KR101234198B1 - Pufa 폴리케타이드 신타제 시스템 및 이의 용도 - Google Patents

Pufa 폴리케타이드 신타제 시스템 및 이의 용도 Download PDF

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KR101234198B1
KR101234198B1 KR1020057018067A KR20057018067A KR101234198B1 KR 101234198 B1 KR101234198 B1 KR 101234198B1 KR 1020057018067 A KR1020057018067 A KR 1020057018067A KR 20057018067 A KR20057018067 A KR 20057018067A KR 101234198 B1 KR101234198 B1 KR 101234198B1
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pufa
nucleic acid
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KR20060006014A (ko
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제임스 지. 메츠
크래그 에이. 위버
윌리엄 알. 바클레이
제임스 에이치. 플래트
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마텍 바이오싸이언스스 코포레이션
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KR1020057018067A 2003-03-26 2004-03-26 Pufa 폴리케타이드 신타제 시스템 및 이의 용도 Expired - Fee Related KR101234198B1 (ko)

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Application Number Priority Date Filing Date Title
US45797903P 2003-03-26 2003-03-26
US60/457,979 2003-03-26
PCT/US2004/009323 WO2004087879A2 (en) 2003-03-26 2004-03-26 Pufa polyketide synthase systems and uses thereof

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KR1020127012277A Division KR101234199B1 (ko) 2003-03-26 2004-03-26 Pufa 폴리케타이드 신타제 시스템 및 이의 용도

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KR20060006014A KR20060006014A (ko) 2006-01-18
KR101234198B1 true KR101234198B1 (ko) 2013-02-19

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KR1020057018067A Expired - Fee Related KR101234198B1 (ko) 2003-03-26 2004-03-26 Pufa 폴리케타이드 신타제 시스템 및 이의 용도
KR1020127026179A Expired - Fee Related KR101234200B1 (ko) 2003-03-26 2004-03-26 Pufa 폴리케타이드 신타제 시스템 및 이의 용도
KR1020127012277A Expired - Fee Related KR101234199B1 (ko) 2003-03-26 2004-03-26 Pufa 폴리케타이드 신타제 시스템 및 이의 용도

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KR1020127026179A Expired - Fee Related KR101234200B1 (ko) 2003-03-26 2004-03-26 Pufa 폴리케타이드 신타제 시스템 및 이의 용도
KR1020127012277A Expired - Fee Related KR101234199B1 (ko) 2003-03-26 2004-03-26 Pufa 폴리케타이드 신타제 시스템 및 이의 용도

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EP (1) EP1623008B1 (cg-RX-API-DMAC7.html)
JP (3) JP2007524377A (cg-RX-API-DMAC7.html)
KR (3) KR101234198B1 (cg-RX-API-DMAC7.html)
CN (1) CN101389213B (cg-RX-API-DMAC7.html)
AU (2) AU2004225485B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0409046A (cg-RX-API-DMAC7.html)
CA (1) CA2520396C (cg-RX-API-DMAC7.html)
ES (1) ES2516641T3 (cg-RX-API-DMAC7.html)
IL (1) IL200625A0 (cg-RX-API-DMAC7.html)
MX (2) MX341785B (cg-RX-API-DMAC7.html)
WO (1) WO2004087879A2 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
EP1707055A3 (en) 2000-01-28 2009-01-14 Martek Biosciences Corporation Enhanced production of lipids containing polyenoic fatty acids by very high density cultures of eukaryotic microbes in fermentors
BRPI0613295A2 (pt) 2005-07-01 2010-12-28 Martek Biosciences Corp produto oleoso contendo ácido graxo poliinsaturado e usos e produção do mesmo
GB0603160D0 (en) * 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
WO2007106903A2 (en) 2006-03-15 2007-09-20 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
EP2415360A3 (en) * 2006-08-29 2012-02-29 Martek Biosciences Corporation Use of DPA(n-6) oils in infant formula
WO2010101218A1 (ja) * 2009-03-04 2010-09-10 国立大学法人宮崎大学 微生物の脂肪酸合成経路の判別方法及びそれに用いるpcrプライマーセット
CN102648207A (zh) 2009-03-16 2012-08-22 马太克生物科学公司 在网粘菌门微生物中产生蛋白质
ES2717102T3 (es) 2009-03-19 2019-06-19 Dsm Ip Assets Bv Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
EP2614829A1 (en) * 2012-01-11 2013-07-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
KR101570771B1 (ko) 2013-11-18 2015-11-23 대한민국 고도불포화지방산 생합성을 위한 재조합 벡터 및 이를 이용하여 제작된 형질전환 식물체
JP6682109B2 (ja) * 2015-01-09 2020-04-15 国立大学法人 宮崎大学 ヤブレツボカビ類を用いたリグニン分解活性を有するタンパク質の製造方法
EP3455351B1 (en) * 2016-05-12 2022-08-24 DSM IP Assets B.V. Method of increasing omega-3 polyunsaturated fatty acids production in microalgae
EP3835412A4 (en) * 2018-08-10 2022-05-11 Kyowa Hakko Bio Co., Ltd. POLYUNSATURATED FATTY ACID PRODUCING MICROORGANISM AND PROCESS FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACID
WO2020032261A1 (ja) * 2018-08-10 2020-02-13 協和発酵バイオ株式会社 エイコサペンタエン酸を生産する微生物及びエイコサペンタエン酸の製造法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042195A2 (en) * 1999-01-14 2000-07-20 Omegatech, Inc. Schizochytrium pks genes
WO2002083870A2 (en) * 2001-04-16 2002-10-24 Martek Biosciences Boulder Corporation Pufa polyketide synthase systems and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
CA2283422A1 (en) * 1997-06-04 1998-12-10 Calgene, Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
DK1911837T3 (da) * 2000-09-28 2011-08-29 Bioriginal Food & Science Corp FAD5-2 fedtsyredesaturasefamiliemedlem og anvendelser deraf
CA2387401C (en) * 2001-05-21 2004-10-12 Ecopia Biosciences Inc. Compositions, methods and systems for the production of enediynes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042195A2 (en) * 1999-01-14 2000-07-20 Omegatech, Inc. Schizochytrium pks genes
WO2002083870A2 (en) * 2001-04-16 2002-10-24 Martek Biosciences Boulder Corporation Pufa polyketide synthase systems and uses thereof

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JP2016000048A (ja) 2016-01-07
BRPI0409046A (pt) 2006-04-18
JP2007524377A (ja) 2007-08-30
JP5890791B2 (ja) 2016-03-22
EP1623008A4 (en) 2009-05-27
JP6134361B2 (ja) 2017-05-24
CN101389213B (zh) 2014-05-28
ES2516641T3 (es) 2014-10-31
CN101389213A (zh) 2009-03-18
AU2008249169B2 (en) 2012-03-15
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WO2004087879A2 (en) 2004-10-14
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KR20120123726A (ko) 2012-11-09
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