CN209149830U - I131 protection and automatic medicine distribution device - Google Patents
I131 protection and automatic medicine distribution device Download PDFInfo
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- CN209149830U CN209149830U CN201821617494.8U CN201821617494U CN209149830U CN 209149830 U CN209149830 U CN 209149830U CN 201821617494 U CN201821617494 U CN 201821617494U CN 209149830 U CN209149830 U CN 209149830U
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- mother liquor
- bottle
- syringe needle
- automatic
- activity meter
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Abstract
The utility model relates to a kind of I131 protection and automatic medicine distribution devices, including mother liquor protection medicinal cupping height room living and draught cupboard and hot cell, operating platform has the rear activity meter well with the medicinal cupping mouth of mother liquor protection medicinal cupping cooperation and the preceding built-in activity meter well with containing mark transparent glass medicine bottle and the built-in well inner injector with automatic push-pull mechanism or micropump；Video camera or optical sight glass of the preceding activity meter well with shooting containing mark；Well inner injector connects ready for injection device and capillary and injection or injection syringe needle by automatic terminal triple valve, saline container and the suction medicine syringe needle of medicine bottle is connect with delivering a child to manage by automatic tee valve, the injection syringe needle of medicine bottle connects the absorption syringe needle of mother liquid multi-cavity bottle, and the air syringe needle of mother liquid multi-cavity bottle connects the manual three-way valve with air filter and syringe.Energy real-time detection medicine liquid volume and activity, the good advantage of protective.
Description
Technical field
The utility model relates to a kind of protection dispensing apparatus of human nuclide drug, more particularly to a kind of I131 protection and
Automatic medicine distribution device.
Background technique
Radio nuclide therapy is the electricity of the core ray (mainly β ray) emitted in decay process using nucleic
Inhibit or destroy a kind for the treatment of method of pathological tissues from the biological effects of radiation.It is controlled from nineteen forty-two Hailton etc. using I131
Since treating hyperthyroidism (hyperthyroidism), I131 is widely used in the field of nuclear medicine.Except being conventionally used as
Outside clinical examination thyroid function and radionuclide imaging in diagnosis, it is more used for hyperthyroidism, function certainly at present
Main property thyroid adenoma and hyperthyroidism, toxicity or non-toxic multinodular goiter, differentiated thyroid carcinoma Postoperative Residual thyroid gland
The radiotherapy of the diseases such as tissue and differentiated thyroid carcinoma transfer stove.
Thyroid cancer is the most common malignant tumour in endocrine system and head and neck neoplasm, main pathological point
For papillary carcinoma and filter blocking cancer, referred to as differentiated thyroid carcinoma (DTC).Past 10 years, thyroid cancer had become morbidity and increases
One of fastest malignant tumour.In the cancer ranking spectrum in every country and area, thyroid cancer precedence last decade is continuous
Rise, morbidity growth rate ranks women first.At present, the global posture that thyroid cancer morbidity increases in " tidal bore ", respectively
Type, each morbidity of thyroid cancer by stages increase and the number of accepting for medical treatment are made constantly to increase.The U.S. in 2011 is more than 48000 and is examined
Break as thyroid cancer, the same year whole world is more than 200000 and is diagnosed as thyroid cancer.South Korea's thyroid cancer incidence was from 2001
9 times were increased by 2011.Wherein the growth rate of thyroid papillary carcinoma (PTC) is most fast, and the growth of PTC is thyroid cancer
The principal element of growth, other types thyroid cancer composition ratio then decline year by year.
The main means for the treatment of DTC patient include operative treatment, thyrotropic hormone (TSH) suppression therapy both at home and abroad
With131Three kinds of I internal radiotherapy, and the treatment means such as molecular targeted therapy, radiotherapy, biological therapy, herbal treatment are in recent years
It is very fast also to develop.Radioiodine therapy (I131) is mainly used for the postoperative patient of DTC, the basic principle is that utilizing thyroid gland
The characteristic of the ingestible radioiodine element of cell, using the parathyroid tissue of the radioiodine element removal postoperative remaining of DTC patient
And cancer cell, to prevent and reduce the recurrence or transfer of DTC.The postoperative use in conjunction I131 treatment of DTC patient can effectively remove
Fail the neoplasm metastasis removed in remaining tissue and art in operation.DTC has just been used successfully to early in nineteen forty-six I131
Treatment, by many decades clinical practice and summary of experience in clinic application it is very mature, as thyroid cancer is sent out
Sick rate increases, and the trend of growth will be also presented in application.
I131 can emit β ray and gamma-rays, and volatility is extremely strong, require divulging information during dispensing and sending medicine
It is carried out in cabinet, and pays attention to the irradiation of β ray and gamma-rays to staff, using special protection glasses and lead brick shield etc..Mesh
There are mainly two types of preceding common medications: compartment operation automatic chemical feeding device and packing protective ventilation cupboard by hand/give automatically
Medicine, these equipment expose number of drawbacks in long-term use, are not able to satisfy clinical demand increasingly.
The automatic chemical feeding device of compartment operation at present, liquid line cannot mostly be replaced, easy to breed in use process
Bacterium, mould, pipeline residual dose cannot detect, and integral protection performance is poor, and administration cannot remove volatilization disperse in time simultaneously
I131。
I131 dispenses protective ventilation cupboard medical and technical staff's manual application, and protective performance is poor, and the arm of operator will receive more
Secondary inevitable radiation, moment large dosage, which can also penetrate protective lead-glass, makes the vitals such as operator's crystal, thyroid gland
It is irradiated by large area, it is poor that there are protective performances, and pipeline, which can not replace, remain dose to detect, dosage and volume feelings
Condition is unable to the problems such as real-time monitoring.Using the protective ventilation cupboard of automatic chemical feeding device, without remnants dose detection function, to being divided
The medical fluid situation of dress cannot accomplish the real-time monitoring of volume and activity, be easy to cause error, patient's medication dose inaccuracy, separately
Outside, built-in biography pencil road cannot equally be replaced, bacterium easy to breed, mould etc..
Summary of the invention
The utility model aim is to overcome the drawbacks described above of the prior art, provide it is a kind of can medicine liquid volume and activity in real time
Detection, protective performance is good, facilitates I131 protection and the automatic medicine distribution device of operation, can also claim to dispense instrument.Certainly, this I131 is protected
And automatic medicine distribution device can be used for the packing of other human nuclide drugs.
To achieve the above object, the utility model I131 protection and automatic medicine distribution device include being protected by interior with collective's mother liquor
The preceding double door height of medicinal cupping hoistable platform room living and configure negative-pressure air fan preceding double door draught cupboard and on connect and connect height under draught cupboard
The vertical shielding that the hot cell of room living is constituted dispenses cabinet, is formed with and collective's mother liquor on the operating platform between hot cell and below high room living
The medicinal cupping mouth and be provided with preceding activity meter well and rear activity meter well that protective drug tank top cooperates；The built-in band capacity of preceding activity meter well is carved
The transparent glass medicine bottle of degree, preceding activity meter well side are configured with for medical fluid containing mark in captured in real-time transparent glass medicine bottle
Video camera or the optical sight glass that video camera is received by optical path, preceding activity meter well configure activity measurement below transparent glass medicine bottle
Probe；The built-in well inner injector with automatic push-pull mechanism or micropump of activity meter well, well inner injector are prolonged by capillary afterwards
Triple valve on the rear activity meter well with automatic executive device is connect, triple valve goes backward through capillary and with holding automatically on rear activity meter well
The terminal triple valve of row device receives ready for injection device and capillary and injection or injection syringe needle, and triple valve is backward on rear activity meter well
Triple valve on preceding activity meter well by capillary and with automatic executive device, triple valve is advanced through capillary on preceding activity meter well
Physiological saline container is received, the suction medicine syringe needle for being inserted to bottom in bottle is inserted on the bottle closure of rubber of transparent glass medicine bottle and is inserted in bottle
The emptying syringe needle and injection syringe needle at top, triple valve, which passes downwardly through capillary and receives, on preceding activity meter well inhales medicine syringe needle, syringe needle
Head is received from the mother liquor that medical fluid is drawn at the mother liquid multi-cavity bottle bottom that collective's mother liquor protects in medicinal cupping by capillary and micropump and draws syringe needle；
Or injection syringe needle receives the mother liquor suction needle that medical fluid is drawn from the mother liquid multi-cavity bottle bottom that collective's mother liquor protects in medicinal cupping by capillary
Head receives air by capillary to the air syringe needle of mother liquid multi-cavity bottle inner top injection air and injects multiple-way valve, air injection
The air intlet of multiple-way valve receives the air implant operation mouth mating manual operation injection of air filter, air injection multiple-way valve
Device.It uses computer control system, and single unit system is three-decker, completes automatic subpackaging administration.Bottom is carrying radioactivity
The automatic rising-sinking platform of drug lead can, centre are flat to be integrated with activity meter, pipe passage, the miniature pump housing, optical sight glass and operation
The hot cell of the key facilities such as platform, upper layer are containing ventilation, the isostructural draught cupboard of manipulator.Micropump or the driving of automatic push-pull mechanism
Radiopharmaceutical mother liquor passes through capillary into preceding activity meter or simple activity meter collection in preceding activity meter perhaps simple activity meter
At on the operational platform, position is on the side of radiopharmaceutical protection medicinal cupping.Interconnecting tube road is replaceable, and connecting line is
Capillary channel has fixed inner diameter and length, so, residual dose is fixed, and is deducted when taking medicine and calculating；Connecting line is equal
For replaceable mounting means, piping material is easy to get, and replacement operation is simple and convenient, does not easily cause radioactive pollution.In real time with energy
The advantages of medicine liquid volume and activity detection, protective benefits are high, facilitate operation.Certainly, this I131 protection and automatic medicine distribution device
It can be used for the packing of other human nuclide drugs.
As optimization, a transparent lead glass window, transparent lead glass window two sides are configured before hot cell in the middle part of alpha ray shield door
Hand hole of each configuration one respectively with transparent lead glass door, operator protrudes into through hand hole to wear the both hands of radiation protection gloves and beats
It opens and removes collective's mother liquor protective drug cover, sterilized to mother liquid multi-cavity bottle bottle closure of rubber, mother liquor absorption syringe needle is inserted to mother liquid multi-cavity bottle bottom and is incited somebody to action
Air syringe needle is inserted to mother liquid multi-cavity bottle inner top；Or the hot cell ceiling between hot cell and draught cupboard is configured to open downwards and move
It walks collective's mother liquor protective drug cover and is sterilized to mother liquid multi-cavity bottle bottle closure of rubber and mother liquor absorption syringe needle is inserted to oneself of mother liquid multi-cavity bottle bottom
Dynamic or hand operating mechanism hand；Or and mother liquor absorption syringe needle is inserted to mother liquid multi-cavity bottle bottom and injects air into syringe needle and is inserted to mother liquid multi-cavity bottle
The automatic or manual manipulator of inner top.
It is cannula structure that the mother liquor that micropump is received, which draws syringe needle, and the casing of root forms ventilation hole on rubber stopper,
Keep the gas pressure in mother liquid multi-cavity bottle identical as in hot cell.After protection medicinal cupping equipped with radiopharmaceutical mother liquor is sent to high room living, doctor
After skill operator will protect medicinal cupping to be placed on automatic rising-sinking platform, protection medicinal cupping rises in hot cell automatically, protects medicinal cupping
Upper surface and operating platform it is horizontal.Manipulator will protect Bottle & Can lid to automatically open and remove, and be completed at the same time radiopharmaceutical mother
The disinfection of liquid bottle bottle closure of rubber.Needle tip automatic puncturing to radiopharmaceutical mother liquid multi-cavity bottle bottom of bottle, is loaded on by manipulator in advance
Puncture needle on mechanical arm is cannula structure, and the casing of root forms ventilation hole on rubber stopper, makes the gas in mother liquid multi-cavity bottle
Pressure is identical as in hot cell.The puncture process strength of manipulator is mild and ensures that bottle bottom is not punctured and causes bottom of bottle rupture leakage
Liquid accident.
As optimization, hot cell hinged one transparent lead glass inside door with two sides hand hole on the inside of alpha ray shield door；Mother liquor
It draws syringe needle to be loaded in advance on the robotic arm, and mother liquor is drawn and configures buffer spring between syringe needle and mechanical arm and for perceiving
Mother liquor draws the pressure sensor of syringe needle resistance when being inserted into mother liquid multi-cavity bottle bottom, and pressure sensor is electrically connected the controller of mechanical arm.
As optimization, video camera is electrically connected configuration in hot cell or the display screen of hot cell side, optical sight glass or video camera
On the path parallel with volume markings, the volume of mother liquor in mother liquid multi-cavity bottle and situation of change are projected at display screen in real time
On.
As optimization, collective's mother liquor protects medicinal cupping hoistable platform and automatic executive device and automatic push-pull mechanism or micropump,
It is electrically connected microcomputer with activity measurement probe, micro electronmechanical be used in conjunction needs dosage number in the real-time volume and activity of input mother liquor and patient
According to input keyboard.
As optimization, automatic push-pull mechanism or micropump are furnished with micro-processor controlled stepper motor, under injection or injection syringe needle
Side is configured with container is taken orally, and the draught cupboard above hot cell is configured with top suction type negative-pressure air fan and equipped in independent loops wind system
Circulating fan.
As optimization, it is configured in the middle part of the rear transparent lead glass window in hot cell and picks and places oral container for patient or hold out into
That is injected is formed with the transparent lead glass door of hand hole, and vertical shielding packing cabinet sealing is inlaid in packaging operation room and patient takes medicine
On division wall between room.Transparent lead glass window connection patient medication platform afterwards.
As optimization, hot cell on the outside of one side configured with the overhanging arm for hanging physiological saline container, the one of draught cupboard
The peep hole for installing transparent lead glass is formed in fan button fly front.
As optimization, collective's mother liquor protection medicinal cupping hoistable platform be high living room front and back bottom beam between be fixedly mounted with match respectively upwards
The front and back track backplate of front and back fluctuating orbit is set, the lifting seat that vertical slide fit is supported by electric putter between the fluctuating orbit of front and back rises
It drops seat and protects medicinal cupping cradle upwardly through longitudinal slide rail and longitudinally reciprocal actuator configuration collective mother liquor.Longitudinally reciprocal driving
Mechanism is that electric putter is hinged between cradle and lifting seat.Cradle front end is formed with collective's mother liquor protection medicinal cupping baffle.Collective
Mother liquor protection medicinal cupping baffle and preceding track backplate are all located at the preceding double door inside of high room former configuration living.Lifting seat connects downwards
The upper push-rod end of electric putter, the base portion of electric putter are fixedly mounted with or support on the ground or be packed in the vertical thick stick being connected between the bottom beam of front and back
On.
As optimization, it is that empty water injects four-way valve that air, which injects multiple-way valve, and the air inlet of empty water injection four-way valve is logical
It crosses capillary and receives air syringe needle, the air intlet of empty water injection four-way valve receives air filter, and empty water injects four-way
The cleaning water inlet of valve receives physiological saline container by capillary.
The function and composed structure of preceding activity meter or simple activity meter: the glass medicine bottle of a 30ml, glass are loaded with
Bottom of bottle face and horizontal plane form 15 ° of -30 ° of angles, and bottle body bottom liquid forms effective cone, is conducive to evacuate liquid in bottle,
Effect is more preferable.On the shell of 30ml vial, it is carved with the clear graduation apparatus parallel with fluid level in bottle, the corresponding liquid of the scale
Ml face indicates the volume of liquid in bottle, i.e.,.In glass medicine bottle bottom, vertical direction is equipped with the spy of semiconductor die bulk measurement
Head can accurately detect the activity of carrier fluid in bottom of bottle.The activity meter calibrating of mistake of the activity meter through measurement verification, i.e. transmitting meter
Amount standard, can be simple and effective the activity of hydrolysis mother liquor.Optical sight glass is housed on the parallel path of volume markings, it can be real-time
The volume of mother liquor in bottle and situation of change are projected on a display screen.
Medical and technical staff pass through preceding activity meter or simple activity meter, can grasp the real-time volume and activity of mother liquor, then will
Data are input in subpackage apparatus or packing instrument control system by operation interface, and system has the automatic computing function of nucleic decay,
The packing volume of required dose (activity) can be calculated in real time, and needs dosage to be automatically performed drug dispensing mistake according to patient at any time
Journey.
Afterwards activity meter or through measurement verification activity meter integrated installation on the operational platform, measure well head and operating platform same
One is horizontal.Afterwards activity meter or through measurement verification activity meter on the side of preceding activity meter or simple activity meter, to prevent itself and preceding work
Mutually influenced testing result by photograph when degree meter or the measurement of simple activity meter, be equipped between the lead sealing of 60mmpb mutually every
From avoiding influencing each other.Automatic push-pull mechanism or the miniature pump housing are mounted on rear activity meter or the activity meter measurement through measurement verification
In well, medical and technical staff can see the accurate activity (mCi or MBq number) of pump output total amount every time.Medical fluid is exported to patient every time
When oral, the dose exported is every pump delivery, and the medical fluid after the defeated good or pump of automatic push-pull mechanism urges syringe is good is after
Activity meter or through measurement verification activity meter detection after output injection to take orally container in.Automatic push-pull mechanism or the miniature pump housing use
Stepper motor drives pump work.
The present apparatus is Double-insurance structure, preceding activity meter or simple activity meter and rear activity meter or through measurement verification activity meter it
Between have amendment calibration function.Administration overall process complies fully with the radiation protection requirement of laws and regulations: draught cupboard front is 70mmpb,
Bottom is 50mmpb, and two sides and behind are 30mmpb, top 20mmpb, equipped with circulating fan each one in negative-pressure air fan and hundred grades
Platform has independent circulation air control system, it is ensured that drug dispensing process is completed under the conditions of hundred grades, and medical and technical staff can supervise by lead glass
Depending on patient pill taker.
Room where patient is isolated with staff room by ventilating kitchen, disperse of volatilizing after patient's medication131I will not
Staff is damaged.
The course of work: 1, after the protection medicinal cupping equipped with radiopharmaceutical mother liquor is sent to high room living, medical technologies operator will prevent
Shield medicinal cupping is placed on automatic rising-sinking platform, and radiopharmaceutical protection medicinal cupping rises in hot cell automatically, protects the upper surface of medicinal cupping
With operating platform level.2, protection Bottle & Can is automatically opened and removes the disinfection for being completed at the same time mother liquid multi-cavity bottle rubber bottle cap by manipulator.
3, manipulator is by needle tip automatically through mother liquid multi-cavity bottle bottom of bottle, and the puncture cannula needle cannula being loaded on the robotic arm is in rubber lid
Upper formation deflation aperture, keeps the atmospheric pressure in mother liquid multi-cavity bottle identical as in hot cell.4, mother liquor enters by protection medicinal cupping by capillary
In glass medicine bottle in the simple activity meter in side, 15 DEG C of angles of medicine bottle inclination, which make bottle body bottom liquid form effective centrum, to be beneficial to take out
Sky is watched the volume change situation of mother liquor on a display screen in real time by optical sight glass, is installed by glass medicine bottle bottom
Semiconductor crystal measuring probe accurately detects the activity of carrier fluid in bottom of bottle.The real-time volume and activity of mother liquor, by staff
It is input in subpackage apparatus or packing instrument control system from operation interface, system has the automatic computing function of nucleic decay, can be real
When calculate the packing volume of required dose (activity).5, packing volume passes through the micro- of step motor control by control system output
The type pump housing pumps out or drives syringe output, the miniature pump housing or automatic push-pull by the automatic push-pull mechanism of step motor control
Mechanism is mounted in CRC-25R activity meter well, and the medical fluid after pump is good is detected by CRC-25R, and medical and technical staff verify every pump output
It is oral to patient in output injection to oral container after the accurate activity of total amount.
Compared with prior art, solve protective performance present in clinical I131 drug dispensing and administration process is poor, pipeline without
Method replacement, dose cannot detect residual, medical fluid situation is unable to the outstanding questions such as real-time monitoring.It is anti-to be that a kind of I131 has
The automation drug dispensing device of protective function, have fully automated unattended operation, protective performance it is good, packing medical fluid real-time monitoring, pipeline
The advantage that replaceable cleanliness is high, packing is accurate, production method is simple, at low cost, is able to satisfy routine clinical diagnosis and treatment requirement, is administered
Overall process complies fully with the requirement of laws and regulations, and easily operated, easily controllable.
Detailed description of the invention
Fig. 1 is the side of the utility model I131 protection and the first embodiment of automatic medicine distribution device when cradle stretches out
To structural schematic diagram；Fig. 2 and 3 and 5 is the utility model I131 protection and automatic medicine distribution device the first embodiment in height
Forward structure schematic diagram when room and hot cell and draught cupboard front door living are opened；Fig. 4 is the utility model I131 protection and automatic point
The first embodiment backsight structural representation of medicine device；Fig. 6 is the utility model I131 protection and automatic medicine distribution device first
The Structure of Drug Flow schematic illustration of kind embodiment.Fig. 7 is that the utility model I131 protection and second of automatic medicine distribution device are real
Apply the Structure of Drug Flow schematic illustration of mode.
Specific embodiment
Embodiment one, as shown in figures 1 to 6, the utility model I131 protection and automatic medicine distribution device include by interior with collective
Mother liquor protects the preceding double door height of medicinal cupping hoistable platform room 1 living and configures the preceding double door draught cupboard 3 of negative-pressure air fan and prolong upwards
It connects draught cupboard 3 and receives the vertical shielding packing cabinet that the hot cell 2 of high room 1 living is constituted downwards, between hot cell 2 and below high room 1 living
Be formed on operating platform 4 with the medicinal cupping mouth 50 that cooperates at the top of collective's mother liquor protection medicinal cupping 5 and before being provided with activity meter well 60 and after
Activity meter well 70；The built-in transparent glass medicine bottle 6 with containing mark of preceding activity meter well 60, preceding 60 side of activity meter well configuration are useful
The optical sight glass of video camera is received in the video camera of medical fluid containing mark in captured in real-time transparent glass medicine bottle 6 or by optical path,
Preceding activity meter well 60 configures activity measurement probe below transparent glass medicine bottle 6；Activity meter well 70 is built-in afterwards matches automatic push-pull machine
The well inner injector 81 of structure or micropump, well inner injector 81 are received on the rear activity meter well with automatic executive device by capillary
Triple valve 91, on rear activity meter well triple valve 91 go backward through capillary and the terminal triple valve 92 with automatic executive device receive it is standby
With syringe 82 and capillary and injection or injection syringe needle 31, on rear activity meter well triple valve 91 go backward through capillary and with from
Triple valve 93 on the preceding activity meter well of actuator is moved, triple valve 93 is advanced through capillary and receives physiological saline on preceding activity meter well
Container 10 is inserted with the suction medicine syringe needle 32 for being inserted to bottom in bottle on the bottle closure of rubber of transparent glass medicine bottle 6 and is inserted to bottle inner top
It is vented syringe needle 33 and injection syringe needle 34, triple valve 93, which passes downwardly through capillary and receives, on preceding activity meter well inhales medicine syringe needle 32, injection
Syringe needle 34 is received from the mother liquor that medical fluid is drawn at 30 bottom of mother liquid multi-cavity bottle that collective's mother liquor protects in medicinal cupping 5 by capillary and draws syringe needle
35, air is received by capillary to the air syringe needle 36 of 30 inner top of mother liquid multi-cavity bottle injection air and injects multiple-way valve 94, it is empty
The air intlet of gas injection multiple-way valve 94 receives the air implant operation mouth mating of air filter 99, air injection multiple-way valve 94
Syringe 83 is manually operated；It is also possible to injection syringe needle to receive out of collective's mother liquor protection medicinal cupping by capillary and micropump
The mother liquor that medical fluid is drawn at mother liquid multi-cavity bottle bottom draws syringe needle.It uses computer control system, and single unit system is three-decker, completes certainly
Dynamic packing administration.Bottom is the automatic rising-sinking platform for carrying radiopharmaceutical lead can, and centre is to be integrated with activity meter, pipeline stream
The hot cell of the key facilities such as road, the miniature pump housing, optical sight glass and operating platform, upper layer are isostructural logical containing ventilation, manipulator
Wind cupboard.Automatic push-pull mechanism or micropump driving radiopharmaceutical mother liquor pass through capillary and enter preceding activity meter or simple activity
In meter, preceding activity meter or simple activity meter are integrated on the operational platform, and position is on the side of radiopharmaceutical protection medicinal cupping.It is interior
Portion's connecting line is replaceable, and connecting line is capillary channel, has fixed inner diameter and length, so, residual dose is fixed,
Medication is deducted when calculating；Connecting line is replaceable mounting means, and piping material is easy to get, and replacement operation is simple and convenient,
Do not easily cause radioactive pollution.The advantages of with that medicine liquid volume and activity can detect in real time, protective benefits are high, facilitate operation.
It is specific: to configure transparent lead glass window 51, a transparent lead glass in the middle part of the 2 opaque alpha ray shield door 21 in front of hot cell
51 two sides of window respectively configure a hand hole 11 respectively with transparent lead glass door 22, the hot cell ceiling between hot cell 2 and draught cupboard 3 to
Under be configured to open remove collective's mother liquor protection medicinal cupping 5 lid, to 30 bottle closure of rubber of mother liquid multi-cavity bottle disinfection, by mother liquor draw syringe needle 35
It is inserted to 30 bottom of mother liquid multi-cavity bottle and injects air into the automatic or manual manipulator that syringe needle 36 is inserted to 30 inner top of mother liquid multi-cavity bottle.It can also
The both hands opening for wear radiation protection gloves with to be operator through hand hole protrude into removes collective's mother liquor protective drug cover and to female
It the disinfection of liquid bottle bottle closure of rubber and mother liquor absorption syringe needle is inserted to mother liquid multi-cavity bottle bottom and injects air into syringe needle and be inserted in mother liquid multi-cavity bottle pushes up
Portion.
It is cannula structure that the mother liquor that micropump is received, which draws syringe needle, and the casing of root forms ventilation hole on rubber stopper,
Keep the gas pressure in mother liquid multi-cavity bottle identical as in hot cell.After protection medicinal cupping equipped with radiopharmaceutical mother liquor is sent to high room living, doctor
After skill operator will protect medicinal cupping to be placed on automatic rising-sinking platform, protection medicinal cupping rises in hot cell automatically, protects medicinal cupping
Upper surface and operating platform it is horizontal.Manipulator will protect Bottle & Can lid to automatically open and remove, and be completed at the same time radiopharmaceutical mother
The disinfection of liquid bottle bottle closure of rubber.Needle tip automatic puncturing to radiopharmaceutical mother liquid multi-cavity bottle bottom of bottle, is loaded on by manipulator in advance
Puncture needle on mechanical arm is cannula structure, and the casing of root forms ventilation hole on rubber stopper, makes the gas in mother liquid multi-cavity bottle
Pressure is identical as in hot cell.The puncture process strength of manipulator is mild and ensures that bottle bottom is not punctured and causes bottom of bottle rupture leakage
Liquid accident.Hot cell 2 is in the 21 hinged transparent lead glass inside door 23 with two sides hand hole 11 in inside of alpha ray shield door；Mother liquor is drawn
Syringe needle is loaded on the robotic arm in advance, and mother liquor is drawn and configures buffer spring between syringe needle and mechanical arm and for perceiving mother liquor
Draw the pressure sensor of syringe needle resistance when being inserted into mother liquid multi-cavity bottle bottom, pressure sensor is electrically connected the controller of mechanical arm.
Video camera is electrically connected configuration in hot cell 2 or the display screen of 2 side of hot cell, optical sight glass or video camera is mounted in and body
On the parallel path of product scale, the volume of mother liquor in mother liquid multi-cavity bottle and situation of change are projected on a display screen in real time.
Collective's mother liquor protects 5 hoistable platform of medicinal cupping and automatic executive device and automatic push-pull mechanism or micropump and activity to survey
The microcomputer that is electrically connected of popping one's head in is measured, micro electronmechanical be used in conjunction needs the input of dosage data in the real-time volume and activity of input mother liquor and patient
Keyboard.
Automatic push-pull mechanism or micropump are furnished with micro-processor controlled stepper motor, are configured with below injection or injection syringe needle 31
The draught cupboard 3 of oral container 39,2 top of hot cell is configured with top suction type negative-pressure air fan and the interior circulation equipped with independent loops wind system
Blower.
It is configured with to pick and place oral container for patient or hold out into the middle part of the rear transparent lead glass window in hot cell 2 and inject
The transparent lead glass door 22 for being formed with hand hole 11, vertical shielding packing cabinet sealing is inlaid in packaging operation room and patient takes medicine room it
Between division wall on.Transparent lead glass window connection patient medication platform afterwards.
Hot cell 2 is configured with the overhanging arm 19 for hanging physiological saline container 10 to one side outside, before the one of draught cupboard 3 fans
The peep hole 12 for being equipped with transparent lead glass is formed in enabling.
Collective's mother liquor protection medicinal cupping hoistable platform be high living room 1 front and back bottom beam between be fixedly mounted with upwards and front and back is respectively configured rises
The front and back track backplate 41 of track drops, and vertical slide fit lifting seat 42 between the fluctuating orbit of front and back, connection electricity pushes away lifting seat 42 downwards
The upper push-rod end of bar, the base portion of electric putter are fixedly mounted with or support on the ground or be packed on the vertical thick stick being connected between the bottom beam of front and back,
Lifting seat 42 protects medicinal cupping cradle 43 upwardly through longitudinal slide rail and longitudinally reciprocal actuator configuration collective mother liquor.It is longitudinal past
Multiple driving mechanism is to be hinged with electric putter between cradle 43 and lifting seat 42.43 front end of cradle is formed with collective's mother liquor protective drug
Tank baffle 44.Collective's mother liquor protection medicinal cupping baffle 44 and preceding track backplate 41 are all located at the preceding double door of high 1 former configuration of room living
Inside.
The function and composed structure of preceding activity meter or simple activity meter: the glass medicine bottle of a 30ml, glass are loaded with
Bottom of bottle face and horizontal plane form 15 ° of -30 ° of angles, and bottle body bottom liquid forms effective cone, is conducive to evacuate liquid in bottle,
Effect is more preferable.On the shell of 30ml vial, it is carved with the clear graduation apparatus parallel with fluid level in bottle, the corresponding liquid of the scale
Ml face indicates the volume of liquid in bottle, i.e.,.In glass medicine bottle bottom, vertical direction is equipped with the spy of semiconductor die bulk measurement
Head can accurately detect the activity of carrier fluid in bottom of bottle.The activity meter calibrating of mistake of the activity meter through measurement verification, i.e. transmitting meter
Amount standard, can be simple and effective the activity of hydrolysis mother liquor.Optical sight glass is housed on the parallel path of volume markings, it can be real-time
The volume of mother liquor in bottle and situation of change are projected on a display screen.
Medical and technical staff pass through preceding activity meter or simple activity meter, can grasp the real-time volume and activity of mother liquor, then will
Data are input in subpackage apparatus or packing instrument control system by operation interface, and system has the automatic computing function of nucleic decay,
The packing volume of required dose (activity) can be calculated in real time, and needs dosage to be automatically performed drug dispensing mistake according to patient at any time
Journey.
Afterwards activity meter or through measurement verification activity meter integrated installation on the operational platform, measure well head and operating platform same
One is horizontal.Afterwards activity meter or through measurement verification activity meter on the side of preceding activity meter or simple activity meter, to prevent itself and preceding work
Mutually influenced testing result by photograph when degree meter or the measurement of simple activity meter, be equipped between the lead sealing of 60mmpb mutually every
From avoiding influencing each other.Automatic push-pull mechanism or the miniature pump housing are mounted on rear activity meter or the activity meter measurement through measurement verification
In well, medical and technical staff can see the accurate activity (mCi or MBq number) of every pump output total amount.Medical fluid is exported every time to patient mouthful
When taking, the dose exported is every pump delivery, and the medical fluid after the defeated good or pump of automatic push-pull mechanism urges syringe is good is living after
Degree is counted or after the detection of measurement verification activity meter in output injection to oral container.Automatic push-pull mechanism or the miniature pump housing use step
Into motor driven pump work.
The present apparatus is Double-insurance structure, preceding activity meter or simple activity meter and rear activity meter or through measurement verification activity meter it
Between have amendment calibration function.Administration overall process complies fully with the radiation protection requirement of laws and regulations: draught cupboard front is 70mmpb,
Bottom is 50mmpb, and two sides and behind are 30mmpb, top 20mmpb, equipped with circulating fan each one in negative-pressure air fan and hundred grades
Platform has independent circulation air control system, it is ensured that drug dispensing process is completed under the conditions of hundred grades, and medical and technical staff can supervise by lead glass
Depending on patient pill taker.
Room where patient is isolated with staff room by ventilating kitchen, disperse of volatilizing after patient's medication131I will not
Staff is damaged.
The course of work: 1, after the protection medicinal cupping equipped with radiopharmaceutical mother liquor is sent to high room living, medical technologies operator will prevent
Shield medicinal cupping is placed on automatic rising-sinking platform, and radiopharmaceutical protection medicinal cupping rises in hot cell automatically, protects the upper surface of medicinal cupping
With operating platform level.2, protection Bottle & Can is automatically opened and removes the disinfection for being completed at the same time mother liquid multi-cavity bottle rubber bottle cap by manipulator.
3, manipulator is by needle tip automatically through mother liquid multi-cavity bottle bottom of bottle, and the puncture cannula needle cannula being loaded on the robotic arm is in rubber lid
Upper formation deflation aperture, keeps the atmospheric pressure in mother liquid multi-cavity bottle identical as in hot cell.4, mother liquor enters by protection medicinal cupping by capillary
In glass medicine bottle in the simple activity meter in side, 15 DEG C of angles of medicine bottle inclination, which make bottle body bottom liquid form effective centrum, to be beneficial to take out
Sky is watched the volume change situation of mother liquor on a display screen in real time by optical sight glass, is installed by glass medicine bottle bottom
Semiconductor crystal measuring probe accurately detects the activity of carrier fluid in bottom of bottle.The real-time volume and activity of mother liquor, by staff
It is input in subpackage apparatus or packing instrument control system from operation interface, system has the automatic computing function of nucleic decay, can be real
When calculate the packing volume of required dose (activity).5, packing volume passes through the micro- of step motor control by control system output
The type pump housing pumps out or drives syringe output, the miniature pump housing or automatic push-pull by the automatic push-pull mechanism of step motor control
Mechanism is mounted in CRC-25R activity meter well, and the medical fluid after pump is good is detected by CRC-25R, and medical and technical staff verify every pump output
It is oral to patient in output injection to oral container after the accurate activity of total amount.
Embodiment two, as shown in fig. 7, the utility model I131 protection and the difference of automatic medicine distribution device and embodiment one exist
In: it is that empty water injects four-way valve 95 that air, which injects multiple-way valve, and the air inlet of empty water injection four-way valve 95 is prolonged by capillary
Air syringe needle 36 is connect, the air intlet of empty water injection four-way valve 95 receives air filter 99, and empty water injects four-way valve 95
Cleaning water inlet physiological saline container 20 is received by capillary.
In short, the utility model I131 protection and automatic medicine distribution device are divided into three-decker up and down: bottom installation carrying is anti-
Protect the automatic rising-sinking platform of medicinal cupping；Middle layer is hot cell, integrates preceding activity meter or simple activity meter (containing optical sight glass), rear activity meter
Or the miniature pump housing and protection lead can hoistable platform position, connecting line, machinery of CRC-25R activity meter and step motor control
Hand etc.；Hot cell bottom is operating platform, and there are lead glass window in hot cell front and back, and rear side lead glass window connects patient's medication platform.Behaviour
Make platform equipped with circulating fan, independent air control system in negative-pressure air fan and hundred grades, entire fume hood system is furnished with computer control
System processed.Each layer is all made of national standard protective materials, and reaches requirement of shelter.
Preceding activity meter or simple activity meter are integrated on the operational platform in hot cell, and position is in the side of protection medicinal cupping, mother liquor
Enter in simple activity meter by capillary.Preceding activity meter or simple activity are calculated as being loaded with the 30ml for having tilted 15 DEG C of angles
Glass medicine bottle, load the liquid level that corresponds in bottle on shell and be carved with clearly milliliter graduation apparatus.Glass medicine bottle bottom, vertical direction
Semiconductor crystal measuring probe is installed, can accurately detect the activity of carrier fluid in bottom of bottle, thus simple and effective hydrolysis mother liquor
Activity.It loads beside the milliliter scale that shell corresponds to liquid level in bottle in preceding activity meter or simple activity meter glass medicine bottle equipped with light
Learn sight glass, can watch on a display screen in real time mother liquor ml and situation of change.Medical and technical staff pass through simple activity meter,
Data are input in packing instrument control system by the real-time volume and activity that can grasp mother liquor by operation interface, and system has
The automatic computing function of nucleic decay, can calculate the packing volume of required dose (activity), and export the dose at any time in real time
The every pump delivery of the miniature pump housing of fixing fabric structure.Activity meter or CRC-25R activity meter integrated installation measure well on the operational platform afterwards
Mouth is horizontal with operating platform, on the side of simple activity meter.To prevent it from mutually being influenced testing result by photograph with simple activity meter,
The lead sealing of 60mmpb is housed between.There is amendment calibration function between simple activity meter and CRC-25R activity meter.Stepping electricity
The miniature pump housing of machine control is mounted in rear activity meter well or CRC-25R activity meter well, activity meter after the medical fluid warp after pump is good
It is oral to patient in output injection to oral container after well or CRC-25R detection.Medical and technical staff can see every pump output
The accurate activity (mCi) of total amount.
Equipped with circulating fan each one in negative-pressure air fan and hundred grades, there is independent air control system, it is ensured that drug dispensing process is hundred
It is completed under the conditions of grade, draught cupboard front is 70mmpb, and bottom 50mmpb, two sides and behind are 30mmpb, top 20mmpb.
Medical fluid dispenses the operation of process full-automatic unmannedization, and medical and technical staff can see that pill taker takes medicine by front and back lead glass
Process.All connection flowpath conduits are capillary, and internal diameter and length are fixed, and residual dose has been excluded through Forecast and Estimate in medication meter
Outside calculating, another all pipelines are replaceable pipeline, easy to operate.
With fully automated unattended operation, radiation protection efficiency is high, dispense liquid dose and volume real-time monitoring, pipeline can
The high feature of cleanliness is replaced, there is the advantage that packing is accurate, production method is simple, at low cost.
Claims (10)
1. a kind of I131 protection and automatic medicine distribution device, it is characterised in that including protecting medicinal cupping hoistable platform with collective's mother liquor by interior
Preceding double door height room living and configure negative-pressure air fan preceding double door draught cupboard and on connect the hot cell structure that high room living is connect under draught cupboard
At vertical shielding dispense cabinet, be formed with and collective's mother liquor protective drug tank top on the operating platform between hot cell and below high living room
The medicinal cupping mouth of cooperation and it is provided with preceding activity meter well and rear activity meter well；Transparent glass with containing mark built in preceding activity meter well
Medicine bottle, preceding activity meter well side are configured with the video camera for medical fluid containing mark in captured in real-time transparent glass medicine bottle or pass through
Optical path receives the optical sight glass of video camera, and preceding activity meter well configures activity measurement probe below transparent glass medicine bottle；Activity afterwards
The built-in well inner injector with automatic push-pull mechanism or micropump of well is counted, well inner injector is received by capillary and executed with automatic
Triple valve on the rear activity meter well of device, triple valve goes backward through capillary and the terminal three with automatic executive device on rear activity meter well
Port valve receives ready for injection device and capillary and injection or injection syringe needle, on rear activity meter well triple valve go backward through capillary and
Triple valve on preceding activity meter well with automatic executive device, triple valve is advanced through capillary and receives physiological saline on preceding activity meter well
Container is inserted with the emptying needle for being inserted to the suction medicine syringe needle at bottom in bottle and being inserted to bottle inner top on the bottle closure of rubber of transparent glass medicine bottle
Head and injection syringe needle, triple valve, which passes downwardly through capillary and receives, on preceding activity meter well inhales medicine syringe needle, and injection syringe needle passes through capillary
It receives with micropump from the mother liquor that medical fluid is drawn at the mother liquid multi-cavity bottle bottom in collective's mother liquor protection medicinal cupping and draws syringe needle；Or injection syringe needle
It is received by capillary from the mother liquor that medical fluid is drawn at the mother liquid multi-cavity bottle bottom that collective's mother liquor protects in medicinal cupping and draws syringe needle, into mother liquid multi-cavity bottle
Top injection air air syringe needle by capillary receive air inject multiple-way valve, air injection multiple-way valve air into
Mouth receives the air implant operation mouth mating manual operation syringe of air filter, air injection multiple-way valve.
2. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that before hot cell in alpha ray shield door
Portion configures a transparent lead glass window, transparent lead glass window two sides respectively configure a hand hole respectively with transparent lead glass door；Behaviour
Author protrudes into through hand hole wear the both hands openings of radiation protection gloves and removes collective's mother liquor protective drug cover, to mother liquid multi-cavity bottle rubber
Mother liquor absorption syringe needle is inserted to mother liquid multi-cavity bottle bottom and injects air into syringe needle and be inserted to mother liquid multi-cavity bottle inner top by bottle stopper disinfection；Or hot cell
Hot cell ceiling between draught cupboard, which is configured to open downwards, removes collective's mother liquor protective drug cover and to mother liquid multi-cavity bottle rubber bottle
Plug disinfection and the automatic or manual manipulator that mother liquor absorption syringe needle is inserted to mother liquid multi-cavity bottle bottom；Or and by mother liquor suction needle
Head is inserted to mother liquid multi-cavity bottle bottom and injects air into the automatic or manual manipulator that syringe needle is inserted to mother liquid multi-cavity bottle inner top；
It is cannula structure that the mother liquor that micropump is received, which draws syringe needle, and the casing of root forms ventilation hole on rubber stopper, makes mother
Gas pressure in liquid bottle is identical as in hot cell.
3. I131 protection and automatic medicine distribution device according to claim 2, it is characterised in that hot cell is on the inside of alpha ray shield door
The hinged one transparent lead glass inside door with two sides hand hole；Mother liquor draws syringe needle and is loaded on the robotic arm in advance, and mother liquor is inhaled
Take the pressure for configuring buffer spring between syringe needle and mechanical arm and drawing resistance when syringe needle is inserted into mother liquid multi-cavity bottle bottom for perceiving mother liquor
Sensor, pressure sensor are electrically connected the controller of mechanical arm.
4. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that video camera is electrically connected configuration in hot cell
Interior or hot cell side display screen, optical sight glass or video camera are on the path parallel with volume markings, in real time by mother liquor
The volume and situation of change of mother liquor project on a display screen in bottle.
5. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that collective's mother liquor protects medicinal cupping lifting
Platform and automatic executive device and automatic push-pull mechanism or micropump and activity measurement probe are electrically connected microcomputer, micro electronmechanical to be used in conjunction in defeated
The real-time volume and activity and patient that enter mother liquor need the input keyboard of dosage data.
6. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that automatic push-pull mechanism or micropump
Equipped with micro-processor controlled stepper motor, configured with container is taken orally below injection or injection syringe needle, the draught cupboard above hot cell is configured
There are top suction type negative-pressure air fan and the interior circulating fan equipped with independent loops wind system.
7. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that the rear transparent lead glass window in hot cell
Middle part, which is configured with, picks and places oral container or the transparent lead glass door for being formed with hand hole injected of holding out into for patient, vertical
Shielding packing cabinet sealing is inlaid on the division wall between packaging operation room and patient's medication room.
8. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that hot cell is configured with to one side outside
For hanging the overhanging arm of physiological saline container, the peep hole for installing transparent lead glass is formed in a fan button fly front of draught cupboard.
9. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that collective's mother liquor protects medicinal cupping lifting
Platform be high living room front and back bottom beam between be fixedly mounted with the front and back track backplate that front and back fluctuating orbit is respectively configured upwards, front and back is gone up and down
The lifting seat that vertical slide fit is supported by electric putter between track, lifting seat is upwardly through longitudinal slide rail and longitudinally reciprocal driving mechanism
It configures collective's mother liquor and protects medicinal cupping cradle.
10. I131 protection and automatic medicine distribution device according to claim 1, it is characterised in that it is empty water that air, which injects multiple-way valve,
Four-way valve is injected, the air inlet of empty water injection four-way valve receives air syringe needle by capillary, and empty water injects four-way
The air intlet of valve receives air filter, and the cleaning water inlet of empty water injection four-way valve receives the physiology salt water capacity by capillary
Device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821617494.8U CN209149830U (en) | 2018-10-01 | 2018-10-01 | I131 protection and automatic medicine distribution device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821617494.8U CN209149830U (en) | 2018-10-01 | 2018-10-01 | I131 protection and automatic medicine distribution device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209149830U true CN209149830U (en) | 2019-07-23 |
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ID=67268733
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821617494.8U Active CN209149830U (en) | 2018-10-01 | 2018-10-01 | I131 protection and automatic medicine distribution device |
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| Country | Link |
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| CN (1) | CN209149830U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110606227A (en) * | 2019-08-05 | 2019-12-24 | 上海盛榕医疗器械科技有限公司 | Full-automatic nuclide subpackaging system and method |
| CN113665895A (en) * | 2021-10-22 | 2021-11-19 | 依贝伽射线防护设备科技(江苏)有限公司 | Radiopharmaceutical operation protector |
| CN117214453A (en) * | 2023-11-07 | 2023-12-12 | 长春迈克赛德医疗科技有限公司 | Sample suction needle system and sample suction method |
-
2018
- 2018-10-01 CN CN201821617494.8U patent/CN209149830U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110606227A (en) * | 2019-08-05 | 2019-12-24 | 上海盛榕医疗器械科技有限公司 | Full-automatic nuclide subpackaging system and method |
| CN110606227B (en) * | 2019-08-05 | 2021-09-03 | 上海盛榕医疗器械科技有限公司 | Full-automatic nuclide subpackaging system and method |
| CN113665895A (en) * | 2021-10-22 | 2021-11-19 | 依贝伽射线防护设备科技(江苏)有限公司 | Radiopharmaceutical operation protector |
| CN113665895B (en) * | 2021-10-22 | 2021-12-17 | 依贝伽射线防护设备科技(江苏)有限公司 | Radiopharmaceutical operation protector |
| CN117214453A (en) * | 2023-11-07 | 2023-12-12 | 长春迈克赛德医疗科技有限公司 | Sample suction needle system and sample suction method |
| CN117214453B (en) * | 2023-11-07 | 2024-04-05 | 长春迈克赛德医疗科技有限公司 | Sample suction needle system and sample suction method |
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