KR101575679B1 - 코어 및 하나 이상의 배리어 층을 포함하는 방출 제어형 경구 투여 제제 - Google Patents
코어 및 하나 이상의 배리어 층을 포함하는 방출 제어형 경구 투여 제제 Download PDFInfo
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- KR101575679B1 KR101575679B1 KR1020097006438A KR20097006438A KR101575679B1 KR 101575679 B1 KR101575679 B1 KR 101575679B1 KR 1020097006438 A KR1020097006438 A KR 1020097006438A KR 20097006438 A KR20097006438 A KR 20097006438A KR 101575679 B1 KR101575679 B1 KR 101575679B1
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- 229960004355 vindesine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
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Classifications
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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- A—HUMAN NECESSITIES
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- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Nutrition Science (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| KR1020097006435A Withdrawn KR20090065519A (ko) | 2006-08-30 | 2007-08-29 | 니솔디핀을 포함하는 방출 제어형 고형 경구 투여 제제 |
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| JP (3) | JP2010501609A (https=) |
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Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| UA96457C2 (ru) | 2006-08-03 | 2011-11-10 | Нитек Фарма Аг | Лечение ревматоидного артрита глюкокортикоидами с отсроченным высвобождением |
| KR101575679B1 (ko) | 2006-08-30 | 2015-12-08 | 자고텍 아게 | 코어 및 하나 이상의 배리어 층을 포함하는 방출 제어형 경구 투여 제제 |
| BRPI0721883A2 (pt) * | 2007-07-23 | 2014-02-18 | Pharmathen Sa | Composição farmacêutica contendo antagonista de canal de cálcio de dihidropiridina e processo para a preparação da mesma |
| AU2008286914B2 (en) * | 2007-08-13 | 2014-10-02 | Ohemo Life Sciences Inc. | Abuse resistant drugs, method of use and method of making |
| TWI441658B (zh) | 2008-03-11 | 2014-06-21 | Takeda Pharmaceutical | 口腔崩解固體製劑 |
| EP2331088A4 (en) | 2008-08-06 | 2011-10-12 | Gosforth Ct Holdings Pty Ltd | COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC ILLNESSES |
| WO2010025459A2 (en) * | 2008-08-29 | 2010-03-04 | The Uab Research Foundation | Novel anti-arrhythmia agent |
| KR20100069170A (ko) * | 2008-12-16 | 2010-06-24 | 삼일제약주식회사 | 라시디핀 함유 과립 및 이를 포함하는 약학 조성물 |
| AU2010207740B2 (en) * | 2009-01-26 | 2016-06-16 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of asthma |
| US20100247646A1 (en) * | 2009-03-26 | 2010-09-30 | Ranbaxy Laboratories Limited | Extended release tablets of nisoldipine |
| US20100260842A1 (en) * | 2009-04-06 | 2010-10-14 | Rashmi Nair | Pseudoephedrine pharmaceutical formulations |
| US20100285125A1 (en) * | 2009-05-07 | 2010-11-11 | Padma Venkitachalam Devarajan | Delivery system for poorly soluble drugs |
| CA3186189A1 (en) | 2009-05-18 | 2010-11-25 | Dose Medical Corporation | Drug eluting ocular implant |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2011006012A1 (en) | 2009-07-08 | 2011-01-13 | Charleston Laboratories Inc. | Pharmaceutical compositions |
| MX365650B (es) | 2009-12-02 | 2019-06-10 | Adamas Pharmaceuticals Inc | Composiciones de amantadina y metodos para su uso. |
| US20110217373A1 (en) * | 2010-01-29 | 2011-09-08 | Kumaravel Vivek | Extended release pharmaceutical compositions of guanfacine hydrochloride |
| KR101767288B1 (ko) * | 2010-03-31 | 2017-08-10 | 모찌다 세이야쿠 가부시끼가이샤 | 복용 용이성 고형 제제 |
| WO2012071321A1 (en) * | 2010-11-22 | 2012-05-31 | Glaxosmithkline Llc | Method of treating cancer |
| US9668915B2 (en) | 2010-11-24 | 2017-06-06 | Dose Medical Corporation | Drug eluting ocular implant |
| HUE034955T2 (en) | 2010-12-22 | 2018-03-28 | Purdue Pharma Lp | Encased tamper resistant controlled release dosage forms |
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| GB201111712D0 (en) | 2011-07-08 | 2011-08-24 | Gosforth Ct Holdings Pty Ltd | Pharmaceutical compositions |
| WO2013046453A1 (ja) | 2011-09-30 | 2013-04-04 | 持田製薬株式会社 | 易服用性固形製剤 |
| ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
| MX2015010041A (es) | 2013-02-05 | 2015-10-30 | Purdue Pharma Lp | Formulacion farmaceuticas resistentes a la alteracion. |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| WO2014146093A2 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| KR102170642B1 (ko) * | 2013-11-14 | 2020-10-27 | 코웨이 주식회사 | 기능성 제재 공급기 및 이를 포함하는 연수기 |
| EP3677229A1 (en) | 2014-05-29 | 2020-07-08 | Glaukos Corporation | Implants with controlled drug delivery features |
| US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| WO2017136745A1 (en) * | 2016-02-05 | 2017-08-10 | Entrega Inc. | Oral dosage form with drying agent for delivery of active agent |
| JP2019507181A (ja) | 2016-03-04 | 2019-03-14 | チャールストン ラボラトリーズ，インコーポレイテッド | 医薬組成物 |
| EP3442479B1 (en) | 2016-04-20 | 2026-03-04 | Glaukos Corporation | Bioresorbable ocular drug delivery device |
| EP3928776B1 (en) | 2016-04-22 | 2025-11-12 | Spoke Sciences, Inc. | Fast-acting plant-based medicinal compounds and nutritional supplements |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| EP3639854B1 (en) | 2017-06-16 | 2026-01-07 | The Doshisha | Mtor-inhibitor-containing medicine for treating or preventing fuchs' endothelial corneal dystrophy |
| US20200121652A1 (en) * | 2017-06-16 | 2020-04-23 | The Doshisha | Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent |
| CA3072764A1 (en) | 2017-08-24 | 2019-02-28 | Adamas Pharma, Llc | Amantadine compositions, preparations thereof, and methods of use |
| MD3684344T2 (ro) * | 2017-10-25 | 2025-09-30 | Chiesi Farm Spa | Comprimate de deferipronă cu eliberare întârziată și metode de utilizare a acestora |
| AU2019385420A1 (en) | 2018-11-19 | 2021-07-08 | Spoke Sciences, Inc. | N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions |
| IT201800011120A1 (it) * | 2018-12-14 | 2020-06-14 | Dpl Pharma S P A | Composizioni farmaceutiche orali solide per la somministrazione di mesalazina o suoi derivati |
| WO2020180690A1 (en) * | 2019-03-01 | 2020-09-10 | Avadel Legacy Pharmaceuticals, Llc | Liquid pharmaceutical compositions with stable drug release profiles |
| CN114630656B (zh) * | 2019-08-26 | 2025-03-21 | 埃斯普投资有限公司 | 黏膜黏附剂组合物及其使用方法 |
| JP2024541083A (ja) * | 2021-11-19 | 2024-11-06 | ポール バーリア スシュマ | フラボキサートの制御放出製剤及びその調製方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62120315A (ja) * | 1985-11-20 | 1987-06-01 | Shin Etsu Chem Co Ltd | 経口投与型徐放性錠剤の製造方法 |
| DE3636123A1 (de) | 1986-10-23 | 1988-05-05 | Rentschler Arzneimittel | Arzneizubereitungen zur oralen verabreichung, die als einzeldosis 10 bis 240 mg dihydropyridin enthalten |
| US5015479A (en) | 1987-02-02 | 1991-05-14 | Seamus Mulligan | Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine |
| US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
| DE3720757A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
| NO883326L (no) * | 1987-08-11 | 1989-02-13 | Bayer Ag | Dhp-retard-tilberedning. |
| DE3814532A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | Dhp-retard-zubereitung |
| IT1237904B (it) | 1989-12-14 | 1993-06-18 | Ubaldo Conte | Compresse a rilascio a velocita' controllata delle sostanze attive |
| US5209933A (en) * | 1990-01-10 | 1993-05-11 | Syntex (U.S.A.) Inc. | Long acting calcium channel blocker composition |
| IT1251153B (it) * | 1991-08-06 | 1995-05-04 | Vectorpharma Int | Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica |
| IL104192A (en) * | 1992-02-17 | 1998-01-04 | Siegfried Ag Pharma | Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient |
| US6235313B1 (en) * | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| US6210714B1 (en) * | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
| IT1265240B1 (it) | 1993-11-30 | 1996-10-31 | Ekita Investments Nv | Compressa farmaceutica a rilascio controllato, di forma lenticolare |
| GB9402203D0 (en) | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US6103263A (en) | 1994-11-17 | 2000-08-15 | Andrx Pharmaceuticals, Inc. | Delayed pulse release hydrogel matrix tablet |
| JP2849047B2 (ja) * | 1994-12-19 | 1999-01-20 | 大正薬品工業株式会社 | ジクロフェナクナトリウム持続性製剤およびその製法 |
| US5534263A (en) * | 1995-02-24 | 1996-07-09 | Alza Corporation | Active agent dosage form comprising a matrix and at least two insoluble bands |
| US6083532A (en) * | 1995-03-01 | 2000-07-04 | Duramed Pharmaceuticals, Inc. | Sustained release formulation containing three different types of polymers and tablet formed therefrom |
| US5736159A (en) | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
| US5900425A (en) | 1995-05-02 | 1999-05-04 | Bayer Aktiengesellschaft | Pharmaceutical preparations having controlled release of active compound and processes for their preparation |
| US5783212A (en) | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| IT1282576B1 (it) | 1996-02-06 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili |
| IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
| US6096339A (en) * | 1997-04-04 | 2000-08-01 | Alza Corporation | Dosage form, process of making and using same |
| US5955096A (en) | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
| IT1289160B1 (it) * | 1997-01-08 | 1998-09-29 | Jagotec Ag | Compressa farmaceutica completamente rivestita per il rilascio controllato di principi attivi che presentano problemi di |
| US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
| IT1294760B1 (it) * | 1997-09-03 | 1999-04-12 | Jagotec Ag | Procedimento per la preparazione di compresse farmaceutiche in grado di cedere,secondo schemi predeterminabili, principi attivi poco |
| US6962717B1 (en) * | 1999-01-29 | 2005-11-08 | Disphar International B.V. | Pharmaceutical compositions |
| DE19906290A1 (de) | 1999-02-15 | 2000-08-17 | Falk Pharma Gmbh | Arzneimittel zur Behandlung bzw. Prävention von Darmkrebs |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| AR030557A1 (es) * | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
| US6866866B1 (en) * | 2000-11-03 | 2005-03-15 | Andrx Labs, Llc | Controlled release metformin compositions |
| DE10115216A1 (de) * | 2001-03-28 | 2002-10-10 | Bosch Gmbh Robert | Kraftstoffeinspritzventil für Brennkraftmaschinen |
| US20040198789A1 (en) * | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
| CA2520660C (en) | 2003-03-28 | 2013-08-20 | Sigmoid Biotechnologies Limited | Solid oral dosage form containing seamless microcapsules |
| JP2005132803A (ja) * | 2003-10-31 | 2005-05-26 | Ono Pharmaceut Co Ltd | 胃内滞留固形剤 |
| US20050187262A1 (en) * | 2004-01-12 | 2005-08-25 | Grogan Donna R. | Compositions comprising (S)-amlodipine and an angiotensin receptor blocker and methods of their use |
| EP2444071A1 (en) | 2004-09-27 | 2012-04-25 | Sigmoid Pharma Limited | Minicapsule formulations |
| KR101575679B1 (ko) | 2006-08-30 | 2015-12-08 | 자고텍 아게 | 코어 및 하나 이상의 배리어 층을 포함하는 방출 제어형 경구 투여 제제 |
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2007
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- 2007-08-29 EP EP07801966A patent/EP2063871A1/en not_active Withdrawn
- 2007-08-29 JP JP2009525976A patent/JP2010501609A/ja active Pending
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- 2007-08-29 WO PCT/EP2007/007549 patent/WO2008025535A1/en not_active Ceased
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|---|---|
| US9622980B2 (en) | 2017-04-18 |
| JP2014114323A (ja) | 2014-06-26 |
| JP2010501607A (ja) | 2010-01-21 |
| KR20090065519A (ko) | 2009-06-22 |
| MX2009002235A (es) | 2009-03-13 |
| CA2662123C (en) | 2015-12-01 |
| US20080057123A1 (en) | 2008-03-06 |
| US9101544B2 (en) | 2015-08-11 |
| EP2063872B1 (en) | 2015-05-06 |
| EP2063871A1 (en) | 2009-06-03 |
| JP5788547B2 (ja) | 2015-09-30 |
| US20160008288A1 (en) | 2016-01-14 |
| CA2662123A1 (en) | 2008-03-06 |
| AU2007291506A1 (en) | 2008-03-06 |
| ES2547226T5 (es) | 2020-06-12 |
| JP2010501609A (ja) | 2010-01-21 |
| WO2008025535A1 (en) | 2008-03-06 |
| AU2007291509A1 (en) | 2008-03-06 |
| US20080063711A1 (en) | 2008-03-13 |
| EP2063872A1 (en) | 2009-06-03 |
| MX2009002236A (es) | 2009-03-13 |
| ZA200901688B (en) | 2014-02-26 |
| KR20090065520A (ko) | 2009-06-22 |
| WO2008025532A1 (en) | 2008-03-06 |
| ES2547226T3 (es) | 2015-10-02 |
| CA2662122A1 (en) | 2008-03-06 |
| EP2063872B2 (en) | 2019-12-04 |
| AU2007291509B2 (en) | 2013-05-02 |
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