KR101387695B1 - The anti-diabetic composition mainly containing extracts of kudzu root, Solomon's seal and E. senticosus - Google Patents

Abstract

The present invention relates to an antidiabetic composition in which natural ingredients are optimally selected and blended to obtain an excellent antidiabetic effect. More particularly, the present invention relates to an antidiabetic composition comprising a root extract, a round stem, and an extract of Audi as a main component. will be.
The present invention has a root extract, a round stem extract, an Audi extract as a main component.
At this time, the root extract is 18 to 22% by weight, the round stalk extract is 13 to 17% by weight, Audi extract is characterized in that it contains 13 to 17% by weight.

Description

The anti-diabetic composition mainly containing extracts of kudzu root, Solomon's seal and E. senticosus}

The present invention relates to an antidiabetic composition in which natural ingredients are optimally selected and blended to obtain an excellent antidiabetic effect. More particularly, the present invention relates to an antidiabetic composition comprising a root extract, a round stem, and an extract of Audi as a main component. will be.

According to the present invention it is possible to achieve an excellent anti-diabetic effect through the combination of the appropriate ingredients while eliminating the side effects of the use of natural materials.

Diabetes is a disease in which glucose metabolism does not work well even if insulin is secreted or secreted abnormally. Insulin promotes the use of glucose to regulate metabolism, so when this action is insufficient, glucose is not properly used and body cells are in a state of energy deprivation. Glucose in the blood remains unused and becomes hyperglycemic, a hallmark of diabetes.

Diabetes is one of the adult diseases such as obesity, high blood pressure, heart disease, and arteriosclerosis caused by a similar diet to the Western diet. It is a serious problem that accounts for 10% of the adult population, and its complications are also serious, causing diabetic neuropathy, retinopathy, and atherosclerosis, leading to stroke or heart disease.

There are two types of diabetes. Type 1 diabetes mellitus is insulin dependent, and β cells are known to be destroyed by genetic factors. It is caused by not producing any insulin at all.

Type 2 diabetes is also referred to as insulin independent or adult diabetes. It is caused by obesity, stress, poor diet, or drugs that antagonize insulin, and more than 95% of all diabetics belong to type 2 diabetes.

The cause of diabetes is not known yet, and it is known to be related to heredity, obesity, viral infections, stress, drug abuse, and lack of exercise. As the exact cause is not known, it is considered difficult to cure and difficult to treat.

In Western medicine, diabetes is controlled by regular diet and exercise while focusing on glycemic control by oral hypoglycemic drugs or insulin injections. not. Also, most of the drugs on the market must be taken on an ongoing basis, so bear the side effects of long-term administration of the drug.

The present invention has been made in the background as described above, the object of the present invention is to provide a composition exhibiting excellent anti-diabetic effect by appropriately blending while eliminating side effects due to drug use using natural materials.

Since the composition of the present invention is in liquid form, it is very easy for the patient to ingest, and when ingested, the blood sugar content continuously decreases.

The present invention as described above is characterized in that the anti-diabetic composition, the main component of the root extract, the round stem extract, the Audi extract.

More specifically, the anti-diabetic composition of the present invention is characterized in that it contains 18-22% by weight of the root extract, 13-17% by weight of the oleander stem extract, and 13-17% by weight of the Audi extract.

More specifically, 20% by weight of the root extract, 15% by weight of the round stalk extract, 15% by weight of the Audi extract, 15% by weight of the onion extract, 15% by weight of the skin extract, pine needle extract 13.5%, vitamin C 2% by weight, vitamin E 2% %, Red ginseng extract 2% by weight, chicory dietary fiber is characterized by consisting of 0.5% by weight.

At this time, the solid content of the root extract is 15-20% by weight, the solid content of the round stalk extract is 20-25% by weight, the solid content of the Audi extract is 20-25% by weight, the solid content of the onion extract is 20-25% by weight, the solid content of the skin extract Silver is 20-25% by weight, solid content of pine needle extract is 20-25% by weight, solid content of red ginseng extract is characterized in that 60-65% by weight.

Also, at this time, the root extract, round stalk extract, audi extract, onion extract and thorny oocyte extract, (1) select each raw material, select it, put it in an extractor, add water and extract it at 80 ~ 90, and then (2) extract the extract in a reduced pressure concentrator. After concentration, (3) characterized in that prepared by adjusting the amount of solids to a predetermined numerical range with water.

The main raw materials used in the present invention will be described.

Brown root is a natural ingredient with many advantages, such as 625 times more phytoestrogens in pomegranates. It is rich in dietary fiber and contains a lot of saponin, which is good for diabetes and high blood pressure. The reed sucks water and nutrients from the ground and stores them in a thick body. When ingested, the body's body can control moisture and nutrients, which can have a great effect on fatigue (recovering liver function), edema, jaundice, etc.

It is pharmacologically acting mainly on blood pressure, heart and blood sugar. Duckle stem is good for weak constitution, pulmonary tuberculosis, dry cough, thirst, and strengthens the heart, so it is good for people with heart disease, such as heart failure, angina pectoris. It is also a good natural food for people who feel frustrated due to cold sweating and fever with their face unknowingly causing the chest to feel stuffy or have limbs in their hands and feet.

Onion dissolves unnecessary fat and cholesterol in the blood to prevent atherosclerosis and hyperlipidemia. It is also excellent for preventing and treating hypertension, and it is a good material for preventing and treating diabetes by promoting the action of lowering blood sugar and promoting insulin secretion. It is low in fat and contains a lot of protein as a vegetable, so it is necessary for even nutrition. In addition, it has a high content of calcium and iron, which plays a role in enhancing the tonic effect. It cleanses the blood, so it is good for skin care and prevents fine lines.

Psoriasis has pharmacological effects such as physiological improvement of overall function, metabolic promoting action, normalization of arterial blood pressure, anti-inflammatory action, anticancer action, antidiabetic action, detoxification action and improvement of adaptation ability to environmental changes.

Audi has the effect of improving all the functions of the body as a whole and clearing eyes and ears. Audi contains a free sugar component composition and a hypoglycemic component. DJJ, known to lower blood sugar, contains mulberry leaves as much as mulberry leaves, and the sugar present in Audi is composed of fructose and glucose, which is very useful for diabetic patients who need to exclude sugar. In addition, it contains a high level of hypertension inhibitor routines and a very high unsaturated fatty acid content of 87%. Dongbogam is also in the liquid juice "Black Audi is the soul of mulberry trees are gathered, good for diabetes, good for the five chapters, long eating will make you forget hunger."

The present invention is characterized by combining the above materials in a manner and in a content that has not been provided before.

According to the present invention it is possible to achieve an excellent anti-diabetic effect through the combination of the appropriate ingredients while eliminating the side effects of the use of natural materials.

In addition, since the composition of the present invention is in liquid form, it is very easy for the patient to consume.

Hereinafter, the present invention will be described in detail with reference to examples.

1. Composition and Content

-20% by weight of root extract (solid 15%)

-15% by weight of round stalk extract (20% solids)

-15% by weight of Audi extract (solid content 20%)

-15% by weight of onion extract (20% solids)

-15% by weight of Shigagapi Extract (20% solids)

-Pine needle extract (20% solids) 13.5% by weight

2% by weight of vitamin C

2% by weight of vitamin E

-Red ginseng extract (60% solids) 2% by weight

-0.5% by weight of chicory dietary fiber

2. Anti-diabetic  Preparation of composition

The raw roots were screened and selected and placed in an extractor, followed by extracting three times at 90 to 6 to 7 hours by adding a solvent (water). The extract was filtered under pressure in a 250mesh filter, transferred to a vacuum concentrator, and concentrated at 400-700 mmHg, 50-80 (at which the solid content was about 60%). Water was added to this concentrate, and the solid content was adjusted to 15%.

Extracts of stalks, onions, prickly pears, mulberry, pine needles, and red ginseng were prepared in the same manner.

Next, each extract was combined with chicory fiber and vitamins C and E.

Chicory dietary fiber is generally commercialized and sold in powder form.

3. Experiment

end. Experimental animal : Experimental male rat (200 ± 10g)

I. Diabetic Reagents

After injection into the abdominal cavity of the experimental animal (rat male body weight 200 ± 10g) using the diabetes-induced reagent Streptozotocin (sigma S-0130), blood was collected from rat eye one week later, and then blood glucose measurement was performed using a blood glucose meter. Rats whose blood glucose was elevated to hyperglycemia were selected and used as experimental animals.

All. Processing method

① Diabetes-induced rats were selected and placed 20 animals in one treatment group.

② The control composition was not fed the mixed composition according to the present invention and 3ml / 1 day / water, 2.5ml / 1 day / water, 2.0ml / 1 day / water and divided into salary groups such as 4 treatment groups. The administration method was oral administration daily using sonde.

③ The experiment period was conducted for 4 weeks. Blood glucose was measured by oral blood collection 5 times a week apart from blood glucose measurement before the start of the experiment.

4. Experimental Results

end. Weight measurement results

As a result of measuring the body weight at weekly interval during the experiment, the mixture group showed a weight loss when the blood sugar level was high for the first time, but increased almost normally after 3 weeks.

On the other hand, the control group (the rat not administered the mixture according to the present invention) showed no signs of recovery for 4 weeks.

<Table 1.Weight Changes in Rats>

Graph 1.Weight Changes in Rats>

I. Blood sugar measurement result

When the mixture was administered, normal blood glucose levels were obtained within two weeks. Therefore, only three weeks of administration and did not administer for a week to see if the normal value continues.

(1) Unadministered group: At 2 weeks after the first 434.90mg /, the patient recovered to 241.10mg /, but deteriorated to 396.44mg / after 4 weeks.

② 2.0ml group: At 2 weeks after the first 293.7mg / 132.80mg / was almost normal recovery, but after 4 weeks 189.00mg / tended to increase again.

③ 2.5ml administration group: After 2 weeks at the first 263mg / 94.8mg / was completely normal.

④ 3.0ml group: The first 333.2mg / 2 weeks after 100.80mg / showed a completely normal result.

Table 2. Blood glucose measurement results for 4 weeks

<Graph 2. Blood glucose measurement graph for 4 weeks>

Table 3. Comparison of Blood Glucose Level between Unmixed and Untreated Mice

5. Evaluation of Experimental Results

end. Of weight measurement results Significance

Representative symptoms of diabetes are the following: polyuria, polyps. As glucose levels in the blood increase, sugar in the blood is excreted in the urine. At this time, the amount of water and the number of urine increases because the body also escapes moisture. In addition, due to the dehydration phenomenon to drink a lot of water. Depending on the person, it is common to drink three to four liters or more per day. And the feeling of fasting worsens, the amount of meals is high. Like this, but the weight is rather missing, in severe cases may fall up to 10kg in 2-3 months. When water is released and you have a lot of food, you lose weight and do not get the nutrients you need, so you can easily feel tired and lethargic.

In the above experiments, when the mixed composition was drunk after three weeks, the weight can be seen to increase almost normally. Significance of weight recovery and gain was all the 2.0ml, 2.5ml, 3.0ml administration group. The larger improvement group that normalized the weight before the experiment or increased before the experiment could be referred to as the 2.5ml and 3ml groups.

These effects, along with lowered blood sugar levels, are important signs of recovery.

I. Blood sugar measurement result

As shown above, the inventors compared the efficacy effects of the mixtures by not administering the invention mixture or adjusting the dose to the diabetic rats.

As a result, the rats treated with the mixture generally showed normal blood glucose levels, but the rats without administration showed no signs of recovery after 4 weeks. Therefore, it can be seen that the extract according to the present invention has an excellent effect on diabetes.

On the other hand, the significance of lowering blood glucose level was all 2.0ml, 2.5ml, 3.0ml administration group. Before the experiment, the blood sugar level returned to normal or below the level before the experiment, and the group showing a greater improvement may be referred to as a 2.5ml, 3ml group. From the above results, it can be seen that the daily administration of 2.5ml and 3.0ml showed the best effect in the animal experiment of body weight 200 ± 10g, and was utilized as a basis for calculation of the daily intake of the product in the practice of the present invention. Can be.

In addition, it can be seen from the above experimental results that a significant amount can be achieved if a certain amount or more is administered.

Claims (5)

Root extract, gourd stem extract, audi extract, onion extract, prickly pear extract, pine needle extract, vitamin C, vitamin E, red ginseng extract and chicory dietary composition comprising the dietary fiber. The method of claim 1,
The root extract is 18-22% by weight, the round stalk extract is 13-17% by weight, the Audi extract is 13 to 17% by weight of the food composition for preventing and improving diabetes. 3. The method of claim 2,
20% by weight of brown root extract, 15% by weight of round stalk extract, 15% by weight of audi extract, 15% by weight of onion extract, 15% by weight of barberry extract, 13.5% by weight of pine needles extract, 2% by weight of vitamin C, 2% by weight of vitamin E, red ginseng Extract 2% by weight, dietary fiber composition for preventing and improving diabetes, characterized in that consisting of 0.5% by weight of chicory dietary fiber. The method of claim 3,
The solid content of the root extract is 15-20% by weight, the solid content of the round stalk extract is 20-25% by weight, the solid content of the Audi extract is 20-25% by weight, the solid content of the onion extract is 20-25% by weight, and the solid content of the thorny skin extract is 20-25% by weight, solid content of pine needle extract is 20-25% by weight, solid content of red ginseng extract is 60-65% by weight, the food composition for preventing and improving diabetes. 5. The method of claim 4,
Brown root extract, round stalk extract, audi extract, onion extract, and thorny oocyte extract, (1) select each raw material, select it, place it in an extractor, add water and extract it at 80 ~ 90 ℃, and then (2) concentrate the extract in a reduced pressure concentrator. Then, (3) the food composition for preventing and improving diabetes, characterized in that prepared by adjusting the amount of solids to a predetermined numerical range with water.