KR101244284B1 - Lquid composition powder freezing dried male silk pupa with an increased stability - Google Patents

Abstract

The present invention relates to a liquid composition containing silkworm pupae lyophilized with improved stability, and more particularly, by using a silkworm pupae lyophilisate, which is an active ingredient, in combination with a specific thickener and suspending agent, ensuring stability. It relates to a liquid composition, drink and functional food for preventing or treating adult diseases.

Description

Lquid composition powder freezing dried male silk pupa with an increased stability}

The present invention relates to a silkworm pupae lyophilisate containing liquid composition having improved stability.

Humanity began to silkworm about three thousand years ago. Silkworms obtained from silkworms have been widely used for the treatment of adult diseases such as diabetes and hypertension, and leprosy obtained by infection of leukemia bacteria has been used as an antispasmodic and analgesic agent. And silkworm pupae has been known to have effects such as treatment of hypertension and improvement of immune function, as well as gangjeong effect, has been eaten a lot since ancient times, and is known to have a clinical effect.

Looking at the technical content of the formulation and commercialization using silkworm pupa as follows.

Patent Literature 1 discloses a composition for food and pharmaceutical preparations using the extract extracted with alcohol after freeze drying silkworm pupae, and Patent Literature 2 likewise uses capsules extracting extracts extracted with lyophilized silkworm pupae with alcohol. The composition is described, and Patent Documents 3 and 4 describe pharmaceuticals and health food compositions using extracts obtained by obtaining extracts from silkworm pupae lyophilized using an organic solvent.

In the case of the invention of the composition using silkworm pupa, it is extracted, filtered using alcohol, an organic solvent, etc., and then used to remove impurities with sodium hydroxide, etc., and to commercialize them, and solid and soft capsule products, Liquid products are presented. However, when the silkworm pupa is lyophilized and then pulverized and extracted with an organic solvent, filtered, and impurities are removed, the extraction process is very complicated, and the organic solvent may remain in the extract. The fat-soluble component is extracted, but in the case of the water-soluble component is not extracted, there is a problem that all of the silkworm pupa inherent active effect is not exhibited.

In addition, in the case of manufacturing by dispersing a material that is difficult to dissolve into a liquid product of food, precipitation occurs when time elapses, and after a longer time becomes a solid phase, there is an inconvenience to be ingested after shaking to disperse when taking, This severe case is very difficult to ingest.

Patent Document 1: Republic of Korea Patent No. 462166 Patent Document 2: Republic of Korea Patent No. 486968 Patent Document 3: Republic of Korea Patent No. 573466 Patent Document 4: Republic of Korea Patent No. 715117

Therefore, the inventors of the present invention while studying the composition to take the fat-soluble components and water-soluble components of silkworm chrysalis, using the silkworm chrysalis lyophilisate and a specific thickener and suspending agent to simultaneously ingest the fat-soluble, water-soluble components It can be, anyone in the liquid state is easy to ingest, the present invention was completed by developing a composition that ensures stability.

Therefore, an object of the present invention is to provide a liquid composition with improved stability of silkworm pupae lyophilizate.

In addition, an object of the present invention is to provide a drink and functional food with improved stability of silkworm pupae lyophilisate.

In addition, the present invention is another object to provide a method for producing a drinking agent improved stability containing silkworm pupae lyophilisate.

The present invention includes silkworm pupae lyophilisate, thickener, suspending agent and purified water, wherein the thickener is characterized by improved stability of the liquid composition is a mixture of xanthan gum and gellan gum.

In addition, the present invention includes silkworm pupae lyophilisate, thickener, suspending agent and purified water, the thickener is characterized by another drink and a method for producing a mixture of xanthan gum and gellan gum.

In addition, the present invention includes silkworm chrysalis lyophilisate, thickener, suspending agent and purified water, the thickener is another feature of the functional food is a mixture of xanthan gum and gellan gum.

The present invention, unlike the conventional method of stabilizing silkworm pupae lyophilisate, which does not use an organic solvent, is expensive, or undergoes a complicated process, uses a specific thickener and suspending agent together to dissolve and mix easily. It can secure stability and can be used as a drink or functional food because it is easy to take.

Hereinafter, the present invention will be described in detail.

The present invention includes silkworm pupae lyophilisate, thickener, suspending agent and purified water, the thickener using a mixture of xanthan gum and gellan gum to ensure the stability of the phase separation does not occur, jeongjeong, hypertension, immunity The present invention relates to a liquid composition effective for preventing and treating geriatric diseases such as function improvement.

In the present invention, silkworm pupae lyophilisate is a lyophilized silkworm pupae and powdered by pulverization, in the embodiment of the present invention was used lyophilized powder. The silkworm pupae lyophilisate is known to have a sedative effect, a hypertension treatment effect, and an immunity improving effect, and to maximize its effect while using a thickener and suspending agent to ensure dispersion stability, the dispersed state is continued throughout the distribution period. It is a feature of the present invention to keep it.

In the present invention, the thickener serves to disperse the insoluble substance and is pharmaceutically acceptable or acceptable in food-related laws such as food or food additives, xanthan gum, gellan gum, methylcellulose, and carboxymethyl. Sodium cellulose, sodium alginate and the like may be included, but it is preferable to use a combination of xanthan gum and gellan gum. More preferably, a mixture of xanthan gum and gellan gum in a weight ratio of 1.5 to 5: 1 is suitable in terms of dispersion stability.

The thickener is preferably used 0.02 to 0.6 parts by weight, more preferably 0.16 to 0.5 parts by weight based on 1 part by weight of silkworm pupae lyophilisate. If the amount is less than 0.04 parts by weight, the viscosity is low and dispersion is not achieved. If the amount is more than 0.6 parts by weight, the viscosity is too high, resulting in semisolidification, which is not worth the product.

In the present invention, the suspending agent serves to maximize the effect of the thickener by solubilizing silkworm pupae lyophilizate and water-soluble components, and is pharmaceutically acceptable or acceptable in food-related laws such as food or food additives. At least one selected from the group consisting of polysorbate (# 60, # 80), sorbitan fatty acid ester, and the like is preferred, and polysorbate # 80 is most preferred.

The suspending agent is preferably 0.05 to 0.8 parts by weight, more preferably 0.1 to 0.5 parts by weight based on 1 part by weight of silkworm pupae lyophilisate. If it is less than 0.05 part by weight, the fat-soluble component and the water-soluble component cannot be solubilized, and if it is more than 0.8 part by weight, phase separation may result in no value as a product.

In addition to the liquid composition according to the present invention, a sweetener, a pH adjuster, a preservative, a scent, and the like may be used as an excipient that is pharmaceutically acceptable or acceptable in a food method such as food or food additives or food additives, but is not limited thereto. The sweetener may be one or more selected from the group consisting of fructose, glucose, sugar, maltose, sorbitol, maltitol, stevioside, and the like, but is not limited thereto. The pH adjusting agent may use one or more selected from the group consisting of citric acid, sodium citrate, malic acid, sodium malate, and the like, but is not limited thereto. The preservative is used to increase the preservation of the liquid product by inhibiting the growth of microorganisms, but can be used natural preservatives such as benzoic acid, sodium benzoate, methyl paraben, ethyl paraben, other grapefruit seed extract, but is not limited. In addition, the incense may be used to give flavor when ingested, and other herbal medicines, vitamins, and the like may be used.

The excipient is preferably used 5 to 25 parts by weight, more preferably 8 to 17 parts by weight based on 1 part by weight of silkworm pupae lyophilisate.

Purified water in the present invention is preferably used 40 to 90 parts by weight based on 1 part by weight of silkworm pupae lyophilisate.

The effective amount of the active ingredient in the composition of the present invention means the amount required for the prevention and treatment of the disease, and generally, the type of disease, the severity of the disease, the type and amount of excipients other than the active drug contained in the composition, the dosage form, the patient. Can be adjusted according to various factors including age, body weight, general state of health, sex, diet, time of administration, route of administration, duration of treatment, and drugs used simultaneously. In the case of silkworm pupae lyophilisate, the active ingredient of the present invention, it is preferable to administer 1,000 mg to 5,000 mg once to several times a day on an adult basis (60 kg / person).

The liquid composition of the present invention is formulated as a liquid product, in particular a drink.

Accordingly, the present invention includes silkworm chrysalis lyophilisate, thickener, suspending agent and purified water, wherein the thickener includes a drink with improved stability which is a mixture of xanthan gum and gellan gum.

The present invention also comprises dissolving a thickener in purified water;

Dissolving a suspending agent in purified water; And

Mixing the respective lysate and silkworm pupae lyophilisate

It includes a method for producing a drink containing a.

In addition, it may further comprise the step of including a pharmaceutically acceptable excipient. When the dissolution is preferably carried out at a temperature of 40 to 90 ℃.

The present invention also includes silkworm pupae lyophilisate, thickener, suspending agent and purified water, wherein the thickener relates to a functional food with improved stability which is a mixture of xanthan gum and gellan gum.

The amount of silkworm pupae lyophilisate in the functional food may be included in a ratio of 0.5 to 5.0 g, preferably 1.0 to 2.5 g based on 100 ml total.

Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described in detail below. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, only the embodiments are to make the disclosure of the present invention complete, and common knowledge in the technical field to which the present invention belongs. It is provided to fully inform the person having the scope of the invention, which is defined only by the scope of the claims.

Reference Example

Silkworm pupae lyophilisate was collected from Namwon Yangjam Cooperative and purchased powder processed into lyophilized silkworm pupae, and powder was pulverized using a blender and sieved to 100 mesh.

Example : Production of drink

A thickener was added to 20 g of purified water and warmed to 80 ° C. to dissolve (lysate 1). Separately, the suspending agent was dissolved in 20 g of purified water warmed to 80 ° C. (lysate 2), and then the lysates 1 and 2 were mixed, and the silkworm pupae lyophilisate was added thereto and the mixture was heated at 3000 rpm using a homomixer. Mix for a minute.

Separately, purified water [amount obtained by subtracting 40 g from the amount of purified water in Tables 1 and 2] was heated to 80 ° C., and excipients such as sweeteners and pH adjusters were dissolved (dissolved substance 3). The lyophilized mixture and lysate 3 were mixed for 10 minutes using a homomixer at 3000 rpm, and then filled and sealed by 50 g in a glass bottle, sterilized at 80 ° C. for 10 minutes, and then at room temperature (25 ° C.). Prepared by cooling.

Division (unit: g) One 2 3 4 5 6 7 8 9 Silkworm pupa lyophilisate 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 Thickener Methyl cellulose - - - - - 0.2 - - - Xanthan gum - - 0.05 - 0.1 - 0.2 - 0.2 Gellan gum - - - 0.05 - - 0.2 - Suspending Agent (Polysorbate # 80) - 0.3 0.3 0.3 0.3 0.3 0.3 0.3 - Sweetener fruit sugar 15 15 15 15 15 15 15 15 15 Stevioside 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 pH regulator Citric acid 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Sodium citrate 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 Purified water 83.56 83.26 83.21 83.21 83.16 83.06 83.06 83.06 83.36 total 100 100 100 100 100 100 100 100 100

Division (unit: g) 10 11 12 13 14 15 16 17 18 Silkworm pupa lyophilisate 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 Thickener Methyl cellulose - - - - - 0.2 - - - Xanthan gum - 0.3 - 0.2 0.2 - 0.3 0.4 0.45 Gellan gum 0.2 - 0.3 0.05 0.1 0.05 0.1 0.05 0.05 Suspending Agent (Polysorbate # 80) - 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Sweetener fruit sugar 15 15 15 15 15 15 15 15 15 Stevioside 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 pH regulator Citric acid 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Sodium citrate 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 Purified water 83.36 82.96 82.96 83.01 82.96 83.01 82.86 82.81 82.76 total 100 100 100 100 100 100 100 100 100

Test Example  1: Check stability

In order to confirm that the phenomenon such as sedimentation, phase separation and coagulation occurred during the distribution period of the product, the experiment was conducted for 6 months at 40 ℃, 75% relative humidity using an accelerated tester, and the following items were observed after 6 months.

1. Check the sedimentation phenomenon

The height at which the solids settled was visually observed from the top of the liquid surface.

[Judging criteria]

◎: no sedimentation phenomenon

○: less than 10% sedimentation phenomenon

△: sedimentation phenomenon 10-30%

X: Sedimentation phenomenon 30% or more

2. Check for coagulation

When the container was inverted upside down, the degree of no movement of the contents was visually observed.

[Judge criteria]

◎: no solidification phenomenon

○: less than 10% of the solidification phenomenon

△: solidification phenomenon 10-30%

X: 30% or more of coagulation

Six months accelerated test result division One 2 3 4 5 6 7 8 9 Sedimentation X X X X △ △ △ △ X Coagulation ◎ ◎ ◎ ◎ ◎ ◎ ◎ ○ ◎ division 10 11 12 13 14 15 16 17 18 Sedimentation ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ Coagulation X X X ◎ ◎ △ ○ ○ ○

Test Example  2: stability check

50 g of the sample was put in a centrifuge tube, and after operating for 10 minutes at 3000 rpm in a centrifuge, the following was observed.

1. Check the sedimentation phenomenon

[Judge criteria]

◎: less than 10% of sedimentation phenomenon

○: sedimentation phenomenon 10-30%

△: sedimentation phenomenon 30 to 50%

X: Sedimentation phenomenon 50% or more

2. Check for coagulation

[Judge criteria]

◎: less than 10% of the solidification phenomenon

○: coagulation phenomenon 10-30%

△: solidification phenomenon 30-50%

X: 50% or more of coagulation

Centrifugal Experiment Result division One 2 3 4 5 6 7 8 9 Sedimentation X X X X X X X ◎ X Coagulation ◎ ◎ ◎ ◎ ◎ ◎ ◎ X ◎ division 10 11 12 13 14 15 16 17 18 Sedimentation ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ Coagulation X X X ◎ ◎ ○ ○ ○ ○

Claims (8)

1 part by weight of silkworm chrysalis lyophilisate,
0.02 to 0.24 parts by weight of a thickener in which xanthan gum and gellan gum are mixed in a weight ratio of 1.5 to 5: 1,
0.05 to 0.8 parts by weight of a suspending agent which is polysorbate or sorbitan fatty acid ester, and
Stability improved liquid composition comprising 40 to 90 parts by weight of purified water.
delete delete delete delete 1 part by weight of silkworm chrysalis lyophilisate,
0.02 to 0.24 parts by weight of a thickener in which xanthan gum and gellan gum are mixed in a weight ratio of 1.5 to 5: 1,
0.05 to 0.8 parts by weight of a suspending agent which is polysorbate or sorbitan fatty acid ester, and
Drinking agent with improved stability, comprising 40 to 90 parts by weight of purified water.
1 part by weight of silkworm chrysalis lyophilisate,
0.02 to 0.24 parts by weight of a thickener in which xanthan gum and gellan gum are mixed in a weight ratio of 1.5 to 5: 1,
0.05 to 0.8 parts by weight of a suspending agent which is polysorbate or sorbitan fatty acid ester, and
Functional food with improved stability, comprising 40 to 90 parts by weight of purified water.
1 part by weight of silkworm chrysalis lyophilisate,
0.02 to 0.24 parts by weight of a thickener in which xanthan gum and gellan gum are mixed in a weight ratio of 1.5 to 5: 1,
0.05 to 0.8 parts by weight of a suspending agent which is polysorbate or sorbitan fatty acid ester, and
Method for producing a drink comprising the step of mixing 40 to 90 parts by weight of purified water.