KR100723189B1 - 눈에 국소적으로 사용하기 위한 브리모니딘과 티몰롤의조합물 - Google Patents
눈에 국소적으로 사용하기 위한 브리모니딘과 티몰롤의조합물 Download PDFInfo
- Publication number
- KR100723189B1 KR100723189B1 KR1020037015881A KR20037015881A KR100723189B1 KR 100723189 B1 KR100723189 B1 KR 100723189B1 KR 1020037015881 A KR1020037015881 A KR 1020037015881A KR 20037015881 A KR20037015881 A KR 20037015881A KR 100723189 B1 KR100723189 B1 KR 100723189B1
- Authority
- KR
- South Korea
- Prior art keywords
- timolol
- brimonidine
- combination
- group
- delete delete
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 title claims abstract description 60
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 229960004605 timolol Drugs 0.000 title claims abstract description 51
- 229960003679 brimonidine Drugs 0.000 title claims abstract description 40
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- 229960000686 benzalkonium chloride Drugs 0.000 claims description 15
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 15
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- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
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- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/001—Arrangement of electric circuit elements in or on lighting devices the elements being electrical wires or cables
- F21V23/002—Arrangements of cables or conductors inside a lighting device, e.g. means for guiding along parts of the housing or in a pivoting arm
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/003—Arrangement of electric circuit elements in or on lighting devices the elements being electronics drivers or controllers for operating the light source, e.g. for a LED array
- F21V23/004—Arrangement of electric circuit elements in or on lighting devices the elements being electronics drivers or controllers for operating the light source, e.g. for a LED array arranged on a substrate, e.g. a printed circuit board
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/02—Arrangement of electric circuit elements in or on lighting devices the elements being transformers, impedances or power supply units, e.g. a transformer with a rectifier
- F21V23/023—Power supplies in a casing
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
- G02B6/0011—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form
- G02B6/0066—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form characterised by the light source being coupled to the light guide
- G02B6/0073—Light emitting diode [LED]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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Applications Claiming Priority (3)
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| US10/126,790 US7030149B2 (en) | 2002-04-19 | 2002-04-19 | Combination of brimonidine timolol for topical ophthalmic use |
| US10/126,790 | 2002-04-19 | ||
| PCT/US2003/010885 WO2003088973A1 (en) | 2002-04-19 | 2003-04-09 | Combination of brimonidine and timolol for topical ophthalmic use |
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| KR20040100844A KR20040100844A (ko) | 2004-12-02 |
| KR100723189B1 true KR100723189B1 (ko) | 2007-05-29 |
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| CN100413503C (zh) * | 2005-01-07 | 2008-08-27 | 冷文 | 一种复方眼药组合物 |
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| US20070238732A1 (en) * | 2006-04-10 | 2007-10-11 | Allergan, Inc. | Brimonidine and timolol compositions |
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| WO2008024846A2 (en) * | 2006-08-25 | 2008-02-28 | Allergan, Inc. | Brimonidine and timolol compositions |
| MX2007010025A (es) * | 2007-08-17 | 2009-02-25 | Arturo Jimenez Bayardo | Composición farmacéutica para tratamiento de hipertensión ocular. |
| MX2007011165A (es) * | 2007-09-12 | 2009-03-11 | Arturo Jimenez Bayardo | Composición farmacéutica estable de timolol, dorzolamida y brimonidina. |
| US20100203165A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
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| US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
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| US20200108064A1 (en) * | 2017-06-08 | 2020-04-09 | Eye Therapies, Llc | Low-dose brimonidine combinations and uses thereof |
| CN110996954A (zh) * | 2017-06-08 | 2020-04-10 | 眼科治疗有限责任公司 | 低剂量的溴莫尼定组合及其用途 |
| AU2018338345B2 (en) * | 2017-09-25 | 2024-10-10 | University Of Florida Research Foundation, Inc. | Preservative removal from eye drops containing hydrophilic drugs |
| US20190134051A1 (en) * | 2017-11-06 | 2019-05-09 | Rheostasis, Llc | Composition for treating ocular disorders such as macular degeneration, retinopathy and glaucoma |
| CA3091313A1 (en) * | 2018-03-28 | 2019-10-03 | Novaliq Gmbh | Pharmaceutical composition comprising timolol |
| US11871308B2 (en) * | 2019-07-29 | 2024-01-09 | TapText llc | System and method for link-initiated dynamic-mode communications |
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2002
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- 2003-04-09 CN CN200910174400A patent/CN101664414A/zh active Pending
- 2003-04-09 EP EP20100171064 patent/EP2241319A1/en not_active Ceased
- 2003-04-09 EP EP03726234.2A patent/EP1496912B9/en not_active Revoked
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- 2003-04-09 CN CNB038004682A patent/CN100558364C/zh not_active Expired - Lifetime
- 2003-04-09 PT PT37262342T patent/PT1496912E/pt unknown
- 2003-04-09 WO PCT/US2003/010885 patent/WO2003088973A1/en not_active Ceased
- 2003-04-09 MX MXPA03008401A patent/MXPA03008401A/es active IP Right Grant
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- 2011-11-30 US US13/308,507 patent/US8354409B2/en not_active Expired - Fee Related
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- 2016-06-24 US US15/192,729 patent/US9474751B1/en not_active Expired - Fee Related
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- 2017-02-22 US US15/439,112 patent/US9770453B2/en not_active Expired - Fee Related
- 2017-08-02 US US15/667,248 patent/US20180042932A1/en not_active Abandoned
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Patent Citations (1)
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| KR20010041473A (ko) * | 1998-04-07 | 2001-05-25 | 제임스 에이. 아노 | 잔탄 검을 포함하는 겔화 안과용 조성물 |
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| US7642258B2 (en) | Combination of brimonidine and timolol for topical ophthalmic use | |
| AU2007254671B2 (en) | Combination of brimonidine and timolol for topical ophthalmic use | |
| AU2003228480C1 (en) | Combination of brimonidine and timolol for topical ophthalmic use | |
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