KR101718497B1 - 레오바이러스과 바이러스의 백신용 바이러스 균주를 제조하는 방법 - Google Patents

레오바이러스과 바이러스의 백신용 바이러스 균주를 제조하는 방법 Download PDF

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KR101718497B1
KR101718497B1 KR1020107014212A KR20107014212A KR101718497B1 KR 101718497 B1 KR101718497 B1 KR 101718497B1 KR 1020107014212 A KR1020107014212 A KR 1020107014212A KR 20107014212 A KR20107014212 A KR 20107014212A KR 101718497 B1 KR101718497 B1 KR 101718497B1
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btv
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폴리 로이
마크 보이체
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런던 스쿨 오브 하이진 앤 트로피컬 메디신
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KR1020107014212A 2007-11-26 2008-11-26 레오바이러스과 바이러스의 백신용 바이러스 균주를 제조하는 방법 Expired - Fee Related KR101718497B1 (ko)

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US98999107P 2007-11-26 2007-11-26
US60/989,991 2007-11-26
US5871608P 2008-06-04 2008-06-04
US61/058,716 2008-06-04
PCT/GB2008/003945 WO2009068870A1 (en) 2007-11-26 2008-11-26 Method for producing vaccinal viral strain of a virus of the reoviridae family

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KR1020157036407A Division KR101749130B1 (ko) 2007-11-26 2008-11-26 레오바이러스과 바이러스의 백신용 바이러스 균주를 제조하는 방법

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KR20100108356A KR20100108356A (ko) 2010-10-06
KR101718497B1 true KR101718497B1 (ko) 2017-03-22

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KR1020107014212A Expired - Fee Related KR101718497B1 (ko) 2007-11-26 2008-11-26 레오바이러스과 바이러스의 백신용 바이러스 균주를 제조하는 방법

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EP (2) EP3037526B1 (enExample)
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CN (2) CN109825517B (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2792118C (en) * 2010-03-12 2022-07-12 Merial Limited Bluetongue virus recombinant vaccines and uses thereof
EP2861248B1 (en) * 2012-06-13 2017-11-15 Merial, Inc. Reassortant btv and ahsv vaccines
WO2014185784A1 (en) * 2013-05-16 2014-11-20 Stichting Dienst Landbouwkundig Onderzoek Vaccines for diseases caused by viruses of the family of reoviridae
WO2017187131A1 (en) * 2016-04-26 2017-11-02 London School Of Hygiene & Tropical Medicine Reoviridae vaccine
JP6762070B2 (ja) * 2016-09-27 2020-09-30 国立大学法人大阪大学 人工組換えロタウイルスの作製方法
CN109321583B (zh) * 2018-09-29 2023-08-15 福建省农业科学院畜牧兽医研究所 一种构建番鸭呼肠孤病毒反向遗传系统的方法
KR102228267B1 (ko) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
CN116732246A (zh) * 2023-04-25 2023-09-12 佛山科学技术学院 一种检测流行性出血热病毒的试剂盒及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101580849B (zh) * 2000-04-28 2012-11-21 圣朱德儿童研究医院 用于产生感染性流感病毒的dna转染系统
DE60233038D1 (de) * 2002-06-20 2009-09-03 Pasteur Institut Infektiöse cDNA eines zugelassenen Impfstammes des Masern Virus. Verwendung in immunogenen Zusammensetzungen
CN1563383A (zh) * 2004-03-17 2005-01-12 云南出入境检验检疫局检验检疫技术中心 蓝舌病病毒vp7基因重组表达质粒载体、vp7表达抗原以及制备方法
JP2007215466A (ja) 2006-02-16 2007-08-30 Fujita Gakuen レオウイルス科ウイルス由来の組換えウイルスを調製する方法、及び組換えロタウイルス調製用のｄｎａコンストラクト

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Virol., Vol. 68, No. 6, pp. 3604-3611 (1994.06.)*
Proc. Natl. Acad. Sci. USA, Vol. 98, No. 14, pp. 8036-8041 (2001.06.26.)*

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법

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CN101970645A (zh) 2011-02-09
MX2010005701A (es) 2010-08-31
JP2011504367A (ja) 2011-02-10
CA2706603C (en) 2021-02-09
CN109825517A (zh) 2019-05-31
EP3037526A3 (en) 2016-10-05
US20100322971A1 (en) 2010-12-23
KR101749130B1 (ko) 2017-06-20
WO2009068870A1 (en) 2009-06-04
KR20160003896A (ko) 2016-01-11
EP3037526A2 (en) 2016-06-29
JP5619614B2 (ja) 2014-11-05
EP2215221A1 (en) 2010-08-11
JP5908948B2 (ja) 2016-04-26
CN109825517B (zh) 2023-04-14
JP2014239683A (ja) 2014-12-25
KR20100108356A (ko) 2010-10-06
CA2706603A1 (en) 2009-06-04
US20140134209A1 (en) 2014-05-15
AU2008331293A1 (en) 2009-06-04
US9457076B2 (en) 2016-10-04
ZA201004531B (en) 2011-03-30
EP3037526B1 (en) 2018-03-14
EP2215221B1 (en) 2016-02-17
CN101970645B (zh) 2018-11-30
US8673315B2 (en) 2014-03-18

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