KR100768021B1 - 시스-2,4,5-트리아릴-이미다졸린 - Google Patents
시스-2,4,5-트리아릴-이미다졸린 Download PDFInfo
- Publication number
- KR100768021B1 KR100768021B1 KR1020057024295A KR20057024295A KR100768021B1 KR 100768021 B1 KR100768021 B1 KR 100768021B1 KR 1020057024295 A KR1020057024295 A KR 1020057024295A KR 20057024295 A KR20057024295 A KR 20057024295A KR 100768021 B1 KR100768021 B1 KR 100768021B1
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- trifluoromethyl
- chloro
- bis
- dihydro
- Prior art date
Links
- 0 CC(C1)C(O)=CC=C1C(C(C([C@]1(C)CCC(CCC(C)=O)=CCC1)=O)NC(c1ccc(C(F)(F)F)cc1C)=C1C)C1c1ccc(C*)cc1 Chemical compound CC(C1)C(O)=CC=C1C(C(C([C@]1(C)CCC(CCC(C)=O)=CCC1)=O)NC(c1ccc(C(F)(F)F)cc1C)=C1C)C1c1ccc(C*)cc1 0.000 description 16
- YIPAODXIWYSIAD-UHFFFAOYSA-N CC(C)Oc(cc(C(F)(F)F)cc1)c1C(N(C1C(C=C2)=CCC2Cl)C(Cl)=O)=NC1C1C=CC(Cl)=CC1 Chemical compound CC(C)Oc(cc(C(F)(F)F)cc1)c1C(N(C1C(C=C2)=CCC2Cl)C(Cl)=O)=NC1C1C=CC(Cl)=CC1 YIPAODXIWYSIAD-UHFFFAOYSA-N 0.000 description 1
- HUPNRVHWPHWMBZ-UHFFFAOYSA-N CC(C)Oc1cc(C(F)(F)F)ccc1C(NC1c(cc2)ccc2Cl)=NC1c(cc1)ccc1Cl Chemical compound CC(C)Oc1cc(C(F)(F)F)ccc1C(NC1c(cc2)ccc2Cl)=NC1c(cc1)ccc1Cl HUPNRVHWPHWMBZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47935103P | 2003-06-17 | 2003-06-17 | |
| US60/479,351 | 2003-06-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20060021902A KR20060021902A (ko) | 2006-03-08 |
| KR100768021B1 true KR100768021B1 (ko) | 2007-10-18 |
Family
ID=33563793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057024295A KR100768021B1 (ko) | 2003-06-17 | 2004-06-08 | 시스-2,4,5-트리아릴-이미다졸린 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1638942A1 (ru) |
| JP (1) | JP2006527712A (ru) |
| KR (1) | KR100768021B1 (ru) |
| CN (1) | CN100465163C (ru) |
| AR (1) | AR044703A1 (ru) |
| AU (1) | AU2004254187A1 (ru) |
| BR (1) | BRPI0411841A (ru) |
| CA (1) | CA2528119A1 (ru) |
| CL (1) | CL2004001484A1 (ru) |
| MX (1) | MXPA05013279A (ru) |
| RU (1) | RU2319696C2 (ru) |
| TW (1) | TW200510387A (ru) |
| WO (1) | WO2005003097A1 (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7579368B2 (en) * | 2005-03-16 | 2009-08-25 | Hoffman-La Roche Inc. | Cis-imidazolines |
| KR101109437B1 (ko) * | 2005-12-01 | 2012-01-31 | 에프. 호프만-라 로슈 아게 | 항암제로서 사용하기 위한 ｐ53 및 ｍｄｍ2 단백질 간상호작용의 저해제로서의 2,4,5-트리페닐 이미다졸린유도체 |
| US8114095B2 (en) * | 2006-11-10 | 2012-02-14 | Bausch & Lomb Incorporated | Intraocular lens injection apparatus and method |
| AU2007332493A1 (en) | 2006-12-14 | 2008-06-19 | Daiichi Sankyo Company, Limited | Imidazothiazole derivatives |
| US7625895B2 (en) * | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
| WO2009151069A1 (ja) | 2008-06-12 | 2009-12-17 | 第一三共株式会社 | ４，７－ジアザスピロ［２．５］オクタン環構造を有するイミダゾチアゾール誘導体 |
| AU2010205201A1 (en) | 2009-01-16 | 2011-08-04 | Daiichi Sankyo Company,Limited | Imidazothiazole derivative having proline ring structure |
| IT1396520B1 (it) | 2009-12-10 | 2012-12-14 | Nuovo Pignone Spa | Accoppiamento per bilanciamento rotore |
| WO2013054153A1 (en) | 2011-10-11 | 2013-04-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nutlin compounds for use in he treatment of pulmonary hypertension |
| JP2019522633A (ja) | 2016-05-20 | 2019-08-15 | ジェネンテック， インコーポレイテッド | Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0433682A2 (en) * | 1989-11-22 | 1991-06-26 | Marion Merrell Dow Inc. | Use of 2,4,5-tri(4-methoxyphenyl)-4,5-dihydroimidazole for the treatment of cancer |
| WO2002020017A2 (de) * | 2000-09-04 | 2002-03-14 | Merck Patent Gmbh | Verwendung von ectoin oder ectoin-derivaten zur stabilisierung von p53 |
| WO2003051359A1 (en) * | 2001-12-18 | 2003-06-26 | F.Hoffmann-La Roche Ag | Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors |
-
2004
- 2004-06-08 RU RU2006100730/04A patent/RU2319696C2/ru not_active IP Right Cessation
- 2004-06-08 EP EP04739704A patent/EP1638942A1/en not_active Withdrawn
- 2004-06-08 KR KR1020057024295A patent/KR100768021B1/ko not_active IP Right Cessation
- 2004-06-08 WO PCT/EP2004/006176 patent/WO2005003097A1/en active Application Filing
- 2004-06-08 BR BRPI0411841-3A patent/BRPI0411841A/pt not_active IP Right Cessation
- 2004-06-08 MX MXPA05013279A patent/MXPA05013279A/es unknown
- 2004-06-08 CN CNB2004800170350A patent/CN100465163C/zh not_active Expired - Fee Related
- 2004-06-08 AU AU2004254187A patent/AU2004254187A1/en not_active Abandoned
- 2004-06-08 CA CA002528119A patent/CA2528119A1/en not_active Abandoned
- 2004-06-08 JP JP2006515856A patent/JP2006527712A/ja not_active Ceased
- 2004-06-11 TW TW093116988A patent/TW200510387A/zh unknown
- 2004-06-15 AR ARP040102068A patent/AR044703A1/es not_active Application Discontinuation
- 2004-06-15 CL CL200401484A patent/CL2004001484A1/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0433682A2 (en) * | 1989-11-22 | 1991-06-26 | Marion Merrell Dow Inc. | Use of 2,4,5-tri(4-methoxyphenyl)-4,5-dihydroimidazole for the treatment of cancer |
| WO2002020017A2 (de) * | 2000-09-04 | 2002-03-14 | Merck Patent Gmbh | Verwendung von ectoin oder ectoin-derivaten zur stabilisierung von p53 |
| WO2003051359A1 (en) * | 2001-12-18 | 2003-06-26 | F.Hoffmann-La Roche Ag | Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200510387A (en) | 2005-03-16 |
| CA2528119A1 (en) | 2005-01-13 |
| RU2006100730A (ru) | 2006-08-10 |
| BRPI0411841A (pt) | 2006-08-08 |
| AR044703A1 (es) | 2005-09-21 |
| CN1809538A (zh) | 2006-07-26 |
| CL2004001484A1 (es) | 2005-05-27 |
| JP2006527712A (ja) | 2006-12-07 |
| AU2004254187A1 (en) | 2005-01-13 |
| KR20060021902A (ko) | 2006-03-08 |
| MXPA05013279A (es) | 2006-03-09 |
| EP1638942A1 (en) | 2006-03-29 |
| CN100465163C (zh) | 2009-03-04 |
| RU2319696C2 (ru) | 2008-03-20 |
| WO2005003097A1 (en) | 2005-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E90F | Notification of reason for final refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |