KR101266148B1 - A pharmaceutical comprising Panax Ginseng, mixed lactic acid bacteria and oligosaccharides, and a healthful food with the pharmaceutical - Google Patents
A pharmaceutical comprising Panax Ginseng, mixed lactic acid bacteria and oligosaccharides, and a healthful food with the pharmaceutical Download PDFInfo
- Publication number
- KR101266148B1 KR101266148B1 KR1020110027290A KR20110027290A KR101266148B1 KR 101266148 B1 KR101266148 B1 KR 101266148B1 KR 1020110027290 A KR1020110027290 A KR 1020110027290A KR 20110027290 A KR20110027290 A KR 20110027290A KR 101266148 B1 KR101266148 B1 KR 101266148B1
- Authority
- KR
- South Korea
- Prior art keywords
- lactic acid
- oligosaccharides
- acid bacteria
- red ginseng
- weight
- Prior art date
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- 239000004310 lactic acid Substances 0.000 title claims abstract description 39
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 39
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A23V2400/00—Lactic or propionic acid bacteria
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- Nutrition Science (AREA)
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Abstract
본 발명은 홍삼(紅蔘, Panax ginseng C.A. Meyer), 혼합 유산균 및 올리고당류를 모두 분말로 형성하여 함유하는 조성물에 관한 것이다.
본 발명에 사용되는 혼합 유산균은 락토바실러스(Lactobacillus) 및 비피도박테리움 (Bifidobacterium) 균속에 포함되는 프로바이오틱(probiotic) 유산균주를 2개 종류 이상 포함하는 것을 특징으로 하고 있다.The present invention relates to a composition comprising red ginseng (紅 蔘, Panax ginseng CA Meyer), mixed lactic acid bacteria and oligosaccharides in powder form.
The mixed lactic acid bacteria used in the present invention are characterized by including two or more types of probiotic lactic acid bacteria contained in Lactobacillus and Bifidobacterium strains.
Description
본 발명은 홍삼(紅蔘, Panax ginseng C.A. Meyer), 혼합 유산균 및 올리고당류를 모두 분말로 형성하여 함유하는 조성물에 관한 것이다.The present invention relates to a composition comprising red ginseng (紅 蔘, Panax ginseng CA Meyer), mixed lactic acid bacteria and oligosaccharides in powder form.
본 발명에 사용되는 혼합 유산균은 락토바실러스(Lactobacillus) 및 비피도박테리움 (Bifidobacterium) 균속에 포함되는 프로바이오틱(probiotic) 유산균주를 2개 종류 이상 포함하는 것을 특징으로 하고 있다.The mixed lactic acid bacteria used in the present invention are characterized by including two or more types of probiotic lactic acid bacteria contained in Lactobacillus and Bifidobacterium strains.
홍삼(紅蔘, Panax ginseng C.A. Meyer)은 오갈피나무과에 속하는 다년생 풀인 4~6년 근 수삼(水蔘)을 선별하여 껍질을 벗기지 않은 상태로 증기에 쪄서 말린 것이다.Red ginseng ( Panax ginseng CA Meyer) is a perennial herb belonging to the Ogalpiaceae, selected for 4-6 years of fresh ginseng and dried in steam without peeling.
한의학적으로는, 성질은 약간 따듯하고 맛은 달고 약간 쓰며, 비, 폐, 심장으로 들어가 원기를 보충하고 진액을 만드는 등, 건강 증진과 질병 예방의 효과가 있는 대표적 한약재로 사용되어 왔다.In oriental medicine, it has been used as a representative herbal medicine with the effect of promoting health and preventing disease, such as being slightly warm, sweet and slightly bitter, entering the rain, lungs, and heart to replenish the energy and make a essence.
특히 홍삼에는 생리활성 유효 성분으로서 진세노사이드(ginsenoside)가 함유되어 있는데, 그 가운데에서 특히 진세노사이드(ginsenoside) Rb1, Rg1및Rc의 함유량이 비교적 높은 것으로 알려져 있다.
In particular, red ginseng contains ginsenosides as physiologically active ingredients, and among them, ginsenosides Rb 1 , Rg 1 and Rc are known to have a relatively high content.
그런데 진세노사이드(ginsenoside)는 분자량이 큰데도 불구하고 인체의 위산 및 소화효소가 이를 잘 분해하지 못하는 등의 원인으로 인체 내 소화 흡수율이 매우 낮은 것으로 연구되어 왔다.By the way, ginsenoside (ginsenoside) has been studied to have a very low digestive absorption rate in the human body due to the fact that the stomach acid and digestive enzymes of the human body does not break down even though the molecular weight is large.
여기에서, 분자량을 살펴보면, 진세노사이드 Rb1 은 1109.29, 진세노사이드Rg1은 801.01, 진세노사이드 Rc는11079.27에 이른다.
Here, looking at the molecular weight, ginsenoside Rb1 is 1109.29, ginsenoside Rg1 is 801.01, ginsenoside Rc is 11079.27.
논문 “Studies on absorption, distribution, and metabolism of ginseng in humans after oral administration”(Jayeul LEE 외 5인, Journal of Ethnopharmacology, Vol. 122, 143~148, 2009.02)에는, 한국인 98명을 조사한 결과 20% 가량은 장내 미생물이 진세노사이드(ginsenoside) Rb1을 컴파운드(compound) K로 전환시키지 못한다고 기재되어 있다.In the paper “Studies on absorption, distribution, and metabolism of ginseng in humans after oral administration” (Jayeul LEE et al. 5, Journal of Ethnopharmacology, Vol. 122, 143-148, 2009.02), about 20% of Koreans were surveyed. Has been described that intestinal microorganisms do not convert ginsenoside Rb1 to compound K.
즉 한국인의 20% 가량은 홍삼을 섭취하더라도 그 효과를 보기 어렵다고 추정될 수 있는데, 이는 신장기능이 좋은 반면에 장 기능이 좋지 못한 소음인 비율인 20~30% 에 해당되는 수치에 해당된다.
In other words, about 20% of Koreans may not be able to see the effect even if they consume red ginseng. This is equivalent to 20-30%, which is the ratio of noise that is not good in intestinal function while having good kidney function.
또한 논문 “인삼사포닌류의 체내동채와 효능에 관한 생화학적 연구현황”(주충노, 고려인삼학회지, Vol. 17, No.13, 250~286, 1993년)은, 실험동물에 인삼을 경구 투여한 후 진세노사이드의 흡수 결과를 논하고 있는데, 위장에서 부분적으로 분해가 되고 대부분이 배설되며, 흡수율이 매우 낮다는 것이 기재되어 있다.
In addition, the study "Biochemical Studies on the Body Composition and Efficacy of Ginseng Saponins" (Joo Choong-no, Journal of Korean Ginseng Society, Vol. 17, No. 13, 250-286, 1993), Later, the results of the absorption of ginsenosides are discussed, with partial degradation in the gastrointestinal tract, the majority being excreted, and the absorption being very low.
따라서 홍삼이 포함하는 유효성분으로서의 진세노사이드(ginsenoside)를 흡수하여 건강 증진 효과를 얻기 위해서는, 장 내 존재하는 미생물총을 활성화할 수 있는 물질과 더불어서 함께 섭취하는 것이 필요하다 하겠다.Therefore, in order to absorb the ginsenoside as an active ingredient included in red ginseng to obtain a health promoting effect, it is necessary to ingest together with a substance that can activate the microflora present in the intestine.
왜냐하면 홍삼을 경구 섭취할 경우, 소장에서 제대로 흡수가 되지 않고 대장에 도달한 후에야 미생물이 분비하는 효소에 의해 분해되어 흡수된다고 볼 수 있으며, 결국 장내에 존재하는 미생물총의 활성에 따라 홍삼의 효과가 좌우된다고 할 수 있기 때문이다.
Because red ginseng is taken orally, it is not absorbed properly in the small intestine, but can be decomposed and absorbed by enzymes secreted by the microorganisms after reaching the large intestine. It can be said that it depends.
한편 프로바이오틱(probiotics) 유산균을 기능성 식품에 사용하기 위하여 유산균의 잠재력에 대한 평가나 선발기준에 대한 연구가 광범위하게 진행되어 왔다.On the other hand, in order to use probiotics lactic acid bacteria in functional foods, researches on the evaluation or selection criteria of lactic acid bacteria potential have been extensively conducted.
여기에서, 프로바이오틱이란 숙주의 장내 미생물 균형을 향상시킴으로써 건강 증진 효과를 나타내는 활성 미생물 식이 보충제를 의미하여, 대표적인 프로바이오틱으로는 유산균을 들 수 있겠다.Here, probiotic means an active microbial dietary supplement that exhibits a health promoting effect by improving the intestinal microbial balance of the host, and a representative probiotic may include lactic acid bacteria.
일 예로, 논문 “과민성 대장 증후군 환자에서의 락토바실러스 애시도필러스(Lactobacillus acidophilus)-SDC 2012, 2013의 효과”(신동현 외 1인, 대한소화관운동학회지, Vol. 25, 90~91, 2009년)에는, 락토바실러스 애시도필러스가 과민성 대장 증후군 환자들에게서 증상 완화 효과가 있다는 것이 기재되어 있다.
For example, the article “Effects of Lactobacillus acidophilus- SDC 2012, 2013 in patients with irritable bowel syndrome” (Shin Dong-hyun and others, Journal of the Korean Gastrointestinal Kinesiology, Vol. 25, 90 ~ 91, 2009) ) Shows that Lactobacillus ashidophilus has a symptomatic effect in patients with irritable bowel syndrome.
따라서 홍삼을 경구 섭취할 경우, 장 내 존재하는 미생물총을 활성화할 수 있는 프로바이오틱 유산균과 더불어 섭취함으로써, 홍삼의 효과를 증진시킬 수 있는 기능성 조성물의 개발이 절실하다 하겠다.Therefore, oral ingestion of red ginseng, by ingesting with probiotic lactic acid bacteria that can activate the microflora present in the intestine, the development of a functional composition that can enhance the effect of red ginseng is urgently needed.
본 발명의 목적은, 홍삼을 경구 섭취할 때, 장 내 존재하는 미생물총을 활성화할 수 있는 물질과 더불어 섭취함으로써, 홍삼의 흡수 효과를 증진시킬 수 있는 기능성 조성물을 제공함에 있다.It is an object of the present invention to provide a functional composition that can enhance the absorption effect of red ginseng by oral ingestion of red ginseng, along with a substance capable of activating the microflora present in the intestine.
본 발명의 목적은, 홍삼을 경구 섭취할 때, 장 내 존재하는 미생물총을 활성화할 수 있는 물질과 더불어 섭취하되, 홍삼 및 장 내 미생물총의 활성화 물질을 모두 분말 형태로 형성함으로써, 섭취 및 휴대가 용이한 기능성 조성물을 제공함에 있다. An object of the present invention, when ingested orally ingested red ginseng, ingested together with a substance capable of activating the microflora present in the intestine, by forming both the active substance of the red ginseng and intestinal microflora in the form of powder, ingestion and carrying It is to provide an easy functional composition.
본 발명은, 홍삼, 혼합 유산균 및 올리고당류를 모두 분말로 형성하여 함유하는 조성물을 제공함으로써, 기술적 과제를 해결하고자 한다.The present invention aims to solve the technical problem by providing a composition containing red ginseng, mixed lactic acid bacteria and oligosaccharides in powder form.
본 발명은, 홍삼2.0중량%, 혼합 유산균 7.5 중량% 및 프락토 올리고당 10 중량%를 모두 분말로 형성하여 함유하되, 식품학적으로 허용 가능한 비타민류, 미네랄류, 산도조절제, 감미제 및 향미제를 추가로 포함하여 100%(w/w)가 되는 조성물을 제공함으로써, 기술적 과제를 해결하고자 한다.The present invention, the red ginseng 2.0% by weight, mixed lactic acid bacteria 7.5% by weight and fructo oligosaccharides containing all 10% by weight of the form, containing vitamins, minerals, acidity regulators, sweetening agents and flavorings By providing a composition comprising 100% (w / w), to solve the technical problem.
본 발명은, 홍삼, 혼합 유산균 및 올리고당류를 모두 분말로 형성하여 스틱(stick) 포장형 제품에 충진하는 건강기능식품을 제공함으로써, 기술적 과제를 해결하고자 한다.The present invention, red ginseng, mixed lactic acid bacteria and oligosaccharides by forming a powder to provide a health functional food to be filled in a stick (pack) packaging type, to solve the technical problem.
본 발명인 홍삼, 혼합 유산균 및 올리고당류를 함유하는 조성물은, 장 내 존재하는 미생물총을 활성화함으로써, 홍삼의 흡수 효과를 증진시킬 수 있는 현저한 효과를 보유하고 있다.The composition containing the red ginseng, mixed lactic acid bacteria and oligosaccharides of the present invention has a remarkable effect of enhancing the absorption effect of red ginseng by activating the microflora present in the intestine.
본 발명인 홍삼, 혼합 유산균 및 올리고당류를 모두 분말로 형성한 조성물을 함유하는 스틱(stick)포장형 건강기능식품은, 섭취 및 휴대가 용이한 현저한 효과를 보유하고 있다. Stick-packed health functional foods containing the composition of the present invention, red ginseng, mixed lactic acid bacteria and oligosaccharides, all in powder form, have a remarkable effect that is easy to ingest and carry.
본 발명인 홍삼, 혼합 유산균 및 올리고당류를 유효성분으로 함유하는 조성물은, 부작용을 가져오지 않으면서 지속적으로 복용함으로써, 홍삼의 건강 증진 기능을 향상시킬 수 있는 현저한 효과를 보유하고 있다.The composition containing the red ginseng, mixed lactic acid bacteria and oligosaccharides of the present invention as an active ingredient has a remarkable effect of improving the health promoting function of red ginseng by continuously taking it without bringing side effects.
도 1 은 본 발명의 실시예에 따른 조성물을 포함하는 식품을 제조하는 방법을 흐름도로서 도시한 도면이다.1 is a flow chart illustrating a method for producing a food comprising a composition according to an embodiment of the present invention.
본 명세서 및 청구범위에 사용된 용어나 단어는 통상적이거나 사전적인 의미로 한정해서 해석되어서는 안 되며, 발명자는 그 자신의 발명을 가장 최선의 방법으로 설명하기 위해 용어의 개념을 적절하게 정의할 수 있다는 원칙에 입각하여 본 발명의 기술적 사상에 부합하는 의미와 개념으로 해석되어야만 한다.
The terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms and the inventor may properly define the concept of the term in order to best describe its invention It should be construed as meaning and concept consistent with the technical idea of the present invention.
따라서 본 명세서에 기재된 실시예와 도면에 도시된 구성은 본 발명의 가장 바람직한 일 실시예에 불과할 뿐이고 본 발명의 기술적 사상을 모두 대변하는 것은 아니므로, 본 출원시점에 있어서 이들을 대체할 수 있는 다양한 균등물과 변형예들이 있을 수 있음을 이해하여야 한다.
Therefore, the embodiments described in the present specification and the configurations shown in the drawings are merely the most preferred embodiments of the present invention and are not intended to represent all of the technical ideas of the present invention. Therefore, various equivalents It should be understood that water and variations may be present.
이하 첨부된 도면을 참조하여 본 발명의 바람직한 실시예를 상세히 설명하기로 한다.
Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.
실시예Example
1. One.
홍삼 분말, 혼합 유산균 및 Red ginseng powder, mixed lactic acid bacteria and
올리고당류를Oligosaccharides
함유한 조성물 Containing composition
의of
제조 Produce
본 발명에 사용되는 홍삼 분말은 홍삼 전체를 분쇄 후 가공 처리한 분말 또는 홍삼 농축액 분말 또는 홍삼 추출물 분말을 의미하며, 진세노사이드(ginsenoside) Rb1 및 Rg1의 함량의 합이 3~80mg이 되도록 처리한다.
Red ginseng powder used in the present invention refers to a powder or red ginseng concentrate powder or red ginseng extract powder processed after grinding the whole red ginseng, and treated so that the sum of the contents of ginsenosides Rb1 and Rg1 is 3 to 80 mg. .
본 발명에 사용되는 혼합 유산균은, 락토바실러스(Lactobacillus) 및 비피도박테리움(Bifidobacterium)의 균속에 포함되는 프로바이오틱(probiotic) 유산균주를 2개 종류 이상 포함하되, 코팅 또는 마이크로 캡슐 처리한 분말형태를 의미한다. Mixed lactic acid bacteria used in the present invention, including two or more types of probiotic lactic acid bacteria strains contained in the fungus of Lactobacillus (Lactobacillus) and Bifidobacterium, powder coated or micro-capsulated It means form.
또한 락토바실러스 및 비피도박테리움 균속 이외에도 본 발명의 목적에 적합하다면 다른 균속에 포함된 유산균주를 선택하여 이용할 수 있음은 물론이다.
In addition to the Lactobacillus and Bifidobacterium strains, if suitable for the purposes of the present invention can be used to select the lactic acid strains included in other strains.
본 발명에 사용되는 올리고당류(oligosaccharides)는, 프리바이틱스 (prebiotics)의 개념으로 이용된다.Oligosaccharides used in the present invention are used in the concept of prebiotics.
즉 대장 내에 존재하는 박테리아의 수를 한정하며 선택적으로 박테리아의 성장을 자극하여 인체에 유리한 영향을 주는 물질로서 이용된다.That is, it limits the number of bacteria present in the large intestine and selectively stimulates the growth of bacteria, which is used as a substance having a beneficial effect on the human body.
프락토 올리고당, 이눌린, 유과올리고당, 락툴로스 등의 올리고당 류에서 선택적으로 포함시키되, 본 발명의 조성물에 사용되는 유산균의 종류에 따라 선택되도록 한다.It is optionally included in oligosaccharides such as fructo oligosaccharide, inulin, fructose oligosaccharide, lactulose, etc., so as to be selected according to the type of lactic acid bacteria used in the composition of the present invention.
또한 상기 열거한 올리고당류 이외에도 본 발명의 목적에 적합하다면 다른 올리고당류를 선택하여 이용할 수 있음은 물론이다.
In addition to the above-mentioned oligosaccharides, other oligosaccharides may be selected and used if suitable for the purposes of the present invention.
본 발명의 실시예에 따른 홍삼 분말, 혼합 유산균 및 올리고당류를 포함하는 조성물에, 약제학적으로 허용되는 담체, 부형제 또는 희석제 등을 추가하여 약제학적 단위 투여형을 제공하도록 할 수 있다.To a composition comprising red ginseng powder, mixed lactic acid bacteria and oligosaccharides according to an embodiment of the present invention, a pharmaceutically acceptable carrier, excipient or diluent may be added to provide a pharmaceutical unit dosage form.
여기에서, 담체, 부형제, 희석제로는 토즈, 덱스트로즈, 수크로스, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로즈, 메틸 셀룰로즈, 미정질 셀룰로스, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다.Examples of the carrier, excipient and diluent include tosse, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, Vaginal cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
또한 상기 약제학적 투여 형태는 약학적 허용 가능한 염의 형태로도 사용될 수 있고, 또한 단독으로 또는 타 약학적 활성 화합물과 결합뿐만 아니라 적당한 집합으로 사용될 수 있다.
The pharmaceutical dosage forms may also be used in the form of pharmaceutically acceptable salts, and may be used alone or in combination with other pharmaceutically active compounds as well as in a suitable set.
또한 상기 홍삼 분말, 혼합 유산균 및 올리고당류를 포함하는 조성물을 제제화 할 경우에는 통상적으로 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면 활성제 등의 희석제 또는 부형제를 사용하여 조제될 수 있다.
In addition, when formulating a composition comprising the red ginseng powder, mixed lactic acid bacteria and oligosaccharides, it may be prepared using a diluent or excipient such as fillers, extenders, binders, wetting agents, disintegrating agents, surfactants, etc. that are commonly used.
또한 상기 약제학적 투여 형태는 각각 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 좌제, 및 멸균 주사용액의 형태로 제형화하여 사용될 수 있다.In addition, the pharmaceutical dosage forms may be used in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral formulations, suppositories, and sterile injectable solutions, respectively, according to conventional methods. .
상기 경구 투여를 위한 고형 제제에는 상기 추출물에 적어도 하나 이상의 부형제 예를 들면, 전분은 칼슘 카보네이트(calcium carbonate), 수크로스(sucrose) 또는 락토오스(lactose), 젤라틴 등을 섞어 조제될 수 있다. 또한 단순한 부형제 이외에 마그네슘 스테아레이트, 탈크 같은 윤활제들도 사용될 수 있다.The solid preparation for oral administration may be prepared by mixing at least one excipient, for example starch, with calcium carbonate, sucrose or lactose, gelatin, and the like in the extract. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used.
상기 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조 제제, 좌제가 포함될 수 있다. The preparation for parenteral administration may include a sterilized aqueous solution, a non-aqueous solvent, a suspension, an emulsion, a freeze-dried preparation, and a suppository.
상기 비 수성용제, 현탁제로는 프로필렌글리콜(propylene glycol), 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸 올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다.Examples of the non-aqueous solvent and the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like.
좌제의 기제로는 위텝솔(witepsol), 마크로골, 트윈(tween) 61, 카카오지, 라우린지, 글리세로제라틴 등이 사용될 수 있다.
Examples of the suppository base include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.
본 발명의 실시예에 따른 유효성분의 바람직한 투여량은 환자의 상태 및 체중, 질병의 정도, 연령, 성별, 약물형태, 투여경로 및 기간에 따라 다르지만, 당업자에 의해 적절하게 선택될 수 있다.
The preferred dosage of the active ingredient according to an embodiment of the present invention depends on the condition and weight of the patient, the extent of the disease, age, sex, drug form, route of administration and duration, but may be appropriately selected by those skilled in the art.
본 발명의 추출물은 쥐, 생쥐, 가축, 인간 등의 포유동물에 다양한 경로로 투여될 수 있다. 투여의 모든 방식은 예상될 수 있는데, 예를 들면, 경구, 직장 또는 정맥, 근육, 피하주사에 의해 투여될 수 있다.
The extract of the present invention can be administered to mammals such as rats, mice, livestock, humans and the like in various routes. All modes of administration may be expected, for example, by oral, rectal or intravenous, muscular, subcutaneous injection.
본 발명의 실시예에 따른 홍삼 분말, 혼합 유산균 및 올리고당류를 포함하는 조성물에 따른 유효성분에, 식품 보조 첨가제를 추가하여 건강 기능성 식품을 제공할 수 있다.To the active ingredient according to the composition comprising a red ginseng powder, mixed lactic acid bacteria and oligosaccharides according to an embodiment of the present invention, food supplements can be added to provide a health functional food.
상기 성분을 첨가할 수 있는 식품으로는, 예를 들어, 각종 식품류, 음료, 껌, 차, 비타민 복합제, 건강 기능성 식품류 등이 있다.Examples of the food to which the above components can be added include various foods, beverages, gums, teas, vitamin complexes, and health functional foods.
또한 항산화 기능을 목적으로 한 식품 또는 음료에 첨가될 수 있다.It may also be added to foods or beverages for the purpose of antioxidant function.
이때, 식품 또는 음료 중의 상기 성분의 양은 전체 식품 중량의 0.01 내지 20 중량% 이 될 수 있으며, 건강 음료 조성물은 100 ml를 기준으로 0.02 내지 5 g, 바람직하게는 0.3 내지 1 g의 비율로 가할 수 있다.
At this time, the amount of the ingredient in the food or beverage may be 0.01 to 20% by weight of the total food weight, the health beverage composition may be added in a ratio of 0.02 to 5 g, preferably 0.3 to 1 g based on 100 ml have.
본 발명의 건강 기능성 음료 조성물은 상기 성분을 함유하는 외의 다른 성분에는 특별한 제한이 없으며 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다.The health functional beverage composition of the present invention is not particularly limited to the other components containing the above components, and may contain various flavors or natural carbohydrates, etc. as additional components, as in general beverages.
상술한 천연 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당; 디사카라이드, 예를 들어 말토스, 슈크로스 등 및 폴리사카라이드, 예를 들어 덱스트린, 시클로덱스트린 등과 같은 통상적인 당, 및 자일리톨, 소르비톨, 에리트리톨 등의 당알코올이다. 상술한 것 이외에 향미제로써 천연 향미제(타우마틴, 스테비아 추출물(예를 들어 레바우디오시드 A, 글리시르히진 등) 및 합성 향미제(사카린, 아스파르탐 등)를 유리하게 사용할 수 있다.Examples of the aforementioned natural carbohydrates include monosaccharides such as glucose, fructose; Disaccharides such as maltose, sucrose and the like and polysaccharides such as dextrins, cyclodextrins and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. In addition to the above, natural flavoring agents (tau martin, stevia extracts (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavorings.
상기 천연 탄수화물의 비율은 본 발명의 조성물 100 ml당 일반적으로 약 1 내지 20 g, 바람직하게는 약 5 내지 12 g이다.
The ratio of the natural carbohydrate is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention.
상기 외에 본 발명의 성분은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 추가로 함유할 수 있다.In addition to the above, the ingredients of the present invention include various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, organic acids, and protection. It may further contain a sex colloid thickener, a pH adjuster, a stabilizer, a preservative, a glycerin, an alcohol, a carbonation agent used in a carbonated beverage, and the like.
그 밖에 본 발명의 성분은 천연 과일 주스 및 과일 주스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다.In addition, the components of the present invention may contain natural fruit juices and pulp for the production of fruit juice beverages and vegetable beverages.
이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. 이러한 첨가제의 비율은 그렇게 중요하진 않지만 본 발명의 추출물 100 중량부 당 0 내지 약 20 중량부의 범위에서 선택되는 것이 일반적이다.
These components may be used independently or in combination. The proportion of such additives is not so critical, but is generally selected in the range of 0 to about 20 parts by weight per 100 parts by weight of the extract of the present invention.
제조예1. 홍삼 분말, 혼합 유산균 및 올리고당류를 함유한 식품의 제조 Preparation Example 1. Preparation of Foods Containing Red Ginseng Powder, Mixed Lactic Acid Bacteria and Oligosaccharides
본 발명에 사용되는 홍삼 분말은 홍삼 전체를 분쇄 후 가공 처리한 분말 또는 홍삼 농축액 분말 또는 홍삼 추출물 분말을 의미하며, 진세노사이드(ginsenoside) Rb1 및 Rg1의 함량의 합이 3~80mg이 되도록 처리한다. Red ginseng powder used in the present invention refers to a powder or red ginseng concentrate powder or red ginseng extract powder processed after grinding the whole red ginseng, and treated so that the sum of the contents of ginsenosides Rb1 and Rg1 is 3 to 80 mg. .
홍삼 분말은 총 중량 기준 0.1~5 중량 %로 선택되며, 바람직하게 2.0 중량 %로 선택될 수 있다.
The red ginseng powder is selected from 0.1 to 5% by weight based on the total weight, preferably 2.0% by weight.
본 발명에 사용되는 혼합 유산균은, 락토바실러스(Lactobacillus) 및 비피도박테리움(Bifidobacterium)의 균속에 포함되는 프로바이오틱(probiotic) 유산균주를 2개 종류 이상 포함하되, 코팅 또는 마이크로 캡슐 처리한 분말형태를 의미한다. Mixed lactic acid bacteria used in the present invention, including two or more types of probiotic lactic acid bacteria strains contained in the fungus of Lactobacillus (Lactobacillus) and Bifidobacterium, powder coated or micro-capsulated It means form.
또한 락토바실러스 및 비피도박테리움 균속 이외에도 본 발명의 목적에 적합하다면 다른 균속에 포함된 유산균주를 선택하여 이용할 수 있음은 물론이다.In addition to the Lactobacillus and Bifidobacterium strains, if suitable for the purposes of the present invention can be used to select the lactic acid strains included in other strains.
바람직하게, 혼합 유산균은 7.5 중량 %로 선택되어 이용된다.
Preferably, the mixed lactic acid bacteria is selected and used at 7.5% by weight.
본 발명에 사용되는 올리고당류(oligosaccharides)는 프락토 올리고당, 이눌린, 유과올리고당, 락툴로스 등의 올리고당 류에서 선택적으로 포함시키되, 본 발명의 조성물에 사용되는 유산균의 종류에 따라 선택되도록 하며, 상기 열거한 올리고당류 이외에도 본 발명의 목적에 적합하다면 다른 올리고당류를 선택하여 이용할 수 있음은 물론이다.Oligosaccharides used in the present invention may be optionally included in oligosaccharides such as fructo oligosaccharide, inulin, fructose oligosaccharide, lactulose, and the like, and are selected according to the type of lactic acid bacteria used in the composition of the present invention. In addition to one oligosaccharide, other oligosaccharides may be selected and used if suitable for the purposes of the present invention.
바람직하게, 프락토 올리고당(Fructo-oligosaccharides)을 사용하되 10 중량 %로 선택되어 이용된다.
Preferably, fructo-oligosaccharides are used but selected by weight of 10% by weight.
본 발명은 주요 성분으로서의 홍삼 분말, 혼합 유산균 및 프락토 올리고당 이외에 비타민류, 미네랄류, 산도조절제, 향미제, 감미제 및 당류 등을 추가로 포함하여 혼합되며, 추가로 포함되는 성분은 다음과 같다.The present invention is mixed with red ginseng powder, mixed lactic acid bacteria and fructo oligosaccharides as main components, including vitamins, minerals, acidity regulators, flavoring agents, sweeteners and sugars, and the like.
비타민C 0.8중량%, 비타민 E 0.1 중량%, 비타민 B1 0.007중량%, 비타민 B6 0.01중량%, 비타민 B2 0.009중량%, 산화아연 0.02중량%, 밀크칼슘 2 중량%, 구연산 1.8 중량%, 오렌지과즙분말 1.0중량%, 식물성크림분말 10 중량%, 니코틴산아미드 0.095 중량%, 콜라겐 2.5 중량%, 판토텐산칼슘 0.035 중량%, 자일리톨 5 중량%, 스테아린산마그네슘 0.5 중량% 이며, 이후 100%(w/w)가 되도록 정제 포도당으로 조정한다.
Vitamin C 0.8%, Vitamin E 0.1%, Vitamin B1 0.007%, Vitamin B6 0.01%, Vitamin B2 0.009%, Zinc Oxide 0.02%, Milk Calcium 2%, Citric Acid 1.8%, Orange Juice Powder 1.0 wt%, vegetable cream powder 10 wt%, nicotinic acid amide 0.095 wt%, collagen 2.5 wt%, calcium pantothenate 0.035 wt%, xylitol 5 wt%, magnesium stearate 0.5 wt%, then 100% (w / w) Adjust to purified glucose.
참고Reference
예Yes
1. One.
스틱stick
(stick) (stick)
포장형Package
식품으로 제조하는 방법 How to make food
본 발명의 실시예 및 제조예에 따른 조성물은 분말형태로서 혼합되어서, 섭취 및 휴대가 용이하도록 스틱(stick) 포장형 제품(2~10g 단위포장의 분말조성)으로 제조될 수 있다.
Compositions according to embodiments and preparations of the present invention may be mixed as a powder form, and may be prepared as a stick packaged product (powder composition of 2 to 10 g unit packaging) for easy ingestion and portability.
도 1 은 본 발명의 실시예에 따른 조성물을 포함하는 식품을 제조하는 방법을 흐름도로서 도시한 도면이다.
1 is a flow chart illustrating a method for producing a food comprising a composition according to an embodiment of the present invention.
먼저, 공정서 규격에 따른 원료검사를 수행하고, 칭량 과정에서는 기본 규격에 적합한 원료를 사용했는지 및 사용기구, 기계의 청결 여부를 확인하며 또한 교차 오염을 점검하게 된다.First, the raw material inspection according to the process standard is performed, and in the weighing process, it is checked whether the raw material suitable for the basic standard is used and the cleanliness of the use equipment and the machine, and the cross contamination is also checked.
혼합 과정에서는 혼합기 회전수 30rpm으로 20~30분간 혼합을 하며, 충진 과정에서는 스틱 포장기를 이용하여 충진하되 중량 편차가 2000mg/포±3%가 되도록 한다.In the mixing process, the mixture is mixed for 30 to 30 minutes at 30 rpm of the mixer. In the filling process, the filling is performed using a stick packing machine, but the weight deviation is 2000 mg / po ± 3%.
반제품 검사 과정에서는, 반제품 규격 및 기준에 따른 적합성 시험, 미생물 시험 등을 수행하며, 완제품 검사에는 성상, 수분, 대장군균 및 프로바이오틱수를 검사한 후, 출고하게 된다.In the semi-finished product inspection process, conformity tests and microbial tests according to semi-finished product specifications and standards are performed, and finished product inspection is carried out after inspection of properties, moisture, E. coli and probiotic water.
Claims (9)
(a) 상기 홍삼 분말은 0.1 ~ 5중량% 포함하되, 진세노사이드(ginsenoside) Rb1 및 Rg1의 함량의 합이 3 ~ 80mg이 되도록 하고,
(b) 상기 혼합 유산균은 7.5 중량% 포함하되, 락토바실러스(Lactobacillus) 및 비피도박테리움(Bifidobacterium) 균속에 포함되는 프로바이오틱(probiotic) 유산균주를 2개 종류 이상 포함하여 상기 홍삼 분말의 흡수를 증진하는 효능을 갖도록 하고,
(c) 상기 올리고당류는 프락토 올리고당(Fructo-oligosaccharides) 10 중량% 포함하여 장내 미생물총의 활성을 자극하는 효능을 갖도록 하는 것을 특징으로 하는 조성물.
Red ginseng ( Panax ginseng CA Meyer), mixed lactic acid bacteria and oligosaccharides are all formed as powders, and 100% (including food-acceptable vitamins, minerals, acidity regulators, sweeteners and flavoring agents). w / w)
(a) the red ginseng powder contains 0.1 to 5% by weight, and the sum of the contents of ginsenosides Rb1 and Rg1 is 3 to 80 mg,
(b) the mixed lactic acid bacteria contained 7.5% by weight, including two or more types of probiotic lactic acid bacteria strains included in Lactobacillus and Bifidobacterium strains to absorb the red ginseng powder Have the effect of promoting
(c) The oligosaccharide composition comprising 10% by weight of fructo oligosaccharides (Fructo-oligosaccharides) to have the effect of stimulating the activity of the intestinal microflora.
(a) 상기 홍삼 분말은 0.1 ~ 5중량% 포함하되, 진세노사이드(ginsenoside) Rb1 및 Rg1의 함량의 합이 3 ~ 80mg이 되도록 하고,
(b) 상기 혼합 유산균은 7.5 중량% 포함하되, 락토바실러스(Lactobacillus) 및 비피도박테리움(Bifidobacterium) 균속에 포함되는 프로바이오틱(probiotic) 유산균주를 2개 종류 이상 포함하여 상기 홍삼 분말의 흡수를 증진하는 효능을 갖도록 하고,
(c) 상기 올리고당류는 프락토 올리고당(Fructo-oligosaccharides) 10 중량% 포함하여 장내 미생물총의 활성을 자극하는 효능을 갖도록 하는 것을 특징으로 하는 건강기능식품.
Red ginseng ( Panax ginseng CA Meyer), mixed lactic acid bacteria and oligosaccharides are all formed as powders, and 100% (including food-acceptable vitamins, minerals, acidity regulators, sweeteners and flavoring agents). w / w)
(a) the red ginseng powder contains 0.1 to 5% by weight, and the sum of the contents of ginsenosides Rb1 and Rg1 is 3 to 80 mg,
(b) the mixed lactic acid bacteria contained 7.5% by weight, including two or more types of probiotic lactic acid bacteria strains included in Lactobacillus and Bifidobacterium strains to absorb the red ginseng powder Have the effect of promoting
(c) The oligosaccharides containing 10% by weight of fructo oligosaccharides (Fructo-oligosaccharides) health functional foods, characterized in that to have the effect of stimulating the activity of the intestinal microflora.
상기 홍삼, 혼합 유산균, 올리고당류 및 식품학적으로 허용 가능한 비타민류, 미네랄류, 산도조절제, 감미제, 향미제는 스틱(stick) 포장형 제품에 분말로 충진되는 것을 특징으로 하는 건강기능식품.The method according to claim 6,
The red ginseng, mixed lactic acid bacteria, oligosaccharides and food acceptable vitamins, minerals, acidity regulators, sweetening agents, flavoring agents, characterized in that the filling (stick) packaged products in the health functional food.
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