KR100811295B1 - 인삼으로부터 활성형의 진세노사이드를 생산하는 방법 - Google Patents
인삼으로부터 활성형의 진세노사이드를 생산하는 방법 Download PDFInfo
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- KR100811295B1 KR100811295B1 KR1020050031523A KR20050031523A KR100811295B1 KR 100811295 B1 KR100811295 B1 KR 100811295B1 KR 1020050031523 A KR1020050031523 A KR 1020050031523A KR 20050031523 A KR20050031523 A KR 20050031523A KR 100811295 B1 KR100811295 B1 KR 100811295B1
- Authority
- KR
- South Korea
- Prior art keywords
- ginseng
- glc
- ginsenoside
- ginsenosides
- microorganisms
- Prior art date
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- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 11
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- E03B7/07—Arrangement of devices, e.g. filters, flow controls, measuring devices, siphons or valves, in the pipe systems
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Abstract
Description
화합물 | R1 | R2 | R3 |
20(S)-프로토파낙사디올 형 | |||
진세노사이드 Rb1 | O-Glc(2-1)Glc | H | O-Glc(6-1)Glc |
Rb2 | O-Glc(2-1)Glc | H | O-Glc(6-1)Arap |
Rc | O-Glc(2-1)Glc | H | O-Glc(6-1)Araf |
Rd | O-Glc(2-1)Glc | H | O-Glc |
F2 | O-Glc | H | O-Glc |
Rh2 | O-Glc | H | OH |
화합물 K | OH | H | O-Glc |
O (Ⅰ) | O-Glc | H | O-Glc(6-1)Arap |
Y (Ⅱ) | OH | H | O-Glc(6-1)Arap |
Mc (Ⅲ) | OH | H | O-Glc(6-1)Araf |
Mc1 (Ⅳ) | O-Glc | H | O-Glc(6-1)Araf |
20(S)-프로토파낙사트리올 형 | |||
진세노사이드 Re | OH | O-Glc(2-1)Rha | O-Glc |
Rf | OH | O-Glc(2-1)Glc | OH |
Rg1 | OH | O-Glc | O-Glc |
Rg2 | OH | O-Glc(2-1)Rha | OH |
F1 | OH | OH | O-Glc |
Rh1 | OH | O-Glc | OH |
성분 | 리터당 함량 |
효모 추출물 쇠고기 추출물 고기 펩톤 아세트산 나트륨 제2인산나트륨 구연산 암모늄 황산 마그네슘 막레익산 활산 망간 덱스트로즈 트윈 80 | 10.0 g 10.0 g 10.0 g 5.0 g 2.0 g 2.0 g 1.0 ㎎ 0.1 ㎎ 0.05 ㎎ 20.0 g 10.0 ㎎ |
효소의 활성 | 루코노스톡 파라메센테로이데스 |
α-글루코시다제 | +++ |
β-글루코시다제 | ++++ |
α-갈락토시다제 | +++ |
β-갈락토시다제 | + |
α-만노시다제 | - |
β-만노시다제 | - |
α-람노시다제 | - |
β-글루쿠로니다제 | - |
β-셀로바이오시다제 | ++ |
α-자일로시다제 | - |
β-자일로시다제 | +++ |
α-아라비노퓨라노시다제 | + |
α-아라비노피라노시다제 | + |
β-아라비노피라노시다제 | _ |
Claims (7)
- 삭제
- 삭제
- 삭제
- 인삼 추출물을 루코노스톡 파라메센테로이스(Leuconostoc paramesenteroides)(기탁번호 KFCC 11351P)와 반응시킴으로써 화학식 1로 표시되는 인삼의 대사산물인 진세노사이드 Rh2, Rg2 및 F2를 생산하는 방법에 있어서, 상기 미생물은 미생물을 파쇄하여 제조되는 조(crude) 미생물 효소의 형태로 사용되는 것을 특징으로 하는 방법.[화학식 1]
화합물 R1 R2 R3 Rh2 O-Glc H OH Rg2 OH O-Glc(2-1)Rha OH F2 O-Glc H O-Glc 상기 표에서 Glc는 Glucose 이며, Rha는 Rhamnose 임 - 삭제
- 삭제
- 인삼 추출물을 기탁번호 KFCC 11351P 인 루코노스톡 파라메센테로이데스(Leuconostoc paramesenteroides) 와 반응시킴으로써 화학식 1로 표시되는 인삼의 대사산물인 진세노사이드 Rh2, Rg2 및 F2를 생산하는 방법에 있어서, 상기 미생물은 미생물을 파쇄하여 제조되는 조(crude) 미생물 효소의 형태로 사용되는 것을 특징으로 하는 방법.[화학식 1]
화합물 R1 R2 R3 Rh2 O-Glc H OH Rg2 OH O-Glc(2-1)Rha OH F2 O-Glc H O-Glc 상기 표에서 Glc는 Glucose 이며, Rha는 Rhamnose 임
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WO2013114650A1 (ja) * | 2012-02-02 | 2013-08-08 | 星野科学株式会社 | 高麗人参薬効成分の製造方法 |
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WO2020036308A1 (ko) * | 2018-08-13 | 2020-02-20 | ㈜아모레퍼시픽 | 신규 진세노사이드, 및 이를 포함하는 항염 조성물 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20000045694A (ko) * | 1998-12-30 | 2000-07-25 | 박명규 | 20(에스)-진세노사이드 알에이취투의 제조방법 |
KR20020058153A (ko) * | 2000-12-29 | 2002-07-12 | 박명규 | 효소적 방법에 의한 진세노사이드 f₂의 제조방법 |
KR20030094757A (ko) * | 2002-06-07 | 2003-12-18 | 주식회사 비티진 | 베타글리코시다제를 이용한 진세노사이드 f₂또는 컴파운드 케이의 제조방법 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20000045694A (ko) * | 1998-12-30 | 2000-07-25 | 박명규 | 20(에스)-진세노사이드 알에이취투의 제조방법 |
KR20020058153A (ko) * | 2000-12-29 | 2002-07-12 | 박명규 | 효소적 방법에 의한 진세노사이드 f₂의 제조방법 |
KR20030094757A (ko) * | 2002-06-07 | 2003-12-18 | 주식회사 비티진 | 베타글리코시다제를 이용한 진세노사이드 f₂또는 컴파운드 케이의 제조방법 |
Non-Patent Citations (1)
Title |
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Chem. Pharm. Bull. (Tokyo) vol.51(4):404-8 |
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WO2013114650A1 (ja) * | 2012-02-02 | 2013-08-08 | 星野科学株式会社 | 高麗人参薬効成分の製造方法 |
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