KR100677664B1 - Automatic injection device of the medical supply solution which is poured in the capsule - Google Patents

Abstract

An automatic injection device of medical supply solution which is poured in capsule is provided to be manufactured and installed in a small size and to be installed at the inside of a hot cell easily. The automatic injection device of medical supply includes a capsule filling plate(7), a fixing member(22), a capsule arranging unit(20), a transferring unit(30), a capsule transferring unit(40), a solution injection slit processing unit(50), a solution injection unit(60), a capsule discharge unit(70), a discharge and injection unit(80) and a control box(130). The solution injection unit is installed to be separated from the solution injection slit processing unit. The capsule discharge unit(70) is installed at the end of the transferring unit.

Description

Automatic injection device of the medical supply solution which is poured in the capsule}

1 is an overall configuration diagram of the automatic injection device for drug solution injected into the capsule according to the present invention,

2A and 2B are plan and front views of a portion of the device of the present invention,

3 and 4 are a cross-sectional side view and a front cross-sectional view of the capsule carrying means of the device according to the invention,

5a to 5c is an operating state of the capsule discharge means,

6 is an external configuration diagram of a control box installed outside the hot cell;

7a to 7d is an overall operation process diagram according to the operating state of the capsule capping member.

※ Brief description of symbols for the main parts of the drawings

5: capsule 5a: capsule lid

5b: capsule body 6: capsule insertion hole

7: capsule filling plate 8: powder material

9: solution injection groove 10: base plate

20: capsule alignment means 22: fixing member

22a: seating portion 22c: position alignment hole

23: support 24: drive motor

25: vertical axis of rotation 27: support lifting member

28: moving member before and after 30: transfer means

40: capsule transport means 42: capsule capping member

43: upper member 44: lower member

45a, 45b: capsule insertion groove 47: vacuum generating means

50: solution injection groove processing means 60: solution injection means

62: solution injection unit 65: injection solution control unit

70: capsule discharge means 72: capsule discharge plate

72a: discharge plate support member 74: capsule discharge pipe

75: wheel cylinder 80: lead container discharge and input means

90: drug solution supply means 91: fixing frame

92: vial 93: slide member

94: slide support member 96: needle fixing block

97: pressurized cylinder 98: discharge hose

100: washing water supply means 105: washing water recovery means

106: recovery vial 107: support member

108: lifting cylinder 109: front and rear moving cylinder

110: radioactivity measuring means 130: control box

The present invention relates to an automatic injection device for a pharmaceutical solution injected into a capsule, and in particular, the pharmaceutical solution used for the treatment and diagnostics of a patient is automatically injected and sealed in a capsule of a certain size, and then the input and discharge into a constant container. The present invention relates to an automatic injection device for a pharmaceutical solution injected into a capsule configured to increase the productivity of a product by automating a process, promote worker safety, and minimize a defect rate of a product.

Today, as the quality of life improves and various diseases occur in all ages, both men and women, the use of patient treatment drugs or diagnostic drugs is increasing.

Moreover, due to changes in diet and living environment, it is difficult to find them in the past, or new types of diseases are occurring, and cases of death from various cancers are increasing.

These diseases and the increasing number of patients are being developed and processed in various forms, ranging from general medicines to specialty cancer treatment and diagnostic medicines.

The present invention relates to an automatic injection device for a medicine solution which is made of an elliptical shape among the various medicines and injected into a capsule used in the manufacture of a capsule medicine provided to a patient by filling a predetermined medicine therein.

In the case of general medicines, the process of filling medicines into capsules for mass production is mass-produced using a certain type of automated equipment, but special medicines, special medicines used only for rare diseases or special diseases (e.g. radiopharmaceuticals) In this case, the amount of use is limited, so there is no mass production system, and most workers fill the capsules with a small amount of medicine by hand, so that the yield is not only low but also the incidence of defects is high. There was a problem that workers can be directly exposed to the drugs.

In particular, in the case of radiopharmaceuticals widely used in recent years for the treatment and diagnosis of various cancers, due to the characteristics of the medicines, a large amount of medicines are manufactured at one time and cannot be used for a long time. Since it must be produced, it was very difficult to meet the requirements in a timely manner by conventional manual work.

In particular, when workers are exposed to such radiopharmaceuticals for a long time, they face a risk of developing a disease that is difficult to treat by radiation emitted from radiopharmaceuticals.

In order to solve these problems, "I-131 capsule assembly and packaging automation device" has been devised in Korea Patent Publication No. 0265691.

In the case of the known domestic patent, in order to meet the increasing demand of radioactive isotope I-131, which is widely used for various industrial, medical, and research purposes, I-131 solution is moved to a closed cell, which is blocked from the outside, and a lower capsule process. Positioning and powder supply process, powder formation process, stock solution injection process, upper capsule supply and assembly process, radioactivity measurement process and inspection, discharge process, and vial capping process are collectively performed by a series of devices installed on a certain base plate. The present invention relates to a capsule assembly and packaging automation device for carrying.

However, such a known I-131 capsule assembly and packaging automation device is configured to perform an integrated process on one base plate, thereby improving productivity, product quality, and minimizing worker exposure risks. Not suitable for the situation is not being used.

That is, since the capsule assembly and packaging automation device should be installed in a narrow space inside the hot cell installed at a constant size in the radioactive area, the size of the capsule assembly and packaging automation device may be very limited, but in the case of the conventional device, a plurality of processes and devices may be used. Because it is configured to be implemented on the base plate of the large size, it is very difficult to install inside the hot cell, so there was a problem that can not be used practically, and many processes other than the filling process of radiopharmaceuticals are made in the limited cell. Rather, there was a problem that productivity is not improved due to poor workability.

The present invention has been made to solve the problems according to the conventional manual work and the problems with the conventional device, the present invention is composed of a constant automation device only a drug input process in the capsule that is a special process is a work process harming the human body The purpose of the present invention is to provide an automatic injection device for pharmaceutical solution injected into a capsule which can be easily installed inside a hot cell, which is a restricted radioactive contamination area of a certain size, so that safe and efficient work can be performed.

In order to achieve the above object, the automatic injection device of the drug solution injected into the capsule according to the present invention is filled with a predetermined powder material therein is provided with a plurality of capsule fitting holes for fixing the capsule consisting of a structure that can be opened and closed Capsule filling plate, and capsule alignment means configured to allow the capsule filling plate to rotate and move forward and rearward and adjust height while supporting the capsule filling plate at a fixed height on one side of the upper surface of the base plate manufactured to be installed inside the hot cell. ; Transfer means installed on the front base plate of the capsule alignment means in a reciprocating manner and moved left and right according to a control command; A capsule carrying means provided with a capsule capping member to open and close the lid while receiving the capsule discharged from the capsule alignment means and moving along the transfer means; Solution input groove processing means fixed to the upper end side of the capsule alignment means to form a solution injection groove on the powder material in the capsule while the lid is opened and moved by the capsule carrying means; A solution injection means which is formed at one side of the solution injection groove processing means so that a solution injection groove is formed to introduce a predetermined amount of the drug solution into the solution injection groove in the capsule moved by the capsule carrying means; After dispensing the solution capsulated capsule is delivered from the capsule carrying means to the capsule discharging means is installed in a structure capable of lifting up and down at the end of the transfer means for input into the prepared lead container on the base plate; A lead container discharge and input unit which is installed outside the hot cell under the capsule discharge means to draw out the lead container into which the capsule has been introduced into the outside of the hot cell and into the empty lead container; Air and vacuum generating means connected to each means at a lower end of the base plate and provided to provide driving force for controlling a required operation of each means; It is configured to include; a control box is provided outside the hot cell is provided with a variety of operation switches for automatic or manual control of each means.

Further, the upper side of the base plate is provided with a medicine solution supply means configured to provide a medicine solution to the solution injection means is installed in a structure in which a plurality of vials each having a different storage capacity of the medicine solution is replaceable, the medicine One side of the solution supply means is provided with a washing water supply means for washing the solution injection passage and the inside of the solution injection means after the solution injection by the solution injection means is completed, the washing water introduced into the solution injection means on one side of the transfer means Washing water recovery means for recovering is further made.

In addition, the capsule aligning means is provided with a seating portion supporting the capsule filling plate at the top, the capsule discharge hole is formed in front of the seating portion to discharge the capsule one by one from the capsule filling plate seated on the seating portion, the upper surface of the seating portion A fixing member provided with a rectangular alignment hole from the center of the seating portion to the front side to move the seated capsule filling plate forward and backward; A driving motor is installed at the lower end of the fixing member, one end is coupled to the center of the upper surface of the driving motor, and the other end penetrates the bottom of the fixing member and is connected to the center of the capsule filling plate to transmit the rotational force of the driving motor. ; It is provided at the lower end of the drive motor before and after the movement of the capsule filling plate installed to move back and forth; A support member is installed at the lower end of the front and rear movement member to support the front and rear movement member, the support is installed in the structure of the one end of the support elevating member can be elevated to adjust the height of the capsule filling plate; It consists of a characteristic structure that is constructed.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

According to the present invention, when a powder material is filled in a capsule of a predetermined standard, the small amount of the pharmaceutical solution on the powder material in the capsule, in particular, a medicine that may harm the human body when exposed to the outside is sealed. The essential configuration of the invention is the characteristic configuration of the device necessary for the process of automatically injecting and discharging the pharmaceutical solution in the capsule to be discharged to the outside of the hot cell by encapsulating the capsule in an assembled container after automatic injection into the hot cell.

The overall configuration and assembly of such a device of the present invention is shown schematically in FIG. 1.

As shown in the figure, since the automatic injection device for drug solution injected into the capsule according to the present invention should be manufactured and installed in accordance with the small size of the hot cell (H) to be installed, a number of necessary devices are collected in a predetermined space The main means are collectively installed on the base plate 10 of a certain size so as to be configured to be organically operated with each other, and the operation of each means provided inside the hot cell H can be controlled outside the hot cell H. The control box 130 is provided, and some means are installed in connection with the inside and outside of the hot cell (H), one side inside the hot cell to remotely perform a predetermined task required for each device from outside the hot cell Manipulated (robot arm) is provided, but the drawings are omitted in the accompanying drawings of the present invention.

Referring to the configuration of the main means according to the invention installed in the hot cell (H) with reference to Figure 1, the base plate 10 of a predetermined size that can be installed inside the hot cell (H) as a reference plane The transfer means 30 is configured to reciprocate at a set speed with respect to the entire length of the base plate 10 on one side of the upper surface, and is fixed to the transfer means 30 in the upper portion of the transfer means 30 The capsule transport means 40 is installed to move the capsule while being moved in accordance with the reciprocating motion of the transport means 30, the plurality of capsules containing the powder material in the front one side based on the transport means 30 is circumferential Capsule alignment means 20 for aligning the capsule filling plate (7) provided in the fitted state coupled in the direction is installed, spaced apart from the capsule alignment means 20 along the traveling direction of the transfer means (30) Staples The lead 10 in which the wash water recovery means 105 and the capsule discharge means 70 are continuously spaced apart a predetermined distance on the bite phase 10, and the capsule is encapsulated outside the hot cell H at the lower end of the capsule discharge means 70. A lead container discharge and input means 80 for discharging the container 120 and supplying a new lead container into the hot cell is installed, and the wash water is disposed on one side of the upper surface of the base plate 10 provided with the capsule alignment means 20. The supply means 100 and the chemical solution supply means 90 is configured to be disposed respectively.

The above-described configuration will be described in more detail by main means, the capsule alignment means 20 is configured to be fitted to each of the capsule fitting hole (6) formed of a plurality of rows of powder filled with a plurality of capsules in one disc After moving the capsule filling plate (7) into the hot cell to position the capsule filling plate (7) by using a manifold to a certain height, the capsule supply means configured to supply one by one capsule provided in the capsule filling plate (7) As such, the fixing member 22 having a seating portion 22a on the upper surface thereof is provided at the top thereof so that the filling plate support member 7a containing the capsule filling plate 7 at a predetermined height may be mounted thereon. The center of the member 22 is coupled to the center of the capsule filling plate 7 in the filling plate support member 7a seated along the seating portion to rotate the capsule filling plate 7 at regular intervals to the capsule filling plate 7. It is possible to dispense the fixed capsule one by one. A vertical rotation shaft 25 having a predetermined height is installed at the lower end of the fixing member 22 (see FIG. 2B), and the vertical rotation shaft 25 is coupled to the driving motor 24 provided at the lower end thereof so as to rotate. And the capsule filling plate 7 coupled to the driving motor 24 and the vertical rotating shaft 25 and the vertical rotating shaft 25 to be moved forward by a predetermined distance in which the transfer means 30 is installed. The front and rear movement member 28 is installed at the lower end of the drive motor 24, and the front and rear movement member 28 has a structure capable of lifting up and down on the support 23 installed vertically on one side of the base plate 10. It is made of a configuration that is fixed to be installed up and down by the support lifting member 27 installed.

Figure 2a shows a partial plan view of the device according to the present invention, the capsule carrying means 40 located in front of the seating portion (22a) to discharge the capsule provided in the capsule filling plate 7 one by one A capsule discharge hole (not shown) is formed through the front of the seating portion 22a, and the capsule filling plate 7 seated on the upper surface of the seating portion 22a is moved forward to move all the capsules inserted into the outermost column. After discharge, a rectangular alignment hole 22c for front and rear movement of the capsule filling plate 7 is formed in the center of the seating portion 22a so as to discharge the capsule provided in the inner circumferential row.

Since the rectangular alignment hole 22c is formed, the capsule filling plate 7 may be rotated as well as moved forward and backward toward the front conveying means 30, and the capsule filling plate 7 may be rotated. Capsules coupled to the capsule filling plate 7 in the circumferential direction in the forward direction can be sequentially discharged one by one from the outer circumferential row to the inner circumferential row, a predetermined cylinder is mounted on the bottom surface of the fixing member 22 Pressing the rear of the filling plate support member 7a on which the capsule filling plate 7 is seated with the pressing member 22b, the filling plate support member 7a is in close contact with the front surface of the fixing member 22, so that it can be fixed without shaking. It is configured to be.

On the other hand, the opening and closing operation of the capsule lid while transporting the capsule fixedly installed on the transfer means 30 from one end of the base plate 10 in which the capsule alignment means 20 is installed to the other end where the capsule discharge means 70 is installed The capsule carrying means 40 is configured to perform the capsule capping member 42 protrudes slightly in front of the transfer means 30 is provided on the front.

3 and 4 show a side cross-sectional view and a front sectional view showing only the capsule transport means 40 to extract the configuration of the capsule transport means 40 in more detail.

As shown in FIG. 3, the capsule capping member 42 provided on the front surface of the capsule carrying means 40 is configured to be separated into an upper material 43 and a lower member 44 up and down to the front of the transfer means 30. It is made of a slightly protruding structure, the capsule fixing grooves (45a, 45b) of a predetermined depth are formed in the upper surface and the bottom center of the upper member 43 and the lower member 44 facing each other, the upper member By the contact of the 43 and the lower member 44, two capsule fixing grooves (45a, 45b) is made of a structure that can wrap one capsule, the lower member of the upper and lower members (43, 44) ( 44 is fixed to the main body of the capsule transport means 40, the upper material 43 is composed of a structure that is moved up and down in the main body of the capsule transport means 40 is the capsule discharged from the capsule alignment means 20 The capsule fixing groove 45b of the member 44 is configured to open and close the cap of the capped capsule while the upper member 43 is lifted when fitted.

In addition, Figure 4 shows the front of the capsule carrying means 40, as shown in the figure, the capsule cap member 42 protruding in front of the capsule carrying means 40 is provided of the capsule It is preferable that the capsule fixing grooves 45a 'and 45b' of different sizes are formed so as to be selectively used according to the size. Each of the outer and outer ends of the upper and lower members 43 and 44 may be formed. The capsule lid or capsule is sucked and fixed inside the capsule fixing groove by generating a predetermined vacuum pressure inside the capsule fixing grooves 45a, 45b, 45a 'and 45b' of the upper and lower members 43 and 44. The vacuum generating means 47 is connected and installed so that the opening and closing of the capsule lid or the discharge operation of the capsule can be made by elevating the upper material 43.

In addition, the upper member 43 of the capsule capping member 42 configured as described above has the lower member 44 for separating or coupling the capsule lid from the capsule whose head portion 46 is inserted into the lower member 44. When contacted with the upper surface of the lower member 44 is elastically in contact with the upper surface of the lower body 44 is applied to the capsule body in the lower force is applied to the predetermined predetermined inside to prevent the capsule from being broken during opening and closing of the capsule lid The elastic spring 48 is provided and made of a structure that can be sunk.

In addition, the solution input groove processing means 50 is installed in one direction of the upper end side of the capsule alignment means 20, that is, the capsule transport means 40 is moved, the solution input groove processing means 50 is a capsule transport Powder material to facilitate the injection of the pharmaceutical solution onto the powder material inside the capsule body fixed to the lower member 44 in a state in which the capsule dropped and moved to the means 40 by the capsule capping member 42 is opened by the capsule capping member 42. In order to form a solution injection groove of a predetermined depth on the upper surface, the groove processing member is moved up and down on a line where the capsule is moved to protrude toward one side of the fixing member 22 to form a solution injection groove of a predetermined depth on the powder material. .

In addition, the capsule carrying means 40 is moved from the solution input groove processing means 50 by a predetermined distance so as to inject the quantitative drug solution into the solution input groove formed on the upper surface of the powder material in the solution input groove processing means 50. The solution injection means 60 of the medicine is installed at the position.

The solution injection means 60 is installed near the front of the transfer means 30, the solution injection portion 62 for directly injecting the solution into the solution injection groove formed on the inside of the capsule body moved by the capsule transport means 40 And an injection solution control unit 65 connected to the solution injection unit 62 by a hose to supply a prescribed amount of the drug solution, and the injection solution control unit 65 is provided on one side of the upper surface of the base plate 10. Is provided so that the medicine solution supplied from the medicine solution supply means 90 is fixed to the vial filled with a certain amount of the drug solution is provided, one side of the medicine solution supply means 90, the injection solution control unit 65 ) Is provided with a washing water supply means 100 for supplying the washing water to clean the pharmaceutical solution in the drug solution supply passage and the supply hose after supplying the drug solution.

The tip of the solution injection unit 62 is provided with a fine injection needle is configured to inject a small amount of the solution into the capsule, the injection solution control unit 65 is provided with a plurality of syringes can be injected at the same time or respectively The injection and withdrawal of the syringe is injected or withdrawn by the injection amount set in the control box by a predetermined cylinder member coupled to the lower end of the syringe to supply the drug solution is made, the drug solution supply means (90) Is preferably installed in plurality in order to fix the different capacity of the vial, the drug solution supply means 90 and the washing water supply means 100 is different only in the content that is filled in the configuration and operation of the device same.

That is, the vial receiving member 94 for supporting the rear end of the vial 92, which is filled up with the medicine solution on the top of the box-shaped fixing frame 91, is fixedly installed to be movable back and forth by the predetermined slide member 93. At the bottom of the vial 95 is installed, a needle fixing block 96 is installed in which a plurality of needles 95 are installed toward the vial, and the needle fixing block 96 is provided at the bottom of the needle fixing block 96. It is configured to be supplied by the injection cylinder 97 to penetrate the inlet of the vial 92, which is placed upside down by pressing the needle 95 upwards, and to insert the needle into the vial to supply the medicine solution, and the inlet of the needle. The discharge hose 98 for withdrawing the drug solution discharged from the vial is configured on the side, respectively, and the drug solution is supplied to the injection solution control unit 65 through the discharge hose. Is adapted to be, one end of the discharge hose (98) there is coupled to each of a predetermined control valve for controlling the flow of drug solution.

On the other hand, the capsule from which the solution is injected by the solution injection means 60 is a capsule from the capsule transport means 40 moved by a certain distance by the transfer means 30 in a state in which the capsule lid is closed by the capsule capping member 42 The capsule discharging means 70 is installed at a predetermined height at the end of the transfer means 30 so as to be introduced into the prepared lead container.

The capsule discharging means 70 is absorbed by the upper material 43 of the capsule capping member 42 as shown in the excerpt sectional view shown in Figure 5a to 5c, the upper material 43 to receive the capsule raised to a certain height The capsule fitting plate 73 is installed at a predetermined height so as to move up and down to the lower end of the capsule discharge plate 72 installed at the top of the discharge plate support member 72a, and the front and rear of the capsule discharge plate 72. The capsule is received from the wheel cylinder 75 installed at the rear of the capsule discharge plate 72 and the capsule discharge plate 72 moved backward while the capsule is seated by the wheel cylinder 75 to enable the sliding movement. Tubular capsule discharge tube having a constant diameter and height of a predetermined size through which the capsule can be passed vertically below the rear end of the discharge plate support member 72a so that the capsule can be inserted into the inside of the lead container 120 located at the bottom 74 is provided with a configuration provided.

In addition, the lead container discharging and injecting means (80) extending from the end of the base plate 10 to the outside of the hot cell (H) discharges the lead container in which the capsule is injected by the capsule discharging means (70) to the outside of the hot cell In order to inject the empty lead container into the hot cell, the capsule discharge means 70 provided at the end of the base plate 10 is configured as a kenveyer system in a predetermined section from the outside of the hot cell, the capsule discharge means 70 In the lead container 120 in which the capsule is discharged from is stored and moved to the upper side of the lead container discharge and input means 80 outside the hot cell to check whether or not the appropriate amount of radioactive elements administered inside the capsule is administered Measuring means 110 is made of a configuration that is additionally installed.

In addition, between the solution injection means 60 and the capsule discharge means 70 after the drug solution injecting process in the capsule is completed, the drug solution supply passage and the discharge hose inside the washing water provided by the wash water supply means (100) Dilution solution) and the washing water recovery means 105 for recovering the washing water discharged to the needle of the solution injection part 62 is provided, and the washing water recovery vial 106 is fixed at the top. At the lower end of the support piece 107 supporting and fixing the recovery vial 106, the height of the recovery vial at the upper end and the elevating and moving cylinders 109 and 109 for advancing to the position of the solution injection part 62 are shown. ) Are each provided with a configuration.

On the other hand, although not shown in the figure, at the end of the transfer means 30 is provided with a cleaning means for vacuum cleaning the capsule capping member of the capsule transport means, the bottom of the base plate for air or vacuum for the operation of each means The generating means is properly arranged, and FIG. 6 shows a control box 130 and an operation panel 135 for automatically or manually controlling the above-described means and devices provided inside the hot cell H from the outside of the hot cell. Doing.

The operation panel 135 is configured to control the entire process for injecting the drug solution into the capsule directly by the operator directly from the outside of the hot cell, the upper side of the control switch and display for adjusting the dose of the drug solution ( 140 is provided, the lower end is provided with an ammeter 141, a voltmeter 142 and a power switch 143, the medicine solution input amount setting button 145, etc., each of the middle portion in accordance with the process of moving the capsule A switch operation control unit 150 capable of controlling the means is provided.

The switch operation control unit 150 is divided into an automatic switch operation unit 151 and a manual switch operation unit 156 so as to adjust each means automatically or manually, respectively, so as to enable automatic or manual control according to the work contents. The manual switch operation unit 156 is configured to control the plurality of capsule capping members 42 provided in the capsule transport means 40, the manual switch operation unit corresponding to the number of capsule capping members up and down Each separated configuration, the lower end is made of a configuration provided with a control switch 160 and gauge 162 for controlling the vacuum and air pressure provided to each means.

Even when the automatic switch operation unit 151 is operated to be automatically controlled, an operation button for inputting medicine solution and a washing vial is provided separately, and the manual switch operation unit 156 discharges capsules and capsules from a capsule alignment step. Each functional switch is provided to control and control the respective means throughout the vacuum cleaning phase of the vehicle. Since the electric and electronic technical configuration and operation description of each functional switch can be easily implemented by conventional techniques. Detailed description thereof will be omitted.

On the other hand, with reference to the operational state diagram of the capsule carrying means 40 and the capsule capping member 42 shown in Figure 7a to 7e will be described the operation and operation of each means.

In the detailed description of the present invention for the description of the device according to the present invention, the drug solution supplying means, the washing water supplying means, and the washing vial fixing means, which are preceded to perform the necessary work of the device of the present invention, are respectively installed, and into the hot cell. The capsule filling plate with the capsule is pre-supplied and seated on the fixing member, and the main work process made by the apparatus of the present invention in the state in which the lead container is supplied to the lower end of the discharge means will be described.

The apparatus according to the present invention is to control the operation panel of the control box 135 provided outside the hot cell (H) as described above to select a method of operation manually or automatically, hereinafter the operation operation that proceeds automatically and The process will be described mainly.

When the operator switches the auto / manual switch automatically while the power is turned on at the control panel 135 of the control box 130, each means enters the work preparation step by a microcomputer provided in the control box, and the transfer means. The capsule carrying means 40 installed in the 30 moves to the front of the capsule alignment means 20 in a state where the upper member 43 and the lower member 44 are spaced apart to insert the capsule formed on the upper surface of the lower member 44. The groove 45b is positioned in a state consistent with the capsule discharge hole 22b formed in the seating portion 22a, and the capsule filling plate 7 seated on the upper surface of the fixing member 22 in this state is before and after. The capsule fitting hole 6 provided in the outermost circumferential row of the capsule filling plate 7 is moved forward by a predetermined distance by the moving member 28 or the rotation of the vertical rotating shaft 25 is the capsule discharge hole 22b. ), The capsule that was inserted into the capsule fitting hole (6) passes through the capsule discharge hole (22b) and the lower member (44). Is inserted in the capsule is dropped screw hole (45b). (Fig. 7a)

After the capsule is fitted to the lower member 44, the capsule carrying means 40 is moved by a predetermined distance along the transfer means 30, and then the upper material 43 is lowered to the upper surface of the lower member 44. Capsule fixing groove (45a) is fitted to the upper end (Fig. 7b).

After the upper member 43 is seated, the capsule fixing grooves 45a and 45b are provided through vacuum supply means 47 provided at both ends of the capsule fixing grooves 45a and 45b of the upper and lower members 43 and 44. When a predetermined vacuum pressure is applied to the upper and lower members 43 and 44 while the capsule is vacuum-adsorbed inside the capsule fixing grooves of the upper and lower members 43 and 44, the cap of the capped capsule is peeled off. The powder material filled in the capsule body fitted into the capsule fixing groove 45b of the member 44 is exposed.

When the capsule carrying means 40 is moved in front of the solution injection groove processing means 50 while the capsule lid is opened, the solution injection groove processing coupled to the fixing member 22 of the capsule alignment means 20 is performed. The means 50 is lowered to form a predetermined solution introduction groove 55 in the upper surface of the central portion of the powder material (FIG. 7C).

After the solution injection groove is formed and the solution injection groove processing means 50 is lowered to its original position, the capsule carrying means 40 is moved back by a predetermined distance by the transfer means 30, and then the front of the solution injection means 60. When positioned in the, the solution injection means 60 is lowered and the injection needle of the solution injection portion 62 enters into the capsule body fixed to the lower member 44 to the solution injection groove inside the injection solution control unit 65 Inject the supplied drug solution.

After injecting the drug solution, the capsule conveying means moved a certain distance after the solution injecting means 60 is raised to the original position, and the upper member 43 of the capsule cap member to which the capsule cap is adsorbed is lowered to lower the lower member 44. In a state where the capsule body is covered with the capsule lid (see FIG. 7D), the vacuum pressure caught in the capsule fixing groove 45b of the lower member 44 is released, and the upper material 44 is again in the state where the vacuum pressure is applied to the upper material again. When 43 is raised, the capped capsule is raised in a state fixed to the upper material 43 (Fig. 7E).

In the state of FIG. 7E, the capsule carrying means 40, which is moved by a certain distance by the transfer means 30, moves forward in which the capsule discharging means 70 is installed, so that the capsule discharging plate 72 of the capsule discharging means 70 is moved. The capsule fixed to the upper material is positioned on the upper part, and in this state, when the vacuum pressure applied to the upper material 43 is released, the capsule 5 is formed on the upper surface of the capsule discharge plate 72. The capsule discharge plate 72 is dropped to the drop, and the capsule is dropped and moved backward by the wheel cylinder (75).

The capsule fitting hole 73 of the capsule discharge plate 72 moved rearward coincides with the capsule discharge hole 72b formed in the discharge plate support member 72a installed at the lower end thereof, and thus the lower end of the discharge plate support member 72a. The capsule is discharged through the capsule discharge pipe 74 installed toward the upper surface of the base plate and is introduced into the lead container 120 located on the upper surface of the lead container discharge and input means 80.

The lead container 120 into which the capsule is inserted is withdrawn to the outside of the hot cell along the lead container input and discharge means 80, and the radioactive measuring means 110 measures the radioactivity contained in the capsule in the middle of the lead container. The product is judged whether or not the appropriate amount of pharmaceutical solution is added to complete or reprocess the product.

When the series of such operation process is completed, the capsule capping member 42 of the capsule carrying means 40 is washed by a vacuum washing means separately installed at the end of the transfer means 30, the washed capsule carrying means 40 is moved back to the capsule alignment means 20 by the transfer means 30, the capsule filling plate 7 is rotated by the displacement set by the vertical rotation shaft 25 to the next capsule is fixed member ( A series of processes to be disposed and discharged in the capsule discharge hole 22b of 22) is continuously performed, and the capsule, which has been coupled to the outermost circumferential row of the capsule filling plate 7, is discharged according to one rotation of the capsule filling plate. After the movement, the front and rear movement member 28 moves by the distance set toward the conveying means 30, and then the capsule fixed to the circumferential row is positioned on the circumferential center line of the capsule discharge hole 22b of the fixing member to rotate the vertical rotation shaft. Sorted by, ship , As the movement operation made, to the outlet of a capsule coupled to the plurality of columns in a capsule filling board is be made of a capsule comprising a drug solution added and assembly.

On the other hand, the operation process and the operation of each means is a series of processes are carried out by the automatically set program, during manual operation of the device, the operator directly controls the operation switch of each means provided on the operation panel 135 It is possible to perform the work in the means step by step, the operation content of each means by the manual operation is the same as that performed by the above-described automatic process, detailed description thereof will be omitted.

In the case of the automatic injection device of the drug solution injected into the capsule according to the present invention operated by the configuration and structure as described above, the capsule filling plate (7) while the plurality of capsules are fitted to the capsule filling plate (7) of the disc shape Since a plurality of capsules fitted into one circumference are automatically supplied according to rotation and advance of the device, the space utilization effect of the device to be installed in a small space can be maximized, and the capsules are vertically supplied from the alignment means 20. Since the work is performed while maintaining the same vertical posture until the capsule is discharged to the lead container by the moving capsule discharge means 70 by one capsule transport means 40, the assembly of the capsule is easy and the medicine in the capsule may leak. Low risk

In addition, since the upper and lower members of the capsule capping member carrying the capsule and carrying out the opening and closing operation of the capsule lid are elevated by being integrally formed in the same support frame, it is possible to minimize the failure rate when assembling the capsule, one capsule from the input Since the next capsule is processed after a series of processes until discharge of lead container, if a problem occurs such as capsule breakage in the assembly process of the capsule, only one capsule needs to be processed by handling the emergency. There is an easy feature.

In addition, the vial in which the drug solution is stored is inserted into the syringe assembled upside down to the drug solution supply means 90, so that the drug solution filled in the vial can be used to the maximum, thereby reducing the radioactive contamination inside the hot cell. When the injection of the medicine is completed, the washing water can be cleaned by passing the washing water to the medicine input path by the washing water supply means to reduce the radioactive contamination inside the hot cell and to improve the precision of the amount of the medicine injected into the capsule. do.

In addition, the capsule carrying means is provided with a plurality of rows of capsule capping device, even when assembling capsules having different capacities, it is possible to perform the work without the need to install or change a separate device, thereby enabling the assembly of capsules of various capacities.

As described above, the capsule auto-injection device of the pharmaceutical solution according to the present invention is manufactured and installed in a miniaturized only for a specific work process that can be exposed to the drug, it is easy to install the device inside a small hot cell, dangerous operation Since the process can be performed inside the hot cell, it is possible to secure the safety of the worker and to provide a useful effect of minimizing the incidence of capsule defects that may occur during capsule assembly and improving the quality.

Claims (8)

Capsule filling plate is provided with a plurality of capsule fitting holes for fixing the capsule consisting of a predetermined powder material inside the upper and lower opening and closing structure, and the capsule filling plate on one side of the upper surface of the base plate made of a size that can be installed inside the hot cell Capsule alignment means configured to enable rotation and forward and rearward movement and height adjustment of the capsule filling plate while maintaining a fixed height; Transfer means installed on the front base plate of the capsule alignment means in a reciprocating manner and moved left and right according to a control command; A capsule carrying means provided with a capsule capping member to open and close the lid while receiving the capsule discharged from the capsule alignment means and moving along the transfer means; Solution input groove processing means fixed to the upper end side of the capsule alignment means to form a solution injection groove on the powder material in the capsule while the lid is opened and moved by the capsule carrying means; A solution injection means which is formed at one side of the solution injection groove processing means so that a solution injection groove is formed to introduce a predetermined amount of the drug solution into the solution injection groove in the capsule moved by the capsule carrying means; After dispensing the solution capsulated capsule is delivered from the capsule carrying means to the capsule discharging means is installed in a structure capable of lifting up and down at the end of the transfer means for input into the prepared lead container on the base plate; A lead container discharge and input unit which is installed outside the hot cell under the capsule discharge means to draw out the lead container into which the capsule has been introduced to the outside of the hot cell and to introduce the empty lead container into the hot cell; Air and vacuum generating means connected to each means at a lower end of the base plate and provided to provide driving force for controlling a required operation of each means; Various control switches for automatic or manual control of the respective means is provided with a control box which is installed outside the hot cell; Automatic injection device for pharmaceutical solution injected into the capsule consisting of. The method of claim 1, The upper side of the base plate is provided with a medicine solution supply means configured to provide a medicine solution to the solution injection means by installing a plurality of vials each having a different storage capacity of the drug solution is installed, the medicine solution supply One side of the means is provided with a washing water supply means for washing the solution passage and the solution injection means after the completion of the solution injection by the drug solution injection means, the washing water injected into the solution passage and the drug solution injection means from one side of the transfer means Automatic injection device for pharmaceutical solution injected into the capsule, characterized in that the wash water recovery means further provided with a washing water recovery vial for recovering. The method of claim 2, One end of the lead container discharge and input means is provided with a radioactivity measuring means for checking whether or not a prescribed amount of pharmaceutical solution in the capsule of the lead container moving from the inside of the hot cell to the outside, the capsule at the end of the transfer means Automatic dispensing device of medicine solution injected into the capsule, characterized in that the vacuum cleaning means for cleaning the capsule carrying means after the discharge is further provided. The method according to claim 2 or 3, The capsule alignment means is provided with a seating portion supporting the capsule filling plate at the top, the capsule discharge hole is formed in front of the seating portion to discharge the capsules one by one from the capsule filling plate seated on the seating portion, seated on the upper surface of the seating portion Fixing member is provided with a rectangular alignment hole from the center of the mounting portion to the front side to move the capsule filling plate forward and backward; A driving motor is installed at the lower end of the fixing member, one end is coupled to the center of the upper surface of the driving motor, and the other end penetrates the bottom of the fixing member and is connected to the center of the capsule filling plate to transmit the rotational force of the driving motor. ; A front and rear moving member provided at a lower end of the driving motor and installed to allow the front and rear movement of the capsule filling plate; The support lifting member is installed at the lower end of the front and rear movement member to support the front and rear movement member, and one end of the support lifting member is installed in a structure capable of lifting up and down to adjust the height of the capsule filling plate. Automatic injection device for drug solution injected into the capsule characterized in that. The method according to claim 2 or 3, The capsule capping member provided at the front of the capsule carrying means has an upper member formed of a structure capable of lifting and lowering the capsule fixing grooves respectively formed on both sides of the upper and lower sides so as to simultaneously fix capsules of different sizes, and in the same vertical line as the upper member. It is composed of the lower member is fixedly installed so as to be located in the upper and lower ends of the upper and lower members to generate a predetermined vacuum pressure in the capsule fixing groove formed in the inner side of the upper and lower members to be fitted in the fixed Vacuum injection means for generating a vacuum pressure to discharge the capsule or to open and close the capsule lid; Automatic injection device for drug solution injected into the capsule, characterized in that the connection structure is installed. The method according to claim 2 or 3, The capsule discharging means is lifted to a height located at the bottom of the upper material to receive the capsule moved by the upper material of the capsule carrying means and the discharge plate supporting member is formed in the rear end of the capsule discharge hole, the capsule is inserted in the front The capsule discharge plate is provided with a capsule insertion hole to be slidable back and forth on the upper surface of the discharge plate support member, and the capsule discharged from the rear discharged capsule discharge plate is disposed on the upper surface of the base plate. Automatic injection device for pharmaceutical solution injected into the capsule, characterized in that consisting of; consisting of a tube-shaped capsule discharge tube installed in the length from the bottom surface of the discharge plate supporting member to the top of the lead container to fall inside the lead container provided in the. The method according to claim 2 or 3, The solution injection means is connected to the medicine solution supply means and the washing water supply means and the injection solution control unit receives the drug solution or the wash water, and the medicine or washing water injected from the injection solution control unit into the capsule or discharged to the wash recovery means Automatic injection device for drug solution injected into the capsule, characterized in that consisting of a configuration provided with a solution injection for. The method of claim 5, The upper member of the capsule capping member has a structure in which the head portion can be sunk so that the upper body of the lower member is elastically contacted with the lower member to open and close the capsule lid so that the force is not applied to the capsule body. Automatic injection device for drug solution injected into the capsule, characterized in that the elastic spring is provided.

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