KR20130074065A - Adhesive gel composition for human body electrode - Google Patents

Abstract

PURPOSE: An adhesive gel composition for an electrode for anthropometry is provided to ensure excellent adhesion and compatibility thereby containing high concentration adhesive polymer into hydrogel. CONSTITUTION: An adhesive gel composition for an electrode for anthropometry contains 13-40 wt% of water, 15-35 wt% of a crosslinked soluble polymer, 5-28 wt% of a moisturizer, 1-15 wt% of an amphiphilic polymer, 30-40 wt% of a plasma-treated adhesive polymer, and 0.5-6 wt% of an electrolyte. The adhesive polymer is selected from the group consisting of natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, and polyisoprene rubber. The gel composition forms a matrix of water soluble polymers.

Description

TECHNICAL FIELD [0001] The present invention relates to an adhesive composition for an anthropometric electrode,

The present invention relates to an adhesive gel composition for an anthropometric electrode, and more specifically, 13 to 40% by weight of water, 15 to 35% by weight of a crosslinked water-soluble polymer; 5 to 28% by weight of a humectant; 1 to 15% by weight of an amphipathic polymer; It relates to a pressure-sensitive adhesive gel composition for an anthropometric electrode comprising a 30-40% by weight plasma-treated adhesive polymer.

BACKGROUND ART Pressure-sensitive adhesives including natural rubber latexes and acrylate-based resins conventionally used are so-called oil-based pressure-sensitive adhesives that have a strong water-repelling property. Therefore, when they are stuck to a living body for a long time, And it accumulates between the surface of the skin and the adhesive tape without causing any penetration, causing a burning or rash (rash). In addition, when perspiration is large, the adhesive strength may decrease.

Further, when the surface of the adherend is wet, if it is adhered, moisture adheres to the adherend surface and adhesive strength is completely lost. Therefore, it is impossible to wipe it completely or stick it until it is dry. In addition, it is practically impossible to use an oily adhesive agent as a conductive adhesive agent for a living body electrode used for the measurement of electrocardiogram or for treatment using electrical stimulation such as low-frequency or medium-frequency electric waves. Hydrogel adhesives have been used.

However, the conventional hydrogel has the following problems. For example, a strong adhesive force is exhibited for a material having high hydrophilicity such as paper or cotton. However, for oily materials such as olefinic films, releasing property rather than adhesion is exhibited. On the surface of human skin, since sebum is usually present, it has a property of oiliness rather than hydrophilicity, so there is a limit to increase the adhesion of hydrogel with high hydrophilicity. Particularly, since the initial tackness immediately after the application of the adhesive is weak, the application position is shifted or missed immediately after the application to the living body. Therefore, it is necessary to fix the adhesive with another adhesive until a certain time elapses, It was a difficult material to use in the field.

In addition, in the case of a living body electrode, a pair of electrodes are often arranged at regular intervals. For example, an electrode for use in a body fat percentage measurement electrode is always known, which can be attached at a constant interval. More specifically, the present invention relates to a non-conductive substrate sheet, comprising: a pair of electrode element portions formed on the surface of a base material sheet using a conductive material; an electrode terminal portion formed integrally with the pair of electrode element portions; And the pair of electrode element portions are formed on the base sheet at regular intervals (see Patent Document 1 and JP-A-9-313456).

The body fat percentage measuring electrode is a body fat ratio measuring instrument for measuring a body fat percentage by measuring a resistance of an electric current by flowing a weak current to a human body, and is used in close contact with the skin surface of the subject. Therefore, the electrode for measuring the body fat percentage has a configuration in which the conductive adhesive layer covers each of a pair of electrode element portions spaced from each other by about 10 to 100 mm, thereby increasing the adhesion between the electrode element portion and the skin. In addition, a film having no elasticity such as polyethylene terephthalate (PET) and having a relatively high viscosity is preferably used for the base sheet in order to keep the gap between the electrode elements at the time of attaching the human skin surface. In order to impart an initial viscosity, a hydrophobic polymer is added to a hydrogel containing a polyhydric alcohol and water in place of the hydrophilic polymer in a matrix which is a hydrophilic polymer. This hydrophobic polymer, i.e., a pressure-sensitive adhesive, has good affinity for sebum and the like, and can be highly viscous. For example, an example of a sticky hydrogel containing glycerin, water, a vinyl acetate-maleic acid dioctyl copolymer, methyl salicylate, and the like is present in a matrix having a synthetic resin skeleton such as polyacrylic acid or polyacrylamide. Of the above compositions, the vinyl acetate-dioctyl maleate copolymer is a hydrophobic polymer and is a pressure-sensitive adhesive. This hydrophobic polymer is said to enhance adhesion. For example, sold under the trade name " Flexbond 150 " by Air Products and Chemicals, Inc.. Patent Document 2 discloses a conductive pressure-sensitive adhesive for a bioelectrode in which a hydrophilic layer containing water, an electrolyte and a wetting agent, and a viscoelastic polymer layer which is a substantially hydrophobic polymer are dispersed and stabilized. In detail, the water-soluble polymer is prepared by mixing 30 to 60% by weight of water, 5 to 35% by weight of a latex emulsion (50% of polymer solid content), 10 to 30% by weight of a wetting agent (such as glycerin) And 0.2 to 10% by weight of an aqueous polymer, a tackifier is added to improve the tackiness, and a film processability improver is added.

The hydrogel may be prepared by adding a hydrophobic polymer emulsion emulsified and dispersed in a hydrophilic matrix, or a method of forming a hydrophilic matrix by mixing a pre-polymerized synthetic polymer, a natural polymer and other compounding ingredients, Is crosslinked. There is also a patent document describing a composition of a polymer material forming two IPN (interpenetrating polymer networks) of a network (1) of polysiloxane and a network (2) of acrylic (Patent Document 3). When the IPN is produced, a mixture of monomer and polymerization initiator required to form both (1) and (2) is prepared and injected into a mold to react. At this time, the network of (1) is first created, and then the network of (2) is generated by heating. Further, it is described that the wettability to water is extremely low with respect to the surface characteristics of a product obtained by heating and cooling.

Patent Document 1: JP-A-9-313456 Patent Document 2: U.S. Patent No. 4588762 Patent Document 3: Japanese Patent No. 2641146

Therefore, an object of the present invention is to provide a sticky gel composition for a human body measuring electrode having excellent adhesiveness.

In order to achieve the above technical problem, the present invention is 13 to 40% by weight of water, 15 to 35% by weight of a crosslinked water-soluble polymer; 5 to 28% by weight of a humectant; 1 to 15% by weight of an amphipathic polymer; Provided is an adhesive gel composition for an anthropometric electrode, comprising 30 to 40% by weight of a plasma-treated adhesive polymer.

The present invention also provides an adhesive gel composition for an anthropometric electrode, wherein the adhesive polymer is at least one selected from the group consisting of natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, and polyisoprene rubber.

INDUSTRIAL APPLICABILITY The pressure-sensitive adhesive gel composition for human body measuring electrodes of the present invention has excellent adhesion and is excellent in compatibility, so that a high-concentration adhesive polymer can be incorporated in the hydrogel.

Hereinafter, the present invention will be described in detail.

The adhesive gel composition for an anthropometric electrode of the present invention comprises 13 to 40% by weight of water and 15 to 35% by weight of a crosslinked water-soluble polymer; 5 to 28% by weight of a humectant; 1 to 15% by weight of an amphipathic polymer; 30 to 40% by weight of the plasma-treated adhesive polymer.

The crosslinked water-soluble polymer used in the present invention is not particularly limited as long as it is a water-soluble polymer including a crosslinked portion. The water-soluble polymer may be obtained by copolymerization of a non-cross-linkable monomer and a cross-linkable monomer. For example, a copolymer of a water-soluble (meth) acrylic monomer and a crosslinkable monomer having two or more alkenyl groups may be used. Examples of the (meth) acrylic monomer include (meth) acrylamide, N-alkyl modified (meth) acrylamide, N, N-dialkyl modified (meth) acrylamide, (meth) acrylic acid, Metha) acrylic monomers can be exemplified. Further, water-soluble monomers such as N-vinylamide can be exemplified. Examples of the crosslinkable monomer having two or more alkenyl groups include crosslinkable monomers such as polyfunctional acrylate and polyfunctional acrylamide.

The pressure-sensitive adhesive gel composition for a human body measuring electrode in the present invention can constitute a matrix of a water-soluble polymer by the crosslinked water-soluble polymer. That is, the adhesive gel composition for a human body measuring electrode comprising a crosslinked water-soluble polymer, water, a humectant and an amphipathic polymer, wherein the water, humectant and amphipathic polymer are contained in a matrix of the water- A composition can be obtained. Specific examples of the non-crosslinkable monomer constituting the water-soluble polymer are (meth) acrylamide, N-methyl (meth) acrylamide, N-ethyl (meth) acrylamide, N-propyl , Non-electrolytic acrylamide derivatives such as N-dimethyl (meth) acrylamide, N, N-diethyl (meth) acrylamide and acryloylmorpholine, t-butyl acrylamide sulfonic acid (TBAS) , N, N-dimethylaminoethylacrylamide (DMAEAA) hydrochloride and N, N-dimethylaminopropylacrylamide (DMAPAA) hydrochloride. Examples of the electrolyte-based acrylamide derivatives include (meth) acrylic acid, maleic acid, itaconic acid, (Meth) acrylate, polyethylene glycol (meth) acrylate, and the like, such as acrylic acid derivatives such as acrylic acid derivatives such as acrylic acid derivatives such as acrylic acid derivatives such as acrylic acid, Be based can be an acrylic derivative.

Specific examples of the crosslinkable monomer include N, N'-methylene bis (meth) acrylamide, ethylene glycol mono (meth) acrylate, polyethylene glycol di (meth) acrylate, glycerin tri have. The content of the crosslinked water-soluble polymer in the pressure-sensitive adhesive gel composition for human body measuring electrode of the present invention is such that when the above-mentioned non-crosslinking monomer and the crosslinking monomer are uniformly dissolved , It is not particularly limited. The crosslinked water-soluble polymer is preferably not less than 15% by weight, and more preferably not less than 18% by weight based on the total amount of the pressure-sensitive adhesive gel composition for a human body measuring electrode in order to maintain the gel strength of the resultant gel, . In order to form the crosslinked water-soluble polymer as a matrix of the pressure-sensitive adhesive gel composition for human measurement electrodes, a non-crosslinkable monomer is used, but the non-crosslinkable monomer is mainly water-soluble and has a sufficiently high solubility in water, A monomer which dissolves in water at an arbitrary ratio is preferable. On the other hand, in addition to water and monomers, it is necessary to dissolve a humectant and, if necessary, an additive such as an electrolytic salt and a polymerization initiator into the adhesive gel composition for human body measurement electrode. In this case, the adhesive gel composition for human body measuring electrode It is preferable that the concentration of the crosslinked water-soluble polymer is set to 35% by weight or less, more preferably 30% by weight or less, based on the total amount of the adhesive gel composition for human measurement electrodes.

The adhesive gel composition for human body measuring electrodes of the present invention preferably contains a humectant in order to improve the moisturizing property and the plasticity. As the moisturizing agent, it is preferable to contain a polyhydric alcohol in the adhesive gel composition for a human body measuring electrode. Examples of polyhydric alcohols include polyhydric alcohols such as glycerin, pentaerythritol and sorbitol, polyhydric alcohols such as polyethylene glycol, polypropylene glycol and polyglycerin, polyoxyethylene glycerin, and the like, as well as diols such as ethylene glycol, propylene glycol and butanediol Or a polyhydric alcohol-modified product thereof. As the moisturizing agent, it is preferable to use a liquid polyhydric alcohol at room temperature. INDUSTRIAL APPLICABILITY Since the PSA gel composition for human body measurement includes water, it is easy for moisture to evaporate and / or dry in a short time without a humectant, deteriorate plasticity, and tackiness, particularly initial adhesion, is likely to remarkably deteriorate. When the pressure-sensitive adhesive gel composition for human body measuring electrodes of the present invention is used for applications requiring conductivity, such as a living body electrode, the impedance of the electrode increases when moisture evaporates, and when the electrode exceeds a specific impedance, it becomes unusable . Therefore, by adding the moisturizing agent to the adhesive gel composition for human body measuring electrodes, it is possible to prevent water from evaporating above a certain level, and if the moisturizing agent is a liquid at room temperature, the moisturizing agent itself also has a function as a plasticizer. The concentration of the moisturizing agent in the adhesive gel composition for human body measuring electrode is preferably 5% by weight or more based on the total amount of the adhesive gel composition for human body measuring electrode in order to maintain moisture retention and plasticity and to exhibit excellent stability. The amount of the moisturizing agent is preferably 28% by weight or less based on the total amount of the adhesive gel composition for a human body measuring electrode in order to ensure a content of resin solids of a certain level or more in order to secure the flexible strength and adhesive force of the obtained gel body .

In order to stably disperse the water-insoluble polymer having stickiness, the concentration of water contained in the pressure-sensitive adhesive gel composition for an anthropometric electrode is preferably at least 13% by weight, more preferably at least 13% by weight based on the total amount of the pressure- More preferably 18% by weight or more. In order to suppress the fluctuation of the gel property by evaporation and drying and to stabilize the gel property, it is preferably 40% by weight or less, more preferably 30% by weight or less based on the total amount of the adhesive gel composition for human body measuring electrode Do.

 The pressure-sensitive adhesive gel composition for an anthropometric electrode of the present invention comprises 30 to 40% by weight of the pressure-sensitive adhesive polymer. As described above, the human body, especially skin, is closer to oily than aqueous due to the presence of sebum and the like. Therefore, it is preferable to use a tacky polymer such as rubber as it is, but the remaining components of the hydrogel are very hydrophilic and therefore very miscible. Accordingly, in the present invention, the adhesive polymer is subjected to plasma treatment to impart a hydrophilic group such as hydroxyl group to the surface of the polymer to improve compatibility and oily properties. The plasma-treated adhesive polymer is to be included in the content of the adhesive gel composition for the entire anthropometric electrode up to 30 to 40% by weight to increase the content compared to the conventional hydrogel to increase the adhesiveness. The adhesive polymer is preferably at least one selected from the group consisting of natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, and polyisoprene rubber, and in the plasma treatment, about 10% of the adhesive polymers may contain a hydrophilic functional group such as a hydroxyl group. Irradiation was made to form.

Since the adhesive gel composition for human body measuring electrodes of the present invention contains an amphipathic polymer copolymer, it is preferable to use a polyester-based or polyurethane-based resin containing a graphite-containing resin as a main component The carbon coat surface, which is the electrode element portion formed by the paste, is good in adhesion. In addition, when the PSA gel composition for human body measurement of the present invention contains a water-insoluble polymer containing an amphipathic polymer and having tackiness, the dispersion stability of the water-insoluble polymer is improved. Particularly, since the dispersion stability of the water-insoluble polymer is improved during the preparation of the compounding liquid, it is possible to obtain a sticky gel composition for a human body measuring electrode which is more uniform and has high quality stability. Examples of the amphipathic polymer include a copolymer of a hydrophilic monomer and a hydrophobic monomer. Examples of the amphipathic polymer include vinylpyrrolidone / vinyl acetate copolymer, vinylpyrrolidone / alkyl acrylate copolymer, and low saponified polyvinyl alcohol. In the present invention, the term amphipathic means that it is soluble in a mixed solvent of at least an organic solvent and water, and is preferably soluble in both water and a polar organic solvent. When the addition amount is too large, the viscosity of the compounding liquid is increased. Therefore, it takes time to remove the bubbles mixed in the preparation of the composition, and when the addition of the electrolyte is large, the polymer insoluble in water tends to aggregate easily. Therefore, the amount of the amphipathic polymer to be added is preferably 7.0% by weight or less, more preferably 4.0% by weight or less, based on the total amount of the gel adhesive composition excluding water. In order to improve the dispersion stability, the effect can be sufficiently obtained with such an amount of addition.

An electrode for measuring a bioelectrical potential used for electrocardiogram (ECG), electroencephalogram, electromyography, etc., an electrode for electric stimulation used for TENS, low-frequency treatment, a dipole plate for an electric scalpel or an electrode for iontophoresis The conductive performance can be improved by adding an electrolyte salt. The electrolytic salt is preferably a chloride of an alkali metal or alkaline earth metal. When the electrolytic salt is added for the purpose of imparting conductivity, it is preferably at least 0.5% by weight or more based on the total amount of the pressure-sensitive adhesive gel composition for a human body measuring electrode excluding water. In addition, when the electrolyte is added in a large amount, the conductivity is improved. However, when the amount of the electrolyte is increased, the tendency of aggregation of the polymer insoluble in water is increased. When the amount is increased more than a certain amount, It is preferable that the addition amount is not more than 6.0% by weight, more preferably not more than 4.0% by weight based on the total amount of the pressure-sensitive adhesive gel composition for a human body measuring electrode except for water.

Hereinafter, the present invention will be described in more detail with reference to examples of the present invention.

Example

First, the isoprene rubber was reformed while continuously passing through the plasma chamber, and then stabilized. The isoprene rubber is mixed with a PVA solution and ion-exchanged water using a stirring / mixing vessel controlled at a temperature in the range of 30 to 40 ° C, stirred and uniformly dissolved, and then glycerin is added as a moisturizing agent. It was stirred until it became uniform. Next, acrylamide was added as a monomer to the vessel, stirred for a few minutes, sodium chloride was added as an electrolyte, and polyethylene glycol dimethacrylate (Blenmer PDE-400, manufactured by Nippon Oil Co., Ltd.) was added as a crosslinking monomer Stir until complete dissolution. A polymerization initiator was added to the resulting mixed solution, which was then dropped onto a silicon-coated PET film, and a silicon-coated PET film was similarly coated thereon. The solution was spread uniformly and fixed to have a thickness of 0.5 mm. This was irradiated with ultraviolet rays to obtain adhesive gel compositions each having a thickness of 0.5 mm. The details of the blending amount are shown in Table 1.

Electrical performance of the adhesive gel compositions obtained in Examples and Comparative Examples to which electrolytes were added was measured during the production of electrodes. The resulting gel composition was applied to an electrode element coated with an Ag / AgCl ink on one side of a 75 mu m PET film by screen printing, and the area of the gel patch portion was 4 cm < 2 > To obtain an electrode. Two pairs of electrodes thus obtained were made into a pair, and the gel faces were bonded to each other to manufacture an electrode pair. The electrode pair impedance was measured. The measurement was performed according to the AAMI (Association for the Advancement of Medical Instrumentation) EC12 Disposable ECG Electrodes. The results are summarized in Table 1.

One 2 3 water 20 13 35 Crosslinked water-soluble polymer 15 28 18 Moisturizer 25 28 10 Amphipathic polymer 4 6 Plasma Treated Isoprene Rubber 34 20 30 Electrolyte 2 5 7 adhesiveness

430
290
340 impedance 120 96 80

The embodiments of the present invention described above should not be construed as limiting the technical idea of the present invention. The scope of protection of the present invention is limited only by the matters described in the claims, and those skilled in the art will be able to modify the technical idea of the present invention in various forms. Accordingly, such improvements and modifications will fall within the scope of the present invention as long as they are obvious to those skilled in the art.

Claims (2)

13-40 wt% water and 15-35 wt% crosslinked water soluble polymer; 5 to 28% by weight of a humectant; 1 to 15% by weight of an amphipathic polymer; A pressure-sensitive adhesive gel composition for an anthropometric electrode, comprising 30 to 40 wt% plasma-treated adhesive polymer and 0.5 to 6 wt% electrolyte. The method of claim 1,
The adhesive polymer is an adhesive gel composition for an anthropometric electrode, characterized in that at least one selected from the group consisting of natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, and polyisoprene rubber.