KR101142101B1 - Conductive hydrogel and preparation method of the same - Google Patents

Abstract

The present invention relates to a conductive hydrogel, comprising a first monomer, a second monomer, a crosslinking agent, a photoinitiator, a wetting agent, an electrolyte, and deionized water, wherein the first monomer is 3-sulfopropyl acrylate potassium salt. The second monomer may be acrylic acid, thereby providing an optimal composition and composition ratio, thereby having an adhesive force, conductivity, moisturizing power, and skin hypoallergenic properties superior to those of a conventional hydrogel.

Hydrogel, first monomer, second monomer, 3-sulfopropyl acrylate potassium salt, acrylic acid, adhesion, conductivity

Description

Conductive hydrogel and its manufacturing method {CONDUCTIVE HYDROGEL AND PREPARATION METHOD OF THE SAME}

The present invention relates to a conductive hydrogel having better adhesion, conductivity, moisturizing power and skin hypoallergenicity than a conventional hydrogel, and a method for preparing the same, and more specifically, 3-sulfopropyl acrylate potassium salt as a first monomer, A conductive hydrogel comprising acrylic acid as a second monomer and comprising a crosslinking agent, a photoinitiator, a humectant, an electrolyte and deionized water, and a method for producing the same.

As one of the accessory materials used in the diagnostic instrumentation in the medical industry, conductive hydrogels are widely used. Such conductive hydrogels are used in medical device electrodes such as electrocardiogram (ECG) electrodes, electroencephalogram (EEG) electrodes, electromyography (EMG) electrodes, percutaneous electrical neural stimulator (TENS) electrodes, high frequency surgical (ESU) ground electrodes, and the like. It is a material that enhances the electrical signal transmission power.

Conductive hydrogels have non-permanent adhesion properties and high moisture content, and can be used to attach electrodes to the skin due to their ability to improve conductivity by being treated with ion conductive materials. Recently, the present invention is not only used as one of the materials used in the diagnostic measuring instrument, but also has been applied to various medical industry fields that regulate the flow of current in the human body, such as physiotherapy accessories and electro-surgical accessary. Therefore, the demand for high performance hydrogel is gradually increasing.

High-performance hydrogels must not only have conductivity but also have strong adhesion to reduce noise that may be caused by patient shaking and minute tremors, and are biocompatible so that they do not cause skin side effects because they adhere directly to the patient's skin. You must also have

On the other hand, advances have been made in terms of the preparation of such medical hydrogels. That is, the development of the UV crosslinking method using the radiation technology has been made to compensate for the disadvantages of using the conventional chemical crosslinking method.

In case of using the conventional chemical crosslinking method, harmful chemical crosslinking agent and heat are used, and residual crosslinking agent must be removed even after crosslinking, and it takes a lot of time, and due to complex ion bonding, gel viscoelastic properties are not high when crosslinking. . However, conductive hydrogels using radiation crosslinking do not require removal of residual crosslinking agent or separate sterilization process, and can be crosslinked within a short time (several seconds) and have strong adhesion and retention due to strong covalent bonds. More effective. Therefore, hydrogels of various uses have been developed using the latter manufacturing method.

Korean Patent Laid-Open Publication No. 2007-0085460 discloses a hydrogel composition using N-vinyl pyrrolidone as a first monomer. N-vinyl pyrrolidone is used as a main raw material of contact lenses and is a transparent and hydrophilic monomer. When the hydrogel is composed of monomers, it has a vinyl group and has a relatively simple polymerization condition, but is not a salt form. It is not conductive and has a disadvantage of poor adhesion.

EP-A-2006-0024402 discloses a hydrogel comprising [2- (methacryloyloxy) ehtyl] trimethyl ammonium chloride) which is a hydrophilic monomer having a cationic group have. Such a hydrogel may be suitable for fixing a physiologically active substance, but it is not preferable as a hydrogel used in an electrode of a medical device because the adhesive force and its conductivity are insufficient and the polymerization rate should be increased to increase the light irradiation time.

In addition, U.S. Patent Application Publication No. 2008-0064839 discloses a composition using 3-sulfopropyl acrylate potassium salt as a hydrophilic monomer, but such a composition is also suitable for surgical materials, and the composition is a conductive hydrogel, which must have conductivity and adhesion. As a composition, it is not preferable.

However, the above-described technologies not only satisfy the demand for a conductive hydrogel having bioadhesion while having excellent adhesive strength and conductivity, but also provide an optimal composition and blending ratio that can be immediately put into practical use in the technical field. It does not provide.

The present invention was conceived to solve the above problems, in the production of a conductive hydrogel using a radiation crosslinking method, 3-sulfopropyl acrylate potassium salt (3-sulfopropyl acrylate potassium salt) and acrylic acid (acrylic acid) ) Provides the composition of the hydrogel with the first monomer and the second monomer, respectively, and also provides the optimum blending ratio, so that it can be immediately used in the technical field while having excellent adhesion, conductivity, moisturizing power, and skin hypoallergenicity. It is an object to provide a conductive hydrogel.

Conductive hydrogel according to the present invention for achieving the above object is a hydrogel comprising a first monomer, a second monomer, a crosslinking agent, a photoinitiator, a wetting agent, an electrolyte and deionized water, wherein the first monomer is 3-sulfopropyl Acrylate potassium salt, and said second monomer is acrylic acid.

Here, the photoinitiator may be selected from the group consisting of 1-hydroxy cyclohexyl phenyl ketone, monoacyl phosphine oxide, benzoin alkyl ether, mercaptobenzothiazoyl and mixtures thereof, and the crosslinking agent is ethylene glycol dimetha Acrylate, poly (ethylene glycol) diacrylate, diethylene glycol dimethacrylate, ethylene glycol diacrylate, 1,3-dihydroxypropyldimethacrylate, and mixtures thereof. .

In addition, the electrolyte may be selected from the group consisting of sodium and potassium chloride, phosphate, citrate, acetate and lactate, glycerol is preferred as the humectant.

In addition, the content of the hydrogel according to the present invention is 24 to 32% by weight of the 3-sulfopropyl acrylate potassium salt, 1 to 4% by weight of the acrylic acid, 0.06 to 0.1% by weight of the crosslinking agent, 0.01 to 0.01% 0.1 wt%, the wetting agent is 32 to 40% by weight, the electrolyte is 2.5 to 3.5% by weight, the deionized water is preferably 28 to 35% by weight, the crosslinking agent is poly (ethylene glycol) diacrylate, More preferably, the photoinitiator is 1-hydroxycyclohexyl phenyl ketone, the humectant is glycerol, and the electrolyte is potassium chloride.

In particular, the conductive hydrogel is 24 to 30% by weight of the 3-sulfopropyl acrylate potassium salt, 3 to 4% by weight of the acrylic acid, 0.08 to 0.1% by weight of the poly (ethylene glycol) diacrylate, 1 Hydroxycyclohexyl phenyl ketone is 0.08 to 0.1% by weight, the glycerol is 35 to 40% by weight, the potassium chloride is 2.5 to 3.0% by weight, the deionized water is 28 to 32% by weight than the more conductive and cohesive It may have excellent physical properties.

In addition, the hydrogel may further include an additive selected from the group consisting of moisturizers, enzymes, surfactants, antibacterial agents, permeation enhancers, pH adjusting agents and mixtures thereof.

The present invention also provides a method for producing a conductive hydrogel comprising the step of controlling the stirring order in order to obtain a uniform composition in the production of the conductive hydrogel, and irradiating with ultraviolet rays to crosslink.

According to the present invention, by providing a specific composition and composition ratio, it adheres to the skin better than before, and provides a bio-compatible hydrogel with less moisturizing power and less irritation to the skin while delivering electrical signals and impulses better. There is an effect that can be immediately applied in the technical field.

The conductive hydrogel according to the present invention is a conductive hydrogel comprising a first monomer, a second monomer, a crosslinking agent, a photoinitiator, a wetting agent, an electrolyte, and deionized water, wherein the first monomer is 3-sulfopropyl acrylate potassium salt. The second monomer is acrylic acid.

Common physical properties of conductive hydrogels include ion transfer properties for biosignal transmission, adhesion to the skin surface, retention ability that can persist even after 24 hours of use, and prevent the hydrogel from drying easily. It should be moisturizing and biocompatible enough to not irritate skin. In general, the hydrogel has a three-dimensional network structure to contain a large amount of water.

In addition, the hydrogel has a property of being insoluble in water, although there is some electrostatic and lipophilic interaction, it has a covalent structure between the polymer backbones, so that the hydrogel is not dissolved in water and can maintain its shape. In other words, it is the basic physical properties of hydrogel to absorb water in an insoluble state and to have mechanical properties and shapes.

In order to improve the conductivity of the hydrogel as described above, the present invention includes 3-sulfopropyl acrylate potassium salt as a first monomer and acrylic acid as a second monomer.

As the first monomer of the present invention, the 3-sulfopropyl acrylate potassium salt acts as a main chain forming the structure of the hydrogel. The 3-sulfopropyl acrylate potassium salt has its own conductivity as a water soluble monomer in the form of an anion salt. In addition, the 3-sulfopropyl acrylate potassium salt may be used to introduce a polar moiety into the polymer chain, which is characterized by giving shear stability in water-soluble polymer dispersion.

When the hydrogel is polymerized using the 3-sulfopropyl acrylate potassium salt, the polymerization rate is very fast within 60 seconds and excellent in self-adhesion.

The content of the 3-sulfopropyl acrylate potassium salt is preferably 24 to 32% by weight, more preferably 24 to 30% by weight. If the content is less than 24% by weight, the content of the humectant may be relatively increased in relation to other compositions, such that the hydrogel may become soft. In addition, potassium chloride may precipitate if the content exceeds 32% by weight.

The acrylic acid plays a role in controlling pH and is essential for polymerization. Therefore, the polymerization reaction may not occur when the acrylic acid is not added. In addition, the hydrogel prepared by using the 3-sulfopropyl acrylate potassium salt as the first monomer and the acrylic acid as the second monomer may have improved polymerization reactivity, easy pH control, and improved moisturizing power. Can be.

When the content of the acrylic acid is 1 to 4% by weight, the pH of the hydrogel is preferably 3.5 to 4.5, but considering the mixing ratio with other compositions, 3 to 4% by weight is most preferred. If the content of acrylic acid is less than 1% by weight, polymerization does not occur well. If the content is more than 4% by weight, the pH may be 3 to 3.2, and the acidity may be too high, causing skin irritation.

As one of the methods for producing a hydrogel, in the present invention, a radiation crosslinking method of irradiating ultraviolet light and crosslinking may be used. Therefore, it is preferable to manufacture by adding a photoinitiator and a crosslinking agent.

In general, a thermal initiator or photoinitiator that is sensitive to heat or light may be used, but in the preparation of the hydrogel of the present invention, a radical polymerization initiator through UV light irradiation is preferable.

The photoinitiator may be selected from the group consisting of 1-hydroxy cyclohexyl phenyl ketone, monoacyl phosphine oxide, benzoin alkyl ether, mercaptobenzothiazoyl and mixtures thereof, but is not necessarily limited thereto. Of these, 1-hydroxy cyclohexyl phenyl ketone is preferable as the photoinitiator. Since the photoinitiator is involved only in the initial reaction, the content thereof is preferably 0.01 to 0.1% by weight, more preferably 0.08 to 0.1% by weight.

In addition, the hydrogel of the present invention may include a crosslinking agent. The crosslinking agent is a polymer that connects oligomers for three-dimensional network structure. Gelling does not proceed unless a crosslinking agent is added in the preparation of the hydrogel.

The crosslinking agent is ethylene glycol dimethacrylate, poly (ethylene glycol) diacrylate, diethylene glycol dimethacrylate, ethylene glycol diacrylate, 1,3-dihydroxypropyldimethacrylate and mixtures thereof. It may be selected from the group consisting of, but is not necessarily limited thereto. Among these, poly (ethylene glycol) diacrylate is preferable as the crosslinking agent.

When the content of the crosslinking agent is 0.06 to 0.1% by weight, it shows improved crosslinkability, and when 0.08 to 0.1% by weight, the best crosslinking property is shown. If the content of the crosslinking agent is less than 0.05% by weight, gelation may proceed, but hydrogel may be broken. In addition, when the content of the crosslinking agent is more than 0.1% by weight, gelation may proceed, but a phenomenon in which adhesive force may decrease may occur.

The hydrogel of the present invention may comprise an electrolyte. The electrolyte serves to reduce electrical resistance and improve conductivity.

The electrolyte may be an ionic inorganic salt or an organic compound. As one specific example, the electrolyte may be selected from the group consisting of sodium and potassium chloride, phosphate, citrate, acetate, and lactate, but is not necessarily limited thereto. Of these, since the first monomer used in the present invention is in the form of potassium salt as the 3-sulfopropyl acrylate potassium salt, it is preferable to add potassium chloride for uniformity of the compound.

When the content of the electrolyte is less than 2% by weight, there is an improvement in the conductivity of the hydrogel, but insignificant compared with the case where only the monomer is administered. If the content of the electrolyte is more than 4% by weight, there is a problem of reprecipitation in the salt state and excess. When added, the viscosity may also drop. Therefore, the content of the electrolyte is preferably 2 to 3.5% by weight, more preferably 2.5 to 3.5% by weight and most preferably 2.5 to 3.0% by weight.

The hydrogel according to the present invention may comprise a humectant. The humectant is used to increase the water retention capacity of the hydrogel. The humectant is preferably glycerol.

Although the 3-sulfopropyl acrylate potassium salt itself, which is a monomer used in the hydrogel of the present invention, has a water retention capability, the cost of glycerol is low in comparison with the monomer, and thus the total cost is increased by increasing the composition ratio of glycerol. It is desirable to reduce the production cost to find a composition ratio that can reduce the same effect.

As the composition ratio of the glycerol increases, the adhesiveness may increase, but a small amount may appear. When the composition ratio decreases to 30% by weight, moisture retention may decrease and potassium chloride may precipitate. The content of the glycerol is preferably 32 to 40% by weight, more preferably 35 to 40% by weight.

One example of a solvent typically used is water. In the present invention, deionized water is used and the deionized water serves as a plasticizer for the polymer. It is a factor that affects osmotic pressure, swelling, viscoelastic properties during crosslinking. Tertiary distilled or quaternary distilled water can be used.

The amount of deionized water may vary and mainly varies depending on the amounts of the first monomer and the second monomer. In the present invention, when the deionized water is contained in an amount of 10% by weight or less, since it is insufficient to dissolve the monomer, it is not preferable to obtain a uniform hydrogel. On the other hand, when the deionized water is included in more than 50% by weight, the content of the humectant may be relatively low, thereby making the hydrogel easy to dry. Therefore, the content of the deionized water is preferably 25 to 40% by weight, more preferably 28 to 35% by weight, most preferably 28 to 32% by weight.

In one embodiment, the conductive hydrogel of the present invention comprises 24 to 32% by weight of 3-sulfopropyl acrylate potassium salt, 1 to 4% by weight of acrylic acid, 0.06 to 0.1% by weight of crosslinking agent, 0.01 to 0.1% by weight of photoinitiator, wetting agent. 32 to 40% by weight, electrolyte 2.5 to 3.5% by weight, and 28 to 35% by weight of deionized water.

More preferably, the conductive hydrogel of the present invention is 24 to 30% by weight of 3-sulfopropyl acrylate potassium salt, 3 to 4% by weight acrylic acid, 0.08 to 0.1% by weight crosslinking agent, 0.08 to 0.1% by weight photoinitiator, 35 to wetting agent 40 wt%, electrolyte 2.5 to 3.0 wt%, and 28 to 32 wt% deionized water. In addition, the crosslinking agent may be poly (ethylene glycol) diacrylate, the photoinitiator is 1-hydroxycyclohexyl phenyl ketone, the humectant is glycerol, and the electrolyte may be potassium chloride.

The conductive hydrogel of the present invention may further include an additive selected from the group consisting of humectants, enzymes, surfactants, antibacterial agents, permeation enhancers, pH adjusters, and mixtures thereof.

The hydrogel may be polymerized by a photocrosslinking method in which the composition is mixed with the above-mentioned composition ratio and irradiated with ultraviolet rays to crosslink. When the composition is blended, when the deionized water is added first and then the first monomer is added, the phenomenon of entanglement occurs before dissolution, so that the stirring sequence is a crosslinking agent, a first monomer, an electrolyte, a humectant, deionized water, and a second. It is preferable to mix | blend in order of a monomer because a uniform composition can be obtained.

After stirring for about 30 to 40 minutes, the less the amount of deionized water increases the stirring time. When the photoinitiator is added together from the beginning, since the prepolymerization reaction by the photoinitiator may occur, the mixture is finally mixed and stirred for about 10 minutes.

After stirring, soaking may be performed for about 10 minutes or vacuum may be performed at low pressure to remove the bubbles.

It is then poured into the mold and irradiated for 60 seconds using a UV lamp. The degree of curing can be controlled by changing the irradiation time or intensity of the UV lamp. The preferred dosage of the hydrogel according to the invention is at least 1200 mJ / cm ² . The polymerization method is not necessarily limited thereto.

The invention can be better understood by the following examples, which are intended for the purpose of illustration of the invention and are not intended to limit the scope of protection defined by the appended claims.

<Examples>

The specification of the components used in Examples 1-4 and Comparative Examples 1-8 is as follows.

(A) 3-sulfopropyl acrylate potassium salt: The 3-sulfopropyl acrylate potassium salt (trade name 251631) of Aldrich Corporation was used.

(A ′) N-vinylpyrrolidone: Aldrich 1-ethyl-2-pyrrolidone (trade name 146358) was used.

(A '') [2- (methacryloyloxy) ethyl] trimethyl ammonium chloride: Aldrich [2- (methacryloyloxy) ethyl] trimethyl ammonium chloride (trade name 408107) was used.

(B) Acrylic acid: Aldrich acrylic acid 99% ANHYDROUS (trade name 147230) was used.

(C) Poly (ethylene glycol) diacrylate: Aldrich poly (ethylene glycol) diacrylate (trade name 437441) was used.

(D) Glycerol: Sigma glycerol 99.5 +% ACS (trade name G7893) was used.

(E) Potassium chloride: Sigma aldrich potassium chloride 99.0 to 100.5% ACS (trade name P3911) was used.

(F) 1-hydroxycyclohexyl phenyl ketone: Aldrich 1-hydroxycyclohexyl phenyl ketone (trade name 405612) was used.

(G) Deionized water: Tertiary distilled water was used.

Example  1-4

Each of the components is added in an amount as shown in Table 1 below, but the stirring order is poly (ethylene glycol) diacrylate, 3-sulfopropyl acrylate potassium salt, potassium chloride, glycerol, deionized water and acrylic acid in that order The mixture was stirred first for about 30-40 minutes. Then 1-hydroxycyclohexyl phenyl ketone was finally put into the stirrer and stirred for about 10 minutes.

Then, by ultrasonication for about 10 minutes to remove the bubbles generated after stirring and put in a mold and irradiated with a UV lamp for 60 seconds. The UV lamp used a high pressure mercury lamp and a wavelength of 300nm. Thus, a hydrogel sample having a diameter of 15 mm and a thickness of 1 mm was obtained.

Comparative example  1-8

The same method as in Examples 1 to 4 was used except that the components were mixed and stirred regardless of the order of stirring.

The physical properties of the sample were measured by the following method and the results are shown in Table 2.

(1) Adhesion: according to ASTM D3330 standard, measured by a 180 ^o Peel Test (180 ^o Peel test). The final test results were calculated as the average of five test results. The unit of adhesion is kg / inch.

(2) pH: pH was measured the final pH using a pH meter in the hydrogel composition.

(3) Impedance: The conductivity of the sample was evaluated by conducting an impedance test at 10 Hz during the electrical performance test of AAMI EC12. The lower the impedance value, the better the conductivity.

(4) Potassium chloride precipitation: The sample was dried at room temperature for one week, and then visually confirmed whether crystals were deposited on the appearance.

(5) Moisturizing power: After the accelerated life test (calculated the product life after storing for 2 years at 70 to 4.6 weeks storage according to the acceleration theory of ASTM TIR-17), the electrical performance was tested to confirm the maintenance of moisturizing power.

 <Moisture retention criterion>

Good: It is sticky when touched by hand and there is no change in impedance value compared with initial value in impedance test (2kΩ or less).

Poor: No stickiness when touched by hand and the impedance value is much different from the initial value in impedance test (2kΩ or more).

Ingredient Example Comparative Example One 2 3 4 One 2 3 4 5 6 7 8 (A) 3-sulfopropyl acrylate potassium salt

24.0
30.0
26.0
28.0
30.0
30.0
-
-
-
22.0
-
30.0 (A ')
N-vinyl pyrrolidone
-
-
-
-
-
-
30.0
20.0
-
-
30.0
- (A '')
[2- (methacryloyloxy) ethyl] trimethyl ammonium chloride
-
-
-
-
-
-
-
-
30.0
-
-
- (B) acrylic acid 4.0 4.0 4.0 4.0 5.0 4.0 - 4.0 4.0 4.0 4.0 4.0 (C) poly (ethylene glycol) diacrylate
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.2
0.1
0.1
0.1
0.1 (D) glycerol 40.0 34.0 38.0 36.0 40.0 34.5 40.0 41.7 40.0 36.0 34.0 30.5 (E) potassium chloride 2.5 2.5 2.5 2.5 4.0 2.0 4.0 4.0 2.5 2.5 2.5 4.0 (F) 1-hydroxycyclohexyl phenyl ketone
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1 (G) deionized water 29.3 29.3 29.3 29.3 20.8 29.3 25.8 30 23.3 35.3 29.3 31.3

Properties Example Comparative Example One 2 3 4 One 2 3 4 5 6 7 8 adhesiveness
(kg / inch)
0.27
0.24
0.27
0.26
0.25
0.25
-
0.15
0.15
0.15
0.14
0.20  PH 3.5 3.4 3.4 3.5 3.0 3.4 - 3.5 3.4 3.4 3.5 3.4
impedance
(Ω)

90 ~
120
100 ~
120
100 ~
130
110 ~
130
100 ~
120
250 ~
300 Polymerization does not occur
20,000
More than
300 ~
350
120 ~
140
20,000
More than
90 ~
110 Potassium chloride
Precipitation X X X X O X - O X X X O Moisturizing Good Good Good Good Good Good - Bad Good Bad Bad Bad

As shown in Table 2, when the 3-sulfopropyl acrylate potassium salt of the present invention and acrylic acid are used simultaneously, conventional N-vinyl pyrrolidone is used alone or [2- (methacryloyl jade). C) ethyl] trimethyl ammonium chloride and acrylic acid can be seen that better adhesion and conductivity than when used simultaneously. In addition, when the components included in the hydrogel of the present invention has a composition ratio of Examples 1 to 4, it can be seen that it shows better adhesion, conductivity, moisturizing and skin hypoallergenic than otherwise.

As shown in Comparative Example 3, when N-vinyl pyrrolidone alone was used as the monomer, polymerization did not occur, indicating that acrylic acid was an essential component as the second monomer, and as shown in Comparative Example 5, acrylic acid was used. Even when used as a monomer, the use of 3-sulfopropyl acrylate potassium salt as the first monomer is far superior to that when using [2- (methacryloyloxy) ethyl] trimethyl ammonium chloride as the first monomer. You can see that. In addition, the composition ratio and the presence of the second monomer are the same, but compared to Comparative Example 7 and Example 2 in which only the first monomer is different, it is better when using the 3-sulfopropyl acrylate potassium salt as the first monomer It can be seen that the adhesion, conductivity and moisturizing power.

In the present invention, it can be seen that the composition ratio of the components included in the hydrogel also affects adhesion, conductivity, and moisturizing power. In Comparative Example 1 in which the acrylic acid content is 4% by weight or more, the pH is 3.0, which causes skin irritation. When compared with Comparative Example 2 having a potassium chloride content of 2.0 or less, it was found that the conductivity was better when the content was 2.5 as in Examples 1 to 4.

In addition, when comparing the composition ratios of Examples 1 to 4 and Comparative Example 6 in which the first monomer content is less than 24% by weight, Examples 1 to 4 show better adhesion, conductivity, and moisturizing ability than Comparative Example 6. In addition, as shown in Comparative Example 8, when the content of potassium chloride is 4% by weight and the content of glycerol is less than 32, the conductivity is good, but the moisturizing power is lowered and shows the re-precipitation of potassium chloride.

Therefore, it can be seen from the above results that the conductive hydrogel of the present invention has superior physical properties than the prior art.

Simple modifications or changes of the present invention can be easily carried out by those skilled in the art, and all such modifications or changes can be seen to be included in the scope of the present invention.

Claims (11)

delete delete delete delete In a hydrogel comprising a first monomer, a second monomer, a crosslinking agent, a photoinitiator, a humectant, an electrolyte, and deionized water, The first monomer is 3-sulfopropyl acrylate potassium salt, The second monomer is acrylic acid, The photoinitiator is selected from the group consisting of 1-hydroxy cyclohexyl phenyl ketone, monoacyl phosphine oxide, benzoin alkyl ether, mercaptobenzothiazoyl and mixtures thereof, The crosslinking agent is ethylene glycol dimethacrylate, poly (ethylene glycol) diacrylate, diethylene glycol dimethacrylate, ethylene glycol diacrylate, 1,3-dihydroxypropyldimethacrylate and mixtures thereof. Selected from the group consisting of The electrolyte is selected from the group consisting of sodium and potassium chloride, phosphate, citrate, acetate and lactate, The wetting agent is a conductive hydrogel, characterized in that glycerol. delete The method of claim 5, The crosslinker is poly (ethylene glycol) diacrylate, The photoinitiator is 1-hydroxycyclohexyl phenyl ketone, The electrolyte is a conductive hydrogel, characterized in that potassium chloride. The method of claim 7, wherein The 3-sulfopropyl acrylate potassium salt is 24 to 30% by weight, The acrylic acid is 3 to 4% by weight, The poly (ethylene glycol) diacrylate is 0.08 to 0.1% by weight, The 1-hydroxycyclohexyl phenyl ketone is 0.08 to 0.1% by weight, The glycerol is 35 to 40% by weight, The potassium chloride is 2.5 to 3.0% by weight, The deionized water is a conductive hydrogel, characterized in that 28 to 32% by weight. The method of claim 8, A conductive hydrogel, further comprising an additive selected from the group consisting of moisturizers, enzymes, surfactants, antibacterial agents, permeation enhancers, pH adjusters, and mixtures thereof. In order to prepare the conductive hydrogel of claim 8, Mixing the first monomer, the second monomer, the crosslinking agent, the photoinitiator, the wetting agent, the electrolyte, and the deionized water to make a composition; And Method for producing a conductive hydrogel comprising the step of crosslinking by irradiating the composition with ultraviolet light. The method of claim 10, In the preparing of the composition, the crosslinking agent, the first monomer, the electrolyte, the wetting agent, the deionized water, and the second monomer are sequentially mixed and stirred, and then a photoinitiator is added to prepare a conductive hydrogel. Way.