KR101592872B1 - 중합체 인공 눈물 시스템 - Google Patents

중합체 인공 눈물 시스템 Download PDF

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Publication number
KR101592872B1
KR101592872B1 KR1020107026488A KR20107026488A KR101592872B1 KR 101592872 B1 KR101592872 B1 KR 101592872B1 KR 1020107026488 A KR1020107026488 A KR 1020107026488A KR 20107026488 A KR20107026488 A KR 20107026488A KR 101592872 B1 KR101592872 B1 KR 101592872B1
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KR
South Korea
Prior art keywords
borate
formulation
galactomannan
present
sorbitol
Prior art date
Application number
KR1020107026488A
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English (en)
Korean (ko)
Other versions
KR20110007228A (ko
Inventor
하워드 알렌 케텔슨
제임스 더블유. 데이비스
데이빗 엘. 메도우스
Original Assignee
알콘 리서치, 리미티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40886688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101592872(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 알콘 리서치, 리미티드 filed Critical 알콘 리서치, 리미티드
Publication of KR20110007228A publication Critical patent/KR20110007228A/ko
Application granted granted Critical
Publication of KR101592872B1 publication Critical patent/KR101592872B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107026488A 2008-04-26 2009-04-24 중합체 인공 눈물 시스템 KR101592872B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4817508P 2008-04-26 2008-04-26
US61/048,175 2008-04-26

Publications (2)

Publication Number Publication Date
KR20110007228A KR20110007228A (ko) 2011-01-21
KR101592872B1 true KR101592872B1 (ko) 2016-02-12

Family

ID=40886688

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107026488A KR101592872B1 (ko) 2008-04-26 2009-04-24 중합체 인공 눈물 시스템

Country Status (17)

Country Link
US (3) US20090270345A1 (pt)
EP (1) EP2278954B1 (pt)
JP (1) JP5659149B2 (pt)
KR (1) KR101592872B1 (pt)
CN (1) CN102046150B (pt)
AR (2) AR071834A1 (pt)
AU (1) AU2009240488B2 (pt)
BR (1) BRPI0910717A2 (pt)
CA (1) CA2722508C (pt)
CL (1) CL2009000985A1 (pt)
ES (1) ES2818619T3 (pt)
MX (1) MX2010011736A (pt)
NZ (1) NZ589323A (pt)
TW (1) TWI526213B (pt)
UY (1) UY31785A1 (pt)
WO (1) WO2009132294A1 (pt)
ZA (1) ZA201007644B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US20050137166A1 (en) * 2003-12-19 2005-06-23 Alcon, Inc. Use of cooling agents to relieve mild ocular irritation and enhance comfort
AU2009240488B2 (en) * 2008-04-26 2013-02-21 Alcon Inc. Polymeric artificial tear system
TWI547522B (zh) * 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
WO2011068872A2 (en) * 2009-12-03 2011-06-09 Alcon Research, Ltd. Carboxyvinyl polymer-containing nanoparticle suspension
TWI478730B (zh) * 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
AU2011248129B2 (en) * 2010-05-05 2014-10-09 Alcon Inc. Stabilized ophthalmic galactomannan formulations
UA113434C2 (uk) * 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
US20130344619A1 (en) 2012-06-21 2013-12-26 Lightship Medical Limited Glucose sensor
TW201938141A (zh) * 2018-02-21 2019-10-01 瑞士商諾華公司 基於脂質的眼用乳劑
US11730699B2 (en) 2018-02-21 2023-08-22 Alcon Inc. Lipid-based ophthalmic emulsion
JP6705495B1 (ja) * 2018-12-26 2020-06-03 株式会社Ｊｖｃケンウッド 車両用記録制御装置、車両用記録装置、車両用記録制御方法およびプログラム
WO2020177714A1 (zh) * 2019-03-04 2020-09-10 中山大学中山眼科中心 一种羊毛甾醇前药化合物的组合物及其制备方法和应用
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
BR112022002467A2 (pt) 2019-09-18 2022-07-19 Alcon Inc Insertos oculares de hidrogel suave embalados a úmido
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006070A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Switchable viscoelastic systems containing galactomannan polymers and borate
WO1999006023A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Ophthalmic compositions containing galactomannan polymers and borate
US20040253202A1 (en) 2003-06-13 2004-12-16 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
GB1593954A (en) * 1977-01-31 1981-07-22 American Home Prod Xanthan gum or locust bean gum topical therapeutic compositions
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
IT1298758B1 (it) * 1998-03-19 2000-02-02 Angelini Ricerche Spa Soluzione umettante e lubrificante per uso oftalmico
US20050129771A1 (en) * 2003-12-11 2005-06-16 Alcon, Inc. Ophthalmic compositions containing a polysaccharide/borate gelling system
DE102006031500A1 (de) 2006-07-06 2008-04-17 Henkel Kgaa O/W-Emulsion
US20100021561A1 (en) * 2006-09-21 2010-01-28 Chowhan Masood A Self-preserved aqueous pharmaceutical compositions
US9096819B2 (en) * 2008-01-31 2015-08-04 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer
US8119112B2 (en) * 2008-01-31 2012-02-21 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
AU2009240488B2 (en) * 2008-04-26 2013-02-21 Alcon Inc. Polymeric artificial tear system
AU2011248129B2 (en) * 2010-05-05 2014-10-09 Alcon Inc. Stabilized ophthalmic galactomannan formulations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006070A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Switchable viscoelastic systems containing galactomannan polymers and borate
WO1999006023A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Ophthalmic compositions containing galactomannan polymers and borate
US20040253202A1 (en) 2003-06-13 2004-12-16 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers

Also Published As

Publication number Publication date
MX2010011736A (es) 2011-01-21
US20140161760A1 (en) 2014-06-12
AU2009240488A1 (en) 2009-10-29
US9259472B2 (en) 2016-02-16
WO2009132294A1 (en) 2009-10-29
CA2722508A1 (en) 2009-10-29
US8685945B2 (en) 2014-04-01
BRPI0910717A2 (pt) 2015-09-29
US20120070402A1 (en) 2012-03-22
EP2278954A1 (en) 2011-02-02
AR112286A2 (es) 2019-10-09
TW200948367A (en) 2009-12-01
TWI526213B (zh) 2016-03-21
CN102046150A (zh) 2011-05-04
CN102046150B (zh) 2013-07-24
KR20110007228A (ko) 2011-01-21
AU2009240488B2 (en) 2013-02-21
ES2818619T3 (es) 2021-04-13
AR071834A1 (es) 2010-07-21
NZ589323A (en) 2012-04-27
UY31785A1 (es) 2009-08-03
US20090270345A1 (en) 2009-10-29
JP2011518842A (ja) 2011-06-30
JP5659149B2 (ja) 2015-01-28
CA2722508C (en) 2016-08-16
ZA201007644B (en) 2011-12-28
EP2278954B1 (en) 2020-08-26
CL2009000985A1 (es) 2010-01-15

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