KR101210695B1 - 친지성 약물의 안정화된 과포화 고체 - Google Patents

친지성 약물의 안정화된 과포화 고체 Download PDF

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Publication number
KR101210695B1
KR101210695B1 KR1020067020937A KR20067020937A KR101210695B1 KR 101210695 B1 KR101210695 B1 KR 101210695B1 KR 1020067020937 A KR1020067020937 A KR 1020067020937A KR 20067020937 A KR20067020937 A KR 20067020937A KR 101210695 B1 KR101210695 B1 KR 101210695B1
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KR
South Korea
Prior art keywords
solvent
composition
compound
lipophilic
steroid
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Expired - Fee Related
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KR1020067020937A
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English (en)
Korean (ko)
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KR20060132999A (ko
Inventor
아드리안 푼케
토르스텐 바그너
랄프 리프
Original Assignee
바이엘 파마 악티엔게젤샤프트
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Application filed by 바이엘 파마 악티엔게젤샤프트 filed Critical 바이엘 파마 악티엔게젤샤프트
Publication of KR20060132999A publication Critical patent/KR20060132999A/ko
Application granted granted Critical
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Assigned to 바이엘 인텔렉쳐 프로퍼티 게엠베하 reassignment 바이엘 인텔렉쳐 프로퍼티 게엠베하 권리의 전부이전등록 Assignors: 바이엘 파마 악티엔게젤샤프트
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
KR1020067020937A 2004-03-10 2005-03-10 친지성 약물의 안정화된 과포화 고체 Expired - Fee Related KR101210695B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US55133004P 2004-03-10 2004-03-10
EP04075714 2004-03-10
EP04075714.8 2004-03-10
EP14075714.8 2004-03-10
US60/551,330 2004-03-10
PCT/IB2005/000748 WO2005087199A2 (en) 2004-03-10 2005-03-10 Stabilised supersaturated solid solutions of steroidal drugs

Publications (2)

Publication Number Publication Date
KR20060132999A KR20060132999A (ko) 2006-12-22
KR101210695B1 true KR101210695B1 (ko) 2012-12-11

Family

ID=34928105

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KR1020067020937A Expired - Fee Related KR101210695B1 (ko) 2004-03-10 2005-03-10 친지성 약물의 안정화된 과포화 고체

Country Status (32)

Country Link
US (1) US8715735B2 (cg-RX-API-DMAC7.html)
EP (2) EP2087883B1 (cg-RX-API-DMAC7.html)
JP (1) JP5006185B2 (cg-RX-API-DMAC7.html)
KR (1) KR101210695B1 (cg-RX-API-DMAC7.html)
CN (1) CN1984644B (cg-RX-API-DMAC7.html)
AR (1) AR048500A1 (cg-RX-API-DMAC7.html)
AT (1) ATE442131T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005221403B8 (cg-RX-API-DMAC7.html)
BR (1) BRPI0507342A (cg-RX-API-DMAC7.html)
CA (1) CA2558582C (cg-RX-API-DMAC7.html)
CR (1) CR8630A (cg-RX-API-DMAC7.html)
DE (1) DE602005016551D1 (cg-RX-API-DMAC7.html)
DK (1) DK1765290T3 (cg-RX-API-DMAC7.html)
EA (1) EA012746B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP066902A (cg-RX-API-DMAC7.html)
ES (2) ES2390406T3 (cg-RX-API-DMAC7.html)
GT (1) GT200500045A (cg-RX-API-DMAC7.html)
HR (1) HRP20090614T1 (cg-RX-API-DMAC7.html)
IL (1) IL177894A0 (cg-RX-API-DMAC7.html)
MY (1) MY142989A (cg-RX-API-DMAC7.html)
NO (1) NO20064473L (cg-RX-API-DMAC7.html)
NZ (1) NZ549793A (cg-RX-API-DMAC7.html)
PA (1) PA8626101A1 (cg-RX-API-DMAC7.html)
PE (1) PE20060016A1 (cg-RX-API-DMAC7.html)
PL (1) PL1765290T3 (cg-RX-API-DMAC7.html)
PT (1) PT1765290E (cg-RX-API-DMAC7.html)
RS (1) RS51076B (cg-RX-API-DMAC7.html)
SI (1) SI1765290T1 (cg-RX-API-DMAC7.html)
SV (1) SV2005002044A (cg-RX-API-DMAC7.html)
TW (1) TWI345986B (cg-RX-API-DMAC7.html)
UY (1) UY28803A1 (cg-RX-API-DMAC7.html)
WO (1) WO2005087199A2 (cg-RX-API-DMAC7.html)

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Publication number Publication date
ES2332229T3 (es) 2010-01-29
US8715735B2 (en) 2014-05-06
US20050207990A1 (en) 2005-09-22
AU2005221403B2 (en) 2009-12-10
PA8626101A1 (es) 2006-07-03
NO20064473L (no) 2006-10-10
JP5006185B2 (ja) 2012-08-22
NZ549793A (en) 2010-06-25
CN1984644A (zh) 2007-06-20
EP1765290B1 (en) 2009-09-09
WO2005087199A2 (en) 2005-09-22
CN1984644B (zh) 2010-12-08
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