KR101066457B1 - 데하이드로글리아스페린 유도체를 유효성분으로 포함하는 nad(p)h:퀴논 산화환원효소 유도용 조성물 및 그 용도 - Google Patents
데하이드로글리아스페린 유도체를 유효성분으로 포함하는 nad(p)h:퀴논 산화환원효소 유도용 조성물 및 그 용도 Download PDFInfo
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- KR101066457B1 KR101066457B1 KR1020080109834A KR20080109834A KR101066457B1 KR 101066457 B1 KR101066457 B1 KR 101066457B1 KR 1020080109834 A KR1020080109834 A KR 1020080109834A KR 20080109834 A KR20080109834 A KR 20080109834A KR 101066457 B1 KR101066457 B1 KR 101066457B1
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- South Korea
- Prior art keywords
- dehydrogliasperin
- nad
- quinone oxidoreductase
- present
- quinone
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
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- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
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Abstract
Description
분획 번호 |
IC50(㎍/ml) | |
hepa1c1c7 세포주 | BPRc1 세포주 | |
1 | 〉100 | 〉100 |
2 | 49 | 43 |
3 | 49 | 48 |
5 | 55 | 41 |
7 | 55 | 33 |
9 | 19 | 17 |
12(데하이드로글리아스페린 C) | 3 | 6 |
14 | 17 | 12 |
16(데하이드로글리아스페린 D) | 10 | 10 |
18(이소안구스톤 A) | 6 | 4 |
Claims (6)
- NAD(P)H:퀴논 산화환원효소 유도활성을 갖는 데하이드로글리아스페린 C, 데하이드로글리아스페린 D 및 이소안구스톤 A로 구성되는 군에서 선택되는 데하이드로글리아스페린 유도체를 유효성분으로 함유하는, 암의 예방 또는 치료용 약학 조성물.
- NAD(P)H:퀴논 산화환원효소 유도활성을 갖는 데하이드로글리아스페린 C, 데하이드로글리아스페린 D 및 이소안구스톤 A로 구성되는 군에서 선택되는 데하이드로글리아스페린 유도체를 유효성분으로 함유하는, 간 질환의 예방 또는 치료용 약학 조성물.
- 제1항 또는 제2항에 있어서,상기 데하이드로글리아스페린 유도체가 감초에서 추출되는 것을 특징으로 하는 약학 조성물.
- NAD(P)H:퀴논 산화환원효소 유도활성을 갖는 데하이드로글리아스페린 C, 데하이드로글리아스페린 D 및 이소안구스톤 A로 구성되는 군에서 선택되는 데하이드로글리아스페린 유도체를 유효성분으로 함유하는, 암 또는 간 질환의 예방용 식품 조성물.
- 제4항에 있어서, 가축 사료용으로 사용되는 것인 식품 조성물.
- 제4항 또는 제5항에 있어서,상기 데하이드로글리아스페린 유도체가 감초에서 추출되는 것을 특징으로 하는 식품 조성물.
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KR1020080109834A KR101066457B1 (ko) | 2008-11-06 | 2008-11-06 | 데하이드로글리아스페린 유도체를 유효성분으로 포함하는 nad(p)h:퀴논 산화환원효소 유도용 조성물 및 그 용도 |
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KR1020080109834A KR101066457B1 (ko) | 2008-11-06 | 2008-11-06 | 데하이드로글리아스페린 유도체를 유효성분으로 포함하는 nad(p)h:퀴논 산화환원효소 유도용 조성물 및 그 용도 |
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KR101066457B1 true KR101066457B1 (ko) | 2011-09-21 |
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CN103070982B (zh) * | 2010-07-21 | 2015-06-10 | 李政育 | 抑制癌细胞生长的中药组合物及其中药萃取物 |
KR101293274B1 (ko) * | 2011-02-11 | 2013-08-02 | 서울대학교산학협력단 | 데하이드로글리아스페린 디를 유효성분으로 포함하는 것을 특징으로 하는 피부질환 예방 또는 치료용 조성물 |
KR101711970B1 (ko) * | 2011-03-22 | 2017-03-03 | 서울대학교 산학협력단 | 감초에 주로 함유되어 있는 데하이드로글리아스페린 c를 유효성분으로 함유하는 인지 기능의 저하 또는 손상을 치료하기 위한 조성물 |
KR101276306B1 (ko) * | 2012-08-10 | 2013-06-18 | 서울대학교산학협력단 | 디하이드로글리아스페린 c 또는 디하이드로글리아스페린 d 또는 이소앙구스톤 a를 함유하는 피부 미백용 조성물 |
CN102846594B (zh) * | 2012-09-18 | 2014-08-13 | 北京大学 | 一种异戊烯基黄酮类化合物的药物用途 |
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JP2003274856A (ja) | 2002-03-26 | 2003-09-30 | Kanegafuchi Chem Ind Co Ltd | 甘草疎水性抽出物を含有してなる食用油脂組成物 |
KR20040111455A (ko) * | 2002-04-04 | 2004-12-31 | 가부시키가이샤 가네카 | 감초 소수성 성분 함유 유지 조성물의 제조 방법 |
KR20080091627A (ko) * | 2007-04-09 | 2008-10-14 | 손창규 | 간보호, 또는 간섬유화 또는 간경화의 예방 또는 치료용조성물 |
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JP2003274856A (ja) | 2002-03-26 | 2003-09-30 | Kanegafuchi Chem Ind Co Ltd | 甘草疎水性抽出物を含有してなる食用油脂組成物 |
KR20040111455A (ko) * | 2002-04-04 | 2004-12-31 | 가부시키가이샤 가네카 | 감초 소수성 성분 함유 유지 조성물의 제조 방법 |
KR20080091627A (ko) * | 2007-04-09 | 2008-10-14 | 손창규 | 간보호, 또는 간섬유화 또는 간경화의 예방 또는 치료용조성물 |
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