KR101122469B1 - 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 - Google Patents
처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 Download PDFInfo
- Publication number
- KR101122469B1 KR101122469B1 KR1020097022900A KR20097022900A KR101122469B1 KR 101122469 B1 KR101122469 B1 KR 101122469B1 KR 1020097022900 A KR1020097022900 A KR 1020097022900A KR 20097022900 A KR20097022900 A KR 20097022900A KR 101122469 B1 KR101122469 B1 KR 101122469B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- nicotine
- present
- dopaminergic
- side effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- SNICXCGAKADSCV-UHFFFAOYSA-N CN(CCC1)C1c1cccnc1 Chemical compound CN(CCC1)C1c1cccnc1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90963707P | 2007-04-02 | 2007-04-02 | |
| US60/909,637 | 2007-04-02 | ||
| US95629607P | 2007-08-16 | 2007-08-16 | |
| US60/956,296 | 2007-08-16 | ||
| US95665707P | 2007-08-17 | 2007-08-17 | |
| US60/956,657 | 2007-08-17 | ||
| PCT/US2008/059174 WO2008122049A2 (en) | 2007-04-02 | 2008-04-02 | Methods and compositions for reduction of side effects of therapeutic treatments |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117012123A Division KR20110075044A (ko) | 2007-04-02 | 2008-04-02 | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100045406A KR20100045406A (ko) | 2010-05-03 |
| KR101122469B1 true KR101122469B1 (ko) | 2012-07-12 |
Family
ID=39409946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097022900A Expired - Fee Related KR101122469B1 (ko) | 2007-04-02 | 2008-04-02 | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 |
| KR1020117012123A Withdrawn KR20110075044A (ko) | 2007-04-02 | 2008-04-02 | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117012123A Withdrawn KR20110075044A (ko) | 2007-04-02 | 2008-04-02 | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US7718677B2 (https=) |
| EP (4) | EP1977746B8 (https=) |
| JP (3) | JP2010523587A (https=) |
| KR (2) | KR101122469B1 (https=) |
| CN (2) | CN103977003A (https=) |
| AU (1) | AU2008232453B8 (https=) |
| CA (1) | CA2682323A1 (https=) |
| ES (1) | ES2521494T3 (https=) |
| GB (2) | GB2461412B (https=) |
| IL (2) | IL201269A (https=) |
| WO (1) | WO2008122049A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| AU2005284908B2 (en) | 2004-09-13 | 2011-12-08 | Morningside Venture Investments Limited | Biosynchronous transdermal drug delivery |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| ATE481096T1 (de) | 2005-04-06 | 2010-10-15 | Adamas Pharmaceuticals Inc | Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| CN103977003A (zh) * | 2007-04-02 | 2014-08-13 | 帕金森氏病研究院 | 用于降低治疗的副作用的方法和组合物 |
| WO2009146031A1 (en) | 2008-03-31 | 2009-12-03 | University Of South Florida | Methods of treating disease-induced ataxia and non-ataxic imbalance |
| JP2011520964A (ja) * | 2008-05-23 | 2011-07-21 | ユニバーシティ・オブ・サウス・フロリダ | ニコチン性アセチルコリン受容体活性を有する化合物を用いる末梢感覚神経喪失の治療方法 |
| FR2931677B1 (fr) * | 2008-06-02 | 2010-08-20 | Sanofi Aventis | Association d'un agoniste partiel des recepteurs nicotiniques et d'un inhibiteur d'acetylcholinesterase, composition la contenant et son utilisation dans le traitement des troubles cognitifs |
| EP2233134A1 (en) | 2009-03-27 | 2010-09-29 | McNeil AB | Multi-portion intra-oral dosage form with organoleptic properties |
| JO3250B1 (ar) * | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| CA2994873A1 (en) * | 2009-12-02 | 2011-06-09 | Adamas Pharma, Llc | Amantadine compositions and methods of use |
| WO2011069051A1 (en) | 2009-12-04 | 2011-06-09 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
| JP6245983B2 (ja) * | 2010-08-11 | 2017-12-13 | ドレクセル ユニバーシティ | パーキンソン病におけるジスキネジアを治療するための新規d3ドーパミン受容体アゴニスト |
| PE20131394A1 (es) | 2010-09-23 | 2014-01-11 | Abbvie Inc | Monohidrato de derivados de aza-adamantano |
| WO2012059815A1 (en) | 2010-11-01 | 2012-05-10 | Intec Pharma Ltd. | Accordion pill comprising levodopa for an improved treatment of parkinson's disease symptoms |
| WO2012101060A1 (en) * | 2011-01-27 | 2012-08-02 | Novartis Ag | Use of nicotinic acetylcholine receptor alpha 7 activators |
| AU2012232711B2 (en) * | 2011-03-18 | 2016-04-28 | Novartis Ag | Combinations of alpha 7 nicotinic acetylcholine receptor activators and mGluR5 antagonists for use in dopamine induced dyskinesia in Parkinson's Disease |
| WO2013006643A1 (en) * | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
| WO2014134221A1 (en) * | 2013-02-26 | 2014-09-04 | Azhir Ari | Compositions and methods for treatment in parkinson's disease patients |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| US20150313891A1 (en) * | 2014-05-02 | 2015-11-05 | Abbvie Inc. | Neuronal nicotinic agonists and methods of use |
| JP6276429B2 (ja) * | 2014-06-18 | 2018-02-07 | イーライ リリー アンド カンパニー | ペルゴリドの経皮製剤およびその使用 |
| EP3848028B9 (en) * | 2014-10-20 | 2024-10-16 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| US10679516B2 (en) | 2015-03-12 | 2020-06-09 | Morningside Venture Investments Limited | Craving input and support system |
| CN106138061B (zh) * | 2015-04-03 | 2019-06-04 | 中国人民解放军第三军医大学第三附属医院 | 预防或减弱肺纤维化的复合物及其制剂和用途 |
| US10143687B2 (en) | 2016-04-11 | 2018-12-04 | Neurocea, LLC | Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases |
| US10292977B2 (en) | 2016-04-11 | 2019-05-21 | Neurocea, LLC | Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases |
| WO2018129363A1 (en) * | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Methods and devices for treating levodopa induced dyskinesia |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| AU2018320946B2 (en) | 2017-08-24 | 2024-05-02 | Adamas Pharma, Llc | Amantadine compositions, preparations thereof, and methods of use |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| CA3139559A1 (en) * | 2019-05-09 | 2020-11-12 | Apkarian Technologies Llc | Methods and compositions for treating pain |
| FR3106978B1 (fr) | 2020-02-11 | 2024-04-26 | Olivier Petitjean | Utilisation d'une molecule inhibitrice de la production de ros d'origine mitochondriale telle que l'anethole trithione pour traiter la maladie de parkinson |
| CA3230630A1 (en) * | 2021-09-08 | 2023-03-16 | Curtis SWIFT | Analytical methods of assessing cytisine purity |
| WO2023057650A1 (en) | 2021-10-10 | 2023-04-13 | Centre Hospitalier Universitaire Vaudois (Chuv) | A method for predicting side effects of drugs and vaccines |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US77276A (en) * | 1868-04-28 | Improvement in spring and body braces for vehicles | ||
| US113452A (en) * | 1871-04-04 | Improvement in table-leaf supports | ||
| US166159A (en) * | 1875-07-27 | Improvement in calcining-kilns | ||
| US3845217A (en) * | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
| US4321387A (en) | 1980-03-21 | 1982-03-23 | Philip Morris, Incorporated | Process for the preparation of optically active nicotine analogs |
| US4590278A (en) | 1981-01-29 | 1986-05-20 | Philip Morris Incorporated | Nicotine analogs |
| US4452984A (en) | 1981-01-29 | 1984-06-05 | Philip Morris, Inc. | Optically active nicotine analogs and process for their preparation |
| US4442292A (en) | 1981-01-29 | 1984-04-10 | Philip Morris Incorporated | Optically active nicotine analogs and process for their preparation |
| US4332945A (en) | 1981-01-29 | 1982-06-01 | Philip Morris, Incorporated | Optically active nicotine analogs and process for their preparation |
| GB8301659D0 (en) * | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
| GB8317576D0 (en) * | 1983-06-29 | 1983-08-03 | Shaw A S W | Consumer tobacco products |
| US4920989A (en) * | 1985-04-25 | 1990-05-01 | Regents Of The University Of California | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
| US4953572A (en) * | 1985-04-25 | 1990-09-04 | Rose Jed E | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| DE3639418A1 (de) * | 1986-11-18 | 1988-06-09 | Forschungsgesellschaft Rauchen | Nikotinhaltiges mittel |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US5073380A (en) | 1987-07-27 | 1991-12-17 | Mcneil-Ppc, Inc. | Oral sustained release pharmaceutical formulation and process |
| DE3853758T2 (de) | 1987-10-05 | 1995-09-07 | Yamanouchi Pharma Co Ltd | Heterozyklische Spiroverbindungen und ihre Herstellung. |
| IE62662B1 (en) * | 1989-01-06 | 1995-02-22 | Elan Corp Plc | Use of nicotine in the treatment of conditions susceptible to said treatment |
| US5525351A (en) * | 1989-11-07 | 1996-06-11 | Dam; Anders | Nicotine containing stimulant unit |
| US5512306A (en) * | 1992-06-19 | 1996-04-30 | Pharmica Ab | Smoking substitute |
| ES2153360T3 (es) | 1991-05-29 | 2001-03-01 | Abbott Lab | Compuestos de isoxazol e de isotiazol que mejoran las funciones de razonamiento. |
| GB9200047D0 (en) * | 1992-01-03 | 1992-02-26 | Univ Alberta | Nicotine-containing nasal spray |
| US5242934A (en) * | 1992-03-02 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US5212188A (en) * | 1992-03-02 | 1993-05-18 | R. J. Reynolds Tabacco Company | Method for treatment of neurodegenerative diseases |
| US5227391A (en) * | 1992-04-10 | 1993-07-13 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US5232933A (en) * | 1992-05-21 | 1993-08-03 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US5248690A (en) * | 1992-07-07 | 1993-09-28 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| US5549906A (en) * | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US6121276A (en) | 1994-04-22 | 2000-09-19 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage forms for ameliorating male erectile dysfunction |
| US5703100A (en) | 1994-11-10 | 1997-12-30 | Sibia Neurosciences, Inc. | Modulators of acetylcholine receptors |
| IL118279A (en) | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
| JPH11512443A (ja) | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
| US5936088A (en) | 1995-09-22 | 1999-08-10 | Novo Nordisk A/S | Substituted azacyclic or azabicyclic compounds with affinity and selectivity for nicotinic cholinergic receptors |
| JP3969741B2 (ja) | 1995-11-17 | 2007-09-05 | マーク アンド カンパニー インコーポレイテッド | アセチルコリン受容体の修飾因子として役立つ新規置換アリール化合物 |
| WO1997034605A1 (en) | 1996-03-21 | 1997-09-25 | Mayo Foundation For Medical Education And Research | Use of nicotine to treat liver disease |
| US5629325A (en) | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| US6020335A (en) | 1997-02-06 | 2000-02-01 | Pfizer Inc | (N-(pyridinylmethyl)-heterocyclic)ylideneamine compounds as nicotinic acetylcholine receptor binding agents |
| US5861423A (en) * | 1997-02-21 | 1999-01-19 | Caldwell; William Scott | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| IL131713A (en) | 1997-03-11 | 2004-08-31 | Arakis Ltd | Dosage forms comprising separate portions of r- and s-enantiomers |
| FR2761072B1 (fr) | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de 2,3-dihydrofuro[3,2-b]pyridine, leur preparation et leur application en therapeutique |
| US5977131A (en) | 1997-04-09 | 1999-11-02 | Pfizer Inc. | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| KR100589872B1 (ko) | 1997-05-30 | 2006-06-15 | 뉴로서치 에이/에스 | 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법 |
| JP2002511068A (ja) | 1997-05-30 | 2002-04-09 | ニューロサーアチ・アクティーゼルスカブ | アザシクロオクタン及びヘプタン誘導体、その製造方法及びこれを用いて治療する方法 |
| WO1998054189A1 (en) | 1997-05-30 | 1998-12-03 | Neurosearch A/S | Spiro-quinuclidine derivatives, their preparation and use |
| WO1998054182A1 (en) | 1997-05-30 | 1998-12-03 | Neurosearch A/S | 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS |
| FR2765874B1 (fr) | 1997-07-09 | 1999-08-13 | Synthelabo | Derives de 6-pyrrolidin-2-ylpyrindines, leur preparation et leur application en therapeutique |
| AR013184A1 (es) | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
| US6034079A (en) * | 1997-08-11 | 2000-03-07 | University Of South Florida | Nicotine antagonists for nicotine-responsive neuropsychiatric disorders |
| EE04588B1 (et) | 1997-10-27 | 2006-02-15 | Neurosearch A/S | Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon |
| WO1999024422A1 (en) | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
| US6057446A (en) * | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
| EP0955301A3 (en) | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
| US6211194B1 (en) * | 1998-04-30 | 2001-04-03 | Duke University | Solution containing nicotine |
| US6232316B1 (en) * | 1998-06-16 | 2001-05-15 | Targacept, Inc. | Methods for treatment of CNS disorders |
| US6365182B1 (en) | 1998-08-12 | 2002-04-02 | Cima Labs Inc. | Organoleptically pleasant in-mouth rapidly disintegrable potassium chloride tablet |
| US6368625B1 (en) | 1998-08-12 | 2002-04-09 | Cima Labs Inc. | Orally disintegrable tablet forming a viscous slurry |
| AU5574799A (en) | 1998-08-25 | 2000-03-14 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
| US6262124B1 (en) * | 1998-10-22 | 2001-07-17 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
| ATE259804T1 (de) | 1998-11-27 | 2004-03-15 | Neurosearch As | 8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate |
| FR2786769B1 (fr) | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
| PT1634498E (pt) * | 1998-12-16 | 2008-10-28 | Univ South Florida | Formulação de exo-s-mecamilamina |
| ES2305373T3 (es) | 1999-01-29 | 2008-11-01 | Abbott Laboratories | Derivados diazabiciclicos como ligandos del receptor nicotinico de la acetilcolina. |
| US6583160B2 (en) * | 1999-04-14 | 2003-06-24 | Steve Smith | Nicotine therapy method and oral carrier for assuaging tobacco-addiction |
| DE60003911T2 (de) | 1999-04-26 | 2004-05-27 | Neurosearch A/S | Heteroaryl-diazacycloalkane, ihre herstellung und verwendung |
| NZ513575A (en) | 1999-05-04 | 2003-07-25 | Neurosearch As | Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators |
| US20040229908A1 (en) | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
| US8256433B2 (en) * | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US20080138398A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| US6799576B2 (en) * | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
| US20080138294A1 (en) * | 1999-07-16 | 2008-06-12 | Igor Gonda | Systems and methods for effecting cessation of tobacco use |
| US20080138399A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| US8188043B2 (en) * | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| FR2798065B1 (fr) | 1999-09-02 | 2003-09-05 | Assist Publ Hopitaux De Paris | Utilisation de la nicotine ou de ses derives dans un medicament pour le traitement des maladies neurologiques, notamment la maladie de parkinson |
| SE9903998D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| JP2001261652A (ja) * | 2000-03-21 | 2001-09-26 | Suntory Ltd | 二置換イミノヘテロサイクリック化合物 |
| US6489025B2 (en) * | 2000-04-12 | 2002-12-03 | Showa Denko K.K. | Fine carbon fiber, method for producing the same and electrically conducting material comprising the fine carbon fiber |
| US6955821B2 (en) | 2000-04-28 | 2005-10-18 | Adams Laboratories, Inc. | Sustained release formulations of guaifenesin and additional drug ingredients |
| WO2002002081A1 (en) | 2000-07-05 | 2002-01-10 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and methods of using same |
| GB0022084D0 (en) * | 2000-09-08 | 2000-10-25 | Univ Aberdeen | Treatment of multiply antibiotic-resistant organisms |
| WO2002030392A2 (en) | 2000-10-12 | 2002-04-18 | Beecham Pharmaceuticals (Pte) Limited | Formulation containing amoxicillin |
| PL364621A1 (en) | 2001-03-26 | 2004-12-13 | Smithkline Beecham Corporation | Nicotine-containing oral dosage form |
| SE0102197D0 (sv) * | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| SE0103211D0 (sv) * | 2001-09-27 | 2001-09-27 | Pharmacia Ab | New formulations and use thereof |
| US20030119879A1 (en) * | 2001-10-15 | 2003-06-26 | Thomas Landh | Nicotine and chocolate compositions |
| US20030087937A1 (en) * | 2001-10-15 | 2003-05-08 | Nils-Olof Lindberg | Nicotine and cocoa powder compositions |
| US20040037879A1 (en) * | 2001-11-02 | 2004-02-26 | Adusumilli Prasad S. | Oral controlled release forms useful for reducing or preventing nicotine cravings |
| US8329217B2 (en) | 2001-11-06 | 2012-12-11 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dual controlled release dosage form |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| SE0104388D0 (sv) | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
| US6852741B2 (en) * | 2001-12-31 | 2005-02-08 | University Of Florida | Compositions and methods for treatment of neurological disorders |
| EP1471909A4 (en) | 2002-01-16 | 2007-07-25 | Endo Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM |
| US20030159702A1 (en) * | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
| US20040166159A1 (en) * | 2002-05-29 | 2004-08-26 | Chien-Hsuan Han | Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa |
| US7767698B2 (en) * | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| US8911781B2 (en) | 2002-06-17 | 2014-12-16 | Inventia Healthcare Private Limited | Process of manufacture of novel drug delivery system: multilayer tablet composition of thiazolidinedione and biguanides |
| US20040052851A1 (en) * | 2002-09-16 | 2004-03-18 | Graff Allan H. | Modified release oral dosage form |
| PT1578422E (pt) * | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
| SE0301320D0 (sv) | 2003-05-06 | 2003-05-06 | Astrazeneca Ab | Positive modulators of nicotinic acetylcholine receptors |
| WO2004103283A2 (en) * | 2003-05-14 | 2004-12-02 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a central nervous system stimulant for the treatment of central nervous system damage |
| US7149574B2 (en) * | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
| DE10338174A1 (de) * | 2003-08-20 | 2005-03-24 | Lts Lohmann Therapie-Systeme Ag | Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit |
| US7282217B1 (en) | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
| AU2004269986A1 (en) * | 2003-09-08 | 2005-03-17 | Pfizer Consumer Healthcare Health Ab | Nicotine formulations and use thereof |
| KR20080109101A (ko) * | 2003-10-20 | 2008-12-16 | 테바 파마슈티컬 인더스트리즈 리미티드 | 레보도파의 지속적 효과를 위한 조성물 및 제형 |
| US20050266032A1 (en) | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
| CN1332667C (zh) * | 2004-05-26 | 2007-08-22 | 中国科学院生物物理研究所 | 一种抗帕金森症(pd)复合制剂 |
| CA2591817A1 (en) * | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| WO2007056125A2 (en) | 2005-11-04 | 2007-05-18 | Eastman Chemical Company | Carboxyalkyl cellulose esters for sustained delivery of pharmaceutically active substances |
| US7958887B2 (en) * | 2006-03-10 | 2011-06-14 | Aradigm Corporation | Nozzle pore configuration for intrapulmonary delivery of aerosolized formulations |
| EP1998755A2 (en) | 2006-03-16 | 2008-12-10 | NicoNovum AB | Chewing gum compositions providing rapid release of nicotine |
| US20070269492A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| CN103977003A (zh) * | 2007-04-02 | 2014-08-13 | 帕金森氏病研究院 | 用于降低治疗的副作用的方法和组合物 |
-
2008
- 2008-04-02 CN CN201410137915.7A patent/CN103977003A/zh active Pending
- 2008-04-02 GB GB0912941A patent/GB2461412B/en not_active Expired - Fee Related
- 2008-04-02 ES ES08251288.0T patent/ES2521494T3/es active Active
- 2008-04-02 CA CA002682323A patent/CA2682323A1/en not_active Abandoned
- 2008-04-02 KR KR1020097022900A patent/KR101122469B1/ko not_active Expired - Fee Related
- 2008-04-02 JP JP2010502274A patent/JP2010523587A/ja not_active Withdrawn
- 2008-04-02 WO PCT/US2008/059174 patent/WO2008122049A2/en not_active Ceased
- 2008-04-02 EP EP08251288.0A patent/EP1977746B8/en not_active Not-in-force
- 2008-04-02 US US12/061,587 patent/US7718677B2/en not_active Expired - Fee Related
- 2008-04-02 EP EP11152129A patent/EP2322168A1/en not_active Withdrawn
- 2008-04-02 AU AU2008232453A patent/AU2008232453B8/en not_active Ceased
- 2008-04-02 CN CN200880016027.2A patent/CN101772346B/zh not_active Expired - Fee Related
- 2008-04-02 EP EP11152139A patent/EP2322167A1/en not_active Withdrawn
- 2008-04-02 KR KR1020117012123A patent/KR20110075044A/ko not_active Withdrawn
- 2008-04-02 EP EP11152137A patent/EP2322166A1/en not_active Withdrawn
- 2008-04-02 GB GB0805991A patent/GB2448224B/en not_active Expired - Fee Related
-
2009
- 2009-07-14 US US12/502,992 patent/US20100029723A1/en not_active Abandoned
- 2009-08-04 US US12/534,941 patent/US20100196463A1/en not_active Abandoned
- 2009-08-04 US US12/534,928 patent/US20100166735A1/en not_active Abandoned
- 2009-08-04 US US12/534,946 patent/US20100159004A1/en not_active Abandoned
- 2009-08-04 US US12/534,935 patent/US20100158895A1/en not_active Abandoned
- 2009-09-30 IL IL201269A patent/IL201269A/en active IP Right Grant
-
2010
- 2010-10-08 US US12/901,354 patent/US20110077276A1/en not_active Abandoned
-
2013
- 2013-05-21 JP JP2013107190A patent/JP2013155209A/ja active Pending
-
2014
- 2014-04-23 IL IL232200A patent/IL232200A0/en unknown
-
2015
- 2015-09-10 US US14/850,840 patent/US20160235732A1/en not_active Abandoned
- 2015-10-16 JP JP2015204271A patent/JP2016020385A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| Movement Disorders, 21(5), pp. 654-659(2006)* |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101122469B1 (ko) | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 | |
| AU2005307772B2 (en) | Methods and compositions for treating pain | |
| US20180110768A1 (en) | Methods and compositions for reduction of side effects of therapeutic treatments | |
| JP2010508298A (ja) | 悪心および嘔吐の削減を伴う疼痛治療方法 | |
| JP7594045B2 (ja) | 薬学的組成物 | |
| Jain et al. | The role of NMDA receptor antagonists in nicotine tolerance, sensitization, and physical dependence: a preclinical review | |
| AU2011203482B2 (en) | Methods and compositions for reduction of side effects of therapeutic treatments | |
| GB2468424A (en) | Composition for the reduction of side-effects of dopaminergic agents | |
| HK1145978B (en) | Methods and compositions for reduction of side effects of therapeutic treatments | |
| CA2239624C (en) | Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| A107 | Divisional application of patent | ||
| A201 | Request for examination | ||
| A302 | Request for accelerated examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0104 | Divisional application for international application |
St.27 status event code: A-0-1-A10-A18-div-PA0104 St.27 status event code: A-0-1-A10-A16-div-PA0104 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PA0302 | Request for accelerated examination |
St.27 status event code: A-1-2-D10-D17-exm-PA0302 St.27 status event code: A-1-2-D10-D16-exm-PA0302 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-5-5-R10-R17-oth-X000 |
|
| FPAY | Annual fee payment |
Payment date: 20150119 Year of fee payment: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20160131 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20160131 |