KR100327674B1 - A cosmetic composition of lightening and removing effects in the melanin-like pigmentation - Google Patents

Abstract

The present invention relates to a composition selected from aloe vera (Dried or Oil), green tea powder (Green Tea Powder) and acetic acid, lactic acid, trichloroacetic acid (TCA) and the like as an organic acid.

Description

A cosmetic composition of lightening and removing effects in the melanin-like pigmentation

FIELD OF THE INVENTION The present invention relates to skin beautifying cleansing compositions for the reduction and elimination of melaninous pigment colonies. Acetic acid is tyrosinase together with lactic acid and pyruvic acid or salts and derivatives thereof. It is well known that it inhibits the formation of but does not interfere with the activity of already formed tyrosinase (EP 345082A: Publication date 1989.12.6).

Trichloroacetic acid (TCA) as an acid is often used as a single diluent in clinicians in combination with a helium-neon laser for the purpose of chemical peeling or dropping, such as scar removal (Acne Prevention and Treatment Research. 3, pp. 52-68, 1999;

Unfavorable side effects such as 1) irreversible alpha denaturation of the skin, 2) pigmented secondary disorders, and 3) contact dermatitis when conventional acid formulations are used for pigment reduction (Muizzudin et al., Am J Contact) Dermt. 9 (3); 170-5 1998. Smit NP et al., Arch Dermatol Res, 290 (6): 342-9 1998). (Clinical Aspects of Dry Skin: Hanyang Medical College, Vol. 18, No. 1, pp. 65-72, 1998 Lee Seung Heon and Lee Chang Woo).

However, there have been no examples of using aloe vera and green tea powder alone or in combination with acid as a composition for skin cleansing agents for the purpose of reducing or removing melanin pigment colonies (spots).

Therefore, the present inventors have compared the use of acetic acid, butyric acid, pyrvic acid, or trichloroacetic acid (TCA) alone or mixed use with ultra-pulse laser alone, the period of use of the supplementary sunscreen, the period of uplift of the dermal layer, and melanin pigmentation In evaluating the alleviation effect, the aloe vera and green tea powder containing acid were used in skin beautifying cleansers for reducing or removing the melanin pigment colony, thereby completing the present invention. Therefore, an object of the present invention is to provide a skin beautifying cleanser for reducing or removing melanin pigment colony having less skin side effects and excellent effects.

Figure 1 shows the removal of diffuse pigments.

Figure 2 shows the removal of diffuse pigments in the examples.

Figure 3 shows the removal of diffuse and image pigments by way of example.

Figure 4 illustrates the removal of the image pigment in an example of two days intervals.

5 shows the removal of the image pigment as a comparative example.

The present invention relates to a composition of skin cleansing agents for the purpose of reducing or eliminating melanin colonies by containing pharmaceutically acceptable excipients with organic acids, aloe vera and green tea powder as active ingredients.

The organic acid used in the present invention may be acetic acid, butyric acid, pyrvic acid or monochloroacetic acid, dichloroacetic acid, trichloroacetic acid (TCA), or salts thereof or derivatives thereof and these may be used alone or in combination, preferred acids are acetic acid, Butyric acid and more preferred acid is acetic acid. The acid may also be used as aquapores (Biersdorf, Scincinety, Beiersdorf Inc BDF Plaza Norwalk CT 06856-5529; petrolatum, mineral oil, mineral wax, woolwax alchol; petrolatum, mineral oil, mineral wax, wool wax alcohol) and It may be used in combination.

Skin beautifying cleansing composition for reducing or removing melanin colonies of the present invention comprises 0.45 to 9.0% by weight of organic acid, 5.0 to 15.0% by weight of aloe vera and 2.5 to 10.0% by weight of green tea powder, diffuse deposition and image Effective for both sex melanin pigments. The composition for the preferred diffuse deposition (when the depth is formed from the skin surface of the melanin pigments) is 0.45 to 0.9% by weight acetic acid and 5.0 to 10.0% by weight aloe vera and green tea powder 2.5 It includes -5.0% by weight, and additionally, the wool extract can be used alone or in combination with acetic acid.

The composition for the preferred image melanogenic pigment colonies (localized areas where the spot-type melanin pigment colonies are formed deep from the skin surface) is 4.5 to 9.0% by weight of acetic acid, 5.0 to 15.0% by weight of aloe vera, and 2.5 to 10.0% by weight of green tea powder. It includes, and can be used additionally 5% by weight of wool extract.

When the amount of aloe vera is 5.0% by weight and the amount of green tea powder is less than 2.5% by weight, the effect is slightly different from that of acetic acid alone, and at 20% by weight or more, there is no significant increase in effect.

In the composition of the present invention, vitamin C, acoupor, lauryl sulphate, petrolatum, carboxymethyl cellulose (CMC), physiological saline, etc. may be used as pharmaceutically acceptable excipients in addition to organic acids, aloe vera and green tea powder. The composition according to the present invention may be used in liquid form or cream, gel, paste or ointment and may be used in a conventional form such as a poultice agent or a film sticking form. Hereinafter, the present invention will be described in more detail with reference to the following examples. These examples do not limit the technical scope of the present invention. Examples 1-8 and Comparative Examples 1-5 in the case of diffuse deposition. The following composition ratios are shown in Table 1, ie 20% by weight petrolatum, 0.1% by weight vitamin C (as ascorbic acid), 10% by weight sodium lauryl sulfate, 0.45 and 0.9% by weight acetic acid, 5% by weight saline To this mixture was added aloe vera and green tea powder according to the present invention and dissolved at room temperature. Subsequently, a saline solution in which carboxymethyl cellulose was dissolved was mixed to 100% by weight to prepare a cream. The melanin-lowering effect and the whitening effect of the composition were carried out in the same manner as in Test Examples 1 and 2. The results are shown in Table 2 and Table 3 below.

Test Example 1.

Eighteen females and eight males with relatively dark diffuse pigmentation of the skin were selected and tested for four weeks or one month on the creamy products of Table 1. Prior to the start of the test, at least two sites per person were selected as the cream of the frostbite on the back, the cuff or the face and two types of examples were applied. Thin coating was applied once a day, and then washed with saline after 10 minutes, and carried out every 7 days on average, and the whitening effect of self-evaluation was recorded on the last day.

Test Example 2.

Test was carried out in the same manner as in Test Example 1, but using a Skin Colorimeter (CW-2002 model), at least two parts per person were selected on the back, wrist, or face and two types of examples were applied. Record the LAB Index before application, apply thinly once a day, and wash it with saline after 10 minutes. The significant difference in the last day's measurement index is 3 or more, 2 or more and less than 3, 1 or more and less than 2, and 1 It was divided into less than.

The compositions of Examples 1 to 8 containing aloe vera and green tea powder according to the present invention shown in Table 1 (Table 2 and Table 3) were superior to the compositions of Comparative Examples 1 and 2, and showed excellent effects of reducing the deposition. In the LAB Index showing the whitening effect of Table 3, the composition of the Example showed a significant change in the measured index compared to the compositions of Comparative Examples 1 and 2. In conclusion, it was confirmed that the compositions of Examples 1 to 8, which were selectively mixed with aloe vera, green tea powder, and vitamin C as L-type ascorbic acid, had a significantly better reducing effect than those of Comparative Examples 1 and 2.

From the above results, it was confirmed that the composition according to the present invention was very effective for a person with relatively dark diffuse pigmentation of the skin, and that the effect was superior to that of a conventional acetic acid alone or a composition containing vitamin C. . Examples 1-8 and Comparative Examples 1-6 in the case of an image melanogenic pigment colony. Composition ratios as shown in Table 4 below: 20 wt% petrolatum, 0.1 wt% vitamin C (as L-ascorbic acid), 10 wt% sodium lauryl sulfate, 4.5 and 9.0 wt% acetic acid, 5 wt% aquapores After adding saline to the mixture, aloe vera and green tea powder according to the present invention were added to the mixture and dissolved at room temperature. Subsequently, a saline solution in which carboxymethyl cellulose was dissolved was mixed to 100 wt% to prepare a cream. The time taken for removing or removing the melanin colony of the composition was measured in the following Test Examples 3 and 4 It was carried out in the same manner as shown, the results are shown in Table 5 and Table 6.

Test Example 3.

Twenty females and ten males with relatively vulcanized melanin pigmentation on the back, cuffs and facial skin were selected as the test subjects and tested for the creamy products of Table 2. Before starting the test, four types of examples were applied by selecting at least 10 sites per person on the back, the cuff or the face part as the frostbite cream. After dripping into colonies once, they were washed with saline after 10 minutes and observed after 7 days on average, and the removal effect according to self-evaluation was recorded on the last day.

Test Example 4.

Twenty females and ten males with relatively vulcanized melanin pigmentation on the back, cuffs and facial skin were selected as subjects and tested against the cream product of Table 2. The results obtained by selecting at least ten sites per person on the back, wrist, or face and applying four types of examples in a single step. On the last day, the mean time to removal and normal recovery following self-assessment or direct observation was recorded. However, Comparative Examples 4 and 5 show the results obtained by daily treatment.

The composition of Examples 1 to 8 containing aloe vera and green tea powder according to the composition of Table 4 is superior to the composition of Comparative Examples 1 to 5 in the removal of pigment colonies, and as shown in Table 6 In the period of recovery, the recovery was remarkably faster than 7 to 8 days compared to 11 to 15 days using the comparative example and the laser, and as shown in FIGS. Appeared to be excellent.

In addition, the acidity of the present composition was found to be 3.5 or more as shown in the following results (Table 7) was confirmed to be suitable for cosmetic standards.

As described above, the composition according to the present invention has a diffuse deposition (Table 2 and Table 3, FIG. 1 and FIG. 2) and vulcanized melanin colonies (Table 5 and Table) as in the case where the melanin colonies are formed thinly from the skin surface. 6, 3 and 4) has a remarkable effect in all the people showing, and also a significant shortening in the period to the normal recovery than in the case of laser treatment and this effect is a technique that was not seen in the prior art, The skin beautifying cleansing composition is expected to contribute to the technical development in the future in the future, and the composition according to the present invention is more effective than the general laser treatment (FIG. 5) in terms of reducing or removing pigmentation and wound recovery. As it is superior, it is expected to contribute to national health.

Claims (9)

A pharmaceutically acceptable excipient is prepared by using any one or more organic acids selected from acetic acid, butyric acid, pyrvic acid or mono, di, trichloroacetic acid (TCA), or salts thereof or derivatives thereof, as well as aloe vera and green tea powder. A composition of the skin cleansing agent for the purpose of alleviating melanin pigmentation which contains. The composition of the skin cleansing agent according to claim 1, wherein acetic acid is used as the organic acid. The composition of the skin-cleaning cleaner for the purpose of alleviating melanin pigmentation according to claim 1, comprising L-ascorbic acid as a pharmaceutically acceptable excipient. The skin cleansing agent of claim 1 comprising 0.45 to 9.0% by weight of an organic acid, 5.0 to 15.0% by weight of aloe vera and 2.5 to 10.0% by weight of green tea powder. Composition. The skin cleansing agent of claim 4, wherein the organic acid comprises 0.45 to 0.9% by weight of acetic acid, 5.0 to 10.0% by weight of aloe vera, and 2.5 to 5.0% by weight of green tea powder. Composition. The skin cleansing agent for the purpose of reducing melanin pigmentation according to claim 4, comprising 4.5 to 9.0 wt% of acetic acid, 5.0 to 15.0 wt% of aloe vera, and 2.5 to 10.0 wt% of green tea powder. Composition. The skin beautifying cleanser according to claim 4, wherein the aloe vera and green tea powder have a mixing ratio of 1: 1 to 1: 2. The composition of the skin cleansing agent according to any one of claims 1 to 7, for the purpose of reducing melanin pigmentation in creams, gels, pastes or ointments. The composition of the skin cleansing agent according to any one of claims 1 to 7, for the purpose of alleviating melanin pigmentation in the form of a poultice agent or a film adhered form.