KR102571383B1 - Adhesive conductive hydrogel using radiation crosslinking method, manufacturing method thereof and sheet of adhesive conductive hydrogel using the same - Google Patents

Abstract

The present invention relates to a conductive hydrogel containing an ionic monomer and a method for producing the same, wherein the conductive hydrogel has an appropriate gelation rate by irradiating an electron beam to a composition in which an ionic monomer, distilled water and a pH adjusting agent are mixed in a predetermined ratio, It can be used without a separate substrate, has excellent conductivity and excellent adhesive strength, and does not use a separate initiator, so it is possible to prevent skin troubles that occur when attached to the skin for a long time.

Description

Adhesive conductive hydrogel for skin attachment using radiation crosslinking method, manufacturing method thereof, and adhesive conductive hydrogel sheet using the same

The present invention relates to an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, a manufacturing method thereof, and an adhesive conductive hydrogel sheet using the same. It relates to an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method prepared by irradiation.

Polymer hydrogels are used in various fields because they contain a wetting agent and water in a matrix composed of cross-linked polymers. Conventionally, a conductive polymer hydrogel containing a wetting agent and water by cross-linking polymerization of an electrolyte polymer such as polyacrylic acid has been used as an electrode for a living body. In particular, since the polymer matrix is hydrophilic and water permeable and contains water at the same time, the polymer hydrogel has the advantage of being easy to add an electrolyte and enabling low impedance. For this reason, it can exhibit sufficient performance as an electrode for high-precision measurement such as electrocardiogram monitoring.

However, the prior art has a disadvantage of causing skin trouble when attached to the skin for a long time by adding a crosslinking agent, an initiator, and a stabilizer to crosslink the polymer.

Specifically, in order to prepare a polymer hydrogel, a hydrogel is prepared through UV photopolymerization by adding a UV initiator to a hydrogel composition, but the hydrogel prepared in this way cannot maintain its shape, so a base film is essential, and a photoinitiator crosslinking There is a disadvantage that is harmful to the human body by using the back.

In addition, a monomolecular electrolyte such as NaCl or NaOH is injected to impart conductivity to the polymer hydrogel. The longer the operating time, the more the monomolecular electrolyte deteriorates and leaks out to the outside, and the conductivity deteriorates. there is

Accordingly, the applicant of the present application intends to propose a technology capable of providing a polymer hydrogel having more improved adhesive strength and conductivity compared to existing polymer hydrogel manufacturing technologies below, and in particular, electron beam irradiation of ionic monomers to crosslink By doing so, we intend to propose a technology for a conductive hydrogel that has an appropriate gelation rate without a separate initiator and can be used without a separate substrate.

Republic of Korea Patent Publication No. 10-2015-0096699

The present invention has been devised in order to solve the above-mentioned problems of the prior art, and is crosslinked by electron beam irradiation on a prehydrogel composition containing an ionic monomer, thereby having an appropriate gelation rate without a separate initiator and usable radiation crosslinking without a separate description. The purpose is to provide an adhesive conductive hydrogel for skin attachment using a method, a manufacturing method thereof, and an adhesive conductive hydrogel sheet using the same.

The present invention is an ionic monomer; Preparing a pre-hydrogel composition by mixing distilled water and a pH adjusting agent; and

After coating the prepared prehydrogel composition, an electron beam irradiation step of crosslinking by irradiating an electron beam having an energy of 1 to 10 MeV with an absorbed dose of 5 kGy to 50 kGy; Including,

The ionic monomer is 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxylethyl acrylate, 2-ethylhexyl acrylate, n-butyl Acrylate (n-butyl acrylate), n-butyl methacrylate (n-butyl methacrylate), acrylic acid (acrylic acid) and 3- (3,4-dihydroxyphenyl) -L-alanine (3- (3, 4-Dihydroxyphenyl) -L-alanine) containing any one or more,

The pH adjusting agent includes at least one of sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium chloride, and potassium chloride,

The conductivity is 0.5 to 5 S / m, and the adhesive force is 600 to 2000 gf / in, which provides a method for producing an adhesive conductive hydrogel.

In addition, the present invention is 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxyethyl acrylate (2-hydroxylethyl acrylate), acrylic acid (acrylic acid) and 3- (3,4-dihydroxy Phenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine) is provided by crosslinking the prehydrogel composition containing any one of the ionic monomers by electron beam irradiation,

The conductivity is 0.5 to 5 S / m, and the adhesive force is 600 to 2000 gf / in, characterized in that it provides an adhesive conductive hydrogel.

In addition, the present invention is 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxyethyl acrylate (2-hydroxylethyl acrylate), acrylic acid (acrylic acid) and 3- (3,4-dihydroxy A prehydrogel composition containing any one ionic monomer of phenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine), and a nonwoven fabric layer provided in the form of a sheet,

The prehydrogel composition is applied to at least one surface of the nonwoven fabric layer and then crosslinked by electron beam irradiation to form an adhesive conductive hydrogel,

The non-woven fabric layer provides an adhesive conductive hydrogel sheet, characterized in that it is bonded to the adhesive conductive hydrogel by grafting.

According to the present invention, the adhesive conductive hydrogel has an appropriate gelation rate, can be used without a separate substrate, and has excellent conductivity by irradiating an electron beam to a prehydrogel composition in which an ionic monomer, distilled water, and a pH adjusting agent are mixed in a predetermined ratio. At the same time, it exhibits excellent adhesive strength, and it is possible to prevent skin troubles that occur when attached to the skin for a long time without using a separate initiator.

1 is a schematic process diagram shown to explain a method for manufacturing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method according to an embodiment of the present invention.
2 is an image showing a cross-sectional view of an adhesive conductive hydrogel sheet for skin attachment using a radiation crosslinking method according to an embodiment of the present invention.
3 is data obtained by evaluating physical properties of an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method according to an embodiment of the present invention.
4 and 5 are data obtained by evaluating the cytotoxicity of the adhesive conductive hydrogel for skin attachment using the radiation crosslinking method according to an embodiment of the present invention.

Preferred embodiments of the present invention will be described with reference to the accompanying drawings, and through this detailed description, the purpose and configuration of the present invention and the characteristics thereof will be better understood.

The present invention, an ionic monomer; A preliminary hydrogel composition preparation step of preparing a preliminary hydrogel composition by mixing distilled water and a pH adjusting agent; and

After applying the prepared prehydrogel composition, an electron beam having an energy of 1 to 10 MeV was applied at 5 kGy to an electron beam irradiation step of crosslinking by irradiating with an absorbed dose of 50 kGy;

The ionic monomers are 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxylethyl acrylate, acrylic acid and 3-(3,4-dihydroxy). Phenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine) containing any one or more,

The pH adjusting agent includes at least one of sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium chloride, and potassium chloride,

The conductivity is 0.5 to 5 S / m, and the adhesive force is 600 to 2000 gf / in, which provides a method for producing an adhesive conductive hydrogel.

As shown in FIG. 1, the method of manufacturing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method according to an embodiment of the present invention may include a preliminary hydrogel composition manufacturing step (S100) and an electron beam irradiation step (S200).

The preliminary hydrogel composition preparation step (S100) is a step of preparing a preliminary hydrogel composition for preparing an adhesive conductive hydrogel by mixing an ionic monomer, distilled water, and a pH adjusting agent.

Specifically, in the preliminary hydrogel composition preparation step (S100), 30 to 60 parts by weight or 45 to 60 parts by weight of distilled water and pH with respect to 40 to 70 parts by weight, 45 to 65 parts by weight, or 45 to 60 parts by weight of the ionic monomer 10 to 30 parts by weight or 15 to 25 parts by weight of the regulator may be mixed.

In the hydrogel composition preparation step (S100), any one of sodium hydroxide, sodium carbonate, potassium hydroxide, lithium hydroxide, sodium chloride, and potassium chloride may be used as a pH adjusting agent. By using such a pH adjusting agent, the pH of the hydrogel composition can be adjusted to 5 to 6.

In the preliminary hydrogel composition preparation step (S100), the preliminary hydrogel composition consists of only 2-acrylamido-2-methylpropanesulfonic acid (AMPS), distilled water and sodium hydroxide, and the preliminary hydrogel composition preparation step is separately performed. It can exhibit excellent adhesiveness and conductivity without adding a photopolymerization initiator and a UV polymerization initiator.

The hydrogel composition manufacturing step (S100) is an ionic monomer; It may further include adding a crosslinking agent after mixing the distilled water and the pH adjusting agent. The crosslinking agent is poly(ethylene glycol) diacrylate (PEG-DA), 2-hydroxylethyl acrylate, acrylic acid and 3-(3,4-dihydride). It may include any one or more of hydroxyphenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine). Specifically, the crosslinking agent may be mixed in an amount of 0.01 to 0.08 parts by weight, 0.02 to 0.07 parts by weight, and 0.03 to 0.06 parts by weight.

In the hydrogel composition preparation step (S100), an adhesive conductive hydrogel having an appropriate gelation rate can be prepared through the electron beam irradiation step (S200) without adding a crosslinking agent to the preliminary hydrogel composition, but as described above, a small amount of the preliminary hydrogel composition In the case of including a crosslinking agent, mechanical strength can be improved without deteriorating adhesive performance.

The electron beam irradiation step (S200) is a step of preparing an adhesive conductive hydrogel by applying an electron beam having a certain amount of energy to crosslink after applying the prehydrogel composition.

In the electron beam irradiation step (S200), an electron beam may be irradiated after applying the prehydrogel composition to a thickness of 0.5 to 10 mm or 0.5 to 5 mm.

In the electron beam irradiation step (S200), after applying the prehydrogel composition, an electron beam having an energy of 1 to 10 MeV or 1 to 10 MeV may be irradiated with an absorbed dose of 5 kGy to 50 kGy to crosslink.

In the electron beam irradiation step (S200), the prehydrogel composition is irradiated with an absorbed dose of 5 kGy to 40 kGy, 5 kGy to 30 kGy, or 5 to 20 KGy to impart adhesiveness and conductivity at the same time when preparing the adhesive conductive hydrogel. can

The gelation rate of the ionic monomer in the adhesive conductive hydrogel prepared through the electron beam irradiation step (S200) may be 50% to 80%, 55% to 80%, or 55% to 75%. The prehydrogel composition may be crosslinked by irradiation with an irradiation beam under the above-described conditions to exhibit the gelation rate as described above, and thus, the mechanical strength may be improved while having excellent adhesiveness.

In the electron beam irradiation step (S200), the applied prehydrogel composition is irradiated with an electron beam as described above so that the ionic monomer is crosslinked to form an adhesive conductive hydrogel without a separate substrate. Can be formed.

In the electron beam irradiation step (S200), an electron beam may be irradiated after applying the prehydrogel composition on the nonwoven fabric. Specifically, the nonwoven fabric may have a hot melt adhesive layer formed on one surface of the nonwoven fabric, and the adhesive conductive hydrogel may be prepared by applying a composition to the surface of the nonwoven fabric on which the hot melt adhesive layer is formed and then irradiating an electron beam.

As described above, when the prepared composition is applied onto the nonwoven fabric having the hot melt adhesive layer and then electron beam is irradiated, the hydrogel and the nonwoven fabric may be grafted while forming a hydrogel layer on the nonwoven fabric. Thus, the bonding strength between the hydrogel layer and the nonwoven fabric is improved, and durability may be excellent.

In addition, the present invention is 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxyethyl acrylate (2-hydroxylethyl acrylate), acrylic acid (acrylic acid) and 3- (3,4-dihydroxy Phenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine) is provided by crosslinking the prehydrogel composition containing any one of the ionic monomers by electron beam irradiation,

The conductivity is 0.5 to 5 S / m, and the adhesive force is 600 to 2000 gf / in, characterized in that it provides an adhesive conductive hydrogel.

The adhesive conductive hydrogel is composed of 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxylethyl acrylate, acrylic acid and 3-(3,4-dihydride). It is crosslinked by electron beam irradiation to any one ionic monomer of 3-(3,4-Dihydroxyphenyl)-L-alanine, and can exhibit excellent adhesiveness and conductivity at the same time.

The electron beam absorbed dose of the adhesive conductive hydrogel may be 5 to 20 KGy or 5 to 15 KGy, and the thickness of the adhesive conductive hydrogel may be 0.5 to 10 mm or 0.5 to 5 mm. When the adhesive conductive hydrogel is formed under the above conditions, the conductivity and adhesiveness of the adhesive conductive hydrogel can be simultaneously improved.

The adhesive conductive hydrogel may have a conductivity of 0.5 to 5 S/m, 0.5 to 4 S/m, or 0.8 to 3 S/m, and the adhesive conductive hydrogel may have a conductivity of 600 to 2000 gf/in, 700 to 1800 gf /in or from 800 to 1700 gf/in.

The adhesive conductive hydrogel for skin attachment using the radiation crosslinking method according to the present invention is prepared by crosslinking ionic monomers by irradiating electron beams without a separate initiator, and can maintain excellent adhesive strength and conductivity without a crosslinking agent. Here, when a small amount of the crosslinking agent is added, the crosslinking rate is improved and the mechanical strength is excellent, but when a certain amount or more of the crosslinking agent is added, the crosslinking rate is too high and the cohesive between the main chains of the hydrogel is lowered, resulting in a lower adhesive property.

The gelation rate of the ionic monomer in the adhesive conductive hydrogel may be 50% to 80%, 55% to 80%, or 55% to 75%. In the case of having the above gelation rate, excellent conductivity and mechanical strength can be exhibited without deterioration in adhesive properties.

The adhesive conductive hydrogel of the present invention can exhibit the gelation rate as described above by crosslinking the prehydrogel composition by irradiating an irradiation beam under the above-mentioned conditions, and thus can improve mechanical strength while having excellent adhesiveness.

Specifically, the tensile strength of the adhesive conductive hydrogel may be 200 kPa to 300 kPa, 200 kPa to 290 kPa, or 200 kPa to 280 kPa.

In addition, the present invention is 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxyethyl acrylate (2-hydroxylethyl acrylate), acrylic acid (acrylic acid) and 3- (3,4-dihydroxy A prehydrogel composition containing any one ionic monomer of phenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine), and a nonwoven fabric layer provided in the form of a sheet,

The prehydrogel composition is applied to at least one surface of the nonwoven fabric layer and then crosslinked by electron beam irradiation to form an adhesive conductive hydrogel,

The non-woven fabric layer provides an adhesive conductive hydrogel sheet, characterized in that it is bonded to the adhesive conductive hydrogel by grafting.

As shown in FIG. 2, the adhesive conductive hydrogel sheet according to an embodiment of the present invention may have a structure in which a hydrogel layer 10, a hot melt adhesive layer 21, and a nonwoven fabric layer 22 are stacked in this order.

The adhesive conductive hydrogel sheet of the present invention may further include a nonwoven fabric layer 22 on at least one surface of the adhesive conductive hydrogel 10. Specifically, the nonwoven fabric may have a hot melt adhesive layer 21 formed on one surface of the nonwoven fabric, and an adhesive conductive hydrogel 10 may be laminated on the surface of the nonwoven fabric on which the hot melt adhesive layer 21 is formed.

As described above, when the prehydrogel composition is applied on the nonwoven fabric having the hot melt adhesive layer and then crosslinked by electron beam irradiation to prepare the adhesive conductive hydrogel, the nonwoven fabric layer can be grafted and combined with the adhesive conductive hydrogel. . Accordingly, the bonding force between the adhesive conductive hydrogel and the nonwoven fabric layer is improved, and durability may be excellent.

On the other hand, in the following, in the manufacturing method of the adhesive conductive hydrogel for skin attachment using the radiation crosslinking method according to the present invention consisting of the above-described steps, tests for physical properties and evaluation of the adhesive conductive hydrogel by this method It was carried out, and the results are shown in Table 2 and Figure 3.

The hydrogel of the example for the test is a mixed solution by mixing ionic monomer 2-acrylamido-2-methylpropanesulfonic acid (AMPS), distilled water, sodium hydroxide, a crosslinking agent, an electrolyte and an adhesion promoter as shown in Table 1 below. manufactured. The prepared mixture was subjected to an electron beam crosslinking process at room temperature using an electron beam accelerator of 10 MeV linear accelerator (8kW, Mevex) under conditions of an electron beam irradiation dose of 15 kGy to prepare a hydrogel.

Example 1 Example 2 Example 3 Example 4 Comparative Example 1 ionic monomer AMPS 50 50 50 50 50 menstruum H ₂ O 50 50 50 66.5 66.5 pH regulator 50% NaOH 20 20 20 20 20 KCl - - 5 - - cross-linking agent PEG-DA - 0.04 - - - adhesion promoter HEA - - - 17 - DOPA - - - - 17 Thickness (mm) 1.5 1.5 1.5 1.5 1.5

As a comparative group, in Comparative Example 2, a hydrogel was prepared using a hydrogel composition using UV photopolymerization from Sekisui, and in Comparative Example 3, a commercially available red dot gel from 3M was used and a hydrogel having a thickness of 0.7 was used.

In order to evaluate the conductive properties of the hydrogel in the present invention, the hydrogels of Examples 1 to 4 and Comparative Examples 1 and 2 were cut into squares of 1 × 1 cm ² and inserted between ITO electrodes, Impedance was measured when an excitation voltage of 10 mV was applied at a frequency of 0.1 Hz to 100 kHz, and the results are shown in Table 2 below.

In addition, in order to evaluate the adhesive properties of the hydrogel in the present invention, the adhesive strength of the hydrogel of Examples 1 to 5 and Comparative Example 1 was measured according to ASTM D3330. Specifically, the hydrogel sample lined on the non-woven fabric was cut into a strip of 25.4 × 300 mm ² , then adhered to the bakelite plate substrate, and then peeled off at an angle of 90 degrees at a rate of 500 mm/min to measure the adhesive strength. It is shown in Table 2 below.

In addition, in order to measure the gelation rate of the hydrogel in the present invention, the hydrogels of Examples 1 to 5 and Comparative Example 1 were cut to a certain size and then weighed. Then, the measured sample was placed in a 100 ml bottle containing purified water, operated in a shaking constant temperature water bath at 37 ° C and 60 rpm for 72 hours, then the sample was taken out and put in an oven at 75 ° C and dried until it reached a certain weight. After measuring the weight of the dried gel, the gelation rate was calculated as in Equation 1 below, and the results are shown in Table 2 below.

[Equation 1]

Gelation rate = (W _d /W _i ) × 100

In Equation 1, W _i- is the initial weight and W _d is the dry weight.

In addition, in order to measure the tensile strength of the hydrogel in the present invention, the hydrogel of Examples 1 to 5 and Comparative Example 1 was cut into a rectangle of 2.5 cm (width) × 10 cm (length) to prepare a sample, After fixing the upper and lower jigs while maintaining an appropriate gauge distance (7~10cm) in the testing machine, the sample was pulled at a speed of 300mm/min to measure the maximum tensile load for 1 minute, and the result value was converted into the load value of the desired width. , and the results are shown in Table 2 below.

Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 conductivity
(S/m) 1.74 0.74 1.94 0.92 0.82 0.12 0.022 adhesiveness
(gf/in) 1480 820 1002 1680 1520 488 470 Gelation rate (%) 65 75 42 53 61.3 not measurable not measurable tensile strength
(kPa) 252.3 280.2 200.2 248.4 245.2 not measurable not measurable

Finally, in addition, in order to confirm the degree of elongation of the hydrogel in the present invention, the degree of elongation was confirmed by pulling the hydrogels of Examples 1 to 5 and Comparative Example 1, and the results are shown in FIG. 3 .

Looking at Table 2, Example 1 showed excellent adhesive strength and conductivity. In general, 3M adhesives (Comparative Example 3) had adhesive strengths of about 300 to 488 gf, but it was confirmed that the adhesive conductive hydrogel prepared through electron beam crosslinking had better adhesive strength than the product. In the case of Example 4 and Comparative Example 1 in which the tackifier was added, it was confirmed that they had better adhesive properties than the basic composition. It can be seen that this is a cause of the increase in adhesive properties due to the addition of a hydroxyl group in the tackifier.

However, looking at Figure 3, in the case of containing 3- (3,4-dihydroxyphenyl) -L-alanine (DOPA) as in Comparative Example 1, there is a problem that the color is discolored due to oxidation in the gel over time, resulting in a transparent hydrogel. was found to be inappropriate. Accordingly, it can be seen that Example 4 in which a small amount of HEA was added is most suitable as a transparent conductive hydrogel.

In addition, the adhesive conductive hydrogels of Examples 1 to 4 exhibit excellent mechanical strength by exhibiting tensile strength of 200.2 kPa to 280.2 kPa without a separate substrate (nonwoven fabric), whereas Comparative Example 2 (Sekisui hydrogel) Without the substrate, the shape is not maintained, making it difficult to measure the tensile strength and gelation rate of the hydrogel alone. does not exist.

In addition, considering that the gelation rate is increased according to the addition of the crosslinking agent, it is possible to prepare a hydrogel having excellent mechanical strength due to the high crosslinking rate, but it is confirmed that the adhesive property is reduced. Through this, it was confirmed that as the crosslinking rate increased, the chemical bonding (cohesive) between the hydrogel backbones was lowered and the adhesive properties were lowered.

Looking at this, it can be seen that the adhesive conductive hydrogel according to the present invention not only has excellent conductivity and adhesive strength, but also improves mechanical strength without a separate substrate.

In order to evaluate the cytotoxicity of the hydrogel in the present invention, samples cut into 1 × 1 cm ² squares from the hydrogel of Example 1 were incubated in 5.0 mL of cell culture medium at a temperature of 37 ° C. It was cultured for 48 hours and 72 hours with gentle shaking, and the culture medium was seeded HaCaT cells or SK-MEL-28 cells at 4x10 ⁴ cells/500 μl. As a control, samples treated with only the CCK-8 reagent were simultaneously tested, and the results are shown in FIGS. 4 and 5 below.

Figure 4 is a scanning electron microscope image of the cell morphology after performing a cytotoxicity test on HaCaT cells and SK-MEL-28 cells. Referring to Figure 4, (a) is the result of the experiment on HaCaT cells, (b) is the result of the experiment on SK-MEL-28 cells. Specifically, it can be seen that when the hydrogel according to the present invention is treated, there is no significant change compared to the control group.

Figure 5 is a graph measuring the cell ratio after the cytotoxicity test on HaCaT cells and SK-MEL-28 cells. Referring to Figure 5, (a) is the result of the experiment on HaCaT cells, (b) is the result of the experiment on SK-MEL-28 cells. Specifically, when the hydrogel according to the present invention was treated, it can be seen that HaCaT cells showed no significant change compared to the control group, and SK-MEL-28 cells showed a cell viability of 90% or more compared to the control group.

Through this, it can be seen that the adhesive conductive hydrogel according to the present invention is harmless even when applied to the human body.

The embodiments described above are merely those of preferred embodiments of the present invention and are not extremely limited to these embodiments, and various modifications and variations or modifications by those skilled in the art within the scope of the technical spirit and claims of the present invention. It will be said that the substitution of steps can be made, and it will be said that it belongs to the technical scope of the present invention.

10: adhesive conductive hydrogel
21: hot melt adhesive layer
22: non-woven fabric layer
S100: composition preparation step
S200: electron beam irradiation step

Claims (15)

In the method for producing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method without adding a separate photopolymerization initiator or UV polymerization initiator,
Preparing a preliminary hydrogel composition by mixing 30 to 60 parts by weight of distilled water and 10 to 30 parts by weight of a pH adjusting agent with respect to 40 to 70 parts by weight of an ionic monomer; and
After coating the prepared prehydrogel composition, an electron beam irradiation step of crosslinking by irradiating an electron beam having an energy of 1 to 10 MeV with an absorbed dose of 5 kGy to 50 kGy; Including,
The ionic monomers are 2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxylethyl acrylate, acrylic acid and 3-(3,4-dihydroxy). Phenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine) containing any one or more,
The pH adjusting agent includes at least one of sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium chloride, and potassium chloride,
The conductivity is 0.5 to 5 S / m, and the adhesive strength is 600 to 2000 gf / in, a method for producing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method. delete delete According to claim 1,
The step of preparing the preliminary hydrogel composition
ionic monomers; Further comprising adding a crosslinking agent after mixing the distilled water and the pH adjusting agent,
The crosslinking agent is poly(ethylene glycol) diacrylate (PEG-DA), 2-hydroxylethyl acrylate, acrylic acid and 3-(3,4-dihydride). Contains any one or more of hydroxyphenyl) -L-alanine (3- (3,4-Dihydroxyphenyl) -L-alanine),
The method for producing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, characterized in that the crosslinking agent is mixed in 0.01 to 0.08 parts by weight based on 100 parts by weight of the prehydrogel composition. According to claim 1,
The prehydrogel composition preparation step is a method for producing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, characterized in that the pH of the prehydrogel composition is adjusted to 5 to 6 by mixing a pH adjusting agent. delete According to claim 1,
The electron beam irradiation step is a method for producing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, characterized in that for applying the prepared hydrogel composition to a thickness of 0.5 to 10 mm. According to claim 1,
The electron beam irradiation step is a method for producing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, characterized in that the electron beam is irradiated after applying the prehydrogel composition on a nonwoven fabric. According to claim 1,
Method for producing an adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, characterized in that the gelation rate of the ionic monomer in the adhesive conductive hydrogel prepared through the electron beam irradiation step is 50% to 80%. In the adhesive conductive hydrogel for skin attachment using a radiation crosslinking method without adding a separate photopolymerization initiator or UV polymerization initiator,
2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxylethyl acrylate, acrylic acid and 3-(3,4-dihydroxyphenyl)-L- An absorbed dose of 5 kGy to 50 kGy of an electron beam having an energy of 1 to 10 MeV was applied to the prehydrogel composition containing any one of the ionic monomers of alanine (3-(3,4-Dihydroxyphenyl)-L-alanine). It is provided by irradiation and crosslinking,
Conductivity is 0.5 to 5 S / m, adhesive force is 600 to 2000 gf / in, and tensile strength is 200 kPa to 300 kPa. Adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, characterized in that. delete According to claim 10,
Adhesive conductive hydrogel for skin attachment using a radiation crosslinking method, characterized in that the thickness of the adhesive conductive hydrogel is 0.5 to 10 mm. According to claim 10,
The adhesive conductive hydrogel for skin attachment using the radiation crosslinking method, characterized in that the gelation rate of the ionic monomer in the adhesive conductive hydrogel is 50% to 80%. delete In the adhesive conductive hydrogel sheet for skin attachment using a radiation crosslinking method without adding a separate photopolymerization initiator or UV polymerization initiator,
2-acrylamido-2-methylpropanesulfonic acid (AMPS), 2-hydroxylethyl acrylate, acrylic acid and 3-(3,4-dihydroxyphenyl)-L- A prehydrogel composition containing any one ionic monomer of alanine (3-(3,4-Dihydroxyphenyl)-L-alanine), and a nonwoven fabric layer provided in the form of a sheet,
The prehydrogel composition is applied to at least one surface of the nonwoven fabric layer and crosslinked by irradiating an electron beam having an energy of 1 to 10 MeV with an absorbed dose of 5 kGy to 50 kGy to prepare an adhesive conductive hydrogel,
The prepared adhesive conductive hydrogel has a conductivity of 0.5 to 5 S/m, an adhesive strength of 600 to 2000 gf/in, and a tensile strength of 200 kPa to 300 kPa,
The adhesive conductive hydrogel sheet for skin attachment using a radiation crosslinking method, characterized in that the nonwoven fabric layer is bonded to the adhesive conductive hydrogel by grafting.