KR100602927B1 - 글루타메이트 수용체로서의 피리미딘, 트리아진 및 피라진유도체 - Google Patents

글루타메이트 수용체로서의 피리미딘, 트리아진 및 피라진유도체 Download PDF

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KR100602927B1
KR100602927B1 KR1020037015685A KR20037015685A KR100602927B1 KR 100602927 B1 KR100602927 B1 KR 100602927B1 KR 1020037015685 A KR1020037015685 A KR 1020037015685A KR 20037015685 A KR20037015685 A KR 20037015685A KR 100602927 B1 KR100602927 B1 KR 100602927B1
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phenyl
formula
carbonitrile
pyrimidine
fluoro
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KR20040003039A (ko
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빙겔리알프레드
마에르키한스-페터
마스켈린티에리
무텔빈센트
윌헴모리스
보스틀볼프강
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에프. 호프만-라 로슈 아게
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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  • Psychiatry (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020037015685A 2001-06-01 2002-05-27 글루타메이트 수용체로서의 피리미딘, 트리아진 및 피라진유도체 Expired - Fee Related KR100602927B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01113379 2001-06-01
EP01113379.0 2001-06-01
PCT/EP2002/005788 WO2002098864A1 (en) 2001-06-01 2002-05-27 Pyrimidine, triazine and pyrazine derivatives as glutamate receptors

Publications (2)

Publication Number Publication Date
KR20040003039A KR20040003039A (ko) 2004-01-07
KR100602927B1 true KR100602927B1 (ko) 2006-07-20

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KR1020037015685A Expired - Fee Related KR100602927B1 (ko) 2001-06-01 2002-05-27 글루타메이트 수용체로서의 피리미딘, 트리아진 및 피라진유도체

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US (1) US6673795B2 (https=)
EP (1) EP1397351B1 (https=)
JP (1) JP4049742B2 (https=)
KR (1) KR100602927B1 (https=)
CN (1) CN1245391C (https=)
AR (1) AR036075A1 (https=)
AT (1) ATE448210T1 (https=)
AU (1) AU2002319183B2 (https=)
BR (1) BR0210102A (https=)
CA (1) CA2448602C (https=)
DE (1) DE60234338D1 (https=)
DK (1) DK1397351T3 (https=)
ES (1) ES2332505T3 (https=)
MX (1) MXPA03010822A (https=)
PT (1) PT1397351E (https=)
WO (1) WO2002098864A1 (https=)
ZA (1) ZA200308859B (https=)

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DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
UA92450C2 (ru) * 2003-01-14 2010-11-10 Арена Фармасьютикалз, Инк. 1,2,3-тризамещенные арильные и гетероарильные производные как модуляторы метаболизма, профилактика и лечение расстройств, связанных с ним, таких как диабет и гипергликемия
SI1599468T1 (sl) * 2003-01-14 2008-02-29 Arena Pharm Inc 1,2,3-trisubstituirani arilni in heteroarilni derivati kot modulatorji metabolizma ter profilaksa in zdravljenje motenj v zvezi z njim, kot diabetesain hiperglikemije
MXPA05007485A (es) * 2003-01-14 2006-01-30 Arena Pharm Inc Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
JP2006521358A (ja) * 2003-03-26 2006-09-21 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体のベンズアミドモジュレータ
DE10320785A1 (de) 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Arylmethyl-substituierte Pyrazolopyrimidine
DE10328479A1 (de) 2003-06-25 2005-01-13 Bayer Ag 6-Arylamino-5-cyano-4-pyrimidinone
AR045047A1 (es) * 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
US7132426B2 (en) 2003-07-14 2006-11-07 Arena Pharmaceuticals, Inc. Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
CA2531619A1 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
PE20050483A1 (es) 2003-10-31 2005-08-25 Arena Pharm Inc Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
SE0303492D0 (sv) * 2003-12-19 2003-12-19 Astrazeneca Ab New use VII
DE102004001873A1 (de) * 2004-01-14 2005-09-29 Bayer Healthcare Ag Cyanopyrimidinone
MY145822A (en) * 2004-08-13 2012-04-30 Neurogen Corp Substituted biaryl piperazinyl-pyridine analogues
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JP5498392B2 (ja) 2007-11-30 2014-05-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用
CN102046609B (zh) * 2008-03-31 2014-05-14 全药工业株式会社 具有细胞保护效果的嘧啶衍生物及其应用
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
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JP4049742B2 (ja) 2008-02-20
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CA2448602C (en) 2009-03-31
ES2332505T3 (es) 2010-02-08
DE60234338D1 (de) 2009-12-24
ATE448210T1 (de) 2009-11-15
US20030060466A1 (en) 2003-03-27
PT1397351E (pt) 2010-01-04
WO2002098864A1 (en) 2002-12-12
EP1397351A1 (en) 2004-03-17
US6673795B2 (en) 2004-01-06
MXPA03010822A (es) 2004-02-17
AU2002319183B2 (en) 2007-05-10
ZA200308859B (en) 2005-02-14
CN1512988A (zh) 2004-07-14
DK1397351T3 (da) 2010-01-18
AR036075A1 (es) 2004-08-11
BR0210102A (pt) 2004-06-08
CN1245391C (zh) 2006-03-15
KR20040003039A (ko) 2004-01-07
CA2448602A1 (en) 2002-12-12

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