KR101225233B1 - Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염 - Google Patents

Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염 Download PDF

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KR101225233B1
KR101225233B1 KR1020107007283A KR20107007283A KR101225233B1 KR 101225233 B1 KR101225233 B1 KR 101225233B1 KR 1020107007283 A KR1020107007283 A KR 1020107007283A KR 20107007283 A KR20107007283 A KR 20107007283A KR 101225233 B1 KR101225233 B1 KR 101225233B1
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salt
fluoro
difluoro
benzo
oxazin
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KR20100049688A (ko
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스테판 콜린 존 테일러
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화이자 리미티드
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Assigned to 리겔 파마슈티칼스, 인크. reassignment 리겔 파마슈티칼스, 인크. 권리의 전부이전등록 Assignors: 화이자 리미티드
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020107007283A 2007-09-05 2008-08-27 Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염 Expired - Fee Related KR101225233B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97003007P 2007-09-05 2007-09-05
US60/970,030 2007-09-05
PCT/IB2008/002288 WO2009031011A2 (en) 2007-09-05 2008-08-27 Xinafoate salt of n4-(2, 2-difluoro-4h-benz0 [1,4] 0xazin-3-one) -6-yl] -5-fluoro-n2- [3- (methylaminocar bonylmethyleneoxy) phenyl] 2, 4-pyrimidinediamine

Related Child Applications (1)

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KR1020127024371A Division KR20120120453A (ko) 2007-09-05 2008-08-27 Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염

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KR20100049688A KR20100049688A (ko) 2010-05-12
KR101225233B1 true KR101225233B1 (ko) 2013-01-22

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KR1020107007283A Expired - Fee Related KR101225233B1 (ko) 2007-09-05 2008-08-27 Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염
KR1020127024371A Withdrawn KR20120120453A (ko) 2007-09-05 2008-08-27 Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염

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KR1020127024371A Withdrawn KR20120120453A (ko) 2007-09-05 2008-08-27 Ｎ4-(2,2-다이플루오로-4ｈ-벤조〔1,4〕옥사진-3-온)-6-일〕-5-플루오로-ｎ2-〔3-(메틸아미노카보닐메틸렌옥시)페닐〕2,4-피리미딘다이아민의 지나포에이트 염

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US (3) US8193181B2 (enExample)
EP (1) EP2215087B1 (enExample)
JP (1) JP2009084270A (enExample)
KR (2) KR101225233B1 (enExample)
CN (1) CN101861314B (enExample)
AR (1) AR068369A1 (enExample)
AU (1) AU2008294473B2 (enExample)
BR (1) BRPI0816278A2 (enExample)
CA (1) CA2697495C (enExample)
ES (1) ES2452965T3 (enExample)
IL (1) IL203973A (enExample)
MX (1) MX2010002518A (enExample)
NZ (1) NZ583582A (enExample)
RU (1) RU2458925C2 (enExample)
TW (1) TWI371277B (enExample)
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US8987456B2 (en) 2011-10-05 2015-03-24 Merck Sharp & Dohme Corp. 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
WO2013052391A1 (en) 2011-10-05 2013-04-11 Merck Sharp & Dohme Corp. PHENYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
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EP2863913B1 (en) 2012-06-20 2018-09-12 Merck Sharp & Dohme Corp. Imidazolyl analogs as syk inhibitors
WO2013192125A1 (en) 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Pyrazolyl derivatives as syk inhibitors
US9376418B2 (en) 2012-06-22 2016-06-28 Merck Sharp & Dohme Corp. Substituted pyridine spleen tyrosine kinase (SYK) inhibitors
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EP2931281B1 (en) 2012-12-12 2018-01-17 Merck Sharp & Dohme Corp. Amino-pyrimidine-containing spleen tyrosine kinase inhibitors
EP2934525B1 (en) 2012-12-21 2019-05-08 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
CN105188759A (zh) * 2013-03-14 2015-12-23 阿勒根公司 持续释放递送的组合物以及在制造过程中稳定蛋白质的方法
EP2988744A4 (en) 2013-04-26 2016-11-02 Merck Sharp & Dohme THIAZOLSUBSTITUTED AMINOHETEROARYLE AS MILZTYROSINKINASE INHIBITOR
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US9670196B2 (en) 2013-12-20 2017-06-06 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
WO2015094997A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
EP3083559B1 (en) 2013-12-20 2021-03-10 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
WO2015138273A1 (en) 2014-03-13 2015-09-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
WO2018189566A1 (en) * 2017-04-10 2018-10-18 Dorian Bevec Use of a chemical compound as a therapeutic agent
US11149029B2 (en) * 2018-07-18 2021-10-19 Astrazeneca Ab Salts of IJAK inhibitors and methods of using the same
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
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CN101861314A (zh) 2010-10-13
KR20120120453A (ko) 2012-11-01
US20100204232A1 (en) 2010-08-12
RU2010108162A (ru) 2011-09-10
RU2458925C2 (ru) 2012-08-20
AU2008294473A1 (en) 2009-03-12
HK1144685A1 (en) 2011-03-04
CN101861314B (zh) 2013-07-24
WO2009031011A2 (en) 2009-03-12
EP2215087B1 (en) 2013-12-18
NZ583582A (en) 2012-02-24
EP2215087A2 (en) 2010-08-11
AR068369A1 (es) 2009-11-11
JP2009084270A (ja) 2009-04-23
ZA201002356B (en) 2010-12-29
WO2009031011A3 (en) 2009-04-30
KR20100049688A (ko) 2010-05-12
ES2452965T3 (es) 2014-04-03
US8486935B2 (en) 2013-07-16
AU2008294473B2 (en) 2013-12-05
US20130281446A1 (en) 2013-10-24
CA2697495A1 (en) 2009-03-12
US20120316160A1 (en) 2012-12-13
TW200927125A (en) 2009-07-01
IL203973A (en) 2013-10-31
TWI371277B (en) 2012-09-01
MX2010002518A (es) 2010-03-26
US8193181B2 (en) 2012-06-05
BRPI0816278A2 (pt) 2015-09-22
CA2697495C (en) 2013-02-05

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