,
Wherein the detergent composition is a shampoo composition, which prevents hair loss, prevents dandruff, and cleanses the scalp itch.
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