KR101135147B1 - ANTI-ACNE COSMETIC COMPOSITION CONTAINING 5-Aminolevulinic acid - Google Patents

Abstract

The present invention relates to a cosmetic composition containing 5-aminolevulinic acid (ALA), a purified water, a hydrophilic solvent, and a humectant, which are photosensitive substances used in PDT (Photo dynamic therapy) for treating acne with light. The present invention relates to a cosmetic composition for treating acne containing 5-aminolevulinic acid that can be easily used by the user by increasing the effects of preserving and improving the stability of the active ingredient, effectively treating acne, improving skin texture, relieving skin troubles, and the like. .

Acne, PDT (Photo dynamic therapy), 5-Aminolevulinic acid (ALA), Rg2

Description

Cosmetic composition for the treatment of acne containing 5-aminolevulinic acid {ANTI-ACNE COSMETIC COMPOSITION CONTAINING 5-Aminolevulinic acid}

The present invention has been made to solve the above problems, 5-aminolevulinic acid (ALA) and purified water and hydrophilic material which is used for PDT (Photo dynamic therapy) to treat acne by light A cosmetic composition containing a solvent and a humectant, which contains ginseng saponin Rg2, improves the preservation of the cosmetic composition and the stability of the active ingredient, effectively treats acne, and improves skin texture and skin trouble relief. It relates to a cosmetic composition for treating acne containing 5-aminolevulinic acid that can be easily used by a user.

It is an inflammatory disease of fur glands, hair follicles and surrounding tissue due to the action of hormones of acne, excessive sebum secretion, bacterial infections.

Acne is a puberty in both men and women hormonal secretion is active and stimulate the sebaceous gland, the sebaceous gland is enlarged, excessive sebum is secreted.

At the same time, the stratum corneum at the inlet of the pores becomes thicker and the adhesion increases, which causes the pores to narrow or become clogged, causing excessive secretion of sebum in the hair follicles, and the acne bacteria living in the hair follicles (Propionibacterium acne) Acne develops as it develops.

Treatment of acne is possible by inhibiting excessive sebum production, normalizing the loss of skin cells in the hair follicles or inhibiting the growth of acne bacteria.

To this end, topical therapeutic ointments, dermabrasions, and medications are being treated. Recently, acne has become known to alleviate its symptoms when the sun is exposed to acne. ought.

When acne gets light, the symptoms are alleviated because porphyrin (Coproporphyrin III) produced by acne bacteria, the main cause of acne, absorbs light and creates free radicals, which destroys acne bacteria and alleviates the symptoms of acne. .

However, the amount of porphyrin produced by acne is so small that it is difficult to achieve a sufficient effect by treatment alone. PDT, which destroys sebaceous glands and acne bacteria by externally applying a porphyrin-like substance to the skin where acne has occurred, absorbing it and stinging rays (Photo Dynamic Therapy) Therapies have been introduced and used to treat acne.

The porphyrin precursor (Precursor) used in the PDT treatment is 5-aminolevulinic acid (hereinafter referred to as "ALA"), and is currently used in many PDT treatments.

PDT treatment with ALA is used for skin diseases such as ultraviolet keratosis, psoriasis, warts and skin cancer, and is relatively selective in the cancer of the skin or other pathological conditions and thus does little harm to the surrounding normal tissues.

However, there is a problem that skin side effects or hypersensitivity occurs due to the composition problem of ALA.

On the other hand, while developing and manufacturing a liquid formulation of the cosmetic composition using ALA, there is a problem that ALA is degraded during distribution due to lack of technology and the functional effect of ALA is inferior.

In addition, due to the lack of ALA stabilization technology among the existing imported products to market the product is applied to the container to be used to dilute the powder raw material in the container for users, but the situation is causing inconvenience to the user.

The present invention relates to a cosmetic composition containing 5-aminolevulinic acid (ALA), a purified water, a hydrophilic solvent, and a humectant, which are photosensitive substances used in PDT (Photo dynamic therapy) for treating acne with light. Providing a cosmetic composition for acne treatment containing 5-aminolevulinic acid that can be easily used by the user by increasing the effect of preserving and improving the stability of the active ingredients, effectively treating acne, improving skin texture, relieving skin troubles, etc. For the purpose of

In addition, to improve the stability of 5-aminolevulinic acid (5-Aminolevulinic acid, ALA), and to provide a cosmetic composition for treating acne containing 5-aminolevulinic acid that can alleviate skin side effects that may occur during treatment For the purpose of

The present invention has been made to solve the above problems, and includes 5-aminolevulinic acid (ALA), which is a photosensitive material used in PDT (Photo dynamic therapy) for treating acne with light. In the cosmetic composition, 5-aminolevulinic acid (5-Aminolevulinic acid, ALA) 1-20% by weight, purified water 0.1-30% by weight, ginseng saponin Rg2 0.001-20% by weight, propylene glycol 1-60% by weight and It is characterized by containing 0.1 to 30% by weight of ethanol.

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In addition, the formulation of the cosmetic composition for acne skin is characterized in that any one selected from the flexible lotion, lotion, cream to treat acne by light.

The present invention relates to the preservation of cosmetic compositions containing 5-aminolevulinic acid (ALA), a hydrophilic solvent and a humectant, which are photosensitive substances used in PDT (Photo dynamic therapy) for treating acne with light. By increasing the stability of the active ingredient can be effectively used to treat acne.

In addition, by improving the stability of 5-aminolevulinic acid (5-Aminolevulinic acid, ALA) it is possible to prevent skin side effects due to the cosmetic composition for treating acne containing it and provides a cosmetic composition for treating acne effective for improving skin texture The effect is that you can.

Hereinafter, a cosmetic composition for treating acne containing 5-aminolevulinic acid according to an embodiment of the present invention will be described in detail.

The cosmetic composition for treating acne containing 5-aminolevulinic acid according to an embodiment of the present invention is a cosmetic composition containing a 5-Aminolevulinic acid (ALA), purified water, a hydrophilic solvent, and a humectant, which is a light-sensitive substance. A cosmetic composition containing saponin Rg2.

5-Aminolevulinic acid (ALA) is a side effect of acne due to its compositional problems compared to the effect of PDT (Photo dynamic therapy) treatment of acne, and stabilization of the composition is unstable to the user There is discomfort.

By adding ginseng saponin Rg2 to the ALA composition, PDT treatment of the ALA cosmetic composition prevents and alleviates skin side effects, and helps to improve skin texture and stabilize ALA.

Ginseng saponin Rg2 is a kind of ginseng saponin, which is contained in red ginseng more than white ginseng.

Ginsenoside, the main active ingredient of ginseng, saponin, contains about 30 kinds of saponins in ginseng. Each of these saponins exhibits various effects and their types and strengths vary depending on the structure.

The ginseng saponin can be briefly reviewed for the prevention of diabetes, hematopoiesis, enhancement of brain function, hepatoprotective action, anticancer activity, heavy metal detoxification, increased immunity, prevention of geriatric diseases, improvement of wrinkles and skin elasticity, anti-aging, acne and skin diseases. It is effective for healing and moisturizing the skin.

Of ginseng saponins, Rg2 maintains skin homeostasis from harmful environment such as ultraviolet rays, stress, or environmental pollution, and promotes collagen synthesis to prevent and reduce wrinkles by preventing wrinkles. It is effective, absorbs well, does not irritate the skin, and maintains the effect on the skin for a long time with a stable effect.

In addition, it has the effect of reducing and improving the side effects of acne and skin diseases and dermatological procedures.

In particular, acne skin with a lot of sebum, thick stratum corneum, large pores and rough skin texture, ginseng saponin Rg2 improves the skin texture by providing moisture and elasticity to the skin, without causing irritation to the skin due to side effects of the procedure Allow time to return to your original skin.

In the present invention, the ginseng saponin Rg2 was extracted by acid hydrolysis of the red ginseng saponin component, which is a method of extracting the red ginseng saponin, which is separated and purified.

The cosmetic composition for acne treatment containing ginseng saponin Rg2 added to the cosmetic composition containing ALA contains 1 to 20 wt% of ALA, 0.1 to 30 wt% of purified water, 0.001 to 20 wt% of Rg2, and 1 to 60 wt% of propylene glycol. It comprises 0.1 to 30% by weight of ethanol.

The ALA may be added in the form of a powder or a liquid, and it is preferable to use the powder in the form of a powder to increase the stability and preservation of the ALA of the final cosmetic composition.

The cosmetic composition for treating acne consisting of the above composition can be prepared by adjusting the amount of purified water and propyllin glycol, and selecting the formulation of the cosmetic composition from a flexible lotion, lotion, cream.

Propylene glycol of the added composition prevents the cosmetic composition from changing or degrading the formulation due to external environmental factors to maintain the stability of the cosmetic composition, and has the effect of inhibiting the antibacterial action and growth of bacteria, wetting agents, moisture agents, preservatives Used in creams, lotions and ointments.

In stabilizing the composition of the cosmetic composition containing the ALA composition and improving skin texture and alleviating skin side effects caused by the procedure, ginseng saponin Rg2 and propylene glycol mutually complementary action to preserve the stability of the ALA cosmetic composition and stability of the active ingredient Increase your chances of treating acne effectively.

Example. The composition of the cosmetic composition.

130g of purified water, 109g of ethanol, 2g of Rg2, and 600g of propylene glycol were added to the magnetic stirrer, and the mixture was mixed well. 150g of powder ALA was slowly added to the solution and dissolved. The cosmetic composition is prepared.

Experiment. Residual ALA Measurement Using UV Spectrum

The residual amount of ALA and the residual amount of ALA after 2 months were investigated using the UV spectrum at the time of preparing the cosmetic composition prepared according to the above embodiment, and are shown in FIG. 1.

For comparison, UV spectra at the time of preparing a liquid composition having a concentration of 7.5% of ALA by adding and melting 252 g of purified water and 400 g of ethanol to a magnetic stirrer as an experimental control, mixing and melting 75 g of powder ALA while stirring slowly. The residual amount of ALA and the residual amount of ALA two months after opening were examined using FIG.

As shown in FIG. 1, when the ALA having a concentration of 15% at the time of composition of the cosmetic composition prepared according to the embodiment of the present invention passes over a period of two months, the concentration of ALA is approximately 14.8% and thus ALA is You can see that it hardly decomposes.

On the contrary, as shown in FIG. 2, in the case of a composition composed of a hydrophilic solvent or the like in ALA, the concentration of ALA before opening was 7.5%, but the concentration of ALA after two months was not detected because ALA was biodegraded.

Therefore, it protects the stability of ALA without irritating the skin of propylene glycol and ginseng saponin Rg2, and it is effective for skin diseases such as acne, and it is complementary to stabilization of unstable ALA with excellent stability, which can enhance the preservation of cosmetic composition and the stability of active ingredients. It can be seen that there is.

Through the above experiments, it can be seen that the stability of the ALA is excellent, and in the PDT treatment of the cosmetic composition, the skin exposed to the radiation emitted during the treatment does not cause side effects, protects the skin, and prevents aging due to light rays. It contains Rg2, which is effective in improving skin texture, and is effective in treating acne, improving skin texture, wrinkles and elasticity.

The present invention is not limited only to the above-described embodiments, and those skilled in the art can variously modify, change, and substitute the present invention without departing from the spirit and scope of the present invention.

1 is a graph showing the residual amount of ALA and the residual amount of ALA after 2 months using the UV spectrum of the cosmetic composition for treating acne according to an embodiment of the present invention.

Figure 2 is a graph showing the residual amount of ALA and the residual amount of ALA after 2 months using the UV spectrum of the liquid ALA cosmetic composition as a control.

Claims (3)

In the cosmetic composition comprising 5-aminolevulinic acid (ALA), which is a photosensitive material used in PDT (Photo dynamic therapy) for treating acne with light, 1-20% by weight of 5-Aminolevulinic acid (ALA), 0.1-30% by weight of purified water, 0.001-20% by weight of ginseng saponin Rg2, 1-60% by weight of propylene glycol and 0.1-30% by weight of ethanol Cosmetic composition for acne treatment containing 5-aminolevulinic acid, characterized in that it contains. delete According to claim 1, wherein the formulation of the cosmetic composition for acne skin is to treat acne with a light acne treatment cosmetic composition containing 5-aminolevulinic acid, characterized in that any one selected from flexible lotion, lotion, cream. .

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