KR101266549B1 - 결정형 무수 도세탁셀을 제조하는 방법 - Google Patents

결정형 무수 도세탁셀을 제조하는 방법 Download PDF

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Publication number
KR101266549B1
KR101266549B1 KR1020097010170A KR20097010170A KR101266549B1 KR 101266549 B1 KR101266549 B1 KR 101266549B1 KR 1020097010170 A KR1020097010170 A KR 1020097010170A KR 20097010170 A KR20097010170 A KR 20097010170A KR 101266549 B1 KR101266549 B1 KR 101266549B1
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KR
South Korea
Prior art keywords
debenzoyl
formula
docetaxel
butoxycarbonyl
tert
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KR1020097010170A
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English (en)
Korean (ko)
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KR20090080986A (ko
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유안-시우 랴오
멩-펜 호
슈-핑 첸
치아-닝 린
유-리 린
쯩-유 샤오
Original Assignee
시노팜 싱가포르 피티이 리미티드
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Publication of KR20090080986A publication Critical patent/KR20090080986A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
KR1020097010170A 2006-10-20 2007-10-19 결정형 무수 도세탁셀을 제조하는 방법 KR101266549B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85334106P 2006-10-20 2006-10-20
US60/853,341 2006-10-20

Publications (2)

Publication Number Publication Date
KR20090080986A KR20090080986A (ko) 2009-07-27
KR101266549B1 true KR101266549B1 (ko) 2013-05-24

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KR1020097010170A KR101266549B1 (ko) 2006-10-20 2007-10-19 결정형 무수 도세탁셀을 제조하는 방법

Country Status (10)

Country Link
US (2) US7662980B2 (zh)
EP (2) EP2094084A4 (zh)
JP (3) JP2010506932A (zh)
KR (1) KR101266549B1 (zh)
CN (1) CN101534642A (zh)
AR (1) AR063347A1 (zh)
AU (1) AU2007309534B2 (zh)
CA (2) CA2756603C (zh)
NZ (1) NZ576355A (zh)
WO (1) WO2008051465A2 (zh)

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KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
EP2173732A4 (en) * 2007-07-04 2011-09-07 Reddys Lab Ltd Dr PROCESSES FOR THE PREPARATION OF DOCETAXEL AND POLYMORPHIC
EP2358693A4 (en) * 2008-11-20 2012-04-18 Reddys Lab Ltd Dr PREPARATION OF DOCETAXEL
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CN106432747B (zh) 2010-03-01 2019-11-05 不列颠哥伦比亚大学 衍生的超支化聚丙三醇
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KR20120096200A (ko) * 2011-02-22 2012-08-30 동아제약주식회사 결정형 도세탁셀 및 이의 제조방법
WO2012131698A1 (en) * 2011-04-01 2012-10-04 Shilpa Medicare Limited Process for preparing docetaxel and its hydrate
US8842114B1 (en) 2011-04-29 2014-09-23 Nvidia Corporation System, method, and computer program product for adjusting a depth of displayed objects within a region of a display
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
JO3685B1 (ar) * 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
KR101508302B1 (ko) * 2013-06-10 2015-04-06 숭실대학교산학협력단 초음파를 이용한 도세탁셀 수화물 제조방법
EP2865675A1 (en) * 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
CN112807299B (zh) 2015-05-15 2022-06-24 珠海贝海生物技术有限公司 包含多西他赛和人血清白蛋白的固体组合物及其制备方法和应用
CN110062622B (zh) 2016-10-27 2022-10-14 珠海贝海生物技术有限公司 多西他赛和人血清白蛋白的中性pH组合物
CN109836401B (zh) * 2017-11-28 2023-02-14 正大天晴药业集团股份有限公司 一种多西他赛的纯化方法
CN111718316A (zh) * 2020-07-02 2020-09-29 无锡紫杉药业有限公司 一种三水多西他赛生产工艺
CN118510503A (zh) 2022-02-25 2024-08-16 珠海贝海生物技术有限公司 多西他赛组合物和方法

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EP2001874A4 (en) * 2006-03-21 2010-04-07 Reddys Lab Ltd Dr DOCETAXEL POLYMORPH AND CORRESPONDING METHODS

Also Published As

Publication number Publication date
US8357811B2 (en) 2013-01-22
CN101534642A (zh) 2009-09-16
AU2007309534A1 (en) 2008-05-02
WO2008051465A3 (en) 2009-04-16
CA2756603A1 (en) 2008-05-02
EP2094084A4 (en) 2010-01-13
JP2010506932A (ja) 2010-03-04
US20080108693A1 (en) 2008-05-08
CA2667416A1 (en) 2008-05-02
CA2667416C (en) 2013-12-17
US20090275762A1 (en) 2009-11-05
JP2015057423A (ja) 2015-03-26
AU2007309534B2 (en) 2012-08-16
AR063347A1 (es) 2009-01-21
US7662980B2 (en) 2010-02-16
CA2756603C (en) 2013-05-28
WO2008051465A2 (en) 2008-05-02
EP2094084A2 (en) 2009-09-02
EP2330101A1 (en) 2011-06-08
NZ576355A (en) 2012-04-27
KR20090080986A (ko) 2009-07-27
JP2013155191A (ja) 2013-08-15

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