KR100787072B1 - 3개의 치환기가 있는 신규 페닐 유도체 및 그 유사체 - Google Patents

3개의 치환기가 있는 신규 페닐 유도체 및 그 유사체 Download PDF

Info

Publication number
KR100787072B1
KR100787072B1 KR1020027007057A KR20027007057A KR100787072B1 KR 100787072 B1 KR100787072 B1 KR 100787072B1 KR 1020027007057 A KR1020027007057 A KR 1020027007057A KR 20027007057 A KR20027007057 A KR 20027007057A KR 100787072 B1 KR100787072 B1 KR 100787072B1
Authority
KR
South Korea
Prior art keywords
alkyl
hydrogen
defined above
formula
alkylaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020027007057A
Other languages
English (en)
Korean (ko)
Other versions
KR20020067537A (ko
Inventor
뷔제마리아
페게르하그조나스
린드스테트알스터마르크에바-롯테
올손벵크트
Original Assignee
아스트라제네카 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20020067537A publication Critical patent/KR20020067537A/ko
Application granted granted Critical
Publication of KR100787072B1 publication Critical patent/KR100787072B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020027007057A 1999-12-03 2000-11-29 3개의 치환기가 있는 신규 페닐 유도체 및 그 유사체 Expired - Fee Related KR100787072B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9904421A SE9904421D0 (sv) 1999-12-03 1999-12-03 New compounds
SE9904421-6 1999-12-03

Publications (2)

Publication Number Publication Date
KR20020067537A KR20020067537A (ko) 2002-08-22
KR100787072B1 true KR100787072B1 (ko) 2007-12-21

Family

ID=20417986

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027007057A Expired - Fee Related KR100787072B1 (ko) 1999-12-03 2000-11-29 3개의 치환기가 있는 신규 페닐 유도체 및 그 유사체

Country Status (23)

Country Link
US (1) US6750252B2 (enExample)
EP (1) EP1237856B1 (enExample)
JP (1) JP2003515583A (enExample)
KR (1) KR100787072B1 (enExample)
CN (1) CN1206212C (enExample)
AR (1) AR033957A1 (enExample)
AT (1) ATE266633T1 (enExample)
AU (1) AU766533B2 (enExample)
BR (1) BR0016130A (enExample)
CA (1) CA2392039A1 (enExample)
DE (1) DE60010747T2 (enExample)
DK (1) DK1237856T3 (enExample)
ES (1) ES2219425T3 (enExample)
IL (2) IL149517A0 (enExample)
MX (1) MXPA02005223A (enExample)
MY (1) MY124727A (enExample)
NO (1) NO20022590L (enExample)
PT (1) PT1237856E (enExample)
SE (1) SE9904421D0 (enExample)
TR (1) TR200401716T4 (enExample)
TW (1) TWI224590B (enExample)
WO (1) WO2001040172A1 (enExample)
ZA (1) ZA200203798B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9812770A (pt) 1997-10-27 2000-12-12 Reddy Research Foundation Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6130214A (en) 1997-10-27 2000-10-10 Dr. Reddy's Research Foundation Benzothiazin and benzoxazin derivatives; their preparation and uses
BR9812772A (pt) 1997-10-27 2000-10-10 Reddy Research Foundation "compostos tricìclicos inéditos e o seu emprego na medicina;processo para a sua preparação e composições farmacêuticas contendo os mesmos"
US6531596B1 (en) 1998-10-29 2003-03-11 Dr. Reddy's Laboratories Ltd. Process for the preparation of new antidiabetic agents
CA2346941A1 (en) 1998-10-29 2000-05-11 Dr. Reddy's Research Foundation An improved process for the preparation of new antidiabetic agents
US6897199B2 (en) 2001-02-05 2005-05-24 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of phenoxazine and phenothiazine compounds
SE0101386D0 (sv) 2001-04-20 2001-04-20 Astrazeneca Ab New compounds
PL369655A1 (en) * 2001-10-16 2005-05-02 Dr.Reddy's Laboratories Ltd. Novel-beta-phenyl-alpha-oxysubstituted propionic derivatives, process for its preparation and their use in the preparation of pharmaceutically important compounds
UA82835C2 (en) 2001-12-03 2008-05-26 Reddys Lab Ltd Dr ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon
SE0104333D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
FR2872159B1 (fr) * 2004-06-28 2007-10-05 Merck Sante Soc Par Actions Si Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete
AU2007253717A1 (en) * 2006-05-22 2007-11-29 Elan Pharmaceuticals, Inc. Preparation of polymer conjugates of therapeutic, agricultural and food additive compounds
KR101558005B1 (ko) 2007-03-08 2015-10-06 알비레오 에이비 2-치환-3-페닐프로피온산 유도체 및 염증성 장 질환 치료에서의 그의 용도
FR2917084B1 (fr) 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
FR2917086B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl acrylique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
DE102007038251A1 (de) * 2007-08-13 2009-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Herstellverfahren

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062872A1 (en) 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative (i)
WO1999062870A1 (en) 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative iii
WO1999062871A1 (en) 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl propionic acid derivatives and analogs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062872A1 (en) 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative (i)
WO1999062870A1 (en) 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative iii
WO1999062871A1 (en) 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl propionic acid derivatives and analogs

Also Published As

Publication number Publication date
AU2035101A (en) 2001-06-12
ATE266633T1 (de) 2004-05-15
IL149517A (en) 2007-07-04
CN1402703A (zh) 2003-03-12
NO20022590L (no) 2002-07-29
CN1206212C (zh) 2005-06-15
PT1237856E (pt) 2004-08-31
JP2003515583A (ja) 2003-05-07
TWI224590B (en) 2004-12-01
MY124727A (en) 2006-06-30
US6750252B2 (en) 2004-06-15
TR200401716T4 (tr) 2004-09-21
IL149517A0 (en) 2002-11-10
DK1237856T3 (da) 2004-08-02
EP1237856B1 (en) 2004-05-12
KR20020067537A (ko) 2002-08-22
BR0016130A (pt) 2002-08-20
AR033957A1 (es) 2004-01-21
US20030149104A1 (en) 2003-08-07
ES2219425T3 (es) 2004-12-01
CA2392039A1 (en) 2001-06-07
EP1237856A1 (en) 2002-09-11
NO20022590D0 (no) 2002-05-31
AU766533B2 (en) 2003-10-16
DE60010747T2 (de) 2005-05-19
MXPA02005223A (es) 2003-09-25
ZA200203798B (en) 2003-10-29
SE9904421D0 (sv) 1999-12-03
DE60010747D1 (de) 2004-06-17
WO2001040172A1 (en) 2001-06-07

Similar Documents

Publication Publication Date Title
KR100787072B1 (ko) 3개의 치환기가 있는 신규 페닐 유도체 및 그 유사체
EP1084102B1 (en) New 3-aryl propionic acid derivatives and analogs
KR100625152B1 (ko) 신규한 3-아릴-2-히드록시프로피온산 유도체 (ｉ)
EP1084101B1 (en) New 3-aryl-2-hydroxypropionic acid derivative iii
RU2243214C2 (ru) Новые производные и аналоги 3-арилпропионовой кислоты
MXPA00011610A (en) New 3-aryl propionic acid derivatives and analogs
HK1034957B (en) New 3-aryl propionic acid derivatives and analogs
HK1035711B (en) New 3-aryl-2-hydroxypropionic acid derivative (i)

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20101213

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20101213

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000