KR101342554B1 - Foam Pack Composition containing a Mud extract and Method of Preparing thereof - Google Patents

Abstract

The present invention contains a mud extract (SEA SILT EXTRACT) and a polycondensation reactant having an antimicrobial function in the foam pack composition, and in addition to the antibacterial function of the mud to improve the skin disease, and to enhance the skin stress due to the activation of skin cells The present invention discloses a foam pack composition that can be resolved to maintain a clear, clean, elastic, and moist moisturizing function.

Description

Foam Pack Composition containing a Mud extract and Method of Preparing pretty}

The present invention relates to an antimicrobial-enhanced foam pack composition containing a mud extract, and in particular, the foam pack composition contains a mud extract (SEA SILT EXTRACT) and a polycondensation reactant having an antibacterial function, thereby preventing diseases of the facial skin. In addition to the antibacterial function of the mud extracts to improve the anti-fungal function, and also to relieve the stress of the facial skin caused by the activation of facial skin cells to provide a clear, clean, elastic and fatigue relief effect will be.

In general, the cosmetic foam pack refers to a product of a wash-off type that is applied to the face for a certain time and then washed with water after drying. The function and purpose of use are skin cleansing, moisturizing and blood circulation. Helps to keep skin beautiful and healthy by promoting.

However, the existing foam packs had main functions such as moisturizing effect due to film formation when applied to the skin and removal of skin contamination by adsorption of several cosmetic inorganic or organic powders such as kaolin and silica, and coarse facial skin such as acne. The antimicrobial effect on the fungus was negligible.

That is, it is known that demodex brevis, a type of DEMODEX (hairworm), lives on the face skin. The demodex brevis is a parasitic ingestion of fatty tissue in the sebaceous glands, causing inflammation of the sebaceous glands and exacerbating acne, and eventually causing skin texture to be coarse.

In other words, demodex brevis is a bacterium that eats adipose tissue of sebaceous glands and lives its life in human skin, roughens the skin and accelerates skin aging. Let's do it. In particular, these bacteria can infect malignant bacteria and cause skin inflammation.

Demodex brevis is a nocturnal worm, so it comes out of the skin at night and irritates the skin's surface with sharp claws, causing itching.

In addition, the basal layer of the epidermis contains cells called melanocytes that form pigments. These cells rarely function when not exposed to sunlight, but when exposed to light, the pigment increases due to the activity of tyrosinase. When skin cell activity is healthy, pigmentation does not occur well, but pigmentation progresses rapidly when physical activity is weakened or skin cell activity is weakened due to the activity of Demodex brevis.

In addition, demodex brevis parasites the sebaceous glands, destroys the major components of the dermis, collagen and elastin, and destroys tissue and capillaries, that is, blood vessels, which promotes premature aging of the skin and roughens the skin.

Therefore, there is an urgent need for the development of a foam pack with enhanced antibacterial function against facial skin diseases and enhanced nutrition supply.

Republic of Korea Patent Registration No. 10-0905852 Republic of Korea Patent Registration No. 10-0633992

The purpose of the present invention is to develop the results of intensive research to solve the problems described above, by the mud extract (SEA SILT EXTRACT) contained in the composition of the foam pack and a polycondensation reaction agent having an antibacterial function, facial skin diseases It provides enhanced antifungal function to improve nutrients, and nourishment by mud extract enhances skin function by activating skin cells, relieves skin stress, and clear, clean, elasticity and fatigue relief effect. One form pack composition is provided.

Anti-microbial enhanced foam pack composition containing a mud extract of the present invention (Sea Silt Extract) for achieving the above object, 0.1 to 60% by weight of the mud extract of claim 1; 10% by weight of a polycondensation reactant having an antibacterial function obtained by polycondensing titanium dioxide to a condensation reaction of silicon dioxide and aluminum oxide; Glycerin 10-25 wt%; Lauryl glycoside 5-30% by weight; 1-10 wt% cocamidopropylbetaine; 1 to 20% by weight of acrylate copolymer; Characterized in that the remaining amount of purified water.

The polycondensation reactant having the antibacterial function is mixed with silicon dioxide (SiO ₂ ) and aluminum oxide (Al ₂ O ₃ ) and then added to isopropylene alcohol (IPA) to obtain a condensation reactant by heating to 30 ~ 75 ℃, this condensation Distilled water and titanium dioxide (TiO2) were added to the reactants, and the resultant was obtained by polycondensation reaction while mixing and stirring.

In addition, the mud extract is 1 to 3 times or 1 to 5 times to remove the salt by washing Boryeong acid mud with purified water, and then mixed with purified water 1: 10 (g / v), for 3 hours at room temperature After stirring and aging for 24 hours, it is characterized in that obtained by filtration with a filter of 2 ~ 3㎛.

According to the present invention, the mud extract (SEA SILT EXTRACT) contained in the composition of the foam pack and the polycondensation reactant having antibacterial function, give the effect of enhanced antifungal function to improve skin diseases of the face, and also mud extract Nourishment by reinforcing the skin function due to the activation of skin cells to relieve skin stress, clear, clean, elastic, and also gives fatigue effect.

1a to 1e is a gram-negative bacteria ( E. coli ) and Gram-positive bacteria ( S.aureus ) and yeast (pityrosporum ovale) in order to determine the bactericidal and antifungal effects on the parasitic bacteria on the skin for the foam pack of the present invention Pictures of the results of the sterilization test,
2 is a manufacturing process diagram of the polycondensation reaction product having an antibacterial function added to the present invention,
Figure 3 is a graph showing the cell proliferation (Cell Proliferation) effect of the mud extract using the fibroblasts (Human Fibroblast),
4 is a graph showing the results of moisturizing mud extracts measured using Corneometer CM 825.

Hereinafter, the more preferable Example of this invention is described in detail.

Polycondensation having a mud extract (SEA SILT EXTRACT) and antibacterial function, which is added to the foam pack cosmetic composition of the present invention to perform skin cell activation, moisturizing, elasticity, skin soothing, and antifungal activity against parasitic bacteria on the facial skin. The reactants are prepared and prepared in the same manner as in Reference Examples 1-2.

Reference Example 1: Preparation of Mud Extract

Boryeong acid mud is washed 1 to 3 times or 1 to 5 times with purified water to remove salt. Subsequently, the salt-free mud is mixed with purified water at 1: 10 (g / v), stirred at room temperature for 3 hours, extracted, and aged for 24 hours. The aged mud is filtered through a filter of 0.2 ~ 0.3㎛ to obtain the final mud extract.

Reference Example 2: Preparation of Polycondensation Reaction with Antibacterial Function

The polycondensation reaction product having antibacterial function is obtained by polycondensation of titanium dioxide to the condensation reaction product of silicon dioxide and aluminum oxide. That is, after mixing silicon dioxide (SiO ₂ ) and aluminum oxide (Al ₂ O ₃ ), isopropylene alcohol (IPA) is added and heated to 30-75 ° C. to obtain a condensation reaction product. Distilled water and titanium dioxide (TiO 2) are added to the condensation reaction product. ) To obtain a polycondensation reaction while mixing and stirring (see also the manufacturing process of FIG. 2).

The mud extract of the reference 1 to 2 prepared as described above and the foam pack cosmetic composition of the present invention to which the polycondensation reactant having an antimicrobial function is added is formulated in the proportions as shown in Table 1 below.

<Components and Blending Ratio of Foam Pack Cosmetic Composition> Material name Content (% by weight) Mud Extract 0.1 to 60 Polycondensation reactants with antimicrobial activity 10 glycerin 10-25 Lauryl glucoside 5 to 30 Cocamidopropyl betaine 1 to 10 Acrylate copolymer 1-20 Purified water Residual quantity 100 total

Glycerin, lauryl glycoside, cocamidopropyl betaine, acrylate copolymer, purified water weighed as shown in Table 1 above, and the mud extract, polycondensation reaction having an antibacterial function is added thereto. To prepare a foam pack cosmetic composition.

In Table 1, glycerin is added to moisturize the skin. If the amount is less than the content, the moisturizing function may be weakened. If the amount is exceeded, the glycerin may be impaired. .

In addition, lauryl glycoside is a nonionic surfactant added to give a mild cleansing ingredient to the skin. If the added amount is less than the above content, the function as a nonionic surfactant may be weakened. If the amount is exceeded, the function of other materials added together may be weakened.

Cocamidofurofilbetaine acts as an amphoteric ionic surfactant and is added as an auxiliary surfactant to lauryl glycoside. If the added amount is less than the above content, the function as the zwitterionic surfactant may be weakened, and if the amount is exceeded, the function of other materials added together may be weakened.

In addition, the acrylate copolymer forms a thin film on the skin and acts as a film forming action to improve the adhesion in use. In addition, if the added amount is less than the above content, there is a risk that the film forming function may be weakened, and if it is exceeded, the function of other materials added together may be weakened.

 The addition of the polycondensation reactant having the antimicrobial function is as shown in the following test example, in order to suppress skin troubles such as acne occurring on the face by having antifungal power against DEMODEX (hairworm) bacteria parasitic on the skin. If the added amount is less than the above content, the antimicrobial function against the skin bacteria may be weakened. On the contrary, if the added amount is less than the above content, the function of other materials added together may be weakened, and the manufacturing cost may be increased.

In addition, the reason for the addition of the mud extract is also shown in the following test example, and if the addition amount is less than the above content, there is a fear that the nutritional supply and antibacterial function of organic enzymes and the like contained in the mud extract on the skin may be weakened, and vice versa. If there is a lowering of the function of the other materials added together, there is a fear of causing an increase in the manufacturing cost. The purified water was added for the solvent function.

10% by weight of glycerin, 5% by weight of lauryl glycoside, 1% by weight of cocamidopropyl betaine, 1% by weight of acrylate copolymer, and the remaining amount of purified water, weighed as Table 1 above, were uniformly dissolved, A mud extract (Sea Silt Extract) 60% by weight, polycondensation reactant having an antimicrobial function 10% by weight was added to prepare a face pack cosmetic composition of the foam type (Foam Type) of the present invention.

25% by weight of glycerin, 30% by weight of lauryl glycoside, 10% by weight of cocamidopropyl betaine, 20% by weight of acrylate copolymer, and the remaining amount of purified water, which are weighed as in Table 1 above, are uniformly dissolved, 0.1 wt% of mud extract (Sea Silt Extract) and 10 wt% of a polycondensation reactant having an antibacterial function were added to prepare a face pack cosmetic composition of the foam type of the present invention.

&Lt; Test Example 1 >

As a result of measuring the salt content according to the number of washing of the mud added to the present invention, it was as Table 2 below.

<Measurement result of salt content> Test Items unit Sample classification Results Test Methods Cl- mg / l First Washing 797 Water Pollution Process Test Method Cl- mg / l Second Washing 65.4 Water Pollution Process Test Method Cl- mg / l 3rd Washing 8.25 Water Pollution Process Test Method

As confirmed in Table 2, it can be seen that there is no problem with salinity when extracted by washing several times to remove salts of mud.

&Lt; Test Example 2 &

Chemical test results of the mud extract added to the present invention was as Table 3 below.

<Chemical test result of mud extract> Test Items unit Results Test Methods Na mg / l 72.9 APHA 20th Edition 1998 Mg mg / l 8.52 APHA 20th Edition 1998 Al mg / l 0.32 APHA 20th Edition 1998 Si mg / l 22.2 APHA 20th Edition 1998 K mg / l 14.9 APHA 20th Edition 1998 Ca mg / l 13.2 APHA 20th Edition 1998 Ti mg / l Undetected (N.D) APHA 20th Edition 1998 Fe mg / l 0.09 APHA 20th Edition 1998

Table 3 shows the results obtained by requesting a chemical test to the Korea Institute of Chemical Testing, the mud extract, the chemical test results of the mud extract can be seen that the highest Na content and the lowest content of Fe. It can be seen that the mud extract contains components useful for the human body, such as minerals. Therefore, when the foam pack of the present invention is used for both men and women, the function of the facial skin due to the nutritional supply by various mineral components contained in the mud extract It can be indirectly confirmed that it is possible to maintain facial skin elasticity, maintain skin tone and maintain moisturizing by strengthening and activating facial skin cells.

<Test Example 3>

The contamination test result of the mud extract added to the present invention was as Table 4 below.

<Contamination test result of mud extract> Test Items unit Results Test Methods Pb mg / l Not detected (N.D) APHA 20th Edition 1998 Cr mg / l Not detected (N.D) APHA 20th Edition 1998 CD mg / l Not detected (N.D) APHA 20th Edition 1998 CN- mg / l Not detected (N.D) APHA 20th Edition 1998 Hg mg / l Not detected (N.D) APHA 20th Edition 1998 As mg / l Not detected (N.D) APHA 20th Edition 1998

Table 4 shows the results obtained by requesting a contaminant test to the Korea Institute of Chemical Testing, the mud extract, it is confirmed that there is no problem in the case of using the foam pack of the present invention on the facial skin as a result of the contamination test of the mud extract.

<Test Example 4>

Experimental results of the biological activity of the mud extract added to the present invention was as shown in FIG.

Figure 3 is a graph showing the cell proliferation (Cell Proliferation) effect of the mud extract using the fibroblasts (Human Fibroblast), the effect on the proliferation of fibroblasts by minerals, aluminum, other chemicals in the mud extracts, etc. The measurement results are shown. As shown in FIG. 3, the proliferative effect of the fibroblasts was about 110% at a concentration of 100 μg / ml.

These test results alone can be indirectly confirmed that the use of the foam pack cosmetics of the present invention can relieve skin stress that can maintain a healthy, clear and transparent facial skin through skin cell activation.

<Test Example 5>

The mud extract added to the present invention was measured using the Corneometer CM 825, the result of measuring the moisture of the mud extract was as shown in FIG. 4 is a graph showing the results of moisturizing mud extracts measured using Corneometer CM 825.

As confirmed in Figure 4, the moisturizing measurement results of the mud extract added to the foam pack of the present invention was found to have a better moisturizing effect than water.

&Lt; Test Example 6 >

In order to examine the antimicrobial effect of the foam pack of the present invention, a bactericidal test was performed on the Gram-negative bacterium E. coli and the Gram-positive bacillus Staphylococcus aureus ( S.aureus ). The results were as shown in Tables 5 to 6 and FIGS. 1A to 1E.

<Sterilization test results> (unit: CFU / ml) Test strain Early After 1 hour E. coli 4.3 × 10 ⁵ 2.6 × 10 ⁵ (39.5%)

S. aureus
3.1 × 10 ⁵
2.0 × 10 ⁴ (93.5%)

* (): Bactericidal rate (%) = (A-B) / A X 100, where A: initial bacterial count, B: bacterial count after a certain time.

<Antibacterial Test Results> (Unit: mm) Test strain Overall diameter (T)  Diameter of sample and disc (D) Inhibition Zone
Width (W) P. acnes 24 6 9

* Growth base: W = (T-D) / 2, where W: width of the low zone (mm), T: total diameter of the sample and low zone (mm), D: diameter of the sample and disc (mm).

The test apparatus and materials used above are as follows.

1. Testing device:

Auto Clave (Sanyo, Japan)

Dry Oven (Jisco, Korea)

Water Bath (Polyscience, USA)

Incubator (Memmert, German)

pH Meter (Thermo Orion, USA)

Stop Watch (Time Art, Japan)

Vortex Mixer (Thermolyne, USA)

Container (Iwaki Pyrex, Japan)

Sterile Pipette (FALCON, USA)

Petri Dish (Green Cross Medical Industry, Korea)

Volumetric Flask (Myung Sung, South Korea)

Mechanical Shaker (Jisco, South Korea)

Clean Bench (Sooyang, Korea)

Colony Counter (Dukwoo Science, South Korea)

Petri Dish (Green Cross, South Korea)

2.test material

1) Test strain: Escherichia coli ATCC 25922

Staphylococcus aureus ATCC 6538

Propionibacterium acnes ATCC 6919

2) Medium and reagent

end. Brain Heart Infusion Broth (DIFCO, USA)

I. Brain Heart Infusion Agar (DIFCO, USA)

All. Tryptic Soy Agar (DIFCO, USA)

la. D / E Neutralizing Broth (DIFCO, USA)

hemp. Fluid Thioglycollate Medium (DIFCO, USA)

bar. Brewer's Anaerobic Agar (DIFCO, USA)

four. Saline solution

Ah. ^{Gaspak TM EZ Anaerobe Container System (DIFCO} , USA)

3.Test Method

3.1. Sterilization test method: Escherichia coli and Staphylococcus aureus were cultured in Brain Heart Infusion Broth (DIFCO), and the cultured bacteria were diluted to adjust the initial bacterial count to 10 ⁵ to 10 ⁶ CFU / mL and used in the test.

The test bacteria (30% (w / v) concentration) was added to 20mL of the test bacteria and mixed, and when left at room temperature for 1 hour, the bacterial count was measured to determine the rate of sterilization reduction for the initial bacterial count. Bacterial counts were measured as physiological saline, and the initial bacterial counts were expressed.

In this case, the initial dilution of all experiments was carried out by neutralizing with D / E Neutralizing Broth (DIFCO), and when bacteria were grown in the medium, the number of bacteria on the medium was multiplied by the dilution factor. When the bacteria did not proliferate in the multiplied by the dilution factor made in the neutralization step was expressed as "<10 (<10)". The bacterial counts at all stages were measured using the TSA (see Section 2), and the viable cell count was determined according to the following 3.3 [Formula 1] and the sterilization reduction rate was determined according to [Formula 2].

3.2.Halo test: Propionibacterium acnes was enriched in Fluid Thioglycollate Medium (DIFCO) medium and used for the test.

Inoculate the Propionibacterium acnes fungus with a sterile swab evenly on the prepared Brewer's Anaerobic Agar (DIFCO) plate medium, process 20 μl of sample stock solution on the sterilized disc (Ø 6.0), and place the disc in the center of the medium. Anaerobic Jar (DIFCO) at incubated for 72 hours in anaerobic conditions was measured the diameter of the formed (Inhibition Zone).

3.3. Calculation of Sterilization Test Results

1) Calculation of viable cells: [Equation 1] N = C × D

N: viable count, C: colony count (average number of two colonies), D: dilution factor (dilution factor of diluent).

2) Calculation of percent reduction (%): [Formula 2] R (%) = [(A-B) / A] × 100

R: bactericidal rate, A: initial bacterial count, B: bacterial count after a certain time.

3.4.Halo test results read

Growth Base: W = (T-D) / 2

Where W is the width of the low zone (mm), T is the total diameter of the sample and the low zone (mm), and D is the diameter of the sample (mm).

4.Result

4.1. E. Sterilization test for coli (see Table 5 and figures 1a and 1b above)

As a result of the sterilization test for E. coli , the initial inoculation bacterial count [4.3 × 10 ⁵ CFU / mL] decreased to 1 hour after treatment [2.6 × 10 ⁵ CFU / mL].

4.2. Sterilization test for S. aureus (see Table 5 and figures 1c and 1d above)

As a result of the sterilization test for S. aureus , the initial inoculation bacterial count [3.1 × 10 ⁵ CFU / mL] decreased to 1 hour [2.0 × 10 ⁴ CFU / mL] after treatment.

4.3. Antimicrobial test for P. acnes (see Table 6 and Figure 1e above)

As a result of measuring the size of the inhibition zone, the sample stock solution formed a 9 mm low zone for P. acnes .

From Test Example 6, the foam pack cosmetics of the present invention can be confirmed that the antimicrobial effect is added to the mud extract is further enhanced antibacterial effect.

<Test Example 7>

The foam pack prepared according to the above example was subjected to a closed patch test for 50 healthy men and women in their 20s and 30s in order to evaluate skin stability according to long-term use. The upper arm of both arms of the test subject was washed with an aqueous 70% isopropyl alcohol solution, and the foam pack composition of the present invention was closed to the site according to a known method. At this time, the amount of coagulation was 25 microliters per unit area (㎠). After 24 hours, the skin of the test area was observed and the same material was repeated 10 times with the same material on the same site Respectively. As a result, skin changes were rarely found.

<Test Example 8>

50 adult men and women were allowed to use the foam pack of the present invention and the existing mud-containing product (control), and the following items were examined, and the results were as shown in Table 7 below.

sample Appearance color incense Oil content Skin tone
(Antibacterial) Skin elasticity Moisturizing Smooth after use Refreshing Overall rating Invention 9 9 8 8 8 9 9 9 9 78 (7.8) Counterpart 8 9 8 7 4 5 9 8 8 66 (6.6)

As confirmed in Table 7, the evaluation area for the test items is calculated by dividing the 0 (very bad) to 10 (very satisfactory), the form pack of the present invention is more satisfactory than the conventional pack Confirmed. In particular, the antibacterial (skin soothing) effect of facial skin was much more satisfying than the control.

As confirmed in the above test examples, the foam pack of the present invention eliminates the skin stress caused by the activation of facial skin cells by providing minerals, aluminum and various useful nutrients contained in the mud extract to make the facial skin tone clear and transparent. In addition, the elasticity and moisturizing function of the facial skin can be continuously maintained, and the added antibacterial liquid solution, in addition to the antibacterial effect of the mud extract, exerts an enhanced antifungal effect to prevent facial skin damage caused by bacteria. It can be seen that.

Figure 1a

Claims (3)

Antimicrobial enhanced foam pack composition containing the mud extract composition as follows.
Sea Silt Extract 0.1 ~ 60% by weight;
10% by weight of a polycondensation reactant having an antibacterial function obtained by polycondensing titanium dioxide to a condensation reaction of silicon dioxide and aluminum oxide;
Glycerin 10-25 wt%;
Lauryl glycoside 5-30% by weight;
1-10 wt% cocamidopropylbetaine;
1 to 20% by weight of acrylate copolymer; And
Purified water remaining amount The polycondensation reaction product of claim 1, wherein the polycondensation reaction product having antibacterial function is condensed by mixing silicon dioxide (SiO ₂ ) and aluminum oxide (Al ₂ O ₃ ) and then adding isopropylene alcohol (IPA) to 30 to 75 ° C. An antimicrobial-enhanced foam pack composition comprising a mud extract obtained by obtaining a reactant, and adding the distilled water and titanium dioxide (TiO2) to the condensation reaction and performing a polycondensation reaction with mixing and stirring. The method of claim 1, wherein the mud extract is washed 1 to 3 times or 1 to 5 times (washing) Boryeong acid mud with purified water to remove the salt, and then mixed with purified water 1: 10 (g / v), Antibacterial enhanced foam pack composition containing a mud extract, characterized in that obtained by stirring for 3 hours at room temperature and then aged for 24 hours and filtered.

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