KR100827350B1 - Herbal medicine composition for descending blood sugar - Google Patents

Abstract

An oral herbal medicine composition is provided to reduce stably and continuously the blood sugar of a patient suffering from insulin-dependent diabetes mellitus or noninsulin-dependent diabetes mellitus, and minimize side effects, so that the composition is useful for prevention and treatment of diabetes. An oral composition for prevention and treatment of diabetes comprises 16-20 parts by weight of Paeonia lactiflora PALL., 5-6 parts by weight of Lithospermum erythrorhizon, 1.5-2.1 parts by weight of Mori radicis cortex, 0.7-1.1 parts by weight of Bupleurum falcatum L. and 0.7-1.1 parts by weight of Rehmanniae Radix Preparata, and further comprises 0.15-0.21 parts by weight of an ionic mineral selected from potassium carbonate, calcium carbonate, magnesium oxide, iron citrate, zinc sulfate, manganese sulfate and copper sulfate, wherein the daily dosage of the herbal medicine extracts is 10-2000 mg/kg.

Description

Herbal medicine composition for descending blood sugar

The present invention relates to a hypoglycemic herbal composition.

Diabetes, which is a representative example of a lifestyle-related disease, is a disease that causes acute symptoms due to significant hyperglycemia or ketoacidosis or various chronic and systemic metabolic abnormalities due to persistent hyperglycemic conditions or decreased glucose tolerance. There are genetic factors and factors such as genetic factors and the environment such as diet and exercise, and because they affect each other, various forms of diabetes mellitus and disease progression. The frequency of occurrence is steadily increasing due to various changes, and the number of people is increasing by 500,000 every year, and it is increasing every year by 1 person per 10 people.

Diabetes is divided into Insulin Dependent Diabetes Mellitus (hereinafter referred to as IDDM; Type I Diabetes) and Insulin Dependent Diabetes Mellitus (hereinafter referred to as NIDDM; Type II Diabetes). IDDM is caused by genetic factors, viral infections, and autoimmune infections that destroy pancreatic β-cells. It is acute and occurs in young people under 30 years of age. Most are skinny, lose weight, and are absolutely deficient in insulin. NIDDM is caused by obesity, stress, eating faults, or drugs that antagonize insulin. Chronic, common in adults, and the most common form of diabetes, the pancreatic beta cells have no abnormality, and are caused by obesity or lack of intracellular insulin receptors. It is epidemiologically recognized that there is some degree of genetic predisposition to this type, but there are a number of acquired factors, including eating wrong, lack of exercise, stress, heavy metal contamination, pregnancy, obesity, endocrine disorders, and side effects of drugs.

In the case of IDDM, only insulin has been selected as the most ideal and effective drug to date. However, its duration is short, it does not show permanent action, and it has the disadvantage of being used only as an injection. Even if this is normal, blood sugar drops and symptoms of hypoglycemia appear. In severe cases, if not treated, convulsions, unconsciousness, and brain damage may result in death.

In addition, patients with diabetes may have turbid blood and various incompatibilities that cause complications of various circulatory organs such as arteriosclerosis, heart disease, renal failure, and in severe cases, blood supply to the distal parts of the body is not smooth, resulting in necrosis of terminal tissues. May be

In the case of NIDDM, in addition to insulin, a blood glucose lowering agent is used. Representative oral blood glucose lowering agents used to date include sulfonylurea, metformin, butol, such as tolbutamide, chlorpropamide, and glybenclamide. Biguanid-based drugs such as formin. However, sulfonic uric acid-based drugs cause hepatotoxicity and hypoglycemia, and biguanide-based drugs also have side effects that cause lactic acidosis. Particularly, among the above-mentioned diabetic drugs, tolbutamide is used for the purpose of treating diabetes by controlling blood sugar drop. However, when tolbutamide is used as a diabetic drug, pancreatic cancer, pain, blood stains, etc., may be overdosed. If there is a blind spot that can pose a fatal risk to life when the health of the patient is not good, blood glucose lowering effect appears quickly, but the effect is not persistent. Accordingly, studies on herbal compositions excellent in blood sugar lowering effects while having fewer side effects are being actively conducted.

Conventionally, as a composition for lowering blood sugar using the herbal composition, S. Korean Patent No. 542809 discloses 16 to 24 parts by weight, 32 to 48 parts by weight of lotus root, 32 to 48 parts by weight of sewage, 32 to 48 parts by weight of ginseng 32 To 48 parts by weight, about 32 to 48 parts by weight, 32 to 48 parts by weight, 32 to 48 parts by weight of Macmundong, 32 to 48 parts by weight of cornus oil, 8 to 12 parts by weight of deer antler, 64 to 96 parts by weight of white hair root, 16 to 100 bags Herbal composition for lowering blood sugar, comprising 24 parts by weight, and 16 to 24 parts by weight of bokbunja, and a herbal composition for lowering blood sugar, which is heated to 90 to 100 ° C. and extracted for 2 to 3 hours to produce a herbal composition, It describes a preparation method thereof and a pharmaceutical preparation including the same.

In addition, the Republic of Korea Patent No. 473529 describes a composition for preventing and treating diabetes mellitus containing a pure herbal extract, that is, extracts of hubak, rhubarb and fruit as an active ingredient and excellent antidiabetic activity.

However, the registered patent No. 542809 has many kinds of main drugs to be prepared in the preparation of the herbal composition for lowering blood sugar, and it is difficult to grasp the main action of the drug. Diuretic effect is composed mainly of herbal medicines.

Thus, the present inventors while studying the prevention and treatment of diabetes well occurring in the sun people and Soyangin, herbal compositions prepared by using the cold water of herbal medicines, lichens, lettuce, baekhwi, sage, sulfur, etc. exhibits a blood sugar enhancing effect It was observed that this invention was completed.

An object of the present invention is to provide a blood sugar lowering herbal composition.

In order to achieve the above object, the present invention provides a hypoglycemic herbal composition comprising a mixed extract of cheonhwabun, cheoncho, baekbaekpi, shiho and sukji sulfur.

In addition, the present invention is an herbal medicine used for diuretic action, herbal medicine to help the circulatory system, herbal medicine used to help digestion absorption, herbal medicine used to help immune function, and extracts of herbal medicine used as a protective agent and stabilizer, and ionic It provides a blood sugar-lowering herbal composition further comprising a mineral.

Hereinafter, the present invention will be described in detail.

The present invention provides a blood sugar lowering herbal composition comprising a mixed extract of cheonhwabun, cheonji, baekbaekpi, shiho and sukji sulfur.

In the ideology of oriental medicine, diabetics account for 95% of the heat constitution, sun people and yangyang people, and if you look at Taein people or noise people, it rarely occurs, but the sun people have physiological heat and heat, and Soyang people have heat. On the other hand, it can be said that the recessive constitution, while the cold constitution Taeumin has a cold nature inside and the noise person is a cold constitution because it is cold inside and outside nature.

Diabetes generates heat from root foods such as red peppers, leeks, and radishes, which are recessive foods such as Sunin and Soyangin, which have weak kidney and bladder functions. If luck occurs and the immune function is reduced, heat is generated in the pancreas of the digestive system, and it is known in Korean medicine that an instant blood glucose is exploded. If this phenomenon is prolonged, diabetes may develop. Therefore, the oriental medicine approach to diabetes can prevent the rise of blood sugar as well as the treatment of diabetes by lowering the heat cloud in these sun people and Soyang people.

Herbal medicines that show coldness in oriental medicine include cheonhwabun, jicho, baekbaekpi, siho, sukjihwang and the like.

Cheonhwabun is the root of the sky feather, and is widely used in herbal medicines for thirst, which causes a lot of thirst due to heat damage, dry mouth, dry tongue, stuffy chest and uncomfortable feelings. It is especially effective when your mouth is dry and you eat a lot of water and food.

The grass is weak. It is effective in lowering heat, releasing poison, removing inflammation, and boosting new life.It is effective in various cancers, constipation, liver disease, arteriosclerosis, women's coldness, treat, and menstrual irregularities. It is used as a medicine for cancer in China. Tongue cancer, stomach cancer, thyroid cancer, uterine cancer, skin cancer is known to have a significant effect by taking a combination of tired and crow weight.

Epidermis is a diuretic that treats seawater and asthma caused by waste heat. It is used for acute pyelonephritis and fragile edema. It has a blood pressure-lowering effect and is also used for nosebleeds and keratosis. It is also used for epidemic hepatitis. Pharmacological action is reported by Jinhae, diuresis, lowering blood pressure, sedation, analgesic, fever, jingyeong, antibacterial action.

Shiho is one of the major medicinal crops of perennial herbaceous plants belonging to the mountain family family, and its roots contain pharmacological components such as psychosaponins and sterols, and are used as herbal medicines in Korea, China and Japan. It is known to have pharmacological effects such as anti-inflammatory activity, anti-hepatotoxic activity, analgesic, sedation, and antipyretic effect.

Sukjihwang is the main medicine of Samul-tang (四 物 이며) and is used for symptoms such as heat resistance, dry throat, and thirst caused by the weakness of various chronic diseases. Samultang is widely used for women with excessive bleeding, weakness, and dizziness due to postpartum and menstruation. It has been effective in treating hudam since ancient times, and it was drunk as a tea, and it was used in combination with cough and asthma in Bokryeong (반 夏).

The herbal composition of the present invention may include 16 to 20 parts by weight of the cheonhwa, 5 to 6 parts by weight of the grass, baekbaekpi 1.5 to 2.1 parts by weight, Shiho and Sukji sulfur in 0.7 to 1.1 parts by weight, respectively.

In addition, the present invention is an herbal medicine used for diuretic action, herbal medicine to help the circulatory system, herbal medicine used to help digestion absorption, herbal medicine used to help immune function, and extracts of herbal medicine used as a protective agent and stabilizer, and ionic It provides a blood sugar-lowering herbal composition further comprising a mineral.

The herbal medicine used for the diuretic action may further include taxa, geryeong, bokyeong, keg, Tongcho, bokbokyeong. At this time, the amount of the herbal medicine used for the diuretic action may be added to each of 3 to 4 parts by weight. The herbal medicine used for the diuretic action to discharge the uric acid in the body, to lower the heat floating to the top can help clear the blood circulation.

In addition, the herbal medicine to help the circulatory may include a larvae, joiner, dermis, scabies, sandalwood and the like. At this time, the added amount of the herbal medicine to help the circulator may be 1.5 ~ 2.1 parts by weight of dermis, tofu, joiner, scabies and sandalwood may be added to 0.7 ~ 1.1 parts by weight, respectively. The herbal medicine to help the circulatory system to clear the blood viscosity is increased by the increase in blood sugar level, help the blood circulation can facilitate the cardiac cycle.

In addition, the herbal medicine to assist in digestion and absorption may include malt, new song, cinnamon, grommets, throat and health. At this time, the added amount of the herbal medicine used to help the digestive absorption may be added to 5 to 6 parts by weight of malt and new song, respectively, cinnamon, grommets, throat and health of 1.5 to 2.1 parts by weight. The herbal medicine to help the digestive absorption may promote the digestion and absorption of the cold herbal medicine to increase the efficacy of the cold herbal medicine.

In addition, the herbal medicines used to help the immune function may include daegye, yugeunpi, sanghae, sewage, white porcelain, almonds and the like. At this time, the amount of the herbal medicine used to help the immune function may be added as 5 ~ 6 parts by weight, Yu-Geun Skin, the raw and sewage 1.5 to 2.1 parts by weight, respectively, 0.7 to 1.1 parts by weight of white porcelain and almonds. The herbal medicine used to help the immune function increases the oxygen utilization rate of the cells, can also be used as an antioxidant can help prevent the complications of diabetes.

In addition, the herbal medicines used as the protective agent and stabilizer may include Angelica, Cheongung, Peony, Longan meat, Cornus, Hyunho color, Jinbum, Jujube, Licorice and the like. At this time, the amount of the herbal medicine used as the protective agent and stabilizer may be added to Hyunho color, Jinbeom, longan meat, jujube, cornus oil and licorice 1.5 to 2.1 parts by weight, respectively, Angelica, Cheongung and Peony 0.7 to 1.1 parts by weight. The herbal medicine used as the protective agent and stabilizer is Angelica, Cheongung, Peony, Longan meat, cornus milk, etc. The herbal medicine exhibits a hematopoietic effect. And as a bridge to the modulatory agent, it can smoothly promote metabolism.

In addition, the ionic mineral may be potassium carbonate, calcium carbonate, magnesium oxide, iron citrate, zinc sulfate, manganese sulfate, copper sulfate and the like. In this case, the amount of the ionic mineral added may be added in 0.15 ~ 0.21 parts by weight. The ionic mineral acts as an electrolyte bridge between the minerals in the herbal and the human body as an electrical function, and can increase the efficiency of weakness by quickly showing the weakness with the sympathetic nerve of the human body.

In the most preferred example of the herbal composition for the present invention, the natural ingredients are 16 to 20 parts by weight, the base, malt, grass and new songs are 5 to 6 parts by weight, respectively, Taeksa, ghost, Tongcho, Bokryeong, keg and bokbokyeong each 3 ~ 4 parts by weight, lettuce, euneunpi, sanggi, earth, hyunho color, jinbeom, longan meat, jujube, cinnamon, thick, neck, health, cornus, sewage, dermis and licorice, respectively, 1.5 ~ 2.1 parts by weight, donkey, cheongung, Peony, Sukjihwang, White porcelain, Joiner, Tobacco, Ogapi, Siho, Hangin and Sandalwood are added at 0.7-1.1 parts by weight, respectively, and are purified ionic minerals to enhance the effect. 0.04 to 0.05 parts by weight of calcium, 0.04 to 0.05 parts by weight of magnesium oxide, 0.007 to 0.010 parts by weight of iron citrate, 0.004 to 0.005 parts by weight of zinc sulfate, 0.002 to 0.004 parts by weight of manganese sulfate, and 0.0005 to 0.0007 parts by weight of copper sulfate. .

In addition, the present invention is a herbal medicine used for diuretic action in cheonhwabun, vinegar, baekbaekpi, shiho and sukjihwang, herbal medicine used for circulatory, herbal medicine used for digestive absorption, herbal medicine used to help immune function, and protection and stabilizer Provided is a method for producing a blood sugar lowering herbal composition comprising a mixture of at least one selected from the group consisting of herbal medicines used as a mixture, heating to obtain an extract, and adding ionic minerals.

The cheonhwa flour, vinegar, baekbaekpi, shiho, sujijihwang and the like as cold medicine in herbal medicines, although not particularly limited, can be purchased or cultivated, and the form used is not particularly limited. At this time, the medicinal herbs having coldness is 16 to 20 parts by weight, 5 to 6 parts by weight of grass, baekbaekpi is 1.5 to 2.1 parts by weight, shiho and sujijihwang may be added to 0.7 to 1.1 parts by weight, respectively.

In addition, the herbal medicine used for the diuretic action may be used, such as taxa, seolyeong, bokyeong, keg, Tongcho, bokbokyeong, etc. In this case, the amount of the herbal medicine used for the diuretic action may be added in 3 to 4 parts by weight, respectively.

In addition, the herbal medicines used in the circulator may be headed, soybean, dermis, organo, sandalwood, etc., wherein the amount of the herbal medicines used in the circulator is 1.5 to 2.1 parts by weight of dermis, soybeans, joiner, organza and sandalwood. 0.7 to 1.1 parts by weight may be added.

In addition, the herbal medicine used to help the digestive absorption may be used malt, new song, cinnamon, thick, neck, health, etc. At this time, the amount of the herbal medicine used to help the digestive absorption is malt and new song respectively 5-6 By weight, cinnamon, groceries, throat and health may be added at 1.5 to 2.1 parts by weight, respectively.

In addition, the herbal medicines used to help the immune function may be used, such as Daegye, Yugeunpi, the raw, sewage, white porcelain, algae, etc. At this time, the amount of the herbal medicines used to aid the immune function is 5-6 parts by weight, Yu-Geun-pi, said fresh and sewage may be added at 1.5 to 2.1 parts by weight, respectively, and white to 0.7% by weight.

In addition, the herbal medicine used as the protective agent and stabilizer may be used Angelica, Cheongung, Peony, longan meat, cornus, Hyunho color, Jinbeom, jujube, licorice, etc., wherein the amount of the herbal medicine used as the protective agent and stabilizer is Hyunho color, Jinbeom, Longan meat, jujube, cornus and licorice may be added at 1.5 to 2.1 parts by weight, respectively, and Angelica, Cheongung and Peony at 0.7 to 1.1 parts by weight, respectively.

The medicinal herb used for diarrhea, herbal medicine used for diuretic action, herbal medicine used for circulatory cycle, herbal medicine used for digestive absorption, herbal medicine used for helping immune function, and protective agent and stabilizer Extraction of the herbal medicine can be extracted by a conventional method in the art, preferably mixing the herbal medicine, adding 3 to 4 times water to the total weight of the mixed herbal medicine, and then applying heat to obtain the extract Can be.

In addition, the herbal composition may be further added to the extract in order to enhance human friendliness and blood sugar lowering efficiency of the extract, thereby preparing a herbal composition. The ionic mineral is not particularly limited as long as it is used in the art, and preferably potassium carbonate, calcium carbonate, magnesium oxide, iron citrate, zinc sulfate, manganese sulfate, copper sulfate, or the like can be used. At this time, the amount of the ionic minerals added may be added as 0.15 ~ 0.21 parts by weight.

In addition, the present invention provides a pharmaceutical preparation for lowering blood sugar, which is formulated in a pharmaceutically acceptable method, using a mixed extract of cheonhwa flour, vinegar, baekbaekpi, shiho and sukji sulfur as an active ingredient.

When the herbal composition according to the present invention was treated to 3T3-L1 adipocytes, the glucose uptake of the herbal composition comprising each of cheonhwa flour, lichen, baekbaekpi, shiho and sukji sulfur was shown to be at least 15 ± 0.43 and at most 33 ± 2.1 Herbal medicine composition comprising, cheonhwa flour, vinegar, baekryepi, shiho and sukji sulfur appear from a minimum of 103 ± 1.6 to a maximum of 142 ± 3.4, the herbal composition according to the present invention can be usefully used as a blood sugar lowering composition, In the case of taking insulin-dependent, insulin-independent, and diabetic patients with herbal compositions containing baekbaekpi, shiho, and succinate sulfur as active ingredients, blood glucose levels can be lowered in a shorter period of time than conventional hypoglycemic agents, and thus may be useful for diabetics. Can be.

The method of taking the herbal composition is taken in liquid form, or dried and pulverized extracts added with ionic minerals to the herbal extracts to be taken in powder form, or mixed with white wheat or syrup to the powder form to prepare as a pill You may.

The herbal composition according to the present invention may be prepared by including one or more pharmaceutically acceptable carriers in addition to the above-described active ingredients for administration. Pharmaceutically acceptable carriers may be used in combination with saline, sterile water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol, ethanol and one or more of these components, as necessary, including antioxidants, buffers, Other conventional additives such as bacteriostatic agents can be added. Diluents, dispersants, surfactants, binders and lubricants may also be added in addition to formulate into injectable formulations, pills, capsules, granules or tablets such as aqueous solutions, suspensions, emulsions and the like. Furthermore, it may be preferably formulated according to each disease or component by a suitable method in the art or using a method disclosed in Remington's Pharmaceutical Science (Mack Publishing Company, Easton PA, 18th, 1990).

The herbal composition of the present invention may be administered parenterally (for example, intravenously, subcutaneously, intraperitoneally or topically) or orally, depending on the desired method, and the dosage is based on the weight, age, sex and health of the patient. The range varies depending on the diet, the time of administration, the method of administration, the rate of excretion and the severity of the disease. The daily dosage of the herbal extract according to the present invention is 10 to 2,000 mg / kg, preferably 50 to 500 mg / kg.

As a result of oral administration of the herbal composition of the present invention to mice, 50% lethal dose (LD ₅₀ ) by oral administration toxicity test was determined to be a safe substance of at least 1 g / kg or more.

The herbal composition of the present invention may be used alone or in combination with methods using surgery, hormonal therapy, drug therapy and biological response modifiers for the prevention and treatment of diabetes.

The herbal composition of the present invention may be added to a health food for the purpose of improving diabetes disease. When the herbal composition of the present invention is used as a food additive, the herbal composition may be added as it is or used with other food or food ingredients, and may be appropriately used according to a conventional method. The mixed amount of the active ingredient may be suitably determined depending on the purpose of use (prevention, health or therapeutic treatment). In general, in the manufacture of food or beverage, the herbal extract of the present invention is added in an amount of 0.01 to 10 parts by weight, preferably 0.05 to 1 part by weight based on the raw materials. However, in the case of long-term intake for health and hygiene or health control purposes, the amount may be below the above range, and the active ingredient may be used in an amount above the above range because there is no problem in terms of safety.

There is no particular limitation on the kind of food. Examples of the food to which the substance can be added include dairy products including meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, ice cream, various soups, drinks, tea, and drinks. Alcoholic beverages and vitamin complexes, and includes all of the health foods in the conventional sense.

The healthy beverage herbal composition of the present invention may contain various flavors or natural carbohydrates and the like as an additional component like a normal beverage. The above-mentioned natural carbohydrates are glucose, monosaccharides such as fructose, disaccharides such as maltose and sucrose, and polysaccharides such as dextrin and cyclodextrin, sugar alcohols such as xylitol, sorbitol and erythritol. As the sweetening agent, natural sweetening agents such as tautin and stevia extract, synthetic sweetening agents such as saccharin and aspartame, and the like can be used. The ratio of the natural carbohydrate is generally about 0.01 to 0.04 g, preferably about 0.02 to 0.03 g per 100 ml of the herbal composition of the present invention.

In addition to the above, the herbal composition of the present invention includes various nutrients, vitamins, electrolytes, flavors, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols. And carbonation agents used in carbonated beverages. In addition, the composition of the present invention may contain a flesh for preparing natural fruit juice, fruit juice beverage and vegetable beverage. These components can be used independently or in combination. The proportion of such additives is not critical but is usually selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition of the present invention.

Hereinafter, examples and experimental examples for explaining the present invention in more detail. However, the following Examples and Experimental Examples are only provided to explain the present invention more easily, and the contents of the present invention are not limited thereto.

< Example  1> Preparation of herbal composition 1

16 to 20 parts by weight of cheonhwa, 5 to 6 parts by weight of ground grass, 1.5 to 2.1 parts by weight of baekbaekpi, and 0.7 to 1.1 parts by weight of Siho and Sukji sulfur, and added 3 to 4 times of water to the total weight of herbal medicines. Thereafter, the mixture was heated at 100 ° C. for 2 to 3 hours to obtain an extract, and sterilized to prepare a herbal composition.

< Example  2> Preparation of herbal composition 2

16 ~ 20 parts by weight of Cheonhwa, 5 ~ 6 parts by weight of ground grass, 1.5 ~ 2.1 parts by weight of Sangbaekpi, 0.7 ~ 1.1 parts by weight of Siho and Sukjiwang, 3 ~ 3 each of Taxi, Angel, Tongcho, Bokryeong, Keg, and Bokbokyeong After mixing to 4 parts by weight, water was added 3 to 4 times the total weight of the herbal medicine, and then heated at 100 ℃ for 2 to 3 hours to obtain an extract, sterilized it to prepare a herbal composition.

< Example  3> Preparation of herbal composition 3

16-20 parts by weight of cheonhwa, 5-6 parts by weight of the ground, 1.5 ~ 2.1 parts by weight of baekhwapi and dermis, mixed with 0.7 ~ 1.1 parts by weight of Shiho, Sukjihwang, tofu, Joiner, Ogapi and sandalwood. Water was added 3 to 4 times, and the extract was obtained by heating at 100 ° C. for 2 to 3 hours, and sterilizing the same to prepare a herbal composition.

< Example  4> Preparation of herbal composition 4

16-20 parts by weight of cheonhwa, 5-6 parts by weight of vinegar, malt and new song, 1.5-2.1 parts by weight of baekhyeol, cinnamon, thick pepper, throat and health, and 0.7-1.1 parts by weight of shiho and sujijihwang. Water was added 3 to 4 times the total weight, and then heated at 100 ° C. for 2 to 3 hours to obtain an extract, which was sterilized to prepare a herbal composition.

< Example  5> Preparation of herbal composition 5

16 ~ 20 parts by weight of cheonhwa, 5 ~ 6 parts by weight of ground grass and base, mixed with white and white skin, Yugeunpi, 1.5 ~ 2.1 parts by weight of sesame seeds and sewage, and 0.7 ~ 1.1 parts by weight of Siho, Sukji sulfur, white porcelain and almonds. Water was added 3 to 4 times the total weight of the herbal medicines, and then heated at 100 ° C. for 2 to 3 hours to obtain an extract, which was sterilized to prepare a herbal composition.

< Example  6> Preparation of herbal composition 6

16 ~ 20 parts by weight of cheonhwa, 5 ~ 6 parts by weight of green grass, baekbaekpi, Hyunho color, 1.5 ~ 2.1 parts by weight of jinbeom, longan meat, jujube, cornus and licorice, 0.7 ~ 1.1 parts by weight of shiho, sukjiji, donkey, cheongung and peony The mixture was added to the mixture, and water was added to 3 to 4 times the total weight of the medicinal herb, followed by heating at 100 ° C. for 2 to 3 hours to obtain an extract, which was sterilized to prepare a herbal composition.

< Example  7> Preparation of herbal composition 7

16 ~ 20 parts by weight of hwahwa, 5 ~ 6 parts by weight of maltose, malt, grass, and new song, 3 ~ 4 parts by weight of each of talc, ghost, tongcho, bokyeong, keg, bokbokyeong, baekbaekpi, yugeunpi, sanggi, earth , Calendula, jinbum, longan meat, jujube, cinnamon, thick, neck, health, cornus, sewage, dermis, licorice 1.5 ~ 2.1 parts by weight, donkey, cheonggung, peony, sage, white porcelain, joiner, larva, ogapi, shiho, Alginate, sandalwood each 0.7-1.1 parts by weight, mixed with water 3 to 4 times the total weight of the herbal medicine, and then heated at 100 ℃ for 2-3 hours to obtain an extract, sterilized it to prepare a herbal composition It was.

< Example  8> Preparation of herbal composition 8

16 ~ 20 parts by weight of hwahwa, 5 ~ 6 parts by weight of maltose, malt, grass, and new song, 3 ~ 4 parts by weight of each of talc, ghost, tongcho, bokyeong, keg, bokbokyeong, baekbaekpi, yugeunpi, sanggi, earth , Calendula, jinbum, longan meat, jujube, cinnamon, thick, neck, health, cornus, sewage, dermis, licorice 1.5 ~ 2.1 parts by weight, donkey, cheonggung, peony, sage, white porcelain, joiner, larva, ogapi, shiho, 0.7-1.1 parts by weight of each of the almonds and almonds were mixed, and water was added thereto 3 to 4 times based on the total weight of the herbal medicine, followed by heating at 100 ° C. for 2 to 3 hours to obtain an extract.

0.06 to 0.085 parts by weight of potassium carbonate, 0.04 to 0.05 parts by weight of calcium carbonate and magnesium oxide, 0.007 to 0.01 parts by weight of iron citrate, 0.004 to 0.005 parts by weight of zinc sulfate, and 0.002 to 0.004 parts by weight of manganese sulfate Parts, 0.15 to 0.21 parts by weight of ionic minerals mixed to 0.0005 to 0.007 parts by weight of copper sulfate were added to the extract, and sterilized to prepare a herbal composition.

< Comparative example  1> Flower pot  Preparation of Herbal Compositions Containing

Only 16-20 parts by weight of cheonhwa was added among the main herbal medicines, and a herbal composition was prepared in the same manner as in Example 8.

< Comparative example  2> Grounding  Preparation of Herbal Compositions Containing

Herbal medicine composition was prepared in the same manner as in Example 8 after adding only 5-6 parts by weight of the main herbal medicine.

< Comparative example  3> Preparation of Herbal Medicine Composition

Only 1.5 to 2.1 parts by weight of the main medicinal herb was added 1.5 to 2.1 parts by weight and the same method as in Example 8 to prepare a herbal composition.

< Comparative example  4> Shiho  Preparation of Herbal Compositions Containing

Only 0.7-1.1 parts by weight of Shiho was added among the main herbal medicines, and a herbal composition was prepared in the same manner as in Example 8.

< Comparative example  5> Preparation of herbal composition containing sulfur

Only 0.7-1.1 parts by weight of Sookji sulfur was added among the main herbal medicines, and a herbal composition was prepared in the same manner as in Example 8.

< Experimental Example  1> Glucose uptake into adipocytes

In order to determine the glucose absorption level of the herbal composition was carried out the following experiment.

The 3T3-L1 cells used in the experiment were purchased from the American Cell Line Bank, and added DMEM with 1% fetal bovine serum (FBS), gentamycine (100 units / ml) and streptomycin (streptomycin (100 µg / ml)). Cultured in (Dulbecco's modified Eagle's medium) medium.

3T3-L1 fibroblasts were incubated until the disc was completely confluent. Two days after the bottom of the culture vessel was completely filled, 0.25 μM of derivatized dexamethasone was added and cultured for three days, and then changed into high-density glucose DMEM solution once every two days to completely convert into fat cells. Glucose uptake was done between days.

The number of adipocytes in the culture vessel was counted and dispensed so that the wells of the 12 well plates could be completely filled without empty space. Adipose cells transferred to well plates were washed with PBS and incubated for 30 minutes at 37 ° C. in HEPES solution after 12 hours in DMEM containing low glucose containing 1% bovine serum albumin. . 1 μCi / mL of [ ¹⁴ C] 2-deoxyglucose and 1 mM glucose were added thereto, followed by incubation at 22 ° C. for 30 minutes, and the degree of glucose uptake into cells was measured by the amount of ¹⁴ C transferred into cells. .

In order to rule out nonspecific glucose uptake, the amount of glucose transported into the cell was measured by subtracting the glucose shift when incubated with cyto B, which inhibits the action of glucose transporter 4 (GLUT4). .

The herbal extracts prepared in Examples 1 to 8 and Comparative Examples 1 to 5 were dissolved at 1 mg / ml in DMSO, diluted to 3 μg / ml with PBS, and treated with 3T3-L1 adipocytes. It was incubated for 1 hour. Cultured cells were washed with PBS containing 10 mM glucose and digested with 0.5 N sodium hydroxide. The lysed cells were neutralized with acetic acid and the content of ¹⁴ C was measured by a beta counter (Tri-Carb 2100TR, Packard Bioscince, IL), and the results are shown in Table 1 below.

Glucose uptake (dpm / mg protein)  DMSO  7 ± 0.27  Example 1  106 ± 1.7  Example 2  110 ± 5.7  Example 3  116 ± 2.7  Example 4  110 ± 2.3  Example 5  117 ± 3.1  Example 6  113 ± 1.6  Example 7  133 ± 2.9  Example 8  142 ± 3.4  Comparative Example 1  33 ± 2.1  Comparative Example 2  15 ± 0.43  Comparative Example 3  26 ± 1.2  Comparative Example 4  29 ± 2.7  Comparative Example 5  19 ± 1.1

(* The above data is expressed as mean ± standard deviation)

As shown in Table 1 above, when only the solvent DMSO was treated, the glucose uptake rate was hardly increased intracellularly. However, when the herbal composition of Comparative Examples 1 to 5 was administered, glucose uptake into the cells was minimal. Could. In contrast, the cell group treated with the herbal compositions of Examples 1 to 8 was found to significantly increase the intracellular glucose uptake. In particular, the highest sugar absorption was observed in the herbal composition comprising the ionic mineral of Example 8.

< Experimental Example  2> insulin dependence In the patient  Effect of herbal composition

Two hours after meals, 20 insulin-dependent diabetic patients with a blood glucose level of 250 to 300 were given three times a day 120 to 130 ml of the herbal composition of Examples 1 to 8, and the control group was not administered insulin, and one day Groups taking oral hypoglycemic drugs provided by two hospitals (control group 1) and groups without insulin control agent and hypoglycemic agent (control group 2) were measured, respectively, and the results are shown in Table 2 below.

 Hypoglycemic content / period  1 month later  2 months later  3 months later  4 months later  5 months later  6 months later  Lowering blood sugar below 250 (Example 1)  33%  52%  68%  85%  Lowering blood sugar to 250 or less (Example 2)  34%  52%  68%  86%  Blood sugar drop below 250 (Example 3)  34%  53%  69%  86%  Blood sugar drop below 250 (Example 4)  33%  52%  68%  86%  Blood sugar drop below 250 (Example 5)  33%  53%  69%  86%  Lowering blood sugar to 250 or less (Example 6)  32%  52%  69%  87%  Blood sugar drop below 250 (Example 7)  35%  57%  72%  89%  Blood sugar drop below 250 (Example 8)  40%  60%  75%  over 90  Blood sugar drop below 160 (Example 8)  30%  45%  60%  75%  over 90  Blood sugar drops below 160 (control 1)  20%  30%  45%  60%  70%  90%   Blood sugar drops below 180 (control 2)  10%  20%  30%  45%  60%  75%  Blood sugar drops below 140 (control 2)  5%  10%  20%  35%  50%  65%

As shown in Table 2, in the case of the control group 1, in which insulin-lowering drugs were administered to insulin-dependent diabetic patients having a blood glucose level of 250 to 300 after 2 hours after eating, 90% of the blood glucose levels were 160 or less after 6 months. The herbal compositions of Examples 1 to 8 all showed a hypoglycemic effect. In particular, in the diabetic patients taking the herbal composition prepared according to Example 8, more than 90% of the blood sugar dropped to 250 or less after 4 months, in particular, more than 90% after the 5 months after taking 160 In the following, it can be seen that a higher effect in the short-term in insulin-dependent diabetes patients than conventional hypoglycemic agents.

< Experimental Example  3> insulin Independence In the patient  Effect of herbal composition

Two hours after a meal, 120 patients with insulin-independent diabetes mellitus having a blood glucose level of 250 to 300 were given 120 to 130 ml of the herbal composition of Examples 1 to 8 three times a day. The group taking the oral glucose lowering agent (control group 1) and the group not receiving the blood glucose lowering agent (control group 2) were measured, respectively, and the results are shown in Table 3 below.

 Blood sugar drop content / duration  1 month later  2 months later  3 months later  4 months later  5 months later  6 months later  Lowering blood sugar below 250 (Example 1)  33%  46%  63%  78%  83%  Lowering blood sugar to 250 or less (Example 2)  33%  46%  63%  78%  83%  Blood sugar drop below 250 (Example 3)  34%  47%  64%  79%  83%  Blood sugar drop below 250 (Example 4)  34%  47%  63%  78%  83%  Blood sugar drop below 250 (Example 5)  33%  46%  63%  78%  83%  Lowering blood sugar to 250 or less (Example 6)  33%  46%  63%  79%  84%  Blood sugar drop below 250 (Example 7)  37%  50%  67%  82%  88%  Blood sugar drop below 250 (Example 8)  40%  53%  70%  85%  over 90  Blood sugar drop below 160 (Example 8)  30%  45%  60%  70%  85%  over 90  Blood sugar drops below 160 (control 1)  25%  35%  50%  65%  75%  More than 85%  Blood sugar drops below 180 (control 2)  15%  30%  40%  55%  67%  More than 75%  Blood sugar drops below 140 (control 2)  10%  20%  35%  50%  60%  More than 70%

As shown in Table 3, in the control group 1, in which insulin-independent diabetic patients with blood glucose levels of 250 to 300 after 2 hours after meals, 85% of the blood sugar levels were 160 or less after 6 months. . The herbal compositions prepared by Examples 1 to 8 showed a higher effect than the existing hypoglycemic agents, in particular, in the diabetic patients taking the herbal composition prepared by Example 8, more than 90% after 5 months The blood sugar level dropped to 250 or less. In particular, after 6 months, 90% or more of the blood sugar levels dropped to 160 or less, which showed a higher effect in the short term in patients with insulin-independent diabetes than the conventional hypoglycemic agents.

< Experimental Example  4> Insulin and Oral Blood Sugar Hypotensive Independent In mild patients  Effect of herbal composition

Two hours after the meal, 120 to 130 ml of the herbal composition of Example 8 was administered three times a day to 20 patients with diabetes with oral hypoglycemic agents, which had a blood glucose level of 250 to 300, three times a day. The results are shown in Table 4 below.

 Blood sugar drop content / duration  1 month later  2 months later  3 months later  4 months later  5 months later  6 months later  Lower blood sugar level below 250  40%  50%  65%  80%  over 90  Lower blood sugar level below 200  30%  45%  55%  70%  85%  over 90  Blood sugar drop below 160  20%  35%  50%  65%  75%  More than 85%  Lower blood sugar level below 140  15%  30%  40%  55%  70%  More than 83%

As shown in Table 4, the diabetic patients 5 months after taking the herbal composition prepared by Example 8 with insulin having a blood glucose level of 250 to 300 and oral hypoglycemic agent-independent diabetic patients 2 hours after eating , More than 90% of the blood sugar dropped to 250 or less, in particular, more than 83% after six months of taking blood sugar below 160, the herbal composition prepared in Example 8 is more or less insulin and oral than conventional hypoglycemic agents In patients with diabetes mellitus-independent diabetic patients, the effect was higher in a short time.

< Experimental Example  5> Comparison of hypoglycemic effect of herbal composition with mineral addition

Two hours after the meal, each of 20 insulin-independent diabetic patients with blood glucose levels of 250 to 300 was taken 120 to 130 ml of the herbal compositions of Examples 8 and 7 three times a day, and their blood glucose levels were measured. The results are shown in Table 5 below.

 1 month later  2 months later  3 months later  4 months later  5 months later  6 months later  Lowering blood sugar level to 140 or less (Example 8)  15%  30%  40%  55%  70%  More than 83%  Lowering blood sugar level to 140 or less (Example 7)  10%  20%  32%  43%  58%  70%

As shown in Table 5, Example 8 in which the ionic mineral (electrolyte) was added to the herbal composition was longer than the example of Example 7 in which the ionic mineral was not added to the herbal composition. It was found that the number of patients whose blood glucose levels fell by% increased. From this, it was found indirectly that the addition of ionic minerals in the herbal composition can increase the efficacy of the herbal composition.

Examples of preparations for the compositions of the present invention are illustrated below.

< Formulation example  1> Preparation of Pharmaceutical Formulations

1-1: Powder  Produce

2 g of the mixed extract according to the present invention

1 g lactose

After mixing the above components, the airtight cloth was filled to prepare a powder.

1-2: Preparation of Tablets

100 mg of the mixed extract according to the present invention

Corn starch 100 mg

Lactose 100 mg

2 mg magnesium stearate

After mixing the above components, tablets were prepared by tableting according to a conventional method for producing tablets.

1-3: Preparation of Capsule

100 mg of the mixed extract according to the present invention

Corn starch 100 mg

Lactose 100 mg

2 mg magnesium stearate

After mixing the above components, the capsule was prepared by filling in gelatin capsules according to the conventional method for producing a capsule.

1-4: Preparation of Injection Solution

10 μg / ml mixed extract according to the present invention

Dilute hydrochloric acid BP until pH 3.5

Injectable sodium chloride BP up to 1 ml

The mixed extract according to the present invention was dissolved in an appropriate volume of sodium chloride BP for injection, the pH of the resulting solution was adjusted to pH 3.5 with dilute hydrochloric acid BP, and the volume was adjusted with sodium chloride BP for injection and thoroughly mixed. . The solution was filled into a 5 ml Type I ampoule made of clear glass, encapsulated under an upper grid of air by dissolving the glass, and sterilized by autoclaving at 120 ° C. for at least 15 minutes to prepare an injection solution.

< Formulation example  2> Manufacture of food

Foods containing the mixed extract according to the present invention were prepared as follows.

2-1: Manufacturing Flour Food

0.1 ~ 10.0 parts by weight of the mixed extract according to the present invention was added to the flour, and using the mixture to prepare bread, cake, cookies, crackers and noodles in a conventional manner to prepare foods for health promotion.

2-2: soup  And juicy ( gravies Manufacturing

0.1 to 1.0 parts by weight of the mixed extract according to the present invention was added to soups and broth to prepare meat products for health promotion, soups of noodles and broth in a conventional manner.

2-3: Ground Ground beef  Produce

10 parts by weight of the mixed extract according to the present invention was added to ground beef to prepare ground beef for health promotion in a conventional manner.

2-4: Dairy Products ( dairy products Manufacturing

0.1-1.0 parts by weight of the mixed extract according to the present invention was added to milk, and various dairy products such as butter and ice cream were prepared in a conventional manner using the milk.

2-5: Linear  Produce

Brown rice, barley, glutinous rice, and yulmu were alphad by a known method, and then dried and roasted to prepare a powder having a particle size of 60 mesh.

Black beans, black sesame seeds, and perilla were also steamed and dried by a known method, and then ground to a powder having a particle size of 60 mesh.

The mixed extract according to the present invention was decompressed and concentrated in a vacuum concentrator, and the dried product obtained by drying with a sprayer and a hot air dryer was pulverized with a particle size of 60 mesh to obtain a dry powder.

The grains, seeds and the mixed extract dry powder according to the present invention prepared above were blended in the following ratio to prepare a conventional method.

Cereals (30 parts by weight brown rice, 15 parts by weight brittle, 20 parts by weight of barley),

Seeds (7 parts by weight perilla, 8 parts by weight black beans, 7 parts by weight black sesame seeds),

Mixed extract dry powder (1 part by weight) according to the present invention,

Ganoderma lucidum (0.5 parts by weight),

Foxglove (0.5 part by weight)

< Formulation example  3> Manufacture of beverage

A beverage containing the mixed extract according to the present invention was prepared as follows.

3-1: Health drink  Produce

After instant sterilization by homogeneously mixing the mixed extract according to the present invention with a subsidiary material such as liquid fructose (0.5%), oligosaccharide (2%), sugar (2%), salt (0.5%) and water (75%) To prepare a healthy drink, it was packaged in small packaging containers such as glass bottles and plastic bottles.

3-2: Vegetable juice  Produce

0.5 g of the mixed extract according to the present invention was added to 1,000 ml of a vegetable juice such as tomato or carrot to prepare a vegetable juice for health promotion in a conventional manner.

3-3: Fruit juice  Produce

0.1 g of the mixed extract according to the present invention was added to 1,000 ml of fruit juice such as apple or grape, thereby preparing a fruit juice for health promotion in a conventional manner.

The herbal composition according to the present invention can be usefully used as a preventive and therapeutic agent for oral diabetes by minimizing the side effects of the existing hypoglycemic agents while stably and continuously lowering the blood sugar level of insulin-dependent or insulin-independent diabetes patients.

Claims (19)

A pharmaceutical composition for lowering blood sugar, which comprises a composite herbal extract extracted from water using a mixed herbal medicine comprising cheonhwabun, gicho, baekbaekpi, shiho and sukji sulfur as an active ingredient. According to claim 1, wherein the mixed herbal medicine is 16 to 20 parts by weight of cheonhwa, 5 to 6 parts by weight of ground grass, 1.5 to 2.1 parts by weight of baekbaekpi, Shiho and Sukji sulfur is characterized in that it comprises 0.7 to 1.1 parts by weight, respectively Pharmaceutical composition for lowering blood sugar. The pharmaceutical composition for lowering blood sugar of claim 1, wherein the mixed herbal medicine further comprises one or more selected from the group consisting of taxa, geryeong, bokyeong, keg, tongcho, and bokbokyeong, which are herbal medicines used for diuretic action. Composition. The pharmaceutical composition for lowering blood sugar according to claim 3, wherein the amount of the herbal medicine used for the diuretic action is added in 3 to 4 parts by weight, respectively. The pharmaceutical composition for lowering blood sugar of claim 1, wherein the mixed herbal medicine further comprises one or more selected from the group consisting of medicinal herb, soybean, dermis, cucumber, and sandalwood, which are medicinal herbs to help the circulatory system. The pharmaceutical composition for lowering blood sugar according to claim 5, wherein the amount of the herbal medicine to assist the circulatory body is 1.5 to 2.1 parts by weight of the dermis, and 0.7 to 1.1 parts by weight of the larvae, filamentous, stamens, and sandalwood, respectively. According to claim 1, wherein the mixed herbal medicines for lowering blood sugar further comprises one or more selected from the group consisting of malt, new song, cinnamon, thick pepper, throat and health, which is a herbal medicine used to help digestion absorption Pharmaceutical compositions. According to claim 7, wherein the amount of the herbal medicine used to help the digestive absorption is maltose and new song 5 to 6 parts by weight, respectively, cinnamon, hunch, throat and health are added to 1.5 to 2.1 parts by weight, respectively, Lowering pharmaceutical composition. According to claim 1, The mixed herbal medicines for lowering blood sugar further comprises one or more selected from the group consisting of medicinal herbs used in order to help the immune function, geungeuk, yugeunpi, said raw, sewage, white porcelain and almond Pharmaceutical compositions. 10. The method of claim 9, wherein the amount of the herbal medicine used to aid the immune function is 5 to 6 parts by weight, the roots of the root, and the raw and sewage are 1.5 to 2.1 parts by weight, respectively, and white porcelain and almonds are added to 0.7 to 1.1 parts by weight, respectively. Pharmaceutical composition for lowering blood sugar, characterized in that. The method of claim 1, wherein the mixed herbal medicine further comprises one or more selected from the group consisting of Angelica, Cheongung, Peony, Longan meat, Cornus, Hyunho color, Jinbeom, Jujube and Licorice, which are herbal medicines used as protective and stabilizing agents. Pharmaceutical composition for lowering blood sugar. The method of claim 11, wherein the amount of the herbal medicine used as the protective agent and stabilizer is added to Hyunho colors, Jinbeom, longan meat, jujube, cornus oil and licorice each 1.5 to 2.1 parts by weight, Angelica, Cheongung and Peony are added 0.7 to 1.1 parts by weight, respectively Pharmaceutical composition for lowering blood sugar, characterized in that. The pharmaceutical composition for lowering blood sugar according to claim 1, further comprising an ionic mineral added to the complex herbal extract. The method of claim 13, wherein the ionic mineral further comprises one or more selected from the group consisting of potassium carbonate, calcium carbonate, magnesium oxide, iron citrate, zinc sulfate, manganese sulfate, and copper sulfate. Pharmaceutical compositions. The pharmaceutical composition for lowering blood sugar according to claim 13, wherein the amount of the ionic mineral is added in an amount of 0.15 to 0.21 parts by weight. The pharmaceutical composition for lowering blood sugar according to claim 1, wherein the complex herbal extract is obtained by mixing water, C ₁ -C ₂ alcohol, or a mixed solvent thereof and heating the mixed herbal medicine. delete 14. A pharmaceutical composition for preventing or treating diabetes, comprising the complex herbal extract of any one of claims 1 to 13 as an active ingredient. delete