KR100927024B1 - 시스-ｆｔｃ의 다형 및 기타 결정형 - Google Patents

시스-ｆｔｃ의 다형 및 기타 결정형

Info

Publication number
KR100927024B1
KR100927024B1 KR1020087016003A KR20087016003A KR100927024B1 KR 100927024 B1 KR100927024 B1 KR 100927024B1 KR 1020087016003 A KR1020087016003 A KR 1020087016003A KR 20087016003 A KR20087016003 A KR 20087016003A KR 100927024 B1 KR100927024 B1 KR 100927024B1
Authority
KR
South Korea
Prior art keywords
ftc
cis
forms
amorphous
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087016003A
Other languages
English (en)
Korean (ko)
Other versions
KR20080065317A (ko
Inventor
케니스 알. 페어스
드발리나 로
유에롱 후
Original Assignee
아보트 래버러토리즈
길리애드 사이언시즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아보트 래버러토리즈, 길리애드 사이언시즈, 인코포레이티드 filed Critical 아보트 래버러토리즈
Publication of KR20080065317A publication Critical patent/KR20080065317A/ko
Application granted granted Critical
Publication of KR100927024B1 publication Critical patent/KR100927024B1/ko
Assigned to 애브비 인코포레이티드 reassignment 애브비 인코포레이티드 권리지분의 전부이전등록 Assignors: 아보트 래버러토리즈
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020087016003A 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형 Expired - Fee Related KR100927024B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27256001P 2001-03-01 2001-03-01
US60/272,560 2001-03-01
US30960501P 2001-08-02 2001-08-02
US60/309,605 2001-08-02
PCT/US2002/006184 WO2002070518A1 (en) 2001-03-01 2002-03-01 Polymorphic and other crystalline forms of cis-ftc

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7011355A Division KR20040002871A (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형

Publications (2)

Publication Number Publication Date
KR20080065317A KR20080065317A (ko) 2008-07-11
KR100927024B1 true KR100927024B1 (ko) 2009-11-17

Family

ID=26955597

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020087016003A Expired - Fee Related KR100927024B1 (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형
KR10-2003-7011355A Ceased KR20040002871A (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형
KR1020107016624A Expired - Fee Related KR101150250B1 (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형
KR1020087016002A Expired - Fee Related KR101015510B1 (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR10-2003-7011355A Ceased KR20040002871A (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형
KR1020107016624A Expired - Fee Related KR101150250B1 (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형
KR1020087016002A Expired - Fee Related KR101015510B1 (ko) 2001-03-01 2002-03-01 시스-ｆｔｃ의 다형 및 기타 결정형

Country Status (14)

Country Link
US (3) US6723728B2 (https=)
EP (3) EP1389207B1 (https=)
JP (4) JP5105689B2 (https=)
KR (4) KR100927024B1 (https=)
CN (4) CN102942563A (https=)
AT (2) ATE312097T1 (https=)
AU (1) AU2002335489B2 (https=)
CA (4) CA2788498C (https=)
CY (2) CY1107983T1 (https=)
DE (2) DE60224592T2 (https=)
DK (2) DK1389207T3 (https=)
ES (3) ES2537007T3 (https=)
PT (2) PT1574512E (https=)
WO (1) WO2002070518A1 (https=)

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CN102942563A (zh) * 2001-03-01 2013-02-27 基利得科学公司 顺-ftc的多晶型物及其它晶型
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
DK1583542T3 (da) 2003-01-14 2008-09-22 Gilead Sciences Inc Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
US6943249B2 (en) * 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
WO2009005338A2 (en) * 2007-07-05 2009-01-08 Ultimorphix Technologies B.V. Solid forms ult-i, ult-2 and ult-3 of emtricitabine
EP2350065A1 (en) 2008-11-12 2011-08-03 Lupin Ltd. A novel polymorph of emtricitabine and a process for preparing of the same
EP2454244B1 (en) 2009-07-15 2013-06-26 Lupin Limited An improved process for preparation of efavirenz

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US5210085A (en) * 1990-02-01 1993-05-11 Emory University Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds

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Non-Patent Citations (1)

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Remington: The Science and Practice of Pharmacy, 20th edition, 2000, 제657면, "Effect of the crystalline state of the drug on dissolution", published by Lippincott Williams & Wilkins, 2000*

Also Published As

Publication number Publication date
ATE312097T1 (de) 2005-12-15
EP1903041B1 (en) 2015-02-18
CN102911166A (zh) 2013-02-06
JP2004530660A (ja) 2004-10-07
KR101015510B1 (ko) 2011-02-16
ES2537007T3 (es) 2015-06-01
JP5105689B2 (ja) 2012-12-26
US20050026934A1 (en) 2005-02-03
KR20080065316A (ko) 2008-07-11
KR20100091265A (ko) 2010-08-18
JP2015028045A (ja) 2015-02-12
DE60207850D1 (de) 2006-01-12
US7544692B2 (en) 2009-06-09
EP1389207A1 (en) 2004-02-18
PT1574512E (pt) 2008-03-05
AU2002335489B2 (en) 2008-06-05
CA2439831C (en) 2010-01-12
CN102911165A (zh) 2013-02-06
EP1574512B1 (en) 2008-01-09
US20030060645A1 (en) 2003-03-27
CA2788498C (en) 2016-02-16
CY1107983T1 (el) 2013-09-04
CN102911166B (zh) 2016-08-17
WO2002070518A1 (en) 2002-09-12
CA2439831A1 (en) 2002-09-12
US8637535B2 (en) 2014-01-28
JP2009197005A (ja) 2009-09-03
CN102911165B (zh) 2016-08-17
CN102942563A (zh) 2013-02-27
EP1903041A2 (en) 2008-03-26
JP2013040192A (ja) 2013-02-28
KR20040002871A (ko) 2004-01-07
EP1574512A1 (en) 2005-09-14
PT1903041E (pt) 2015-06-23
CY1107913T1 (el) 2013-09-04
DE60224592D1 (de) 2008-02-21
ES2253544T3 (es) 2006-06-01
DK1574512T3 (da) 2008-03-03
KR20080065317A (ko) 2008-07-11
CN1503796A (zh) 2004-06-09
CA2690137C (en) 2012-11-13
US20090306114A1 (en) 2009-12-10
CA2867970A1 (en) 2002-09-12
DK1389207T3 (da) 2006-04-18
DE60207850T2 (de) 2006-08-10
ES2299950T3 (es) 2008-06-01
EP1903041A3 (en) 2008-04-23
DE60224592T2 (de) 2009-01-29
KR101150250B1 (ko) 2012-06-12
ATE383355T1 (de) 2008-01-15
CN1503796B (zh) 2012-07-04
EP1389207B1 (en) 2005-12-07
CA2788498A1 (en) 2002-09-12
CA2690137A1 (en) 2002-09-12
US6723728B2 (en) 2004-04-20

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