ES2399045T3 - Combinación de brimonidina y timolol para uso oftálmico tópico - Google Patents
Combinación de brimonidina y timolol para uso oftálmico tópico Download PDFInfo
- Publication number
- ES2399045T3 ES2399045T3 ES03726234T ES03726234T ES2399045T3 ES 2399045 T3 ES2399045 T3 ES 2399045T3 ES 03726234 T ES03726234 T ES 03726234T ES 03726234 T ES03726234 T ES 03726234T ES 2399045 T3 ES2399045 T3 ES 2399045T3
- Authority
- ES
- Spain
- Prior art keywords
- timolol
- brimonidine
- combination
- group
- month
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 title description 49
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 title description 47
- 229960004605 timolol Drugs 0.000 title description 44
- 229960003679 brimonidine Drugs 0.000 title description 31
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- 239000000203 mixture Substances 0.000 claims abstract description 26
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims abstract description 22
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
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- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/003—Arrangement of electric circuit elements in or on lighting devices the elements being electronics drivers or controllers for operating the light source, e.g. for a LED array
- F21V23/004—Arrangement of electric circuit elements in or on lighting devices the elements being electronics drivers or controllers for operating the light source, e.g. for a LED array arranged on a substrate, e.g. a printed circuit board
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- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/02—Arrangement of electric circuit elements in or on lighting devices the elements being transformers, impedances or power supply units, e.g. a transformer with a rectifier
- F21V23/023—Power supplies in a casing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Power Engineering (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/126,790 US7030149B2 (en) | 2002-04-19 | 2002-04-19 | Combination of brimonidine timolol for topical ophthalmic use |
| US126790 | 2002-04-19 | ||
| PCT/US2003/010885 WO2003088973A1 (en) | 2002-04-19 | 2003-04-09 | Combination of brimonidine and timolol for topical ophthalmic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2399045T3 true ES2399045T3 (es) | 2013-03-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03726234T Expired - Lifetime ES2399045T3 (es) | 2002-04-19 | 2003-04-09 | Combinación de brimonidina y timolol para uso oftálmico tópico |
Country Status (17)
| Country | Link |
|---|---|
| US (16) | US7030149B2 (enExample) |
| EP (2) | EP2241319A1 (enExample) |
| JP (1) | JP2005523316A (enExample) |
| KR (1) | KR100723189B1 (enExample) |
| CN (2) | CN101664414A (enExample) |
| BR (1) | BR0302584A (enExample) |
| CA (1) | CA2440764C (enExample) |
| CY (1) | CY1114048T1 (enExample) |
| DK (1) | DK1496912T3 (enExample) |
| ES (1) | ES2399045T3 (enExample) |
| MX (2) | MXPA03008401A (enExample) |
| NO (1) | NO326579B1 (enExample) |
| NZ (1) | NZ528945A (enExample) |
| PT (1) | PT1496912E (enExample) |
| SI (1) | SI1496912T1 (enExample) |
| TW (1) | TWI351959B (enExample) |
| WO (1) | WO2003088973A1 (enExample) |
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| US20050244458A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
| CN100413503C (zh) * | 2005-01-07 | 2008-08-27 | 冷文 | 一种复方眼药组合物 |
| US7534795B2 (en) * | 2005-10-25 | 2009-05-19 | Allergan, Inc. | Compounds and their use related to compositions for treating disease |
| US20070238732A1 (en) * | 2006-04-10 | 2007-10-11 | Allergan, Inc. | Brimonidine and timolol compositions |
| US20080051406A1 (en) * | 2006-08-25 | 2008-02-28 | Richard Graham | Brimonidine and timolol compositions |
| WO2008024846A2 (en) * | 2006-08-25 | 2008-02-28 | Allergan, Inc. | Brimonidine and timolol compositions |
| MX2007010025A (es) * | 2007-08-17 | 2009-02-25 | Arturo Jimenez Bayardo | Composición farmacéutica para tratamiento de hipertensión ocular. |
| MX2007011165A (es) * | 2007-09-12 | 2009-03-11 | Arturo Jimenez Bayardo | Composición farmacéutica estable de timolol, dorzolamida y brimonidina. |
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| US20100298335A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and Methods for Ameliorating or Reducing Presbyopia |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
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| BR112012017319A2 (pt) * | 2009-12-22 | 2016-04-19 | Allergan Inc | composições e métodos para abaixar a pressão intraocular |
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| PT2598119T (pt) | 2010-07-29 | 2018-12-17 | Allergan Inc | Soluções de brimonidina e timolol isentas de conservantes |
| US8445526B2 (en) | 2011-02-03 | 2013-05-21 | Glaucoma & Nasal Therapies Llc | Compositions and methods for treatment of glaucoma |
| UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
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| CN104114154A (zh) * | 2011-12-16 | 2014-10-22 | 阿勒根公司 | 包含聚乙烯基己内酰胺-聚乙酸乙烯酯-聚乙二醇接枝共聚物(Soluplus)的眼用组合物 |
| US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
| US20180078500A1 (en) * | 2015-03-19 | 2018-03-22 | Allergan, Inc. | Fixed dose combination of brimonidine and timolol |
| CA3033507A1 (en) | 2016-08-12 | 2018-02-15 | Silk Technologies, Ltd. | Silk-derived protein for treating inflammation |
| WO2018033854A1 (en) | 2016-08-15 | 2018-02-22 | Santen Pharmaceutical Co., Ltd. | Ophthalmic composition and a method for treating ocular hypertension and glaucoma |
| EP3576770A1 (en) * | 2017-02-01 | 2019-12-11 | Shire Human Genetic Therapies, Inc. | Compounds and compositions for the treatment of ophthalmic disorders |
| MX2019014748A (es) * | 2017-06-08 | 2020-08-03 | Eye Therapies Llc | Combinaciones de brimonidina de dosis baja y usos de las mismas. |
| US20200108064A1 (en) * | 2017-06-08 | 2020-04-09 | Eye Therapies, Llc | Low-dose brimonidine combinations and uses thereof |
| CN111132640B (zh) * | 2017-09-25 | 2023-01-10 | 佛罗里达大学研究基金会股份有限公司 | 从含亲水药物的滴眼剂中除去防腐剂 |
| US20190134051A1 (en) * | 2017-11-06 | 2019-05-09 | Rheostasis, Llc | Composition for treating ocular disorders such as macular degeneration, retinopathy and glaucoma |
| AU2019246035B2 (en) * | 2018-03-28 | 2024-07-18 | Novaliq Gmbh | Pharmaceutical composition comprising timolol |
| US11871308B2 (en) * | 2019-07-29 | 2024-01-09 | TapText llc | System and method for link-initiated dynamic-mode communications |
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| IL293976A (en) | 2019-12-19 | 2022-08-01 | Tearclear Corp | Preservative removal from eye drops |
| CN120617269A (zh) * | 2025-06-16 | 2025-09-12 | 鲁南贝特制药有限公司 | 一种溴莫尼定噻吗洛尔滴眼液及其制备方法 |
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| US7030149B2 (en) | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US7642258B2 (en) | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
| KR100521364B1 (ko) * | 2002-11-18 | 2005-10-12 | 삼성전자주식회사 | 플레쉬 메모리 셀들의 프로그램 오판을 방지하고 균일한문턱 전압 산포를 가질 수 있는 플레쉬 메모리 장치 및 그프로그램 검증 방법 |
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2002
- 2002-04-19 US US10/126,790 patent/US7030149B2/en not_active Expired - Lifetime
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2003
- 2003-02-03 US US10/357,622 patent/US7323463B2/en not_active Expired - Lifetime
- 2003-04-09 SI SI200332241T patent/SI1496912T1/sl unknown
- 2003-04-09 WO PCT/US2003/010885 patent/WO2003088973A1/en not_active Ceased
- 2003-04-09 ES ES03726234T patent/ES2399045T3/es not_active Expired - Lifetime
- 2003-04-09 CA CA002440764A patent/CA2440764C/en not_active Expired - Lifetime
- 2003-04-09 DK DK03726234.2T patent/DK1496912T3/da active
- 2003-04-09 CN CN200910174400A patent/CN101664414A/zh active Pending
- 2003-04-09 CN CNB038004682A patent/CN100558364C/zh not_active Expired - Lifetime
- 2003-04-09 NZ NZ528945A patent/NZ528945A/en not_active IP Right Cessation
- 2003-04-09 EP EP20100171064 patent/EP2241319A1/en not_active Ceased
- 2003-04-09 MX MXPA03008401A patent/MXPA03008401A/es active IP Right Grant
- 2003-04-09 EP EP03726234.2A patent/EP1496912B9/en not_active Revoked
- 2003-04-09 JP JP2003585725A patent/JP2005523316A/ja active Pending
- 2003-04-09 BR BR0302584-5A patent/BR0302584A/pt not_active Application Discontinuation
- 2003-04-09 PT PT37262342T patent/PT1496912E/pt unknown
- 2003-04-09 MX MX2014003586A patent/MX368377B/es unknown
- 2003-04-09 KR KR1020037015881A patent/KR100723189B1/ko not_active Ceased
- 2003-04-18 TW TW092109050A patent/TWI351959B/zh not_active IP Right Cessation
- 2003-10-14 US US10/685,941 patent/US7320976B2/en not_active Expired - Lifetime
-
2004
- 2004-10-19 NO NO20044450A patent/NO326579B1/no not_active IP Right Cessation
-
2007
- 2007-11-28 US US11/946,828 patent/US8133890B2/en not_active Expired - Fee Related
-
2011
- 2011-11-30 US US13/308,507 patent/US8354409B2/en not_active Expired - Fee Related
-
2012
- 2012-12-26 US US13/727,106 patent/US20130116255A1/en not_active Abandoned
-
2013
- 2013-03-01 CY CY20131100193T patent/CY1114048T1/el unknown
- 2013-03-13 US US13/801,252 patent/US20130196995A1/en not_active Abandoned
- 2013-08-01 US US13/957,287 patent/US8748425B2/en not_active Expired - Fee Related
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2014
- 2014-04-28 US US14/263,740 patent/US20150087647A1/en not_active Abandoned
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2016
- 2016-06-24 US US15/192,729 patent/US9474751B1/en not_active Expired - Fee Related
-
2017
- 2017-02-22 US US15/439,112 patent/US9770453B2/en not_active Expired - Fee Related
- 2017-08-02 US US15/667,248 patent/US20180042932A1/en not_active Abandoned
- 2017-11-02 US US15/802,229 patent/US9907802B1/en not_active Expired - Fee Related
- 2017-11-02 US US15/802,179 patent/US9907801B1/en not_active Expired - Fee Related
-
2019
- 2019-05-07 US US16/405,813 patent/US20200129520A1/en not_active Abandoned
-
2021
- 2021-02-05 US US17/168,513 patent/US20210405280A1/en not_active Abandoned
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