KR100854788B1 - 락토페록시다제의 제조 방법 - Google Patents
락토페록시다제의 제조 방법 Download PDFInfo
- Publication number
- KR100854788B1 KR100854788B1 KR1020067016075A KR20067016075A KR100854788B1 KR 100854788 B1 KR100854788 B1 KR 100854788B1 KR 1020067016075 A KR1020067016075 A KR 1020067016075A KR 20067016075 A KR20067016075 A KR 20067016075A KR 100854788 B1 KR100854788 B1 KR 100854788B1
- Authority
- KR
- South Korea
- Prior art keywords
- lactoperoxidase
- cation exchanger
- manufacturing
- solid
- eluate
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/16—Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/07—Processes using organic exchangers in the weakly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/50—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents
- B01J49/53—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents for cationic exchangers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Water Supply & Treatment (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Description
시료 | 단백질 함량(%) | 비활성(unit/mg) |
시료 1 | 3.30 | 0.2 |
시료 2 | 0.26 | 132.5 |
시료 3 | 1.64 | 220.3 |
시료 4 | 92.30 | 224.4 |
Claims (27)
- (1) 이온교환기로서 약산성기를 갖는 양이온 교환체에 유원료(milk material)를 접촉시켜서 흡착 처리하는 공정, (2) 상기 흡착 처리 후의 양이온 교환체를 세정 처리하는 공정, (3) 상기 세정 처리 후의 양이온 교환체에 락토페록시다제(lactoperoxidase)를 용출시키는 용출 용매를 접촉시켜, 이 용출 용매 중에 락토페록시다제가 용출된 용출액을 얻는 공정, (4) 상기 용출액을 한외여과막으로 농축된 용출액 중의 단백질 함량이 0.9∼15%가 되도록 농축함으로써 이 농축된 용출액 중에 불순물의 침전을 생성시키는 공정, 및 (5) 상기 농축된 용출액으로부터 침전을 제거하여 락토페록시다제 용액을 얻는 공정을 포함하는 락토페록시다제의 제조 방법.
- 제1항에 있어서,상기 양이온 교환체에 있어서의 락토페린 흡착능이 85mg/10ml 이상이고 100mg/10ml 이하인 락토페록시다제의 제조 방법.
- 제1항에 있어서,상기 이온교환기가 카르복시메틸기인 락토페록시다제의 제조 방법.
- 제2항에 있어서,상기 이온교환기가 카르복시메틸기인 락토페록시다제의 제조 방법.
- 삭제
- 삭제
- 삭제
- 제1항에 있어서,상기 (3) 공정에서 사용하는 용출 용매의 이온 강도가 0.07∼0.3인 락토페록시다제의 제조 방법.
- 제2항에 있어서,상기 (3) 공정에서 사용하는 용출 용매의 이온 강도가 0.07∼0.3인 락토페록시다제의 제조 방법.
- 제3항에 있어서,상기 (3) 공정에서 사용하는 용출 용매의 이온 강도가 0.07∼0.3인 락토페록시다제의 제조 방법.
- 삭제
- 제8항에 있어서,상기 (3) 공정에서 사용하는 용출 용매가 염화나트륨, 염화칼륨, 염화칼슘, 및 염화마그네슘으로 이루어진 염류 군으로부터 선택되는 적어도 일종을 포함하는 수용액인 락토페록시다제의 제조 방법.
- 제9항에 있어서,상기 (3) 공정에서 사용하는 용출 용매가 염화나트륨, 염화칼륨, 염화칼슘, 및 염화마그네슘으로 이루어진 염류 군으로부터 선택되는 적어도 일종을 포함하는 수용액인 락토페록시다제의 제조 방법.
- 제10항에 있어서,상기 (3) 공정에서 사용하는 용출 용매가 염화나트륨, 염화칼륨, 염화칼슘, 및 염화마그네슘으로 이루어진 염류 군으로부터 선택되는 적어도 일종을 포함하는 수용액인 락토페록시다제의 제조 방법.
- 삭제
- 제1항에 있어서,상기 (5) 공정에서 얻어지는 락도페록시다제 용액의 용매를 제거함으로써 고체상의 락토페록시다제를 얻는 공정을 갖는 락토페록시다제의 제조 방법.
- 제2항에 있어서,상기 (5) 공정에서 얻어지는 락도페록시다제 용액의 용매를 제거함으로써 고체상의 락토페록시다제를 얻는 공정을 갖는 락토페록시다제의 제조 방법.
- 제3항에 있어서,상기 (5) 공정에서 얻어지는 락도페록시다제 용액의 용매를 제거함으로써 고체상의 락토페록시다제를 얻는 공정을 갖는 락토페록시다제의 제조 방법.
- 삭제
- 제8항에 있어서,상기 (5) 공정에서 얻어지는 락도페록시다제 용액의 용매를 제거함으로써 고체상의 락토페록시다제를 얻는 공정을 갖는 락토페록시다제의 제조 방법.
- 제12항에 있어서,상기 (5) 공정에서 얻어지는 락도페록시다제 용액의 용매를 제거함으로써 고체상의 락토페록시다제를 얻는 공정을 갖는 락토페록시다제의 제조 방법.
- 제16항에 있어서,고체상의 락토페록시다제의 순도가 80~100%인 락토페록시다제의 제조 방법.
- 제17항에 있어서,고체상의 락토페록시다제의 순도가 80~100%인 락토페록시다제의 제조 방법.
- 제18항에 있어서,고체상의 락토페록시다제의 순도가 80~100%인 락토페록시다제의 제조 방법.
- 삭제
- 제20항에 있어서,고체상의 락토페록시다제의 순도가 80~100%인 락토페록시다제의 제조 방법.
- 제21항에 있어서,고체상의 락토페록시다제의 순도가 80~100%인 락토페록시다제의 제조 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004039704 | 2004-02-17 | ||
JPJP-P-2004-00039704 | 2004-02-17 |
Publications (2)
Publication Number | Publication Date |
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KR20060113769A KR20060113769A (ko) | 2006-11-02 |
KR100854788B1 true KR100854788B1 (ko) | 2008-08-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020067016075A KR100854788B1 (ko) | 2004-02-17 | 2005-02-08 | 락토페록시다제의 제조 방법 |
Country Status (11)
Country | Link |
---|---|
US (1) | US7932069B2 (ko) |
EP (1) | EP1717311B1 (ko) |
JP (1) | JP3946747B2 (ko) |
KR (1) | KR100854788B1 (ko) |
CN (1) | CN100480378C (ko) |
AU (1) | AU2005212069B2 (ko) |
CA (1) | CA2553733C (ko) |
DK (1) | DK1717311T3 (ko) |
ES (1) | ES2395937T3 (ko) |
NZ (1) | NZ548457A (ko) |
WO (1) | WO2005078078A1 (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008105113A1 (ja) | 2007-02-28 | 2008-09-04 | Morinaga Milk Industry Co., Ltd. | 口腔内用殺菌剤、及び該殺菌剤を含有する食品添加剤 |
US9055752B2 (en) | 2008-11-06 | 2015-06-16 | Intercontinental Great Brands Llc | Shelf-stable concentrated dairy liquids and methods of forming thereof |
UA112972C2 (uk) | 2010-09-08 | 2016-11-25 | Інтерконтінентал Грейт Брендс ЛЛС | Рідкий молочний концентрат з високим вмістом сухих речовин |
CZ2013885A3 (cs) | 2013-11-15 | 2015-08-19 | Univerzita PalackĂ©ho | Způsob separace syrovátkových proteinů z mléčného média a zařízení k provádění tohoto způsobu |
US11109604B2 (en) | 2019-05-09 | 2021-09-07 | Memtec LLC | Dairy processing systems and methods |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516675A (en) * | 1992-01-29 | 1996-05-14 | Snow Brand Milk Products, Co., Ltd. | Separation of lactoperoxidase, secretory component and lactoferrin from milk or whey with a cation exchange resin |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
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BE901672A (fr) * | 1985-02-07 | 1985-08-07 | Oleofina Sa | Procede de purification de proteines du lait et de ses derives. |
IE61701B1 (en) * | 1986-07-17 | 1994-11-30 | Morinaga Milk Industry Co Ltd | Process for producing bovine lactoferrin in high purity |
FR2616628B1 (fr) | 1987-06-19 | 1989-09-29 | Entremont Sa | Procede pour extraire des proteines du lactoserum par adsorption et elution |
SE458818B (sv) | 1987-11-27 | 1989-05-16 | Svenska Mejeriernas Riksforeni | Foerfarande foer utvinning av rena fraktioner av laktoperoxidas och laktoferrin ur mjoelkserum |
JP2686831B2 (ja) | 1989-09-22 | 1997-12-08 | 雪印乳業株式会社 | 鉄結合性蛋白質を分離、精製し、採取する方法 |
GB9015910D0 (en) * | 1990-07-19 | 1990-09-05 | Univ Bruxelles | Novel use |
ATE148631T1 (de) | 1990-11-13 | 1997-02-15 | Santen Pharmaceutical Co Ltd | Therapeutische agens bei hornhautverletzungen |
JP3103615B2 (ja) | 1991-05-13 | 2000-10-30 | 株式会社イムノ・ジャパン | 養殖水生動物の配合飼料に添加される病原菌感染予防及び治療剤 |
NL9101032A (nl) | 1991-06-14 | 1993-01-04 | Joyvalle Nv | Werkwijze voor het isoleren van eiwitten uit melk en werkwijze voor het verwerken van melk. |
JP3103167B2 (ja) | 1991-10-30 | 2000-10-23 | 雪印乳業株式会社 | 老化防止剤 |
NZ249235A (en) * | 1992-01-15 | 1995-12-21 | Campina Melkunie Bv | Isolating lactoperoxidase or lactoferrin from milk and/or milk derivatives |
JP2985158B2 (ja) | 1992-01-24 | 1999-11-29 | 雪印乳業株式会社 | 活性の高いラクテニン画分の回収方法 |
DK114392D0 (da) * | 1992-09-17 | 1992-09-17 | Kem En Tec As | Isolering af biomolekyler |
SE506529C2 (sv) * | 1996-01-23 | 1997-12-22 | Semper Ab | Användning av ett laktoperoxidassystem för framställning av ett läkemedel mot Helicobacter pylori |
JPH1013560A (ja) | 1996-06-21 | 1998-01-16 | Matsushita Electric Ind Co Ltd | 設備機器の管理装置 |
NL1005677C2 (nl) | 1997-03-27 | 1998-09-29 | Campina Melkunie Bv | Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan. |
JP3502921B2 (ja) | 1999-10-29 | 2004-03-02 | Tdk株式会社 | 現像ローラー及びその製造方法 |
JP4679687B2 (ja) | 2000-02-16 | 2011-04-27 | 雪印乳業株式会社 | 肝機能改善剤 |
JP4382295B2 (ja) | 2001-02-15 | 2009-12-09 | 森永乳業株式会社 | ウレアーゼ不活性化組成物及び飲食品 |
JP2003246753A (ja) | 2002-02-22 | 2003-09-02 | Morinaga Milk Ind Co Ltd | 腸内フローラ改善剤及び飲食品 |
FR2841747B1 (fr) * | 2002-07-02 | 2004-08-20 | Cie Laitiere Europeenne | Isolat de proteines de lait et procede pour sa preparation |
JP2005202098A (ja) | 2004-01-15 | 2005-07-28 | Fuji Photo Film Co Ltd | フイルム装填装置 |
-
2005
- 2005-02-08 ES ES05710256T patent/ES2395937T3/es active Active
- 2005-02-08 DK DK05710256.8T patent/DK1717311T3/da active
- 2005-02-08 JP JP2005518040A patent/JP3946747B2/ja active Active
- 2005-02-08 CA CA2553733A patent/CA2553733C/en active Active
- 2005-02-08 CN CNB2005800049820A patent/CN100480378C/zh not_active Expired - Fee Related
- 2005-02-08 AU AU2005212069A patent/AU2005212069B2/en active Active
- 2005-02-08 EP EP05710256A patent/EP1717311B1/en active Active
- 2005-02-08 WO PCT/JP2005/002356 patent/WO2005078078A1/ja not_active Application Discontinuation
- 2005-02-08 KR KR1020067016075A patent/KR100854788B1/ko active IP Right Grant
- 2005-02-08 NZ NZ548457A patent/NZ548457A/en unknown
- 2005-02-08 US US10/597,347 patent/US7932069B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516675A (en) * | 1992-01-29 | 1996-05-14 | Snow Brand Milk Products, Co., Ltd. | Separation of lactoperoxidase, secretory component and lactoferrin from milk or whey with a cation exchange resin |
Also Published As
Publication number | Publication date |
---|---|
US7932069B2 (en) | 2011-04-26 |
NZ548457A (en) | 2008-08-29 |
AU2005212069B2 (en) | 2008-01-24 |
EP1717311B1 (en) | 2012-09-19 |
CA2553733A1 (en) | 2005-08-25 |
CN1918289A (zh) | 2007-02-21 |
WO2005078078A1 (ja) | 2005-08-25 |
EP1717311A4 (en) | 2007-03-14 |
DK1717311T3 (da) | 2013-01-14 |
AU2005212069A1 (en) | 2005-08-25 |
CA2553733C (en) | 2011-02-22 |
CN100480378C (zh) | 2009-04-22 |
US20080227171A1 (en) | 2008-09-18 |
JPWO2005078078A1 (ja) | 2007-10-18 |
EP1717311A1 (en) | 2006-11-02 |
ES2395937T3 (es) | 2013-02-18 |
JP3946747B2 (ja) | 2007-07-18 |
KR20060113769A (ko) | 2006-11-02 |
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