KR100959203B1 - Anti-dandruff Composition - Google Patents

Abstract

The present invention relates to a composition for preventing dandruff,

More specifically, fructan may be used alone or in combination of two or more of zinc pyrithione, klimbazole, tar, sulfur, salicylic acid and pyroxtonolamine, which are known anti-dandruff ingredients having antifungal, anti-fungal and anti-inflammatory effects. It provides an anti-dandruff composition, the anti-dandruff composition according to the present invention has a moisturizing effect on the moisturizing effect and the inflammatory response to skin irritants, has a histamine secretion inhibitory effect and excellent safety for the human body.

Fructan, dandruff, dandruff, zinc pyrithione, pyroxtonolamine, anti-inflammatory effect, anti-dandruff

Description

Anti-dandruff composition {Anti-dandruff Composition}

The present invention relates to a composition for preventing dandruff. More specifically, fructan, a carbohydrate found in plants and microorganisms, alone or zinc antipyretic ingredient zinc pyrithione, klimbazole, tar, which has antifungal, anti-inflammatory and anti-inflammatory effects. It relates to a composition for preventing dandruff, which can be used by mixing two or more of sulfur, salicylic acid and pyroctone olamine (Piroctone Olamine).

In general, dandruff comes from the metabolism of old dead cells of the scalp in the form of hard keratin peeled off, which occurs physiologically in anyone. Dandruff is a noticeable increase in the amount of dandruff, which is often recurring and usually accompanied by itching.

When dandruff develops, excessive scrubs of the scalp due to dandruff or itching, etc., may cause scarring on the scalp, or in some cases may cause inflammation of the scalp or cause hair loss.

Histologically, dandruff shows that new cells are created in the basal layer of the scalp, and the cells are pushed up, pushed up to the top layer of the stratum corneum, and then peeled off.

It usually takes about a month for the cells to form and peel off, which is called turn-over. If this cycle is shortened, the amount of dandruff increases, and dandruff is caused by abnormal lipid secretion function in the sebaceous gland, lifestyle or stress, or environmental or hormonal abnormalities such as ambient temperature or humidity depending on individual differences, gender, and age. The secretion of sebum is increased and sebum accumulates, and turnover of epidermal cells by irritants such as free fatty acids caused by the cells of dermal fungi or dermal fungi decomposes triglycerides in lipids. The cycle is shorter and the keratinocyte division is more active than the normal one, so the stratum corneum is thickened and hyperkeratinized, the human eye is observed, the infiltration of inflammatory cells occurs, and the inflammatory findings are observed.

Recent studies have been found to be deeply involved in the development of dandruff, which is a fungus, called Pityrosporum ovale , in people with dandruff. A lot is present in the scalp.

Therefore, there have been many studies to improve dandruff by effectively removing the dandruff cause, especially zinc pyrithione and pyrotonolamine has been found to have the effect of inhibiting dandruff and itching, and is widely used in hair cosmetics as an antidandruff agent come.

The zinc pyrithione is effective in the treatment and improvement of dandruff by showing a good effect on the scleroderma keratose suppression and antifungal, but it is difficult to uniformly dispersed in the composition because it is water insoluble and high specific gravity, in particular contact dermatitis (Nielsen, NH, Allergic contact dermatitis caused by zinc pyrithione associated with pustular psoriasis. Am J Contact Dermat. 8, 170, 1997) and environmental toxicity has been reported, which has limited problems in applying to hair cosmetics at high concentrations. .

In addition, in the case of pyrotonolamine, 0.5 to 2.0% should be used in order to show a sufficient effect, and this component also has a restriction on the amount of usage due to safety problems for the human body (Cosmetics and Toiletries, 102, 6, Dec. , 1987).

Accordingly, there has been a demand for a complex prescription capable of supplementing this effect while reducing the concentration of antidandruff agents such as zinc pyridionone and pyrotonolamine. In particular, synthetic substances such as zinc pyrinthion and pyrotonolamine are excellent in their antibacterial properties, but they are not safe for skin side effects and synthetic chemicals. An inhibitory composition was desired.

In addition, in addition to the causes of dandruff causes described above, dandruff may occur due to frequent scalp or strong scalp removal of the scalp, dryness of the scalp and itching and dry dandruff. Prevention becomes important

In general, atopic dermatitis and atopic dermatitis are reported to be related to arachidonic acid metabolite related to inflammatory mediators. A reaction similar to the action on the mast cells in the skin by the compound or compound 48/80 appears, and prostaglandins and leukotrienes by a pathway involving cyclooxygenase or lipoxygenase in addition to histamine and basic enzymes already present in the mast cells. It is known that platelet activating factor (PAF) is secreted, causing complex inflammatory reactions and stimulating nerve cells to cause itching.

Therefore, simply preventing the action of scalp hyperkeratosis and antifungal treatment cannot fundamentally cure dandruff, has a moisturizing effect for the prevention of scalp dryness, and a stimulating effect on the inflammatory response to skin irritants, and inhibits histamine secretion. There has been a demand for the emergence of an anti-dandruff component having an effect and excellent safety to the human body.

In order to solve the above problems, the present inventors, such as to reduce the dandruff and itching caused by the scalp drying and to reduce the irritation caused by zinc pyrithione, etc., which are used in many conventional hair products for dandruff. During the study, it was found that fructan, which has moisturizing effect and stimulating effect on skin irritant, stimulating histamine secretion and safety for human body, has an excellent effect on treating dandruff and itching. In addition, when zinc pyrithione and pyroctone olamine having antifungal action are further used, it was found that the anti-dandruff and itch suppression effects were remarkably doubled, thus completing the present invention.

That is, an object of the present invention is to provide an anti-dandruff composition comprising fructan, which has a moisturizing effect on the moisturizing effect and an inflammatory response to a skin irritant substance, has a histamine secretion inhibitory effect, and is excellent for human safety.

It is another object of the present invention to provide an anti-dandruff hair cosmetic composition prepared using the anti-dandruff composition.

The above and other objects of the present invention can be achieved by the present invention described below.

The present invention to achieve the above object,

It provides a composition for preventing dandruff, characterized in that fructan is contained.

The fructan may be contained in an amount of 0.001 to 20% by weight based on the total weight of the composition.

In another aspect, the present invention provides an anti-dandruff composition in the anti-dandruff hair composition further comprises an amount of 0.01 to 5% by weight based on the total weight of the composition.

The anti-dandruff agent may be used alone or in combination of two or more in the group consisting of zinc pyrithione, pyroxtonolamine, klimbazole, tar, sulfur, salicylic acid.

Hereinafter, the present invention will be described in detail.

Fructan is a carbohydrate found in plants and microorganisms. It is a polysaccaride in which fructose is linked to β-2 and 6 bonds.

Fructan is usually cultured for about 24 hours using a medium consisting of microorganisms ( Zymomonas mobilis ), sucrose, and yeast extract that produce fructan, and then the cells are removed, precipitated and dried by adding alcohol. It is proposed to commercialize what is obtained.

In the present invention, the content of fructan is preferably used 0.01 to 10% by weight based on the total amount of the composition. Fructan was not expected to be effective at less than 0.01% by weight, moisturizing and stimulating effects at 0.01% by weight or more, and also showed an excellent itching effect. If fructan is more than 10.0% by weight, there is a problem in product usability and stability. It is not desirable because it is not economical. More preferably, fructan may be used by mixing 0.05 to 5.0% by weight.

Zinc pyrithione is a problem due to skin irritation at a concentration of 1% or more, the effect is less than 0.01% is preferably used to mix 0.5%.

Pyroctonolamine is also problematic due to skin irritation at a concentration of 1% or more, and the effect is insignificant at 0.01% or less, and preferably 0.5% is mixed.

Hereinafter, the following experiment was conducted to confirm the anti-inflammatory and skin moisturizing effects of fructan.

Experimental Example 1 Experiment for Measuring Anti-inflammatory Effect of Fructan

In order to confirm the anti-inflammatory effect of fructan, after inducing inflammation using histamine, the following experiments were carried out to confirm the inhibitory effect of fructan.

The hairs on the back of the Sprague-Dawley rats (SD rat, Sprague-Dawley rat), 5 to 6 weeks old, were removed with a clipper, and the hair removed was randomly divided into 4 parts. Dissolved in saline was 50µl injection, the left side was injected with the same amount of physiological saline only as a control.

One hour after the injection of fructan, 50 μl of histamine in 0.1% saline was dissolved in physiological saline, and 50% of evans blue solution was injected into the tail vein. 30 minutes after the injection of Evans Blue solution, the skin of the back area was removed and the diameter of the circle where Evans Blue was exuded into the tissue was measured to evaluate the inhibitory effect of fructan-induced inflammation. 1 is shown.

Inflammation inhibitory effect by fructan (diameter mm) density 0.01% 0.1% One % Fructan 18 11 6 Glucocorticosteroids 34 23 17 Control group (physiological saline) 50

The greater the effect of the test substance on inhibiting histamine-induced inflammation, the smaller the diameter of the Evans Blue circle exuded into the tissue. The fructan is the original Evans Blue extruded in proportion to the concentration as shown in Table 1 above. Diameter was reduced and the effect was superior to the steroid (glucocorticosteroid) that is commonly used as an anti-inflammatory agent.

Experimental Example 2 Experiment for Measuring Moisturizing Effect of Fructan

Changes in the moisturizing power of the skin were measured using a Corneometer CM 825. 10 μl of sample was applied to 4 cm ² of skin inside the tester's arm to measure the change in moisture content of the skin at regular time intervals, and the results are shown in Table 2 below. The experiment was conducted at room temperature 20 ℃ and relative humidity 20%.

Moisturizing effect of fructan (Corneometer value, 0.2% solution) time 5 min 10 min 20 min 30 min Fructan 11.5 6.2 4.1 2.6 Hyaluronic acid 9.6 5.3 3.7 1.9

As can be seen in Table 2, it was found that the moisturizing effect of fructan is much higher and its duration is longer than that of hyaluronic acid, which is generally used as a moisturizing agent.

Through the above experiments, it was found that the fructan used in the present invention is excellent in moisturizing effect as well as anti-inflammatory effect.

Hereinafter, the present invention will be described in more detail with reference to the following examples and comparative examples, but the scope of the present invention is not limited to the examples.

[Examples 1 to 4 and Comparative Examples 1 to 3] Hair Cleaning Agent

First, Examples 1 to 4 and Comparative Examples 1 to 3 were prepared as follows.

After adding 30% sodium lauryl sulfate, 30% sodium polyoxyethylene lauryl sulfate, palm oil fatty acid diethanolamide, propylene glycol and fructan according to the present invention and other raw materials in a composition ratio as shown in Table 3 below, The mixture was warmed to a temperature of 60 ° C., dissolved uniformly, and cooled to 40 ° C. Subsequently, a dye (blue No. 1), a paraoxybenzoic acid ester, a flavoring agent and citric acid were added to the mixture, followed by cooling to room temperature to prepare a shampoo.

However, in the above embodiment, this was carried out in the form of a hair cleanser, but the scope of the present invention is not limited thereto, and it will be apparent that the use of a solution, a hair tonic, etc., falls within the scope of the present invention. .

Raw material name Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3  Sodium Lauryl Sulfate (30%) 20.0 20.0 20.0 20.0 20.0 20.0 20.0 Polyoxyethylene lauryl
Sodium sulfate (30%) 20.0 20.0 20.0 20.0 20.0 20.0 20.0  Palm oil fatty acid diethanolamide 2.0 2.0 2.0 2.0 2.0 2.0 2.0  Propylene glycol 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Fructan 2.0 2.0 2.0 2.0 - - - Zinc pyrithione - 0.5 - 0.5 - 0.5 - Pyrotonolamine － － 0.5 0.5 - 0.5  Paraoxybenzoic acid ester 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Pigmentation (blue 1) Quantity Quantity Quantity Quantity Quantity Quantity Quantity Fragrance (Combination Fragrance SKP-3473) * Quantity Quantity Quantity Quantity Quantity Quantity Quantity Citric acid Quantity Quantity Quantity Quantity Quantity Quantity Quantity water Add until 100% by weight

* Hasegawa Co., Ltd. was used.

The efficacy test for dandruff and itching for the product thus prepared was carried out according to the following test example.

Test Example 1 Anti-dandruff effect test 1

Men and women with relatively high dandruff were selected and tested for 10 months in each product for 1 month for the shampoo of Table 3 above. The weight of the dandruff collected by trituration with a conventional shampoo and the accumulation of dandruff accumulated for 3 days before the start of the test, and the weight of the dandruff accumulated three days after the end of the test by trituration every two days with the shampoo composition shown in Table 3 above. Comparative evaluation.

At this time, the collection of the accumulated dandruff was made by skilled testers to wash the scalp of the test subjects using about 5 g of sample, and then washed with about 2 to 3 liters of water. The washed water was filtered through a 800 micropore filter medium, and then the dry weight of the dandruff on the filter medium was measured. The results are shown in Table 4.

Reduction rate of dandruff (%) = [(weight of mg dandruff before the start of the test—one month after the start of the test

Weight (mg)) / Weight of dandruff before test start (mg)] × 100

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Dandruff Reduction (%) 23.7 37.2 32.9 40.2 13.1 29.7 27.8

As shown in Table 3, the fructan-containing shampoo formulation according to the present invention showed an excellent anti-dandruff effect, and added fructan to zinc pyrithione and pyrotonolamine which are commonly used anti-dandruff components. When used as (Examples 2 to 4) it was found that there is a further improved dandruff reduction effect.

Test Example 2 Anti-dandruff Effect Test 2

After selecting the men and women who usually feel dandruff and itching a lot, the products of Examples 1 to 4 and Comparative Examples 1 to 3 were used for 8 weeks, once every two days for 10 people per product, and then evaluated as shown in Table 5 below. It was evaluated according to the criteria and expressed as the average of the ratings. The results are shown in Table 6.

Evaluation
(Anti-dandruff effect) grade There is very. 5 have. 4 is average. 3 none. 2 Nothing at all One

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Anti dandruff effect 3.1 3.9 3.6 4.1 2.1 3.4 3.2

As shown in Table 6, the fructan-containing shampoo according to the present invention showed an excellent inhibitory effect of dandruff occurrence, and adds zinc pyrithione and pyrotonolamine which are commonly used anti-dandruff components. When used as (Examples 2 to 4) was improved dandruff reduction effect than when using the fructan alone (Example 1)

Test Example 3 Itching Inhibition Effect Test 1

After selecting men and women who usually feel a lot of itching and using the products in Examples 1 to 4 and Comparative Examples 1 to 3 for 8 weeks, once every two days for 10 people per product, the evaluation criteria as shown in Table 7 below Was evaluated according to the average of the rating. The results are shown in Table 8.

Evaluation
(Itch reduction effect) grade There is very. 5 have. 4 is average. 3 none. 2 Nothing at all One

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Scalp itching effect 3.7 4.4 4.1 4.5 2.1 3.5 3.3

As shown in Table 8, in the shampoo containing fructan according to the present invention, the effect of suppressing itching was found to be excellent, and zinc pyrithione and pyrotonolamine, which are commonly used here, were added. When used in (Example 2 to 4) was very improved itching reduction effect

As described above, the anti-dandruff composition according to the present invention has a moisturizing effect on the moisturizing effect and an inflammatory response to skin irritants, has a histamine secretion effect, and an anti-dandruff effect and scalp itching, on the human body. It is a useful invention to provide a composition for preventing dandruff comprising fructan excellent safety.

Although the present invention has been described in detail with reference to the described embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the scope and spirit of the present invention, and such modifications and modifications fall within the scope of the appended claims. It is also natural.

Claims (4)

An anti-dandruff composition, characterized in that fructan is contained as an active ingredient in an amount of 0.001 to 20% by weight based on the total weight of the composition. delete The method of claim 1, The anti-dandruff composition for the anti-dandruff hair composition is further contained in an amount of 0.01 to 5% by weight based on the total weight of the composition. The method of claim 3, wherein The anti-dandruff agent is an anti-dandruff composition, characterized in that it is used alone or in combination of two or more in the group consisting of zinc pyrithione, pyrotonolamine, klimbazole, tar, sulfur, salicylic acid.