KR101119555B1 - Methods for manufacturing pills of red ginseng using Centrifugal Coating - Google Patents

Abstract

The present invention relates to a red ginseng concentrate pill manufacturing method using a centrifugal coating method, and more particularly, a step of injecting a pill manufacturing seed into a housing of a centrifugal coating machine, and floating the seed inside the housing by centrifugal force under atmospheric pressure. , And spraying the red ginseng concentrate on the seed and the red ginseng concentrate is coated on the seed to grow into red ginseng concentrate particles of the desired size.

Description

Method for manufacturing red ginseng concentrate pills using centrifugal coating method {Methods for manufacturing pills of red ginseng using Centrifugal Coating}

The present invention relates to a red ginseng concentrate pill manufacturing method using a centrifugal coating method, and more specifically, a step of injecting a pill manufacturing seed into a housing of a centrifugal coating machine (Centrifugal coating machine), the seed by the centrifugal force under normal pressure housing It relates to a method for producing red ginseng concentrate pill comprising the step of floating therein, and spraying the red ginseng concentrate on the seed and the red ginseng concentrate is coated on the seed to grow into red ginseng concentrate particles of a desired size.

The main active ingredient of ginseng is ginsenoside, and the chemical structure is elucidated and pharmacologically active ingredient is revealed through continuous research. The main characteristic of saponin, an active ingredient of ginseng, has a large lipolysis ability in the human body, promotes absorption and digestion of nutrients, activates enzymes in cells to promote metabolism, promotes serum protein, and restores energy. It is known to have an effect on improving anorexia, etc.

Ginseng is divided into three types: fresh ginseng, red ginseng, and white ginseng, which maintain the original shape of ginseng. Because it contains moisture, it is prone to decay or damage during distribution, so long-term storage is difficult without special storage facilities or packaging.

Red ginseng is light yellow brown or light red ginseng which is dried by steaming steamed ginseng without selecting the ginseng, which is a reticulum. The steaming process causes steam hydrolysis to cause ginsenosides Rg3, Rg2, Rg5, Rh2. It is known that red ginseng unique components such as Rh4 are produced. Recently, red ginseng in a form that maximizes the efficacy of ginseng is widely used in various formulations, and processing methods for increasing ginsenoside components have been introduced.

On the other hand, red ginseng concentrate has a very high viscosity and very strong hygroscopicity of powder, so it is not easy to prepare pills using conventional methods such as a recirculator or spray drying method, and a carrier material must be added to the final product. The content of the red ginseng concentrate contained must be low.

Commercially available red ginseng concentrate pill products are made by mixing red ginseng concentrate with dried red ginseng powder, rice powder, crystalline cellulose, glutinous rice powder, green tea powder, etc. without carrier extract as a carrier for adsorption of concentrate. In order to increase the red ginseng content, this process is repeated, so the process takes a long time and the ratio of the actual concentrate component content in the final product is also low.

Recently, techniques using a fluidized bed spray method have been reported to compensate for this disadvantage. For example, Korean Patent Laid-Open Publication No. 10-2007-0118020 relates to a method for preparing ginseng extract granules and pills, and injecting seeds into a fluidized bed process and spraying red ginseng concentrate to prepare red ginseng concentrate rings for the process. It was shortened and the concentrate content contained in the final product was improved.

However, the fluidized bed process used in this patent allows the liquid, powder, and granules to be fluidized by air nozzles under reduced pressure in a closed space, resulting in drying by surface exposure. However, if the manufacture of pills in a confined space is not possible to add additional red ginseng concentrate or red ginseng powder during the process, it is necessary to inject air to float the seed.

Thus, the present inventors, when using the centrifugal coating machine in the manufacture of red ginseng concentrate pill can be added to the red ginseng concentrate or red ginseng powder during the manufacturing process of the red ginseng concentrate pill can further shorten the manufacturing time of the pill, centrifugal rotational power Since the seed particles can be suspended alone, a new method for producing an economical red ginseng concentrate pill was developed and the present invention was completed.

Accordingly, the main object of the present invention is to provide a method for producing red ginseng concentrate pills, which is economical and improves hygroscopicity and solubility of pills by shortening the time required for the manufacturing process by using a centrifugal coating method in preparing red ginseng concentrate pills. There is.

According to one aspect of the invention, the present invention comprises the steps of a) injecting a seed for manufacturing pills into the housing of the centrifugal coating machine, b) floating the seed inside the housing by centrifugal force under atmospheric pressure, And c) spraying red ginseng concentrate on the seed, the red ginseng concentrate is coated on the seed to grow red ginseng concentrate pill of the desired size.

The seed of the present invention (seed) refers to a starting material for growing the red ginseng concentrate as a pill, it can be prepared by adding a spirit to the red ginseng concentrate powder to produce a granule and then drying it. The seed may be any size that can be grown by growing the red ginseng concentrate on the surface, for example, a seed having a particle size of 0.4 ~ 0.7 mm can be used. In addition, the seed of the present invention and the red ginseng concentrate pill prepared therefrom may be given only the red ginseng component product 100% that could not be implemented in the existing red ginseng pill product because it is manufactured only with the red ginseng component, thereby securing marketability and marketability.

In the method of the present invention, the centrifugal coating machine is characterized in that it has an openable door located in the upper housing, a rotary plate located in the lower housing, and an inlet for introducing the red ginseng concentrate into the openable door.

The seed floating by the rotational force of the centrifugal coating machine can float the seed particles by centrifugal rotation, and the red ginseng concentrate is sprayed onto the floating seed, and the particles grow, and the seed particles are formed inside the housing by the rotational force of the lower rotating plate. Friction with the seed can cause the seed to grow in the form of a circular pellet.

In the present invention, it is preferable to further include an annular air inlet around the rotating plate. The air inlet is a space existing between the circumferential surface of the rotating plate and the inner wall of the housing and is formed in an annular shape along the circumferential surface of the rotating plate. The spacing of the air inlet is preferably smaller than the diameter of the seed, and blows air through the air inlet, which serves to prevent seed particles from being caught or dropped in the air inlet during the pill manufacturing process. In addition, it also helps the seed to float.

A preferred embodiment of the centrifugal coating machine used in the method of the present invention can be seen in FIG. In Figure 4, the centrifugal coating machine includes a housing (C) therein, a retractable door positioned on the housing, a rotating plate (D) located under the housing, and an inlet (B) for introducing red ginseng concentrate into the retractable door. . Suction air (A) is injected through the annular air inlet around the rotating plate, the red ginseng concentrate is injected through the inlet (B) at the upper part of the housing, and the red ginseng powder is injected through the other inlet at the upper part of the housing. . In addition, the housing of the centrifugal coating machine of the present invention may be provided with a red ginseng powder supply device (F), a red ginseng concentrate pump (G), a red ginseng concentrate container (H), a moisture sensor (I), and a blower (J).

In the method of the present invention, in step b) it is preferred that the rotating plate speed 1000-1500 rpm, injection air temperature 60-70 ℃, and injection air pressure 3-4 bar. In this case, it is impossible to float the seed particles only by the rotational force when the rotation speed is lower than the rotational speed, and when the transmission speed is higher than the rotational speed, the seed particles are broken or damaged due to collision or friction with the particles or the housing base wall, so as to maintain a circular shape. it's difficult. In addition, when the injected air is lower than the air temperature range, the seed particles are weakly bound, or the seed particles and the red ginseng concentrate (or powder) are weakly bound to grow the seed particles into pills. The binding of red ginseng concentrate (or powder) is easy while brittle. The pressure of the injection air may be appropriately selected in consideration of the volume inside the housing, but the pressure in the above range is preferable to aid in the floating of the seed particles.

In the method of the present invention, the spray rate of the red ginseng concentrate in step c) is preferably 1-1000 g / min. If the spraying speed of the concentrate exceeds the range, too much amount is sprayed and the drying time is insufficient, so there is a drawback to stick to the base wall.

In the method of the present invention, preferably, in step c), additionally, red ginseng concentrate powder is added to increase the growth rate of the pill particles.

In the present invention, the red ginseng concentrate powder or red ginseng powder may be additionally added during the process that cannot be realized by the conventional fluidized bed spray method, thereby greatly improving the growth rate of the pill particles. Specifically, as shown in Figure 4, the red ginseng concentrate powder or red ginseng powder may be additionally added through the inlet provided in the upper housing separately from the red ginseng concentrate inlet.

Hereinafter, the present invention will be described in more detail with reference to Examples. These embodiments are only for illustrating the present invention, and thus the scope of the present invention is not construed as being limited by these embodiments.

Example 1 Preparation of Red Ginseng Extract and Powder

Red ginseng concentrate was extracted 1,000 times (10 times, v / w) to 100 g of red ginseng and extracted three times at 85 ℃ for 5 hours. The extract was centrifuged (5,000 rpm, 30 minutes) and the supernatant was concentrated below 70 ℃ to prepare a red ginseng concentrate. The red ginseng concentrate prepared by the above method was found to have 64% solids and 36% moisture.

Red ginseng concentrate powder was prepared by adding 1,000 ml (10 times, v / w) of distilled water to 100 g of red ginseng concentrate (36% water content), followed by spray drying (200 ° C.), followed by separation (100 mesh).

Example 2 Preparation of Red Ginseng Concentrate Seeds

250 ml of red ginseng concentrate powder (5% moisture) was added to 50 ml of 85.5% alcohol and mixed, and granules were prepared with an oscillator (granulator, granulator, Samjeong, Korea), and then hot air dried at 50 ° C. or lower for 4 to 5 hours. This was passed through different sieves (sizes by size) to produce seed particles such that the particle size was 0.4-0.7 mm. 1 is a photograph of the actual red ginseng concentrate seed prepared.

Example 3 Preparation of Red Ginseng Concentrate Pills Using Centrifugation

First, red ginseng concentrate was prepared by adding 2,000 g of water to 1,000 g of red ginseng concentrate (64% of solid content) and diluting with stirring at 100 rpm at 45-50 ° C. to adjust the solid content to 15-50%. Next, the red ginseng concentrate prepared in Example 2 was introduced into the housing of the centrifugal coating machine before the machine operation, and then the sprayed red ginseng concentrate was sprayed sequentially under the following conditions by centrifugal coating (Centrifugal (CF) Coating). To prepare a red ginseng concentrate ring. Red ginseng concentrate powder or red ginseng powder can be added at any time during machine operation: suction air temperature 60-70 ° C, spray air pressure 3.0-4.0 bar, inlet temperature 20-50 ° C, feed rate 1-1,000 g / min, rotating plate speed 1,000-1,500 rpm, outlet temp 25-40 ° C.

The red ginseng concentrate ring prepared above was sifted to prepare a ring having a diameter of 0.85 to 1.00 mm (ring A), and a diameter of 1.00 to 2.00 mm (ring B) (FIGS. 2 and 3). Preparation time and yield of the prepared red ginseng concentrate ring are shown in Table 1 below.

TABLE 1 Preparation time and yield of red ginseng concentrate ring

Experimental Example 1. Evaluation of hygroscopicity of red ginseng concentrate ring

Hygroscopicity during storage for the red ginseng concentrate powder (control) and the red ginseng concentrate ring prepared in the above example as a control was evaluated by the following method. 10 g of each sample (control, ring A and ring B) was placed in a 50 ml vial bottle, capped and stored in an incubator controlled at 40 ° C. and 75% RH (relative humidity) for 3 months of accelerated testing. The degree of hygroscopicity of each sample was evaluated. The degree of hygroscopicity was assessed visually using the five-point scale of 15 trained sensory evaluation personnel, and the results are shown in Table 2 below.

TABLE 2 Hydration Evaluation of Red Ginseng Extract Ring

 * Hygroscopicity: Visual observation

 * Sample hygroscopicity: +++++ (very much), +++ (medium), + (low)

In Table 2, the pill of the present invention can be seen that the hygroscopicity is very improved compared to the control red ginseng concentrate powder. In general, the red ginseng concentrate has a very high viscosity and a very strong hygroscopicity of the powder, so it is not easy to prepare the pills by conventional methods such as a recirculator or a spray drying method, but the pill of the present invention has improved hygroscopicity as described above. It can be seen that ease.

Experimental Example 2. Red Ginseng Extract Ring Red Ginseng Component Content

The red ginseng component content of the red ginseng concentrate as a control and the red ginseng concentrate ring prepared in Example were measured as follows according to the <Health Food Supplement 2008> method.

① About 1 g of the sample was placed in a 250 ml reflux flask, and 50 ml of 50% methanol solution was added thereto, followed by reflux extraction for 1 hour in a water bath at 70-80 ° C., followed by cooling and centrifugation to obtain a supernatant. ② 50 ml of 50% methanol solution was added to the residue, and the mixture was extracted under reflux for 1 hour in a water bath at 70-80 ° C., cooled, and centrifuged to obtain a supernatant. The supernatant (①) of the red ginseng concentrate and the supernatant (②) obtained from the residue were combined, put into a 250 ml concentration flask, and concentrated under reduced pressure at 60 ° C. or lower. ③ The concentrate was dissolved in 2 ml of a water-acetonitrile (80:20, v / v) mixed solvent and filtered through a 0.45 μm membrane filter and analyzed by HPLC. HPLC analysis conditions used at this time were column ODS (4.6 mm x 250 mm), detector UV (wavelength 203 nm), mobile phase water-acetonitrile mixed solvent (flow rate 1.6 ml / min). 20 μl of test solution (③) and 20 μl of red ginseng saponin ginsenoside standard solution (standard separation product, KT & G Central Research Institute) were injected into HPLC and analyzed by the HPLC analysis method described above, respectively. Ginsenoside-Rg1, -Re,- Total ginsenoside content by obtaining peak areas of Rf, -Rh1, -Rg2 (S), -Rg2 (R), -Rb1, -Rc, -Rb2, -Rd, -Rg3 (S) and -Rg3 (R) And individual ginsenosides content was calculated and the results are shown in Tables 3 and 4.

TABLE 3 Total ginsenoside content of red ginseng concentrate ring

TABLE 4 Individual Ginsenoside Contents of Red Ginseng Extract Rings

In Table 3 and Table 4, the ginsenoside content of the red ginseng concentrate was investigated by HPLC. As a result, the total ginsenoside content of the red ginseng concentrate ring of the present invention was stable without significant difference from the control red ginseng concentrate powder. In addition, the contents of the individual ginsenosides were stable without difference from the control.

Example 3. Physical Properties of Red Ginseng Extract Ring

As a control, the physical properties of red ginseng concentrate and red ginseng concentrate ring prepared in Example were investigated. The specific gravity of the ring was determined by measuring the weight (g) per constant volume (ml), and the solubility was measured by putting 1 g of the sample in 50 ml of purified water and stirring (300 rpm). The results are shown in Table 5 below.

TABLE 5 Physical Characteristics of Red Ginseng Extract Ring

In Table 5, the physical properties of the red ginseng concentrate, especially the specific gravity and solubility of the red ginseng concentrate pill of the present invention, the solubility of the control did not show a significant difference with the red ginseng concentrate powder, but rather improved and showed a large difference in specific gravity Seemed. This shows that the solubility is excellent as the pills of the present invention maintain a low specific gravity.

As described above, according to the present invention by floating the red ginseng concentrate seed by the rotational force by centrifugal force and spraying the red ginseng concentrate or red ginseng powder into the process, it is possible to manufacture red ginseng concentrate pills with improved solubility while reducing the manufacturing time. Therefore, the red ginseng concentrate prepared according to the present invention contains only 100% red ginseng components, which can be developed into a product having high commerciality and a shortened manufacturing time, thereby improving economic efficiency.

1 is a photograph of the red ginseng concentrate seed prepared according to the present invention.

Figure 2 is a photograph of a red ginseng concentrate pill prepared according to the present invention with a diameter of 0.85 ~ 1.00 mm in size, screened with a sieve of 20-18 mesh (mesh).

3 is a red ginseng concentrate prepared according to the present invention 18- It is the photograph of the pills of size 1.00-2.00 mm which were screened by the sieve of 10 mesh.

4 is a view for explaining the structure of the centrifugal coating machine according to the present invention. A: inlet air, B: outlet air, C: housing, D: rotor, E: spray system, F: red ginseng powder feeder ), G: liquid pump, H: liquid vessel, I: moisture sensor, J: blow air generator system, K: product outlet.

Claims (6)

a) injecting a pill manufacturing seed into a housing of a centrifugal coating machine having a retractable door positioned above the housing, a rotating plate positioned below the housing, and an inlet for feeding red ginseng concentrate into the retractable door; ; b) suspending the seed inside the housing by centrifugal force at atmospheric pressure; And c) spraying red ginseng concentrate on the seed, the red ginseng concentrate is coated on the seed and grown to red ginseng concentrate particles of a desired size while additionally adding red ginseng concentrate powder or red ginseng powder to improve the growth rate of the pill particles. Pill manufacturing method. delete The method of claim 1, further comprising an annular air inlet around the rotating plate. The method of claim 1, wherein the b) the rotating plate speed 1000-1500 rpm, inlet air temperature 60-70 ° C, and inlet air pressure 3-4 bar. According to claim 1, wherein the spray rate of the red ginseng concentrate in step c) is characterized in that 1-1000 g / min. delete

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