KR101517748B1 - 스피로사이클릭 사이클로헥산 유도체 - Google Patents

스피로사이클릭 사이클로헥산 유도체 Download PDF

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Publication number
KR101517748B1
KR101517748B1 KR1020097019738A KR20097019738A KR101517748B1 KR 101517748 B1 KR101517748 B1 KR 101517748B1 KR 1020097019738 A KR1020097019738 A KR 1020097019738A KR 20097019738 A KR20097019738 A KR 20097019738A KR 101517748 B1 KR101517748 B1 KR 101517748B1
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acid
unsubstituted
alkyl
substituted
cyclohexane
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Expired - Fee Related
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KR20090114470A (ko
Inventor
슈테판 슌크
슈테판 ?크
데릭 사운더스
슈테파니 하를핑거
존야 슈토이프멜
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그뤼넨탈 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
KR1020097019738A 2007-02-22 2008-02-19 스피로사이클릭 사이클로헥산 유도체 Expired - Fee Related KR101517748B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007009319.7 2007-02-22
DE102007009319A DE102007009319A1 (de) 2007-02-22 2007-02-22 Spirocyclische Cyclohexan-Derivate
PCT/EP2008/001271 WO2008101660A1 (de) 2007-02-22 2008-02-19 Spirocyclische cyclohexan-derivate

Publications (2)

Publication Number Publication Date
KR20090114470A KR20090114470A (ko) 2009-11-03
KR101517748B1 true KR101517748B1 (ko) 2015-05-06

Family

ID=39531427

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KR1020097019738A Expired - Fee Related KR101517748B1 (ko) 2007-02-22 2008-02-19 스피로사이클릭 사이클로헥산 유도체

Country Status (25)

Country Link
US (1) US7960404B2 (https=)
EP (1) EP2121691B1 (https=)
JP (1) JP5514556B2 (https=)
KR (1) KR101517748B1 (https=)
CN (1) CN101622256B (https=)
AT (1) ATE554089T1 (https=)
AU (1) AU2008217277B2 (https=)
BR (1) BRPI0806794A2 (https=)
CA (1) CA2679173C (https=)
CO (1) CO6220948A2 (https=)
CY (1) CY1112725T1 (https=)
DE (1) DE102007009319A1 (https=)
DK (1) DK2121691T3 (https=)
EC (1) ECSP099621A (https=)
ES (1) ES2386387T3 (https=)
HR (1) HRP20120511T1 (https=)
IL (1) IL200496A (https=)
MX (1) MX2009007387A (https=)
NZ (1) NZ578589A (https=)
PL (1) PL2121691T3 (https=)
PT (1) PT2121691E (https=)
RU (1) RU2470933C2 (https=)
SI (1) SI2121691T1 (https=)
WO (1) WO2008101660A1 (https=)
ZA (1) ZA200906584B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006033114A1 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
ES2464102T3 (es) 2008-03-27 2014-05-30 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
ES2375543T3 (es) 2008-03-27 2012-03-01 Grünenthal GmbH Derivados de espiro(5.5)undecano.
CN102046591B (zh) 2008-03-27 2014-12-03 格吕伦塔尔有限公司 羟甲基环己胺
JP5529843B2 (ja) 2008-03-27 2014-06-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換シクロヘキシルジアミン
AU2009228647B2 (en) 2008-03-27 2013-07-04 Grunenthal Gmbh Substituted spirocyclic cyclohexane derivatives
US8637501B2 (en) 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
PL2649044T3 (pl) 2010-12-08 2018-02-28 Grünenthal GmbH Sposób syntezy podstawionych pochodnych aminocykloheksanonu
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
ES2577861T3 (es) * 2011-12-12 2016-07-19 Grünenthal GmbH Proceso para la preparación de (1R,4R)-6'-fluor-(N,N-dimetil- y N-metil)-4-fenil-4',9'-dihidro-3'H-espiro[ciclohexano-1,1'-pirano-[3,4,b]indol]-4-amina
PT2970284T (pt) 2013-03-15 2018-02-08 Gruenenthal Gmbh Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
BR112017000762A2 (pt) 2014-07-15 2017-11-21 Gruenenthal Gmbh derivados de azaspiro(4.5)decano substituído.
CA2974578C (en) * 2015-01-23 2020-11-17 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
CN107383027A (zh) * 2017-07-24 2017-11-24 扬州大学 一种四氢螺类化合物的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108565A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2426730C2 (ru) * 2001-04-18 2011-08-20 Эро-Селтик, С.А. Аналоги ноцицептина
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108565A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit

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CY1112725T1 (el) 2016-02-10
PL2121691T3 (pl) 2012-09-28
CN101622256B (zh) 2015-07-22
CA2679173C (en) 2015-11-24
RU2470933C2 (ru) 2012-12-27
ATE554089T1 (de) 2012-05-15
JP5514556B2 (ja) 2014-06-04
DK2121691T3 (da) 2012-07-02
ES2386387T3 (es) 2012-08-20
PT2121691E (pt) 2012-05-25
EP2121691B1 (de) 2012-04-18
KR20090114470A (ko) 2009-11-03
US20100048553A1 (en) 2010-02-25
ZA200906584B (en) 2010-06-30
HRP20120511T1 (hr) 2012-07-31
DE102007009319A1 (de) 2008-08-28
CA2679173A1 (en) 2008-08-28
NZ578589A (en) 2012-02-24
US7960404B2 (en) 2011-06-14
CO6220948A2 (es) 2010-11-19
AU2008217277B2 (en) 2012-09-06
WO2008101660A1 (de) 2008-08-28
ECSP099621A (es) 2009-10-30
HK1136827A1 (en) 2010-07-09
IL200496A0 (en) 2010-04-29
IL200496A (en) 2014-02-27
RU2009135070A (ru) 2011-03-27
MX2009007387A (es) 2009-07-17
AU2008217277A1 (en) 2008-08-28
SI2121691T1 (sl) 2012-06-29
JP2010519265A (ja) 2010-06-03
BRPI0806794A2 (pt) 2011-09-13
CN101622256A (zh) 2010-01-06
EP2121691A1 (de) 2009-11-25

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