CA2697495C - Xinafoate salt of n4-[(2,2-difluoro-4h-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-n2-[3-(methylaminocarbonylmethyleneoxy)phenyl]-2,4-pyrimidinediamine - Google Patents
Xinafoate salt of n4-[(2,2-difluoro-4h-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-n2-[3-(methylaminocarbonylmethyleneoxy)phenyl]-2,4-pyrimidinediamine Download PDFInfo
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- CA2697495C CA2697495C CA2697495A CA2697495A CA2697495C CA 2697495 C CA2697495 C CA 2697495C CA 2697495 A CA2697495 A CA 2697495A CA 2697495 A CA2697495 A CA 2697495A CA 2697495 C CA2697495 C CA 2697495C
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- xinafoate salt
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- oxazin
- asthma
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| CA2760766A1 (en) | 2009-05-21 | 2010-11-25 | Nicholas James Bennett | Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases |
| US9145391B2 (en) | 2011-05-10 | 2015-09-29 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as Syk inhibitors |
| JP2014513687A (ja) | 2011-05-10 | 2014-06-05 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｓｙｋ阻害薬としてのピリジルアミノピリジン |
| CN103619172A (zh) | 2011-05-10 | 2014-03-05 | 默沙东公司 | 作为syk抑制剂的氨基嘧啶 |
| WO2013052393A1 (en) | 2011-10-05 | 2013-04-11 | Merck Sharp & Dohme Corp. | 3-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
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| EP2768480A1 (en) * | 2011-10-21 | 2014-08-27 | Rigel Pharmaceuticals, Inc. | Method and device for administering xinafoate salt of n4-(2,2-difluoro-4h-benzo [1,4]oxazin-3-one) -6-yl]-5-fluoro-n2- [3- (methylaminocarbonylmethyleneoxy) phenyl]2,4-pyrimidinediamine |
| EP2863914B1 (en) | 2012-06-20 | 2018-10-03 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
| US9487504B2 (en) | 2012-06-20 | 2016-11-08 | Merck Sharp & Dohme Corp. | Imidazolyl analogs as syk inhibitors |
| US9416111B2 (en) | 2012-06-22 | 2016-08-16 | Merck Sharp & Dohme Corp. | Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors |
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| EP2968574A1 (en) * | 2013-03-14 | 2016-01-20 | Allergan, Inc. | Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process |
| WO2014176216A1 (en) | 2013-04-26 | 2014-10-30 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors |
| EP2988744A4 (en) | 2013-04-26 | 2016-11-02 | Merck Sharp & Dohme | THIAZOLSUBSTITUTED AMINOHETEROARYLE AS MILZTYROSINKINASE INHIBITOR |
| WO2015095445A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
| WO2015094997A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
| US9670196B2 (en) | 2013-12-20 | 2017-06-06 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors |
| WO2015138273A1 (en) | 2014-03-13 | 2015-09-17 | Merck Sharp & Dohme Corp. | 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors |
| WO2018189566A1 (en) * | 2017-04-10 | 2018-10-18 | Dorian Bevec | Use of a chemical compound as a therapeutic agent |
| CN118580223A (zh) * | 2018-07-18 | 2024-09-03 | 阿斯利康(瑞典)有限公司 | 抑制jak的化合物的昔萘酸盐 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| GB9808802D0 (en) * | 1998-04-24 | 1998-06-24 | Glaxo Group Ltd | Pharmaceutical formulations |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0208609D0 (en) * | 2002-04-13 | 2002-05-22 | Glaxo Group Ltd | Compositions |
| CA2500922A1 (en) * | 2002-10-04 | 2004-04-22 | Pharmacia Corporation | Pharmaceutical compositions for treatment of parkinson's disease |
| US8178671B2 (en) * | 2003-07-30 | 2012-05-15 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds |
| EP1896026B1 (en) * | 2005-06-15 | 2013-10-09 | Boehringer Ingelheim International GmbH | Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof |
| KR101402398B1 (ko) * | 2006-06-30 | 2014-06-03 | 노파르티스 아게 | 퀴놀리논 유도체 및 이의 제약 조성물 |
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2008
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- 2008-08-27 MX MX2010002518A patent/MX2010002518A/es active IP Right Grant
- 2008-08-27 ES ES08806983.6T patent/ES2452965T3/es active Active
- 2008-08-27 NZ NZ583582A patent/NZ583582A/en not_active IP Right Cessation
- 2008-08-27 WO PCT/IB2008/002288 patent/WO2009031011A2/en not_active Ceased
- 2008-08-27 US US12/676,075 patent/US8193181B2/en not_active Expired - Fee Related
- 2008-08-27 CA CA2697495A patent/CA2697495C/en not_active Expired - Fee Related
- 2008-08-27 RU RU2010108162/04A patent/RU2458925C2/ru active
- 2008-08-27 AU AU2008294473A patent/AU2008294473B2/en not_active Ceased
- 2008-08-27 CN CN200880105757XA patent/CN101861314B/zh not_active Expired - Fee Related
- 2008-08-27 KR KR1020127024371A patent/KR20120120453A/ko not_active Withdrawn
- 2008-08-27 KR KR1020107007283A patent/KR101225233B1/ko not_active Expired - Fee Related
- 2008-08-27 EP EP08806983.6A patent/EP2215087B1/en not_active Not-in-force
- 2008-09-03 JP JP2008225403A patent/JP2009084270A/ja active Pending
- 2008-09-04 TW TW097133970A patent/TWI371277B/zh not_active IP Right Cessation
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2010
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2012
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| US8486935B2 (en) | 2013-07-16 |
| CA2697495A1 (en) | 2009-03-12 |
| RU2010108162A (ru) | 2011-09-10 |
| EP2215087B1 (en) | 2013-12-18 |
| ES2452965T3 (es) | 2014-04-03 |
| WO2009031011A2 (en) | 2009-03-12 |
| EP2215087A2 (en) | 2010-08-11 |
| US20130281446A1 (en) | 2013-10-24 |
| TWI371277B (en) | 2012-09-01 |
| US20120316160A1 (en) | 2012-12-13 |
| US8193181B2 (en) | 2012-06-05 |
| US20100204232A1 (en) | 2010-08-12 |
| CN101861314A (zh) | 2010-10-13 |
| JP2009084270A (ja) | 2009-04-23 |
| AU2008294473B2 (en) | 2013-12-05 |
| AR068369A1 (es) | 2009-11-11 |
| MX2010002518A (es) | 2010-03-26 |
| AU2008294473A1 (en) | 2009-03-12 |
| RU2458925C2 (ru) | 2012-08-20 |
| WO2009031011A3 (en) | 2009-04-30 |
| ZA201002356B (en) | 2010-12-29 |
| IL203973A (en) | 2013-10-31 |
| NZ583582A (en) | 2012-02-24 |
| TW200927125A (en) | 2009-07-01 |
| KR20120120453A (ko) | 2012-11-01 |
| CN101861314B (zh) | 2013-07-24 |
| HK1144685A1 (en) | 2011-03-04 |
| KR101225233B1 (ko) | 2013-01-22 |
| BRPI0816278A2 (pt) | 2015-09-22 |
| KR20100049688A (ko) | 2010-05-12 |
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