KR101114982B1 - 천연 원료로부터 파클리탁셀의 개선된 분리 및 정제 방법 - Google Patents

천연 원료로부터 파클리탁셀의 개선된 분리 및 정제 방법 Download PDF

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KR101114982B1
KR101114982B1 KR1020057015967A KR20057015967A KR101114982B1 KR 101114982 B1 KR101114982 B1 KR 101114982B1 KR 1020057015967 A KR1020057015967 A KR 1020057015967A KR 20057015967 A KR20057015967 A KR 20057015967A KR 101114982 B1 KR101114982 B1 KR 101114982B1
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South Korea
Prior art keywords
paclitaxel
solution
acetone
mixture
silica gel
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Korean (ko)
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KR20050114627A (ko
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트렁 부이-캑
미첼 포티에르
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챠이쳄 파마슈티컬즈 인터내셔널
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
KR1020057015967A 2003-02-27 2004-01-27 천연 원료로부터 파클리탁셀의 개선된 분리 및 정제 방법 Expired - Fee Related KR101114982B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/375,474 US6759539B1 (en) 2003-02-27 2003-02-27 Process for isolation and purification of paclitaxel from natural sources
US10/375,474 2003-02-27
PCT/CA2004/000107 WO2004076435A1 (en) 2003-02-27 2004-01-27 Improved process for isolation and purification of paclitaxel from natural sources

Publications (2)

Publication Number Publication Date
KR20050114627A KR20050114627A (ko) 2005-12-06
KR101114982B1 true KR101114982B1 (ko) 2012-03-06

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KR1020057015967A Expired - Fee Related KR101114982B1 (ko) 2003-02-27 2004-01-27 천연 원료로부터 파클리탁셀의 개선된 분리 및 정제 방법

Country Status (9)

Country Link
US (1) US6759539B1 (enExample)
EP (1) EP1608636B1 (enExample)
JP (1) JP4563994B2 (enExample)
KR (1) KR101114982B1 (enExample)
CN (1) CN1774431B (enExample)
AT (1) ATE382613T1 (enExample)
CA (1) CA2516811C (enExample)
DE (1) DE602004011034T2 (enExample)
WO (1) WO2004076435A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101455694B1 (ko) * 2012-09-18 2014-11-03 학교법인 선목학원 에틸아세테이트 및 아세토니트릴의 유기용매 혼합액을 이용한 액체-액체 추출법을 포함하는 약물 검출법

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR054215A1 (es) * 2006-01-20 2007-06-13 Eriochem Sa Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
KR101381502B1 (ko) * 2012-09-28 2014-04-04 공주대학교 산학협력단 파클리탁셀의 정제방법
CN103877600B (zh) * 2014-03-27 2017-04-05 沈祖鸿 含有红豆杉提取物的喷雾剂及其制造方法和制造配方
CN104031008B (zh) * 2014-06-30 2015-12-09 牛兆颖 一种紫杉醇粗提物的制备方法
CN108101869A (zh) * 2017-12-20 2018-06-01 上海金和生物制药有限公司 一种天然紫杉醇的提取方法
CN109384749A (zh) * 2018-12-26 2019-02-26 重庆市碚圣医药科技股份有限公司 一种紫杉醇的纯化方法
CN110845451A (zh) * 2019-11-28 2020-02-28 云南皓瑞逸生物科技有限公司 一种从红豆杉中提取紫杉醇的方法
CN112521349B (zh) * 2020-11-11 2023-04-07 福建齐衡科技有限公司 一种紫杉醇的纯化方法
JP2023552685A (ja) * 2020-11-16 2023-12-19 ヘモテック アーゲー 被覆された医療製品

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources

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FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5019504A (en) 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5475120A (en) 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
US5312740A (en) 1991-02-12 1994-05-17 Nippon Steel Corporation Process for producing taxol by cell culture of taxus species
EP0580759B1 (en) 1991-04-19 1999-05-26 The University Of Mississippi Methods and compositions for isolating taxanes
CA2072400C (en) 1991-07-05 2003-08-19 Jayaprakash B. Nair Supercritical extraction of taxanes
IT1258838B (it) 1992-01-31 1996-02-29 Indena Spa Processo per l'estrazione di tassolo e derivati da cultivar del genere taxus
US5445809A (en) 1992-03-03 1995-08-29 Research And Development Institute At Montana State University Production of taxol from the yew tree
US5451392A (en) 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
CA2092849C (en) 1992-04-07 2003-11-18 Paul M. Cino Callus cell induction and the preparation of taxanes
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DE69325454T2 (de) 1992-04-17 2000-01-20 Abbott Laboratories, Abbott Park Taxol-derivate
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US5279949A (en) * 1992-12-07 1994-01-18 Board Of Trustees Operating Michigan State University Process for the isolation and purification of taxol and taxanes from Taxus spp
CA2126698A1 (en) * 1992-12-07 1994-06-23 Muraleedharan G. Nair Process for the isolation and purification of taxol and taxanes from taxus spp.
EP1260507A1 (en) 1993-02-05 2002-11-27 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable A-nng side chains
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5440055A (en) 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5516676A (en) 1993-06-15 1996-05-14 Bristol-Myers Squibb Company Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US5405972A (en) 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
EP1054065B1 (en) 1993-11-15 2002-07-31 Mitsui Chemicals, Inc. A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate
US5508447A (en) 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5616330A (en) 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
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FR2736355B1 (fr) * 1995-07-07 1997-11-07 Pf Medicament Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101455694B1 (ko) * 2012-09-18 2014-11-03 학교법인 선목학원 에틸아세테이트 및 아세토니트릴의 유기용매 혼합액을 이용한 액체-액체 추출법을 포함하는 약물 검출법

Also Published As

Publication number Publication date
ATE382613T1 (de) 2008-01-15
DE602004011034T2 (de) 2009-02-12
CN1774431A (zh) 2006-05-17
EP1608636A1 (en) 2005-12-28
KR20050114627A (ko) 2005-12-06
EP1608636B1 (en) 2008-01-02
HK1087109A1 (en) 2006-10-06
CA2516811C (en) 2009-04-14
JP4563994B2 (ja) 2010-10-20
WO2004076435A1 (en) 2004-09-10
CN1774431B (zh) 2011-03-23
JP2006519184A (ja) 2006-08-24
US6759539B1 (en) 2004-07-06
DE602004011034D1 (de) 2008-02-14
CA2516811A1 (en) 2004-09-10

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