KR101234198B1 - Pufa 폴리케타이드 신타제 시스템 및 이의 용도 - Google Patents
Pufa 폴리케타이드 신타제 시스템 및 이의 용도 Download PDFInfo
- Publication number
- KR101234198B1 KR101234198B1 KR1020057018067A KR20057018067A KR101234198B1 KR 101234198 B1 KR101234198 B1 KR 101234198B1 KR 1020057018067 A KR1020057018067 A KR 1020057018067A KR 20057018067 A KR20057018067 A KR 20057018067A KR 101234198 B1 KR101234198 B1 KR 101234198B1
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- KR
- South Korea
- Prior art keywords
- seq
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- domain
- pufa
- nucleic acid
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- Expired - Fee Related
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45797903P | 2003-03-26 | 2003-03-26 | |
| US60/457,979 | 2003-03-26 | ||
| PCT/US2004/009323 WO2004087879A2 (en) | 2003-03-26 | 2004-03-26 | Pufa polyketide synthase systems and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127012277A Division KR101234199B1 (ko) | 2003-03-26 | 2004-03-26 | Pufa 폴리케타이드 신타제 시스템 및 이의 용도 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20060006014A KR20060006014A (ko) | 2006-01-18 |
| KR101234198B1 true KR101234198B1 (ko) | 2013-02-19 |
Family
ID=33131738
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057018067A Expired - Fee Related KR101234198B1 (ko) | 2003-03-26 | 2004-03-26 | Pufa 폴리케타이드 신타제 시스템 및 이의 용도 |
| KR1020127026179A Expired - Fee Related KR101234200B1 (ko) | 2003-03-26 | 2004-03-26 | Pufa 폴리케타이드 신타제 시스템 및 이의 용도 |
| KR1020127012277A Expired - Fee Related KR101234199B1 (ko) | 2003-03-26 | 2004-03-26 | Pufa 폴리케타이드 신타제 시스템 및 이의 용도 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127026179A Expired - Fee Related KR101234200B1 (ko) | 2003-03-26 | 2004-03-26 | Pufa 폴리케타이드 신타제 시스템 및 이의 용도 |
| KR1020127012277A Expired - Fee Related KR101234199B1 (ko) | 2003-03-26 | 2004-03-26 | Pufa 폴리케타이드 신타제 시스템 및 이의 용도 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1623008B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2007524377A (cg-RX-API-DMAC7.html) |
| KR (3) | KR101234198B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101389213B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2004225485B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0409046A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2520396C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2516641T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL200625A0 (cg-RX-API-DMAC7.html) |
| MX (2) | MX341785B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004087879A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7217856B2 (en) | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| EP1707055A3 (en) | 2000-01-28 | 2009-01-14 | Martek Biosciences Corporation | Enhanced production of lipids containing polyenoic fatty acids by very high density cultures of eukaryotic microbes in fermentors |
| BRPI0613295A2 (pt) | 2005-07-01 | 2010-12-28 | Martek Biosciences Corp | produto oleoso contendo ácido graxo poliinsaturado e usos e produção do mesmo |
| GB0603160D0 (en) * | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
| WO2007106903A2 (en) | 2006-03-15 | 2007-09-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems |
| EP2415360A3 (en) * | 2006-08-29 | 2012-02-29 | Martek Biosciences Corporation | Use of DPA(n-6) oils in infant formula |
| WO2010101218A1 (ja) * | 2009-03-04 | 2010-09-10 | 国立大学法人宮崎大学 | 微生物の脂肪酸合成経路の判別方法及びそれに用いるpcrプライマーセット |
| CN102648207A (zh) | 2009-03-16 | 2012-08-22 | 马太克生物科学公司 | 在网粘菌门微生物中产生蛋白质 |
| ES2717102T3 (es) | 2009-03-19 | 2019-06-19 | Dsm Ip Assets Bv | Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos |
| EP2614829A1 (en) * | 2012-01-11 | 2013-07-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons |
| KR101570771B1 (ko) | 2013-11-18 | 2015-11-23 | 대한민국 | 고도불포화지방산 생합성을 위한 재조합 벡터 및 이를 이용하여 제작된 형질전환 식물체 |
| JP6682109B2 (ja) * | 2015-01-09 | 2020-04-15 | 国立大学法人 宮崎大学 | ヤブレツボカビ類を用いたリグニン分解活性を有するタンパク質の製造方法 |
| EP3455351B1 (en) * | 2016-05-12 | 2022-08-24 | DSM IP Assets B.V. | Method of increasing omega-3 polyunsaturated fatty acids production in microalgae |
| EP3835412A4 (en) * | 2018-08-10 | 2022-05-11 | Kyowa Hakko Bio Co., Ltd. | POLYUNSATURATED FATTY ACID PRODUCING MICROORGANISM AND PROCESS FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACID |
| WO2020032261A1 (ja) * | 2018-08-10 | 2020-02-13 | 協和発酵バイオ株式会社 | エイコサペンタエン酸を生産する微生物及びエイコサペンタエン酸の製造法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000042195A2 (en) * | 1999-01-14 | 2000-07-20 | Omegatech, Inc. | Schizochytrium pks genes |
| WO2002083870A2 (en) * | 2001-04-16 | 2002-10-24 | Martek Biosciences Boulder Corporation | Pufa polyketide synthase systems and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5340742A (en) * | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| CA2283422A1 (en) * | 1997-06-04 | 1998-12-10 | Calgene, Llc | Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants |
| US6677145B2 (en) * | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| DK1911837T3 (da) * | 2000-09-28 | 2011-08-29 | Bioriginal Food & Science Corp | FAD5-2 fedtsyredesaturasefamiliemedlem og anvendelser deraf |
| CA2387401C (en) * | 2001-05-21 | 2004-10-12 | Ecopia Biosciences Inc. | Compositions, methods and systems for the production of enediynes |
-
2004
- 2004-03-26 KR KR1020057018067A patent/KR101234198B1/ko not_active Expired - Fee Related
- 2004-03-26 WO PCT/US2004/009323 patent/WO2004087879A2/en not_active Ceased
- 2004-03-26 MX MX2011000195A patent/MX341785B/es unknown
- 2004-03-26 ES ES04758405.7T patent/ES2516641T3/es not_active Expired - Lifetime
- 2004-03-26 MX MXPA05010214A patent/MXPA05010214A/es active IP Right Grant
- 2004-03-26 KR KR1020127026179A patent/KR101234200B1/ko not_active Expired - Fee Related
- 2004-03-26 JP JP2006509351A patent/JP2007524377A/ja not_active Withdrawn
- 2004-03-26 AU AU2004225485A patent/AU2004225485B2/en not_active Expired
- 2004-03-26 CN CN200480014646.XA patent/CN101389213B/zh not_active Expired - Fee Related
- 2004-03-26 KR KR1020127012277A patent/KR101234199B1/ko not_active Expired - Fee Related
- 2004-03-26 BR BRPI0409046-2A patent/BRPI0409046A/pt not_active Application Discontinuation
- 2004-03-26 EP EP04758405.7A patent/EP1623008B1/en not_active Expired - Lifetime
- 2004-03-26 CA CA2520396A patent/CA2520396C/en not_active Expired - Lifetime
-
2008
- 2008-11-21 AU AU2008249169A patent/AU2008249169B2/en not_active Ceased
-
2009
- 2009-08-27 IL IL200625A patent/IL200625A0/en unknown
-
2013
- 2013-02-28 JP JP2013038130A patent/JP5890791B2/ja not_active Expired - Lifetime
-
2015
- 2015-09-18 JP JP2015185444A patent/JP6134361B2/ja not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000042195A2 (en) * | 1999-01-14 | 2000-07-20 | Omegatech, Inc. | Schizochytrium pks genes |
| WO2002083870A2 (en) * | 2001-04-16 | 2002-10-24 | Martek Biosciences Boulder Corporation | Pufa polyketide synthase systems and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004087879A3 (en) | 2008-07-24 |
| JP2016000048A (ja) | 2016-01-07 |
| BRPI0409046A (pt) | 2006-04-18 |
| JP2007524377A (ja) | 2007-08-30 |
| JP5890791B2 (ja) | 2016-03-22 |
| EP1623008A4 (en) | 2009-05-27 |
| JP6134361B2 (ja) | 2017-05-24 |
| CN101389213B (zh) | 2014-05-28 |
| ES2516641T3 (es) | 2014-10-31 |
| CN101389213A (zh) | 2009-03-18 |
| AU2008249169B2 (en) | 2012-03-15 |
| MX341785B (es) | 2016-09-01 |
| EP1623008B1 (en) | 2014-07-30 |
| JP2013143945A (ja) | 2013-07-25 |
| EP1623008A2 (en) | 2006-02-08 |
| CA2520396A1 (en) | 2004-10-14 |
| KR101234200B1 (ko) | 2013-02-19 |
| AU2008249169A1 (en) | 2008-12-11 |
| AU2004225485B2 (en) | 2008-08-21 |
| HK1088632A1 (en) | 2006-11-10 |
| AU2004225485A1 (en) | 2004-10-14 |
| WO2004087879A2 (en) | 2004-10-14 |
| KR20120097502A (ko) | 2012-09-04 |
| KR20120123726A (ko) | 2012-11-09 |
| MXPA05010214A (es) | 2005-12-14 |
| KR101234199B1 (ko) | 2013-02-20 |
| CA2520396C (en) | 2016-08-09 |
| IL200625A0 (en) | 2011-07-31 |
| KR20060006014A (ko) | 2006-01-18 |
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