AU2004225485B2 - PUFA polyketide synthase systems and uses thereof - Google Patents

PUFA polyketide synthase systems and uses thereof Download PDF

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Publication number
AU2004225485B2
AU2004225485B2 AU2004225485A AU2004225485A AU2004225485B2 AU 2004225485 B2 AU2004225485 B2 AU 2004225485B2 AU 2004225485 A AU2004225485 A AU 2004225485A AU 2004225485 A AU2004225485 A AU 2004225485A AU 2004225485 B2 AU2004225485 B2 AU 2004225485B2
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Australia
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seq
acid sequence
domain
pufa
amino acid
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AU2004225485A
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AU2004225485A1 (en
Inventor
William R. Barclay
James H. Flatt
James G. Metz
Craig A. Weaver
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DSM IP Assets BV
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DSM IP Assets BV
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Priority to AU2008249169A priority Critical patent/AU2008249169B2/en
Assigned to DSM IP ASSETS B.V. reassignment DSM IP ASSETS B.V. Request for Assignment Assignors: MARTEK BIOSCIENCES CORPORATION
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
AU2004225485A 2003-03-26 2004-03-26 PUFA polyketide synthase systems and uses thereof Expired AU2004225485B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2008249169A AU2008249169B2 (en) 2003-03-26 2008-11-21 PUFA polyketide synthase systems and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45797903P 2003-03-26 2003-03-26
US60/457,979 2003-03-26
PCT/US2004/009323 WO2004087879A2 (en) 2003-03-26 2004-03-26 Pufa polyketide synthase systems and uses thereof

Related Child Applications (1)

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AU2008249169A Division AU2008249169B2 (en) 2003-03-26 2008-11-21 PUFA polyketide synthase systems and uses thereof

Publications (2)

Publication Number Publication Date
AU2004225485A1 AU2004225485A1 (en) 2004-10-14
AU2004225485B2 true AU2004225485B2 (en) 2008-08-21

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AU2008249169A Ceased AU2008249169B2 (en) 2003-03-26 2008-11-21 PUFA polyketide synthase systems and uses thereof

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AU2008249169A Ceased AU2008249169B2 (en) 2003-03-26 2008-11-21 PUFA polyketide synthase systems and uses thereof

Country Status (11)

Country Link
EP (1) EP1623008B1 (cg-RX-API-DMAC7.html)
JP (3) JP2007524377A (cg-RX-API-DMAC7.html)
KR (3) KR101234198B1 (cg-RX-API-DMAC7.html)
CN (1) CN101389213B (cg-RX-API-DMAC7.html)
AU (2) AU2004225485B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0409046A (cg-RX-API-DMAC7.html)
CA (1) CA2520396C (cg-RX-API-DMAC7.html)
ES (1) ES2516641T3 (cg-RX-API-DMAC7.html)
IL (1) IL200625A0 (cg-RX-API-DMAC7.html)
MX (2) MX341785B (cg-RX-API-DMAC7.html)
WO (1) WO2004087879A2 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
EP1707055A3 (en) 2000-01-28 2009-01-14 Martek Biosciences Corporation Enhanced production of lipids containing polyenoic fatty acids by very high density cultures of eukaryotic microbes in fermentors
BRPI0613295A2 (pt) 2005-07-01 2010-12-28 Martek Biosciences Corp produto oleoso contendo ácido graxo poliinsaturado e usos e produção do mesmo
GB0603160D0 (en) * 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
WO2007106903A2 (en) 2006-03-15 2007-09-20 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
EP2415360A3 (en) * 2006-08-29 2012-02-29 Martek Biosciences Corporation Use of DPA(n-6) oils in infant formula
WO2010101218A1 (ja) * 2009-03-04 2010-09-10 国立大学法人宮崎大学 微生物の脂肪酸合成経路の判別方法及びそれに用いるｐｃｒプライマーセット
CN102648207A (zh) 2009-03-16 2012-08-22 马太克生物科学公司 在网粘菌门微生物中产生蛋白质
ES2717102T3 (es) 2009-03-19 2019-06-19 Dsm Ip Assets Bv Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
EP2614829A1 (en) * 2012-01-11 2013-07-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
KR101570771B1 (ko) 2013-11-18 2015-11-23 대한민국 고도불포화지방산 생합성을 위한 재조합 벡터 및 이를 이용하여 제작된 형질전환 식물체
JP6682109B2 (ja) * 2015-01-09 2020-04-15 国立大学法人 宮崎大学 ヤブレツボカビ類を用いたリグニン分解活性を有するタンパク質の製造方法
EP3455351B1 (en) * 2016-05-12 2022-08-24 DSM IP Assets B.V. Method of increasing omega-3 polyunsaturated fatty acids production in microalgae
EP3835412A4 (en) * 2018-08-10 2022-05-11 Kyowa Hakko Bio Co., Ltd. POLYUNSATURATED FATTY ACID PRODUCING MICROORGANISM AND PROCESS FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACID
WO2020032261A1 (ja) * 2018-08-10 2020-02-13 協和発酵バイオ株式会社 エイコサペンタエン酸を生産する微生物及びエイコサペンタエン酸の製造法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042195A2 (en) * 1999-01-14 2000-07-20 Omegatech, Inc. Schizochytrium pks genes
US6140486A (en) * 1997-06-04 2000-10-31 Calgene Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
WO2002083870A2 (en) * 2001-04-16 2002-10-24 Martek Biosciences Boulder Corporation Pufa polyketide synthase systems and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
DK1911837T3 (da) * 2000-09-28 2011-08-29 Bioriginal Food & Science Corp FAD5-2 fedtsyredesaturasefamiliemedlem og anvendelser deraf
CA2387401C (en) * 2001-05-21 2004-10-12 Ecopia Biosciences Inc. Compositions, methods and systems for the production of enediynes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140486A (en) * 1997-06-04 2000-10-31 Calgene Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
WO2000042195A2 (en) * 1999-01-14 2000-07-20 Omegatech, Inc. Schizochytrium pks genes
WO2002083870A2 (en) * 2001-04-16 2002-10-24 Martek Biosciences Boulder Corporation Pufa polyketide synthase systems and uses thereof

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WO2004087879A3 (en) 2008-07-24
JP2016000048A (ja) 2016-01-07
BRPI0409046A (pt) 2006-04-18
JP2007524377A (ja) 2007-08-30
JP5890791B2 (ja) 2016-03-22
EP1623008A4 (en) 2009-05-27
JP6134361B2 (ja) 2017-05-24
CN101389213B (zh) 2014-05-28
ES2516641T3 (es) 2014-10-31
CN101389213A (zh) 2009-03-18
AU2008249169B2 (en) 2012-03-15
KR101234198B1 (ko) 2013-02-19
MX341785B (es) 2016-09-01
EP1623008B1 (en) 2014-07-30
JP2013143945A (ja) 2013-07-25
EP1623008A2 (en) 2006-02-08
CA2520396A1 (en) 2004-10-14
KR101234200B1 (ko) 2013-02-19
AU2008249169A1 (en) 2008-12-11
HK1088632A1 (en) 2006-11-10
AU2004225485A1 (en) 2004-10-14
WO2004087879A2 (en) 2004-10-14
KR20120097502A (ko) 2012-09-04
KR20120123726A (ko) 2012-11-09
MXPA05010214A (es) 2005-12-14
KR101234199B1 (ko) 2013-02-20
CA2520396C (en) 2016-08-09
IL200625A0 (en) 2011-07-31
KR20060006014A (ko) 2006-01-18

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