KR100828807B1 - 새로운 용도의 덱스트란 설페이트 - Google Patents
새로운 용도의 덱스트란 설페이트 Download PDFInfo
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- KR100828807B1 KR100828807B1 KR1020057009717A KR20057009717A KR100828807B1 KR 100828807 B1 KR100828807 B1 KR 100828807B1 KR 1020057009717 A KR1020057009717 A KR 1020057009717A KR 20057009717 A KR20057009717 A KR 20057009717A KR 100828807 B1 KR100828807 B1 KR 100828807B1
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- dextran sulfate
- blood
- cell
- ibmir
- lmw
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Abstract
Description
LMW-DS없이 배양된 API | LMW-DS (0.01mg/ml)로 배양된 API | LMW-DS (0.1mg/ml)로 배양된 API | LMW-DS (1 mg/ml)로 배양된 API | |
생존율(% IEQ) | 57.0±5.2 | 43.6±6.7 | 58.4±4.3 | 68.9±2.6 |
SGS 시험에서의 자극 지수 | 1.77±0.17 | 2.26±0.51 | 3.22±0.89 | 1.42±0.35 |
ADP/ATP 비율 | 0.11±0.03 | 0.08±0.03 | 0.10±0.03 | 0.11±0.01 |
인슐린/DNA 비율(pmol/㎍) | 79.0 ±11.4 | 66.1±5.8 | 69.1±9.6 | 71.6±7.4 |
실험 1 | 실험 2 | 실험 3 | 실험 4 | |
첨가제 없음 | 5.6 | 6.3 | 6.9 | 5.5 |
LMW-DS(0.01mg/ml) | >60 | >60 | >60 | >60 |
LMW-DS(0.1mg/ml) | >60 | >60 | >60 | >60 |
LMW-DS(0.01mg/ml) | 15.8 | 36.9 | 21.0 | 38.3 |
LMW-DS(0.1mg/ml) | >60 | >60 | >60 | >60 |
LMW-DS(0.01mg/ml) | 19.2 | 11.3 | ||
LMW-DS(0.1mg/ml) | 25.2 | 25.8 | ||
LMW-DS(0.01mg/ml) | 19.8 | 13.8 | ||
LMW-DS(0.1mg/ml) | 14.2 | 33.2 |
이식 부위 | 처리 | n | 각각의 이식 생존(일) | 평균 이식 생존(일) |
간 | 식염수 | 6 | 1,1,2,3,6,8 | 3.5±1.2* |
LMW-DS | 5 | 4,6,8,12,14 | 8.8±1.9* | |
신장피막하 | - | 5 | > 56(×5) | > 56* |
Claims (28)
- 즉각적 혈액-매개 염증 반응 (IBMIR)의 치료 약제의 제조를 위한 덱스트란 설페이트.
- 제 1항에 있어서, 상기 IBMIR은 세포 이식물의 외부 수용체로의 이식을 수반하는, 혈액에 대한 세포 이식물의 노출에 의하여 유발되는 것을 특징으로 하는 덱스트란 설페이트.
- 이식된 세포 이식물의 형태학적 파괴의 치료 약제의 제조를 위한 덱스트란 설페이트.
- 제 3항에 있어서, 상기 세포 이식물의 형태학적 파괴는 즉각적 혈액-매개 염증 반응 (IBMIR)으로 인한 것임을 특징으로 하는 덱스트란 설페이트.
- 세포 이식물의 이식 거부의 치료 약제의 제조를 위한 덱스트란 설페이트.
- 제 5항에 있어서, 상기 세포 이식물의 이식 거부는 즉각적 혈액-매개 염증 반응 (IBMIR)으로 인한 것임을 특징으로 하는 덱스트란 설페이트.
- 제 2항 내지 6항 중 어느 한 항에 있어서, 상기 세포 이식물은 수용체 인체로 이식되는 것을 특징으로 하는 덱스트란 설페이트.
- 제 2항 내지 6항 중 어느 한 항에 있어서, 상기 세포 이식물은 다음 목록에서 선택되는 것을 특징으로 하는 덱스트란 설페이트:- 동종이계(allogeneic)의 세포 이식물; 또는- 이종의(xenogeneic) 세포 이식물.
- 제 2항 내지 6항 중 어느 한 항에 있어서, 상기 세포 이식물은 다음 목록에서 선택되는 것을 특징으로 하는 덱스트란 설페이트:각각의 세포;세포의 덩어리; 또는비-혈관 조직.
- 제 2항 내지 6항 중 어느 한 항에 있어서, 상기 세포 이식물은 랑게르한스섬인 것을 특징으로 하는 덱스트란 설페이트.
- 제 1항 내지 6항 중 어느 한 항에 있어서, 상기 덱스트란 설페이트는 20,000 Da 미만의 분자량을 가지는 것을 특징으로 하는 덱스트란 설페이트.
- 제 11항에 있어서, 상기 덱스트란 설페이트는 10,000 Da 미만의 분자량을 가지는 것을 특징으로 하는 덱스트란 설페이트.
- 제 1항 내지 6항 중 어느 한 항에 있어서, 상기 덱스트란 설페이트는 10-25 %의 황 함량을 가지는 것을 특징으로 하는 덱스트란 설페이트.
- 제 13항에 있어서, 상기 덱스트란 설페이트는 15-20 %의 황 함량을 가지는 것을 특징으로 하는 덱스트란 설페이트.
- 즉각적 혈액-매개 염증 반응(IBMIR)의 치료가 필요한 인간 이외의 포유류에게 덱스트란 설페이트의 치료적 유효량을 투여하는 단계를 포함하는 즉각적 혈액-매개 염증 반응(IBMIR)의 치료 방법.
- 제 15항에 있어서, 상기 IBMIR은 상기 인간 이외의 포유류의 수용체 신체 내부로의 세포 이식물의 이식을 수반하는 외부 혈액에 대한 세포 이식물의 노출에 의해 유발되는 것을 특징으로 하는 즉각적 혈액-매개 염증 반응(IBMIR)의 치료 방법.
- 즉각적 혈액-매개 염증 반응의 치료가 필요한 인간 이외의 포유류에게 덱스트란 설페이트의 치료적 유효량을 투여하는 단계를 포함하는, 세포 이식물의 이식 거부의 치료 방법.
- 제 17항에 있어서, 상기 세포 이식물의 이식 거부는 즉각적 혈액-매개 염증 반응 (IBMIR)으로 인한 것임을 특징으로 하는, 세포 이식물의 이식 거부의 치료 방법.
- 이식된 세포 이식물의 형태학적 파괴의 치료가 필요한 인간 이외의 포유류에게 덱스트란 설페이트의 치료적 유효량을 투여하는 단계를 포함하는, 이식된 세포 이식물의 형태학적 파괴의 치료 방법.
- 제 19항에 있어서, 상기 세포 이식물의 형태학적 파괴는 즉각적 혈액-매개 염증 반응 (IBMIR)으로 인한 것임을 특징으로 하는, 이식된 세포 이식물의 형태학적 파괴의 치료 방법.
- 제 15항 내지 20항 중 어느 한 항에 있어서, 상기 덱스트란 설페이트의 치료적 유효량은 상기 인간 이외의 포유류의 혈액 중에 5 mg/ml 미만의 덱스트란 설페이트 농도로 결과되는 것을 특징으로 하는 치료 방법.
- 제 21항에 있어서, 상기 덱스트란 설페이트의 치료적 유효량은 상기 인간 이외의 포유류의 혈액 중에 0.01-1 mg/ml 미만의 덱스트란 설페이트 농도로 결과되는 것을 특징으로 하는 치료 방법.
- 제 22항에 있어서, 상기 덱스트란 설페이트의 치료적 유효량은 상기 인간 이외의 포유류의 혈액 중에 0.05-0.2 mg/ml 미만의 덱스트란 설페이트 농도로 결과되는 것을 특징으로 하는 치료 방법.
- 제 16항, 17항 또는 19항 중 어느 한 항에 있어서, 상기 덱스트란 설페이트는 상기 덱스트란 설페이트에 용해된 상기 세포 이식물을 주사함으로써 투여되는 것을 특징으로 하는 치료 방법.
- 제 15항 내지 20항 중 어느 한 항에 있어서, 상기 덱스트란 설페이트는 20,000 Da 미만의 분자량을 가지는 것을 특징으로 하는 치료 방법.
- 제 25항에 있어서, 상기 덱스트란 설페이트는 10,000 Da 미만의 분자량을 가지는 것을 특징으로 하는 치료 방법.
- 제 15항 내지 20항 중 어느 한 항에 있어서, 상기 덱스트란 설페이트는 10-25 %의 황 함량을 가지는 것을 특징으로 하는 치료 방법.
- 제 27항에 있어서, 상기 덱스트란 설페이트는 15-20 %의 황 함량을 가지는 것을 특징으로 하는 치료 방법.
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CA2666840C (en) * | 2006-10-20 | 2015-07-14 | The Australian National University | Inhibition of degradation of extracellular matrix |
US20110008343A1 (en) * | 2007-06-08 | 2011-01-13 | Lambris John D | Method Of Reducing Tissue Loss In Pancreatic Islet Cell Transplantation |
CN102917711A (zh) * | 2010-03-12 | 2013-02-06 | 澳大利亚国立大学 | 硫酸乙酰肝素替代疗法 |
WO2012008908A1 (en) * | 2010-07-16 | 2012-01-19 | Tx Medic Ab | Cell therapy |
CN102973592A (zh) * | 2012-11-26 | 2013-03-20 | 合肥博太医药生物技术发展有限公司 | 硫酸葡聚糖在制备治疗糖尿病药物中的应用 |
SE537742C2 (sv) | 2013-05-13 | 2015-10-13 | Tx Medic Ab | Dextransulfat för cellmobilisering |
GB201408233D0 (en) | 2014-05-09 | 2014-06-25 | Austrianova Singapore Pte Ltd | Use of polyanionic composition |
WO2015190989A1 (en) * | 2014-06-12 | 2015-12-17 | Tx Medic Ab | The use of dextran sulfate having an average molecular weight below 10000 da for inducing angiogenisis in a subject |
CN106573012B (zh) | 2014-06-12 | 2020-02-28 | Tx医生公司 | 平均分子量低于10000Da的硫酸葡聚糖用于诱导受试者中的血管新生的用途 |
SE538503C2 (en) | 2014-11-11 | 2016-08-16 | Tx Medic Ab | New dextran sulfate |
SE539575C2 (en) * | 2015-07-30 | 2017-10-17 | Tx Medic Ab | Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis |
CN111263636A (zh) * | 2017-09-08 | 2020-06-09 | Tx医生公司 | 硫酸葡聚糖的新用途 |
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IL88554A0 (en) * | 1988-12-01 | 1989-07-31 | Hadassah Med Org | Compositions containing a compound binding to a heparin receptor |
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