KR101151004B1 - 소의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 소의 대장균증 및 살모넬라균증의 예방 및 치료용 백신조성물 - Google Patents

소의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 소의 대장균증 및 살모넬라균증의 예방 및 치료용 백신조성물 Download PDF

Info

Publication number
KR101151004B1
KR101151004B1 KR1020090081430A KR20090081430A KR101151004B1 KR 101151004 B1 KR101151004 B1 KR 101151004B1 KR 1020090081430 A KR1020090081430 A KR 1020090081430A KR 20090081430 A KR20090081430 A KR 20090081430A KR 101151004 B1 KR101151004 B1 KR 101151004B1
Authority
KR
South Korea
Prior art keywords
salmonella
coli
strain
vaccine
gene
Prior art date
Application number
KR1020090081430A
Other languages
English (en)
Korean (ko)
Other versions
KR20110023502A (ko
Inventor
이존화
김희정
정구남
김은성
김삼웅
Original Assignee
전라북도
전북대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 전라북도, 전북대학교산학협력단 filed Critical 전라북도
Priority to KR1020090081430A priority Critical patent/KR101151004B1/ko
Priority to PCT/KR2010/005895 priority patent/WO2011025344A2/fr
Publication of KR20110023502A publication Critical patent/KR20110023502A/ko
Application granted granted Critical
Publication of KR101151004B1 publication Critical patent/KR101151004B1/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020090081430A 2009-08-31 2009-08-31 소의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 소의 대장균증 및 살모넬라균증의 예방 및 치료용 백신조성물 KR101151004B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020090081430A KR101151004B1 (ko) 2009-08-31 2009-08-31 소의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 소의 대장균증 및 살모넬라균증의 예방 및 치료용 백신조성물
PCT/KR2010/005895 WO2011025344A2 (fr) 2009-08-31 2010-08-31 Mutants de salmonelle atténués dans lesquels l'adhésine de escherichia coli pathogène bovin des transformée et composition vaccinale contenant ces mutants utilisée pour empêcher et traiter la colibacillose et la salmonellose bovines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020090081430A KR101151004B1 (ko) 2009-08-31 2009-08-31 소의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 소의 대장균증 및 살모넬라균증의 예방 및 치료용 백신조성물

Publications (2)

Publication Number Publication Date
KR20110023502A KR20110023502A (ko) 2011-03-08
KR101151004B1 true KR101151004B1 (ko) 2012-06-22

Family

ID=43628655

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020090081430A KR101151004B1 (ko) 2009-08-31 2009-08-31 소의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 소의 대장균증 및 살모넬라균증의 예방 및 치료용 백신조성물

Country Status (2)

Country Link
KR (1) KR101151004B1 (fr)
WO (1) WO2011025344A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101371355B1 (ko) 2012-03-29 2014-03-14 전북대학교산학협력단 생물형 면역증강제를 이용한 경구용 가금티푸스 백신 조성물

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101481789B1 (ko) * 2011-05-17 2015-01-14 전북대학교산학협력단 약독화, 면역강화 살모넬라 엔테리티디스의 변이균주를 포함하는 살모넬라증 예방용 생균 백신 조성물
KR101374649B1 (ko) * 2011-07-22 2014-03-17 전북대학교산학협력단 가금류의 병원성 대장균의 병원성 인자를 발현하는 살모넬라균을 포함하는 가금류의 병원성 대장균증 및 살모넬라균증의 예방 및 치료용 백신 조성물.
KR101893827B1 (ko) * 2016-01-04 2018-08-31 전북대학교 산학협력단 약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물
CN109797198A (zh) * 2019-02-18 2019-05-24 扬州大学 一种抗羊f17大肠杆菌感染的基因筛选方法
CN112852698B (zh) * 2021-01-30 2022-11-29 军事科学院军事医学研究院军事兽医研究所 牛种布鲁氏菌A19株asd基因缺失株的构建方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080082156A (ko) * 2007-03-07 2008-09-11 전북대학교산학협력단 ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신
US20080286310A1 (en) 2004-10-26 2008-11-20 University Of Maryland Baltimore Live Attenuated Bacterial Vaccine to Reduce or Inhibit Carriage and Shedding of Enterohemorrhagic Escherichia Coli in Cattle
KR20110022428A (ko) * 2009-08-27 2011-03-07 주식회사 중앙백신연구소 돼지의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 돼지의 병원성 대장균증 및 살모넬라균증의 예방 및 치료용 백신 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080286310A1 (en) 2004-10-26 2008-11-20 University Of Maryland Baltimore Live Attenuated Bacterial Vaccine to Reduce or Inhibit Carriage and Shedding of Enterohemorrhagic Escherichia Coli in Cattle
KR20080082156A (ko) * 2007-03-07 2008-09-11 전북대학교산학협력단 ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신
KR20110022428A (ko) * 2009-08-27 2011-03-07 주식회사 중앙백신연구소 돼지의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 돼지의 병원성 대장균증 및 살모넬라균증의 예방 및 치료용 백신 조성물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101371355B1 (ko) 2012-03-29 2014-03-14 전북대학교산학협력단 생물형 면역증강제를 이용한 경구용 가금티푸스 백신 조성물

Also Published As

Publication number Publication date
WO2011025344A3 (fr) 2011-08-25
KR20110023502A (ko) 2011-03-08
WO2011025344A2 (fr) 2011-03-03

Similar Documents

Publication Publication Date Title
Wyszyńska et al. Oral immunization of chickens with avirulent Salmonella vaccine strain carrying C. jejuni 72Dz/92 cjaA gene elicits specific humoral immune response associated with protection against challenge with wild-type Campylobacter
KR101178415B1 (ko) 돼지의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 돼지의 병원성 대장균증 및 살모넬라균증의 예방 및 치료용 백신 조성물
Grangette et al. Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum
JP5480812B2 (ja) アイメリアに対する免疫応答を強化する組成物および方法
KR101151004B1 (ko) 소의 병원성 대장균의 부착인자가 형질전환된 약독화 살모넬라균 변이주 및 이를 포함하는 소의 대장균증 및 살모넬라균증의 예방 및 치료용 백신조성물
CN101522210A (zh) 增强免疫应答的组合物和方法
Cárdenas et al. Stability, immunogenicity and expression of foreign antigens in bacterial vaccine vectors
JP2021506782A (ja) レンサ球菌感染防御のためのワクチン
Hur et al. Immune responses to new vaccine candidates constructed by a live attenuated Salmonella Typhimurium delivery system expressing Escherichia coli F4, F5, F6, F41 and intimin adhesin antigens in a murine model
US20130236948A1 (en) Recombinant microorganisms and uses thereof
Hur et al. A new enterotoxigenic Escherichia coli vaccine candidate constructed using a Salmonella ghost delivery system: comparative evaluation with a commercial vaccine for neonatal piglet colibacillosis
Riquelme-Neira et al. Vaccination with DNA encoding truncated enterohemorrhagic Escherichia coli (EHEC) factor for adherence-1 gene (efa-1′) confers protective immunity to mice infected with E. coli O157: H7
JP2022506634A (ja) 豚レンサ球菌感染防御のためのワクチン
CN102732473B (zh) 表达猪肺炎支原体p46蛋白的重组猪霍乱沙门氏菌及制备方法与应用
EP0314224B1 (fr) Vaccin contre la septicémie à E.Coli chez la volaille
US20050232947A1 (en) Bacterial spores
Nandre et al. Adjuvant effect of Escherichia coli heat labile enterotoxin B subunit against internal egg contamination in domestic fowl immunised with a live Salmonella enterica serovar Enteritidis vaccine
CN105602981B (zh) 一种猪流行性腹泻病毒基因工程亚单位口服组合疫苗的制备方法及应用
US20150238590A1 (en) Use of the salmonella spp type iii secretion proteins as a protective vaccination
EP1210445B1 (fr) Micro-organismes de recombinaison
CN114650840A (zh) 一种针对副猪嗜血杆菌的新型疫苗
Hur et al. Protective efficacy by various doses of Salmonella ghost vaccine candidate carrying enterotoxigenic Escherichia coli fimbrial antigen against neonatal piglet colibacillosis
US7524507B1 (en) Recombinant microorganisms
JP4705573B2 (ja) 弱毒細菌生ワクチン
KR101712012B1 (ko) 개선된 고스트 살모넬라 변이주를 유효성분으로 포함하는 돼지 대장균증의 예방 또는 치료용 백신 조성물

Legal Events

Date Code Title Description
A201 Request for examination
N231 Notification of change of applicant
E902 Notification of reason for refusal
AMND Amendment
E601 Decision to refuse application
X091 Application refused [patent]
AMND Amendment
X701 Decision to grant (after re-examination)
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20150302

Year of fee payment: 4

FPAY Annual fee payment

Payment date: 20160512

Year of fee payment: 5

FPAY Annual fee payment

Payment date: 20170522

Year of fee payment: 6

FPAY Annual fee payment

Payment date: 20180920

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee