KR101327772B1 - 광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제 - Google Patents

광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제 Download PDF

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Publication number
KR101327772B1
KR101327772B1 KR1020107026841A KR20107026841A KR101327772B1 KR 101327772 B1 KR101327772 B1 KR 101327772B1 KR 1020107026841 A KR1020107026841 A KR 1020107026841A KR 20107026841 A KR20107026841 A KR 20107026841A KR 101327772 B1 KR101327772 B1 KR 101327772B1
Authority
KR
South Korea
Prior art keywords
amino
benzothiazole
compound
compounds
isobutyl
Prior art date
Application number
KR1020107026841A
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English (en)
Korean (ko)
Other versions
KR20100137584A (ko
Inventor
도미니크 루이스 네스터 기스레인 서레러스
피에트 톰 베르트 파울 위거린크
다니엘 피. 게트만
Original Assignee
얀센 알 앤드 디 아일랜드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 얀센 알 앤드 디 아일랜드 filed Critical 얀센 알 앤드 디 아일랜드
Priority claimed from PCT/EP2003/050359 external-priority patent/WO2004014371A1/en
Publication of KR20100137584A publication Critical patent/KR20100137584A/ko
Application granted granted Critical
Publication of KR101327772B1 publication Critical patent/KR101327772B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020107026841A 2002-08-02 2003-08-04 광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제 KR101327772B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP02078231.4 2002-08-02
EP02078231 2002-08-02
US42786202P 2002-11-20 2002-11-20
US60/427,862 2002-11-20
PCT/EP2003/050359 WO2004014371A1 (en) 2002-08-02 2003-08-04 Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020057001206A Division KR20050025647A (ko) 2002-08-02 2003-08-04 광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ프로테아제 저해제

Publications (2)

Publication Number Publication Date
KR20100137584A KR20100137584A (ko) 2010-12-30
KR101327772B1 true KR101327772B1 (ko) 2013-11-11

Family

ID=38068099

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107026841A KR101327772B1 (ko) 2002-08-02 2003-08-04 광범위 2-아미노-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제

Country Status (5)

Country Link
JP (1) JP4879484B2 (ja)
KR (1) KR101327772B1 (ja)
CN (1) CN101445493A (ja)
OA (1) OA12893A (ja)
ZA (1) ZA200500926B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA103013C2 (uk) * 2007-12-06 2013-09-10 Тиботек Фармасьютикелз Амідні сполуки як активатори противірусних препаратів
MX2013012266A (es) * 2011-04-21 2013-11-22 Gilead Sciences Inc Compuestos de benzotiazol y su uso farmaceutico.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
WO2001025240A1 (en) * 1999-10-06 2001-04-12 Tibotec Pharmaceuticals Ltd. HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU7722296A (en) * 1995-11-15 1997-06-05 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
ES2275866T3 (es) * 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
WO2001025240A1 (en) * 1999-10-06 2001-04-12 Tibotec Pharmaceuticals Ltd. HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Also Published As

Publication number Publication date
ZA200500926B (en) 2006-03-29
KR20100137584A (ko) 2010-12-30
OA12893A (en) 2006-10-13
JP2006503815A (ja) 2006-02-02
CN101445493A (zh) 2009-06-03
JP4879484B2 (ja) 2012-02-22

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