KR100704754B1 - Galenic composition for promoting hair-resotoration - Google Patents

Abstract

The present invention relates to a herbal composition for promoting hair growth, the herbal composition for promoting hair growth of the present invention containing kelp, black sesame, sewage, baekjaja, medicinal beans and gardenia as a main component promotes hair growth and metabolism of the scalp, hair loss Not only prevents, but also has a hair growth promoting effect.

Kelp, black sesame seeds, sesuo, white squirrel, yam, gardenia

Description

Herbal composition for promoting hair growth {Galenic composition for promoting hair-resotoration}

The present invention relates to a herbal composition for promoting hair growth. More specifically, the present invention relates to a hair growth promoting herbal composition containing kelp, black sesame, sewage, white squirt, medicinal beans and gardenia as main components.

Human hair is composed of three layers of tissue forming from 'hair follicles' about 4 mm below the skin. The outermost layer is a thin, hard, scaly protective layer that does not show color. The middle layer is the thickest, hair-bearing structure that determines whether the hair is straight or humped, and the color of the hair. The innermost layer is the layer of living cells that nourish hair growth.

There is a papilla in the hair follicle, where small blood vessels are distributed to provide the nutrients needed for hair growth, and the side of the teat has a seborrheic gland that provides shine to the hair. This growth of hair follicles is under the influence of 'testosterone', where the hairs of the armpits and genitals are particularly sensitive to this hormone and appear first in puberty than other parts of the body. On the other hand, the hair of the head is affected by 'dihydrotestosterone (DHT)', a derivative of male hormone.

Hair follicles are originally formed in the prenatal period, and no new hair follicles are formed after childbirth. The numbers remain the same even in adults, but decrease in later life. The first hair to appear during fetal periods is called lanugo hair, which falls off in the mother's womb in about eight months. After birth is vellus hair, thin, light, colorless and within 2 cm in size. This hair can also be seen in the anterior head when androgenetic alopecia progresses. During puberty, cilia are transformed into terminal hair, turning into thick, strong, colored hair.

The growth of the Virgin is influenced by male hormones. In the case of male alopecia, DHT affects the formation of soft hair and eventually causes hair loss. The head usually has an average of 100,000 virgins, which repeat their creation and disappearance with periodic changes in growth, degeneration, and resting phases.

In addition, hair is affected by various factors such as age, season, race, physiological factors, stress, and disease, and usually 50-100 normal 'degenerative hair loss' occurs every day. Normal hair growth is about 2 to 6 years and growth continues at this time, with growth rates of 4 to 6 mm per month. The growth rate is fastest when it is hot and late when it is cold. Hair loss occurs more frequently in autumn and winter than in spring and summer. Hair growth is usually most active between the ages of 15 and 30, and gradually degenerates at the age of 40 and 50. When you are 50 years old or older, natural hair loss begins to occur, and hair loss accelerates after 70 years.

The types, causes and treatment of hair loss are as follows.

The most common complaints of alopecia are subjective and conceptual. Of course, there are cases of obvious hair loss and lesions, but there are no obvious lesions, and the number of complaints is not counted objectively or the appearance of hair is observed without complaints. In other words, the number of hair is reduced, the hair is thinner or smaller, or sometimes breaks easily and breaks, which is often the case. Therefore, when you have hair loss, it is important to accurately assess your current hair condition and to understand your physical and mental health in general.

These alopecia are classified into alopecia areata, resting alopecia, growing alopecia, scalp disease and androgenetic alopecia, looking at them as follows.

Alopecia areata usually occurs suddenly in the scalp of one to two circular hair loss. In addition to the scalp, it can be seen in beards, eyebrows, pubic hair, etc. The cause is not yet known, but it is thought to be caused by autoimmune mechanisms, and genetic and mental (particularly stress) causes. Although it may heal naturally, it is a good idea to treat it if symptoms persist for more than three months or progress further. The most common treatment is intra-lesional injection of corticosteroids and treatment of immune response.                         

In the stage of alopecia areata, 50 to 100 alopecia hair loss occurs in a normal adult. If the number of hair loss is greater than the normal alopecia, a lot of cases can be found. The causes are as follows.

The first is drug use, including anticoagulants, antidepressants, antihypertensives, gastric ulcers, anti-arthritis agents, anticonvulsants, vitamin A derivatives (acne treatments), contraceptives, etc. If you are experiencing hair loss problems while using these drugs, try another agent that has the same effect.

Second is excessive diet, hair loss can occur if there is anemia due to lack of protein or iron due to excessive diet.

Third, stress or fever, severe infectious diseases, chronic diseases, major surgery, etc. These cases can cause hair loss within about 3 months of the cause.

Fourth, hyperthyroidism or hypothyroidism can cause hair loss.

In most cases, hair growth is restored after about six months if the causative irritation disappears.

Growing alopecia is a condition in which hair follicles in the growing stage are acutely severely damaged and more than 80% to 90% of the hair falls out rapidly, and chemotherapy and X-ray irradiation are used to treat malignant tumors. In this case, the hair follicles are recovered within a few weeks after stopping the administration of the causative agent, which is good afterwards.

Scalp disease may show partial hair loss in seborrheic scalpitis, fungal disease, scleroderma, lupus, nymphitis, tumor, syphilis (3rd stage). Seborrheic scalp infection is the most common of the above diseases and is similar to that of alopecia areata. Seborrheic scalp infections often occur with androgenetic alopecia because this phenomenon is also affected by seborrheic glands by DHT.

In many cases, androgenetic alopecia starts from the sides of the forehead and goes up to the 'M-' shape, leading to hair loss at the forehead. At the same time, it is a common phenomenon that the hair experiences thinning, smallness and loss of power along with hair loss.

Androgenetic alopecia is affected by three factors: age, genetic factors and DHT.

The mechanisms by which these factors cause androgenetic alopecia are as follows.

Testosterone in the body is converted to the DHT form by a 5-reduction enzyme during metabolism, which acts on the hair follicles with a male hair loss genetic factor, causing the hair follicles to contract and eventually die off or form a small downy hair. It will result in the remaining. Therefore, if 5-reductase is inhibited, DHT is not formed during the metabolism of male hormones, but male hormones are normally maintained, so male sexual characteristics are maintained but hair loss is prevented.

Alopecia in women is much higher than normal people think, and about two-thirds of women experience it once in their lifetime. The types of female hair loss include the following types of female hair loss and pregnancy hair loss.

Female alopecia is similar to male alopecia, and hair loss occurs gradually with age, but unlike men, hair loss occurs in general without any form. It usually occurs from 25 to 30 years old, and the hair becomes gradually thinner and shorter, and the hair part becomes thinner. Fifty percent of hair loss in adult women does not have this or unfortunately no cure, and hair loss is permanent and genetic.

Hair loss due to pregnancy can occur during pregnancy or at the end of 6 months, and in many cases it is almost recoverable, but there are some cases of permanent hair loss.

As discussed above, alopecia is a disease that must be treated because it has a profound effect on mental health, such as losing confidence in those with alopecia.

There are two methods for overcoming alopecia: using artificial hair, drinking, and applying a hair restorer. Among them, the use of artificial hair has a hassle, and the effect is insignificant when drinking, and in general, a method of infiltrating and infiltrating a hair regrowth is generally used.

Conventionally, the method of applying a female hormone, blood promoter, vitamin E, carotene dissolving agent, fungicide and the method of drinking minoxidil and finasteride have been used as a regrowth for hair loss treatment. Is being reported.                         

Therefore, some countries are developing hair repellents based on herbal medicines with few side effects, but they are not effective.

Considering these problems, the proposed prior art is known as 'hair growth agent and manufacturing method of ginseng-themed Korean patent application No. 1998-0047340' and 'hair loss prevention and hair growth agent' of the domestic patent application No. 2000-0058989.

Korean Patent Application No. 1998-0047340, 'Ginseng-themed hair regrowth and its manufacturing method,' is cold-pressed ginseng, Chinese herbal medicine Cheongung, Hannyeoncho, Bogolji, Angelica, Saengyeop, safflower, red sewage, green rust with 50-70% ethanol. Alternatively, the extract is heated at 50 to 80 ° C., and the extract is centrifuged at 8,000 rpm, the supernatant is taken to dissolve the sugar extract and filtered to prepare a herbal extract, and then dl-α-tocopheral acetate, calcium pantothenate, pyridoxine hydrochloride The present invention relates to a hair regrowth agent prepared by blending and dissolving a component such as propylene glycol, glycerin and fruit flavor in 50% ethanol.

However, unlike conventional hair regrowth chemicals, there are no direct harms to the human body. However, as shown in the experiment, only 45% of nine people had a slight effect. The remaining 11 patients (55%) had no response or deterioration, so there was a problem that the hair growth and hair regeneration were not so effective.

In addition, the 'hair loss prevention and hair growth agent' of the Korean Patent Application No. 2000-0058989 adds water to the ogapi, buckwheat, and three hundred seconds, and heats it at a high temperature of 120 ℃ for several hours, so that the ingredients contained in each material are destroyed and the drug efficacy is remarkable. There is a disadvantage that is reduced, this is just a tonic dose used as dandruff, constipation, hangover.

Therefore, the object of the present invention by using herbal medicines such as kelp, black sesame, sewage, baekgangjam, medicinal beans and gardenia to solve the problems as described above, the herbal medicine for promoting hair growth with excellent penetrability without the side effects It is intended to provide a composition.

The object of the present invention is mixed with 20 to 25% by weight of kelp, 25 to 30% by weight of black sesame seeds, 5 to 10% by weight of sewage, 10 to 15% by weight of Baekjap, 20 to 30% by weight of weak beans and 10 to 15% by weight of gardenia. To prepare a herbal composition for promoting hair growth, animal experiments were conducted using the composition to investigate the toxicity, and then the composition of the present invention was prepared by using a topical coating for spray and a pill for taking hair growth.

The present invention promotes hair growth by mixing 20-25% by weight of kelp, 25-30% by weight of black sesame seeds, 5-10% by weight of sewage, 10-15% by weight of Baekjap, 20-30% by weight of soybeans and 10-15% by weight of gardenia. Manufacturing a herbal composition for dragon; Toxicity test step of the composition; Preparation of the composition of the present invention as a spray topical coating and a pill for taking; It consists of a hair growth efficacy test step of the topical coating and pills.

According to a preferred embodiment of the present invention, the herbal composition for promoting hair growth of the present invention is 20 to 25% by weight, 25 to 30% by weight, black sesame seeds, 5 to 10% by weight, sewage 5 to 10% by weight, 10 to 15% by weight, white beans 20 ~ 30 wt% and Gardenia 10-15 wt% are mixed and put into an extractor, added with water, subjected to high temperature and high pressure, and then uniformly packed in a plastic pack with an automatic packaging machine to produce a liquid product.

According to another preferred embodiment of the present invention, the topical coating agent for spraying using the herbal composition for promoting hair growth of the present invention 20 to 25% by weight, 25 to 30% by weight black sesame, 5 to 10% by weight sewage, 10-15 A mixture of 20% by weight, 20-30% by weight and 10-15% by weight of gardenia was added, extracted with ethanol and distilled water, and the extract was put into a vacuum vacuum concentrator and concentrated to prepare ethanol by evaporation.

In addition, according to another preferred embodiment of the present invention, a convenient pill to take 20 to 25% by weight of kelp, 25 to 30% by weight black sesame, 5 to 10% by weight of sewage, 10 to 15% by weight Baekjap, medicinal beans 20 to 30% by weight and 10 to 15% by weight of gardenia are mixed and extracted by adding ethanol and distilled water, and the extract is put in a vacuum condenser to evaporate ethanol and the extract is 40 kg of solids having a moisture content of less than 10% in a vacuum dryer. It is then prepared by pulverizing it and mixing it with a mixture of honey and water in a ratio of 3: 7 to a blender.

Looking at the characteristics of the herbal extracts of the complex extract adopted in the present invention, kelp, black sesame, sewage, baekjajam, weak beans and gardenia,

In addition to various pigments such as carotene, xanthophylls, and chlorophyll, kelp contains many carbohydrates, such as manit and laminarin, which are made by carbon assimilation, and alginic acid, which is a component of cell walls, and amino acids such as iodine, vitamin B2, and glutamic acid. This contains. In addition, kelp is rich in iodine (I), the main ingredient of thyroid hormone, which is involved in all physiological metabolism of the human body, and is rich in alginate fiber, which is excellent in absorbing harmful heavy metals, excessive salt, and extracorporeal release of cholesterol. It is contained (30%), so it is the best alkaline food and the effect of improving the constitution is a fast food.

Black sesame has been a favorite natural remedy for hair loss and baldness in Japan and China. Especially in China, it is necessary to strengthen the liver and promote blood circulation. Black sesame has been a favorite. Black sesame seeds are rich in high-quality protein and contain vitamin E-containing linolenic acid, calcium, vitamins B1, B2 and iron, which provide the hair with nutrition and reduce blood cholesterol levels. In addition, unsaturated fatty acids such as linoleic acid and linolenic acid, which are rich in black sesame, soften blood, and vitamin E regulates metabolism such as promoting blood flow in peripheral blood vessels. In particular, tryptophan, which is contained in black sesame, works to cleanse the skin and shine the hair. In addition, lecithin, the main ingredient of black sesame seeds, helps transport fat, promotes blood circulation in capillaries, provides the necessary nutrients to the root of the hair, and prevents cholesterol from accumulating in the body. It is also known that the effect of strengthening.

Hasao is known to have black hair when taken from ancient times, and has good nickname and tonic effect in China. Ingredients include anthraquinoids, chrysophanol, emodin, rhein, physcion, chrysophanol anthron, and many starches. And 3.1% fat, lecithin. Emodine and fishion exist in two forms, free and glycosides. As a stilbene derivative, 2, 3, 5,4'-tetrahydroxystilben-2-0-β-D-glucoside is 1.2% or more. It is contained. Animal experiments have stimulated the nervous system, lowering blood glucose levels first and then lowering them below normal. In the pharmacological experiments on the isolated frog heart, not only the excitability of the heart but also the heart of the tired heart (强 心 作用) was rather. It inhibits the increase in cholesterol levels in the serum, which is pointed out that sewage components reduce the absorption of cholesterol in the intestinal tract. It is reported that the active ingredient of sewage is not only caused by the binding of cholesterol, but also by relieving arteriosclerosis, thereby preventing the retention of serum in the oily substance and preventing the deposition on the inner artery wall. This is believed to be related to the action of lecithin. Notably, it is reported that the active ingredient in sewage has a similar effect on corticotropin, an corticosteroid stimulant. It is reported that Saeng Sew is to enhance the peristalsis of the intestinal tract, and that shame is weakened because its glycosides are decomposed. Therefore, the sewage can be said that the effect of Sakha operation, anti-inflammatory action, and Boik Ganshin is realized by the coexistence of anthraquinoids and other active ingredients.

Baeksijam is a gray silkworm that has died. It contains protein, minerals, and oil. It has been used to whiten pigments such as blemishes since ancient times, and has a whitening effect. Baekjap has a protein moisturizing structure similar to the skin mucosa, and has an excellent effect on preventing whitening as well as aging.

Medicinal beans are known to have the best detoxification and weakness among more than 10,000 kinds of beans. They also lower high blood pressure and inhibit blood clot production, while preventing and treating various diseases such as cancer, diabetes, liver disease, high blood pressure, arteriosclerosis, neuralgia and arthritis. It is known to be helpful. Recently in Japan, various extracts of this medicine are used to make extracts and to treat diabetes, decreased vision, skin diseases, gastrointestinal diseases, urinary fetuses, and high blood pressure.

It is said that the fruit of gardenia is gardenia. In oriental medicine, it is used for the treatment of insomnia and jaundice. It is known to have anti-inflammatory, hemostatic and diuretic effects. It is used as a colorant for food, and in the old days, it was stored in gardenia water and steamed to prevent the deterioration of military taste. It is also used for jaundice, plump or in the mountains, and when used to drink fruit, it is used to swell the boils of children's heads or the swelling of adults.

The ingredients contained in the herbal composition for promoting hair growth of the present invention are all used as herbal medicines, food ingredients and foods, and have excellent safety for the human body when taken or ingested.

The formulation of the preferred food composition according to the present invention is a pill that can be liquefied, sprayed, or taken according to a conventional method, but extracted with hot water or an organic solvent, dried with a carrier, encapsulated, or other tablets, granules, powders, It may be formulated in the form of a drink, porridge, and the like.

Hereinafter, the specific configuration and effects of the present invention will be described with reference to examples, but the selection of food types and the change in composition ratio may deteriorate the effects of health foods and intentionally and intentionally change the scope of rights among those skilled in the art. Of course, such a change in numerical range is within the scope of the present invention.

EXAMPLE

Example 1: Preparation of herbal composition for promoting hair growth of the present invention

20% by weight of kelp, 30% by weight of black sesame seeds, 5% by weight of sewage, 10% by weight of white yam, 25% by weight of medicinal beans and 10% by weight of gardenia were added to the extractor, and 10 L of water was added to the mixture at 130 ° C and 2.5 pressure. After daring for an hour to prepare a liquid product by uniformly packaging 90 mL in a plastic pack with an automatic packaging machine.

Experimental Example 1: Toxicity test of herbal composition for promoting hair growth of the present invention

In order to investigate the toxicity of the herbal composition for promoting hair growth of the present invention, acute oral toxicity test and acute skin toxicity test for rabbits and skin irritation test and rabbit in accordance with the toxicity tester and the OECD toxicity test guidelines of medicines, etc. Mucosal irritation test, phototoxicity test and skin sensitization test for guinea pig were performed. At this time, the concentration of the herbal composition of the present invention to the experimental animal was administered orally at 25 to 100% per 1kg of the experimental animal body weight for 3 days.

As a result, no test animals died during the test period, and no abnormalities were observed in weight changes or slaughter autopsy of all living animals. In addition, it was confirmed that when the herbal composition of the present invention was applied to the hair loss site, there was no change in skin tissue (not shown).

Example 2 Preparation of Topical Coating for Spray

In order to prepare a topical coating agent for spraying using the herbal composition for promoting hair growth of the present invention, 20% by weight of kelp, 30% by weight of black sesame seeds, 5% by weight of sewage, 10% by weight of white sperm, 25% by weight of medicinal beans and 10% by weight of gardenia The mixture was added to the mixture, and 40 L of ethanol and 10 L of distilled water were added thereto, and the process of extracting at room temperature for 24 hours was repeated twice to obtain 80 L of an extract. The extract was placed in a rotary vacuum evaporator and concentrated at 45 ° C. for 3 hours to obtain 40 L of an extractant suitable for spraying after evaporation of ethanol.

Example 3 Preparation of Dose Pills

To prepare a convenient pill to take the herbal composition for promoting hair growth of the present invention, 20% by weight of kelp, 30% by weight of black sesame seeds, 5% by weight of sewage, 10% by weight of Baekjap, 25% by weight of medicinal beans and 10% by weight of gardenia The mixture was introduced into a mixer, mixed well, and 40 L of ethanol and 10 L of distilled water were added thereto, and the extraction was performed at room temperature for 24 hours. The extract obtained therefrom was put in a vacuum condenser and warmed at 45 ° C. for 3 hours to evaporate the ethanol contained therein to obtain 60 kg of extract suitable for pills. The extract was poured into a vacuum drier and heated for about 1 hour to 40 kg of solids having a moisture content of less than 10%. 10 L of a mixture of honey and water in a ratio of 3: 7 was added to the blender and blended into a pill molding machine to obtain 40 kg of pills suitable for taking and dried at room temperature for 24 hours.

Experimental Example 1: Efficacy test of topical coatings and pills of the present invention

In order to examine the hair growth promoting effects of the topical coatings and pills of the present invention according to Examples 2 and 3, the following clinical trials were performed on 120 male bald patients who have never been treated.

Those who suffered from serious illness and those who were treated with hormones or hair restorers, except for this experiment, divided 120 patients into three groups and 40 patients into treatment groups, and compared the general data of the three groups as shown in Table 2. Did not show any particular difference.                     

General data for each treatment group division Number of patients Average age Average weight Average baldness A treatment group 40 51.6 70.5 15.0 B treatment group 40 52 68 14.5 C treatment group 40 50 71 15.1

In the treatment group A, the spray-type herbal composition of Example 2 was sprayed on the bald area once or twice a day for 10 weeks, and in the treatment group B, the pills of Example 3 were injected in the morning, lunch and dinner for 10 weeks for 40 tablets. Take a total of three doses, and in the C treatment group, spray the herbal composition of Example 2 into hair loss area once or twice a day for 10 weeks, and at the same time, take 40 tablets of breakfast in the morning, lunch and dinner. A total of three doses were taken.

The hair growth effect of each group after 10 weeks is shown in Table 2.

Hair growth effects in each treatment group division Great usually No change Hair loss No response A treatment group 45% 20% 25% 5% 5% B treatment group 35% 25% 25% 5% 10% C treatment group 70% 20% 5% One% 4%

The hair growth effect of the hair shown in Table 2 was expressed in the following three stages.

No change: almost no hair grows again.

Normal: It seems to grow little by little.                     

Excellent: You can see the hair growing back as if full.

As shown in the above results, the clinical trials of 120 patients showed that the hair regrowth composition of the present invention increased hair growth in men, rather than the spray-type herbal composition alone or pills alone. The effect was greatest in the C treatment group which treated them together.

As described in the above embodiment, the present invention relates to a herbal composition for promoting hair growth, the inventive herbal composition for promoting hair growth containing kelp, sesame seeds, sesame seeds, white sperm, weak beans, and gardenia is the production of hair roots and budding of the scalp. It not only promotes metabolism, prevents hair loss, but also has a hair growth promoting effect. Therefore, the herbal composition for promoting hair growth of the present invention is a very useful invention in the health supplement food industry.

Claims (2)

Hair growth characterized by containing 20 to 25% by weight of kelp, 25 to 30% by weight of black sesame seeds, 5 to 10% by weight of sewage, 10 to 15% by weight of white cob, 20 to 30% by weight of soybeans, and 10 to 15% by weight of gardenia. Herbal composition for promotion. The herbal composition according to claim 1, wherein the composition is in the form of concentrated extract, spray, beverage, pill, granule, capsule or powder.