KR101660915B1 - Hair Composition Containing Red Ginseng Extract and Preparation Method of the Same - Google Patents

Abstract

The present invention relates to an active ingredient comprising red ginseng extract; And a composition for hair containing at least one member selected from the group consisting of an extract of Mulberry bark extract and a golden extract, and a process for producing the composition. The composition for hair has excellent hair roughening effect and is applicable to various hair products.

Red ginseng extract, manganese berry extract, golden extract, hair, hair root strengthening, shampoo

Description

TECHNICAL FIELD The present invention relates to a hair composition containing red ginseng extract,

The present invention relates to a hair composition containing red ginseng extract and a method for producing the same.

In modern society, which emphasizes beauty, many people, both men and women, use hair dye, permanent hair, and the like in order to satisfy their individuality expression needs. However, in some sensitive scalp, stimulation such as itching or stinging of the scalp and inflammation may be caused by chemical procedures such as dyeing or perming. Such irritation or inflammation leads to environmental hair loss.

In addition, the hair and scalp are part of the body, and as the skin ages, it becomes aging like skin. As the aging progresses, various changes and problems also appear in the hair and scalp.

Accordingly, it is an object of the present invention to provide a composition capable of alleviating scalp irritation and inflammation caused by use of various hair dyes, permanent agents, etc., protecting hair from harmful environments, strengthening hair roots, preventing hair loss, Development is required.

It is an object of one embodiment of the present invention to provide a composition for hair which is believed to enhance hair root enhancement.

Another object of one embodiment of the present invention is to provide a method for producing a hair composition.

The composition for hair according to one embodiment of the present invention comprises, as an active ingredient, red ginseng extract; And at least one selected from the group consisting of an extract of Mulberry bark extract and a golden extract. The present invention also provides a method for producing the hair composition.

The composition for hair according to the present invention is excellent in strengthening hair roots that effectively acts on weakened hair follicles and scalp and nourishes the hair roots and restores damaged hair roots and scalp. In addition, there is an effect of enhancing hair root strengthening through promotion of blood circulation.

The composition for hair according to one embodiment of the present invention is characterized by containing red ginseng extract as an active ingredient. In another embodiment, the composition for hair may further contain, as an active ingredient, at least one extract selected from the group consisting of an extract of Root Extract, and a golden extract, in addition to the red ginseng extract.

The composition for hair includes red ginseng extract, which is a typical medicinal food; And an extract of Mulberry bark extract and a golden extract, it is possible to provide hair root strengthening effect through vigorous blood circulation. In addition, saponin is contained in red ginseng extract, and rich in flavonoids in extracts of Ganoderma lucidum extract and gold extract. These ingredients promote the blood circulation of the hair follicles and nourish the hair that gets weaker and thinner as you get older.

In one embodiment, the composition for hair includes, as an active ingredient, an extract of red algae; And extracts of one or more members selected from the group consisting of extracts of Eucalyptus extracts and gold extracts. The content of the active ingredient may be, for example, 0.01 to 10.0% by weight, more specifically 0.05 to 5.0% by weight, based on the total weight of the composition. When the content is less than the above range, it is difficult to expect hair root strengthening effect due to the addition of the active ingredient, and if it exceeds the above content range, it may affect the feeling of use and repellency of the product.

In one embodiment, the ratio of the content of the extract of Mulberry and the extract of gold can be 1: 1 to 9: 1, more specifically 3: 1, based on the volume ratio. This is to increase the synergy effect of hair root strengthening.

In the present invention, red ginseng refers to a pale yellowish brown or light reddish brown ginseng which is selected by steam ginseng and steamed by steam without peeling the ginseng. Ginseng is usually cultivated in the field after 4 to 6 years of cultivation. Ginseng, which is mined, is called ginseng. Because ginseng usually contains about 75% of water, it is difficult to store for more than a week when it is mined, and it is likely to be corrupted or damaged especially during distribution.

Processed in the form of red ginseng in order to enhance the preservability of fresh ginseng. Processed red ginseng, during the process of steaming and drying, produces a variety of new physiologically active ingredients beneficial to the body. These physiologically active ingredients are not unique to ginseng or white ginseng, but are unique to red ginseng. Red ginseng contains glycosides, panacen, nitrogenous components, polyacetylene compounds, flavonoids, vitamins (B group), trace elements, enzymes, antioxidants, organic acids and amino acids.

Red ginseng has sedative and excitatory effects on the central nervous system and acts on the circulatory system to prevent hypertension or arteriosclerosis. In addition, it reduces hematopoiesis (hematopoietic action) and blood sugar level (blood sugar level), protects the liver, acts on the endocrine system, and acts indirectly on sexual behavior (sexual behavior) and reproductive effect. In addition, there are anti-inflammatory and anti-tumor effects (anti-tumor effect), protective effect against radiation, and skin protecting and softening action. Among the various effects of red ginseng, the adaptogen effect is also included. The adaptogen effect increases the ability to defend against various illnesses and various stresses from the surrounding environment, thereby enhancing the biocompatibility with the surrounding environment.

The origin of the alfalfa is temperate and subtropical, and it is known that more than 30 species are cultivated in the world. In Korea, the Mount (山桑; M. bombycis), Whites (白桑; alba M.), the hearth; and three species are grown for (魯桑M. lhou), Among Whites is grown most. Leaves are used to raise silkworms, and berries are called orchids. Root skin is prescribed in the oriental medicine, such as fever, deep sea bream, diuretic, or extinction. The wood part is also used as furniture.

In one room, the mulberry roots may be referred to as mulberry bark, specifically, scaly-like bark portions with the cork layer of the mulberry root bark removed. Mulberry root bark has been shown to be effective in anti-inflammatory drugs, such as anti-inflammatory diuretics, fever reducers or cough suppressants. Specifically, cough, bronchitis and lungs in the lungs, such as gungija roots and licorice root joints, together with red beans and red bean with the prescribed symptoms, diabetes, thrush and write alone. Dried leaves are called 'upper leaves', and they are effective against fever, shinhae, and geomung, and antimicrobial action is also recognized. In addition, the upper leaves have a remarkable effect on redness of eyes, migraine and hematochezia, and they are also effective in improving diabetes mellitus. I take the juice of the leaf and listen to it when I apply it to the bite of the boil or insect. The young branches are dried in the sun or dried in the fire called 'upper limbs' and drink arthritis, rheumatism or hypertension. It is effective as an energetic agent for helping the energetic person. It is also used as an analgesic drug. It is also effective for constipation, tinnitus and diabetes. The white juice from the bark or leaves is applied to the boil or ring on the mouth of the child and to the bleeding caused by trauma. In addition, it is said that the hump that occurs in the tree is called "screening" and it is said that it is heard by drinking in rheumatism and stomach.

Gold is the root of the perennial plant of the perennial plant. It is a perennial plant with a height of about 1 m, with leaf-shaped leaves facing each other. Gold is a cold, flavorful ingredient. It is poisonous, and it treats fever, osteoporosis, fever, fever, jaundice, jaundice, mulberry, fever, and fever. The gold is often used as it is, but after soaking it in some alcohol, it is taken out and roasted. It is aimed at clearing the heat of the stomach by climbing up the strength of the power of alcohol, and to make the fetus safe, the gold is roasted a little in order to weaken the cold nature of gold to some extent.

There are many kinds of flavonoids in the root, and other β-sitosterol and free amino acids. The flavonoid component of the golden extract has excellent properties of absorbing ultraviolet rays and is excellent in the effect of removing active oxygen, so it is a useful raw material for whitening and anti-aging function. In addition, gold enhances glucose metabolism and has an anti-inflammatory effect. According to copper therapy, gold is effective against inflammation, fever, redness, inflammation and fever, appetite, nausea, vomiting, diarrhea, respiratory infections and cough, Sexually active, inflammatory conjunctivitis. In the private sector, it can be used for acute and chronic infectious diseases, acute rheumatism, myocarditis, arrhythmia, colds, mumps, fractures, pulmonary tuberculosis, or pneumonia.

The present invention also provides a method for producing the above-mentioned composition for hair. In one embodiment, the method of making the hair composition comprises:

Red ginseng extract; And

Wherein the composition for hair is prepared by mixing one or more kinds of extracts selected from the group consisting of mulberry extract, mulberry bark extract and gold extract.

In one embodiment, the red ginseng extract may be prepared by ultrasonic extraction. Specifically, the red ginseng can be washed and pulverized, the pulverized product can be immersed in a mixed solvent of 1,3-butylene glycol and water, and extracted with ultrasonic waves. For example, the red ginseng may be 6 years old red ginseng, and the red ginseng extract is a pale yellowish brown liquid, which has a somewhat unusual smell and smell.

In another embodiment, the bark extract may be prepared using a low temperature extraction method. For example, an extract is prepared by mixing the raw materials of the bark of alabaster and 1,3-butyleneglycol in a weight ratio of 1: 2 to 1: 8, specifically 1: 5, and aging for 5 to 7 days.

In another embodiment, the gold extract can be prepared by extracting with a mixed solvent of 1,3-butyleneglycol and water, followed by cooling. Concretely, the raw material is thoroughly washed and immersed in a 30% 1,3-butylene glycol solvent, aged at 25 캜 for 5 to 7 days and agitated. Then, the extract is frozen at low temperature for 24 hours, filtered with centrifugal separator, and treated with activated carbon. If necessary, the color and odor of the extract are removed, and then filtered once more.

The composition for hair according to the present invention can be formulated into various types of products without particular limitation. The composition for hair may be formulated, for example, as a hair tonic, a hair nutritional lotion, a sense, a serum, a treatment, a scalp treatment, a conditioner, a shampoo or lotion.

In addition, the ingredients other than the essential ingredients mentioned in the respective formulations can be suitably selected and mixed according to the kind of the external preparation, the purpose of use, and the like without difficulty by those skilled in the art.

For example, the hair shampoo composition of the present invention may be added with suitable components according to the type thereof. Specifically, in the case of a shampoo composition, a synthetic surfactant, which is a cleaning component, can be prepared by mixing preservatives, thickeners, viscosity adjusters, pH adjusters, perfumes, dyes, hair conditioning agents, and water. The synthetic surfactant may be selected from at least one of anionic, amphoteric or nonionic surfactants, and may be used singly or in combination. The content of the synthetic surfactant may be 10 to 70% by weight, specifically 10 to 30% by weight, based on the total weight of the composition.

Examples of the anionic surfactant include alkyl and alkyl ether sulfates. Specific examples thereof include sodium lauryl sulfate, ammonium lauryl sulfate, triethanolamine lauryl sulfate, sodium polyoxyethylene lauryl sulfate, and polyoxyethylene lauryl sulfate. . As the amphoteric surfactant, alkyl betaine and alkylamidopropyl betaine may be used. Specific examples thereof include cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethyl alpha-carboxyethylbetaine, cetyldimethyl Carboxymethylbetaine, cocamidopropylbetaine, and the like. As the nonionic surfactant, alkanolamide and amine oxide can be used. Specific examples thereof include lauryldiethylamine oxide, palm oil alkyldimethylamine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid Monoethanolamide and the like.

As the preservative, at least one selected from the group consisting of methyl parahydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, methyl chloroisothiazolinone, methyl isothiazolinone, and sodium benzoate may be mixed and used. As the viscosity modifier, amide type nonionic surfactants such as cocamide mie (CME), cocamide dihee (CDE), sodium chloride and the like can be used. As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid or sodium citrate may be used. As the hair conditioning agent, a dimethicone base and a cationic polymer may be used alone or in combination of two or more.

Depending on the type of hair conditioner composition, suitable components may be added and used. Specifically, conventional conditioner components may contain a tertiary amidoamine and a quaternary ammonium compound, a high melting point compound and a silicone compound as optional components, a preservative, an increasing agent, a viscosity adjusting agent, a pH adjusting agent, a perfume, etc. as a cationic surfactant have.

The quaternary ammonium compound as a cationic surfactant in the hair conditioning agent composition is selected from alkyl (14-22) trimethylammonium chloride, dialkyl (14-22) dimethylammonium chloride, hydrogenated tallowalkyltrimethylammonium chloride, ditallowalkyldimethylammonium chloride And the like. The tertiary amidoamine includes, for example, cocamidopropyldimethylamine, stearamidopropyldimethylamine, behenylamidopropyldimethylamine, oleamidopropyldimethylamine, isostearamidopropyldimethyl Amine and the like. Amines can be neutralized with an acid such as L-glutamic acid, lactic acid, hydrochloric acid, malic acid, succinic acid, acetic acid, fumaric acid, citric acid or EDTA. The cationic surfactants may be used alone or in admixture of two or more, and may be used in an amount of 1 to 30% by weight, specifically 5 to 20% by weight, based on the total weight of the composition.

As the high melting point compound, a compound comprising a fatty alcohol type, a fatty acid type, a fatty alcohol derivative, a hydrocarbon type, etc., and a mixture thereof may be used. The high melting point compound includes, for example, cetyl alcohol, stearyl alcohol or cetostearyl alcohol, and 1 to 10% by weight based on the total weight of the conditioner composition can be used.

The silicone compound includes polyalkylsiloxane-based, polyarylsiloxane-based, polyalkylarylsiloxane-based, polyether siloxane copolymer, and mixtures thereof, cyclopolysiloxane and suitable alkylamino substituted compounds, amodimethicone, etc., and the total weight of the conditioner composition By weight based on the total weight of the composition. As the preservative, at least one selected from the group consisting of methyl parahydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, methyl chloroisothiazolinone, methyl isothiazolinone, and sodium benzoate may be mixed and used. As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, sodium citrate and the like can be used.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the scope of the present invention is not limited to these examples.

[Production Example 1] Production of Examples 1 to 3 and Comparative Examples 1 to 4

The compositions of Examples 1 to 3 and Comparative Examples 1 to 4 were prepared with the compositions shown in Table 1 below. Example 1 contained a mixture of red ginseng extract and mulberry bark extract (red ginseng extract: mulberry extract = 4: 1 (v / v)) while Example 2 contained red ginseng extract and gold extract (red ginseng extract: Example 3 is a mixture of red ginseng extract, mulberry bark extract and golden extract (red ginseng extract: mulberry extract: golden extract = 3: 1: 1 (v / v)) . In addition, Comparative Example 1 contained no extract, Comparative Example 2 contained only red ginseng extract, Comparative Example 3 contained only the extract of mulberry bark extract, and Comparative Example 4 contained only the golden extract. The red ginseng extract was used as a natural solution, the manganese berry extract and the gold extract were purchased from Bioland.

In the following Table 1, the content ratio (%) means the content of the extract relative to the volume of the medium. The medium used was MEM-α (medium containing Fetal Bovine Serum, 100 unit / ml penicillin-streptomycin, 0.5% non essential amino acid (NEAA) Essential Medium-a, Minimum Essential Medium-a, GIBCO).

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 Example 3 Red ginseng extract - 0.5 - - 0.4 0.4 0.3 Eucalyptus extract - - 0.5 - 0.1 0.1 Golden extract - - - 0.5 - 0.1 0.1

[Test Example 1] Evaluation of hair root strengthening efficacy

The hair root strengthening test was performed to evaluate the hair root strengthening efficacy by measuring the Wnt activity. Wnt signaling is a signal transduction process that is crucial to the normal development of an individual that determines the differentiation destiny of a cell during development. In addition, the endothelium maintains homeostasis as a regulator of cell proliferation and differentiation even after development. For this reason, many types of cancer are associated with excessive Wnt signaling. Wint induces the formation of hair follicles in the embryo, and regulates the hair stem cell and hair cycle after birth to induce the production of new hair. Therefore, activation of the winter signaling process can be expected to enhance the hair follicle by inducing the hair follicle anagen phase.

Cell culture for specific experimental methods and experiments is as follows. The mouse embryonic fibroblast C3H / 10T1 / 2 (ACTT) cells were cultured in RPMI 1640 medium supplemented with 10% Fetal Bovine Serum, 100 units / ml penicillin-streptomycin, 0.5% (Minimum Essential Medium-a, GIBCO) containing amino acids (Non-essential amino acid, NEAA) and cultured at 37 ° C and 5% CO ₂ .

Plasmid transfection was performed using a TOP-Luc plasmid (Invitrogen Inc.) and a β-gal plasmid capable of monitoring the activation of the wint. Transfection was carried out using lipofectamine 2000 (Lipofectamine 2000, Invitrogen) and referring to the experimental method provided by the manufacturer. Briefly, C3H cells were divided into 24 wells at a concentration of 2 x ¹⁰ cells / well and cultured overnight in an incubator. The culture medium was replaced with medium without penicillin-streptomycin, and 1 μg of plasmids and 6 μl of Lipo2000 were mixed with Opti-MEM (Gibco) to form a DNA-Lipo complex, which was then sprayed onto the cells To introduce the plasmid into the cell. After 4 to 6 hours of plasmid introduction, the cells were washed twice with PBS, and then cultured in the original culture medium to help recover the cells.

Since the activity of wint activity is also used to measure the activity of luciferase, the detailed experimental method is as follows. The plasmids were introduced into the cells and cultured for 24 hours to stabilize them. The stabilized cells were treated with the test materials of Comparative Examples 1 to 4 and Examples 1 to 3 and cultured again for 24 hours. At the end of incubation, the cells were washed twice with cold PBS, and cells were treated with reporter lysis buffer (Promega) for 15 minutes to destroy the cells. The resulting cell eluate was transferred to a microtube and centrifuged at 12,000 rpm for 3 minutes at 4 ° C to separate the cell residue to obtain a pure cell eluate.

The winter activity of each experimental group was compared by mixing the lysiferase substrate (Promega) with the cell extract at a ratio of 4: 1 and measuring the amount of light emitted by the luminometer. The cell extract was treated with the same amount of 2X β-galactosidase enzyme assay buffer (Promega), reacted at 37 ° C. for 1 hour, and then the absorbance at 420 nm was measured to determine β - galactosidase activity were compared. The winter activity of each experimental group was divided by the activity of each? -Galactosidase to correct the difference according to the degree of introduction of the plasmid, and the final activity was calculated by statistical processing of this correction value. The results are shown in FIG.

As can be seen from Fig. 1, in the case of treating Comparative Example 2 containing only the red ginseng extract, the winter activity was higher than that of Comparative Example 1, It can be seen that the winter activity is almost equal. However, when Example 3 containing both red ginseng extract, manganese berry extract, and gold extract was treated, it was found that the activity of winter was much better than that of Comparative Example 2.

Through this, it can be confirmed that when the extract of Mulberry bark extract and the extract of gold extract are used at the same time as the case of using the red ginseng extract alone, the synergistic effect shows better winter activity. Therefore, it can be seen that the composition for hair according to one embodiment of the present invention is excellent in the active activity of winter and has excellent effect of strengthening hair roots.

[Production Example 2] Production of Example 4 and Comparative Example 5

The shampoo formulations of Example 4 and Comparative Example 5 having the composition shown in the following Table 2 were prepared according to a conventional shampoo manufacturing method. Example 4 was prepared so as to contain a mixture of red ginseng extract, mulberry bark extract, and golden extract (red ginseng extract: mulberry bark extract: golden extract = 3: 1: 1 (v / v)) used in Example 3 above. In Comparative Example 5, as in Comparative Example 2, red ginseng extract alone was contained. For the red ginseng extract, a natural solution, an alum extract and a golden extract were purchased from Bioland.

Furtherance Comparative Example 5
(weight%) Example 4
(weight%) Ammonium lauryl sulfate
/ Ammonium laureth sulfate 16 16 Trihydroxystearin 0.3 0.3 Cetyl alcohol 0.6 0.6 Cocamide miai 1.0 1.0 Guarhydroxytrimonium chloride 0.2 0.2 Spices 1.0 1.0 antiseptic 0.03 0.03 Citric acid 0.05 0.05 Example 3 Red ginseng extract / mulberry bark extract / golden extract - 0.8 / 0.2 The red ginseng extract of Comparative Example 2 1.0 - Purified water To 100 To 100

[Test Example 2] Use quality test

The panel was composed of 10 women aged 20 ~ 30 years. Specifically, after using the shampoo of Example 4 and Comparative Example 5 for two weeks each day, the quality of use was evaluated in such a manner that a 7-point scale (higher score is better) was used in the following questionnaire. The results are shown in Table 3 below.

Survey item Comparative Example 5 Example 4 1. Bubbles are fine and bubbles are good. 5.4 5.8 2. Feels good when rinse and finger passes well 5.3 5.8 3. It is easy to comb and smooth when semi-dry. 5.4 5.7 4. It is easy and soft to care after hair drying 5.6 6.1 5. After drying, the scalp and root part feel good. 5.1 5.5 6. I feel the richness of the hair after 2 weeks. 5.3 6.0

As can be seen from the results of Table 3, when Example 4 containing both red ginseng extract, manganese bark extract and golden extract was used, as compared with the case of using Comparative Example 5 containing only red ginseng extract, And scalp hairiness and hairiness. Therefore, it can be confirmed that the composition for hair according to the present invention is also superior in terms of quality at the time of use.

From the above test results, it can be confirmed that the composition for hair according to the present invention imparts an effect of enhancing hair root strengthening through the activation of the scalp and hair root.

FIG. 1 is a graph showing the results of comparative measurement of the winter activity of the hair composition according to an embodiment of the present invention.

Claims (10)

As an active ingredient, Red ginseng extract, manganese berry extract, and golden extract. The method according to claim 1, Wherein the composition for hair comprises the extract of Morus alba L. and the extract of gold at a volume ratio of 1: 1 to 9: 1. The method according to claim 1, Wherein the content of the active ingredient is 0.01 to 10.0% by weight, based on the total weight of the composition. The method according to claim 1, Wherein the composition is a hair firming composition. 5. The method according to any one of claims 1 to 4, Wherein the composition of the composition is a hair tonic, a hair nutritional lotion, a hair essence, a hair serum scarf treatment, a hair treatment, a hair conditioner, a hair shampoo or a hair lotion. 6. A method of producing a composition for hair according to any one of claims 1 to 4, A method for preparing a composition for hair, which is prepared by mixing red ginseng extract, mulberry bark extract, and golden extract. The method according to claim 6, Wherein the red ginseng extract is prepared by ultrasonic extraction. The method according to claim 6, Wherein the mixture of the extracts of Mongolia bark extract and gold extract is mixed at a volume ratio of 1: 1 to 9: 1. The method according to claim 6, Wherein the extract of Mulberry bark extract is prepared by low temperature extraction. The method according to claim 6, Wherein the golden extract is prepared by extracting using a mixed solvent of 1,3-butylene glycol and water, followed by cooling.

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