KR100841877B1 - 국소적으로 가용화 된 난용성 약물의 제어 방출형 제제조성물 및 그의 제조 방법 - Google Patents
국소적으로 가용화 된 난용성 약물의 제어 방출형 제제조성물 및 그의 제조 방법 Download PDFInfo
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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Abstract
Description
성분명 | 중량 (g) | ||||
실시예 1 | 실시예 2 | 실시예 3 | 비교예 1 | 비교예 2 | |
펠로디핀 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
카보폴 | 3.5 | 4.5 | 5.5 | 20.0 | - |
폴록사머 | 16.5 | 15.5 | 14.5 | - | 20.0 |
성분명 | 중량 (g) | |
실시예 4 | 실시예 5 | |
펠로디핀 | 0.5 | 0.5 |
카보폴 | 3.5 | 3.5 |
폴록사머 | 10.5 | 10.5 |
L-HPC | 6.0 | - |
미결정셀룰로오스 | - | 6.0 |
성분명 | 중량 (g) | |
실시예 9 | 실시예 10 | |
펠로디핀 | 0.5 | 0.5 |
카보폴 | 1.0 | 1.0 |
폴록사머 | 14.0 | 14.0 |
미결정셀룰로오스 | 1.0 | - |
락토오스 | 4.0 | - |
Cellactose® | - | 5.0 |
Claims (8)
- 삭제
- 삭제
- 삭제
- 삭제
- 난용성약물; 가용화제로 폴리에칠렌옥사이드와 폴리프로필렌옥사이드의 공중합체(상품명:폴록사머); 폴리아크릴산유도체(상품명:카보폴), 히드록시프로필셀룰로오스, 히드록시프로필메틸셀룰로오스의 셀룰로스유도체, 메타크릴산계고분자(상품명:유드라짓 알엘), 폴리비닐아세테이트(상품명:콜리돈 에스알)와 폴리비닐피롤리돈의 혼합물, 키토산, 에텔셀룰로스유도체(상품명: 에토셀)중에서 선택되는 1종 이상의 서방성 기제; 및 약제학적으로 허용되는 부형제를 혼합하여 직타법으로 타정하여 난용성 약물의 제어 방출형 정제제제를 제조하는 방법.
- 제5항에 있어서, 난용성 약물은 폴록사머의 임계 미셀농도 이상에서 용해도가 4배 이상 증가하는 약물인 것을 특징으로 하는 난용성 약물의 제어 방출형 정제제제를 제조하는 방법.
- 제5항에 있어서, 난용성 약물은 펠로디핀, 니페디핀, 암로디핀의 디히드로피리딘 유도체 또는 그의 약제학적으로 사용가능한 그 염인 것을 특징으로 하는 난용성 약물의 제어 방출형 정제제제를 제조하는 방법.
- 삭제
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KR1020060083253A KR100841877B1 (ko) | 2006-08-31 | 2006-08-31 | 국소적으로 가용화 된 난용성 약물의 제어 방출형 제제조성물 및 그의 제조 방법 |
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KR1020060083253A KR100841877B1 (ko) | 2006-08-31 | 2006-08-31 | 국소적으로 가용화 된 난용성 약물의 제어 방출형 제제조성물 및 그의 제조 방법 |
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KR20080020165A KR20080020165A (ko) | 2008-03-05 |
KR100841877B1 true KR100841877B1 (ko) | 2008-06-27 |
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CN102302469B (zh) * | 2011-07-13 | 2016-01-06 | 合肥华方医药科技有限公司 | 非洛地平双层渗透泵控释片的制备方法 |
CN115251049A (zh) * | 2022-07-29 | 2022-11-01 | 浙江工业大学 | 一种农药增溶载体及其制备方法与应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010078703A (ko) * | 1999-07-20 | 2001-08-21 | 다비드 에 질레스 | 신규 제약 제제 |
US20040115134A1 (en) | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
KR20060043898A (ko) * | 2004-11-10 | 2006-05-16 | 한국유나이티드제약 주식회사 | 미분화된 펠로디핀 함유 지속 방출성 제제 |
KR100617902B1 (ko) | 2004-05-24 | 2006-08-30 | 충남대학교산학협력단 | 초임계 유체공정을 이용한 난용성 약물인 펠로디핀고체분산체와 이를 포함하는 서방성 제제의 제조방법 |
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- 2006-08-31 KR KR1020060083253A patent/KR100841877B1/ko active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040115134A1 (en) | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
KR20010078703A (ko) * | 1999-07-20 | 2001-08-21 | 다비드 에 질레스 | 신규 제약 제제 |
KR100617902B1 (ko) | 2004-05-24 | 2006-08-30 | 충남대학교산학협력단 | 초임계 유체공정을 이용한 난용성 약물인 펠로디핀고체분산체와 이를 포함하는 서방성 제제의 제조방법 |
KR20060043898A (ko) * | 2004-11-10 | 2006-05-16 | 한국유나이티드제약 주식회사 | 미분화된 펠로디핀 함유 지속 방출성 제제 |
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